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ANATOMY & CLINICAL 
SIGNIFICANCE OF 4TH 
CRANIAL NERVE 
Dr.Ashok Kumar 
Valuroutu
TROCHLEAR NERVE 
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FUNCTIONAL COMPONENTS 
• SOMATIC EFFERENT-concerned with 
movement of eye ball through SO. 
• GENERAL SOMATIC AFFERENT-carries 
proprioceptive impulses from SO which are 
relayed in the mesencephalic nucleus of 5th 
nerve. 
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COURSE AND DISTRIBUTION 
1)Fascicular part 
2)Pre cavernous part 
3)Intra cavernous part 
4)Intra orbital part 
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• SITUATION: at the level of inferior colliculus 
in the ventromedial part of central gray 
metter of midbrain dorsal to medial 
longitudinal bundle. 
• Caudal & continous with 3rd nucleus 
complex. 
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FASCICULAR PART: 
• axons leave the nucleus 
• curve posteriorly around the aquiduct in the 
central greymatter 
• decussate in the anterior medullary velum. 
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PRECAVERNOUS PART: 
leaves the brainstem on the dorsal surface 
just caudal to inferior colliculus 
winds around brainstem 
runs forwards beneath the free edge of 
tentorium 
pierces the dura on the posterior corner of 
the roof of cavernous sinus to enter in to it. 
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INTRACAVERNOUS PART: 
Runs forwards in the lateral wall of the 
sinus,lying below 3rd nerve and above the 1st 
division of 5th nerve. 
In the anterior part of the sinus, it rises, 
crosses over the 3rd nerve 
passes through the superior orbital fissure, 
above and lateral to annulus of zinn. 
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INTRA ORBITITAL PART: 
• Enters the orbit through lateral part of SOF 
• Frontal & lacrimal nerves laterally, 
ophthalmic vein inferiorly. 
• Divides in to fan shaped manner into 3 or 4 
branches 
• Ends by supplying SO on its orbital surface 
near lateral border. 
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CONNECTIONS: 
1)Cerebral cortex 
Motor cortex - cortico nuclear tracts 
Visual cortex - supeior colliculus & tactobulbar 
Frontal eye field. tracts. 
2)Nuclei of 3rd ,6th&8th -MLF 
3)Superior colliculi -descending predorsal bundle 
4)Vertical & torsional gaze centres 
5)Cerebellum - vestibular nuclei. 
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UNIQUE CHARACTERS 
• Only cranial nerve to emerge from dorsal 
aspect of brain. 
• Only crossed cranial nerve 
• Longest Intra cranial course(about 75 mm)& 
thinnest of all cranial nerves 
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CLINICAL FEATURES 
SYMPTOMS: 
• Ac.onset of double vision, 
• Difficulty in going downstairs, 
• Vertigo 
SIGNS: 
• Hyperdeviation ,limitation of depression in adduction, 
• Extorsion, vertical diplopia, 
• Hypertropia on opposite gaze 
• Charecteristic head posture-head 
tilted to opposite side 
face turned towards opposite side 
chin depressed 
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SPECIAL TESTS 
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PARK’S 3 STEP TEST: 
STEP 1: Identify the HYPERTROPIC EYE in 
primary position. 
depressors of hypertropic eye- SO,IR. 
elevators of hypotropic eye-SR,IO. 
STEP 2: Determine whether hypertropia is 
greater in Rt or Lt gaze. 
on Lt gaze Lt SR, Rt.SO 
on Rt gaze Rt IR, Lt IO 
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STEP 3: Tilt the head towards each shoulder, 
look for vertical sqint. 
BEILSCHOWSKY HEAD TILT TEST: 
same principle as the 3rd step of PARK TEST 
Pt fixates, head tilted Rt &Lt 
of Lt hypertropia on Lt head tilt- Lt SO 
of Lt hypertropia on Rt head tilt- Lt IR 
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DOUBLE MADDOX ROD TEST : 
For measuring the degree of cyclodeviation. 
In unilateral palsy – cyclodeviation <10 deg 
In bilateral palsy – cyclodeviation >10 deg 
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Differential Diagnosis of Vertical 
Binocular Diplopia 
• Superior Oblique Palsy 
• Thyroid Ophthalmopathy 
• Myasthenia Gravis 
• Brown Syndrome 
• Orbital fracture with entrapment 
• Cyclovertical paresis or overaction 
• Skew Deviation/Ocular Tilt 
• Dissociated Vertical Deviation 
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Isolated Superior Oblique Palsy 
• Most common etiologies are congenital and 
traumatic 
• Also vascular; less commonly tumor, 
demyelinating 
• In absence of other neurological symptoms 
and presence of vascular risk factors, 
reasonable to observe 
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TREATMENT 
• CONGENITAL:large hypertropia in PP treated by 
SO tucking 
• ACQUIRED: 
SMALL- ipsilateral IO weakening. 
MODERATE- ipsilateral IO weakening with 
ipsilateral SR weakening . 
PURE EXCYCLOTROPIA: without hypertropia – 
HARADA- Ito procedure 
Splitting & ALT OF lateral half of SO tendon. 
Free Template from www.brainybetty.com 29
4th cranial nerve

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4th cranial nerve

  • 1. ANATOMY & CLINICAL SIGNIFICANCE OF 4TH CRANIAL NERVE Dr.Ashok Kumar Valuroutu
  • 2. TROCHLEAR NERVE Free Template from www.brainybetty.com 2
  • 3. FUNCTIONAL COMPONENTS • SOMATIC EFFERENT-concerned with movement of eye ball through SO. • GENERAL SOMATIC AFFERENT-carries proprioceptive impulses from SO which are relayed in the mesencephalic nucleus of 5th nerve. Free Template from www.brainybetty.com 3
  • 4. COURSE AND DISTRIBUTION 1)Fascicular part 2)Pre cavernous part 3)Intra cavernous part 4)Intra orbital part Free Template from www.brainybetty.com 4
  • 5. • SITUATION: at the level of inferior colliculus in the ventromedial part of central gray metter of midbrain dorsal to medial longitudinal bundle. • Caudal & continous with 3rd nucleus complex. Free Template from www.brainybetty.com 5
  • 6. Free Template from www.brainybetty.com 6
  • 7. Free Template from www.brainybetty.com 7
  • 8. FASCICULAR PART: • axons leave the nucleus • curve posteriorly around the aquiduct in the central greymatter • decussate in the anterior medullary velum. Free Template from www.brainybetty.com 8
  • 9. Free Template from www.brainybetty.com 9
  • 10. PRECAVERNOUS PART: leaves the brainstem on the dorsal surface just caudal to inferior colliculus winds around brainstem runs forwards beneath the free edge of tentorium pierces the dura on the posterior corner of the roof of cavernous sinus to enter in to it. Free Template from www.brainybetty.com 10
  • 11. INTRACAVERNOUS PART: Runs forwards in the lateral wall of the sinus,lying below 3rd nerve and above the 1st division of 5th nerve. In the anterior part of the sinus, it rises, crosses over the 3rd nerve passes through the superior orbital fissure, above and lateral to annulus of zinn. Free Template from www.brainybetty.com 11
  • 12. Free Template from www.brainybetty.com 12
  • 13. INTRA ORBITITAL PART: • Enters the orbit through lateral part of SOF • Frontal & lacrimal nerves laterally, ophthalmic vein inferiorly. • Divides in to fan shaped manner into 3 or 4 branches • Ends by supplying SO on its orbital surface near lateral border. Free Template from www.brainybetty.com 13
  • 14. Free Template from www.brainybetty.com 14
  • 15. Free Template from www.brainybetty.com 15
  • 16. Free Template from www.brainybetty.com 16
  • 17. CONNECTIONS: 1)Cerebral cortex Motor cortex - cortico nuclear tracts Visual cortex - supeior colliculus & tactobulbar Frontal eye field. tracts. 2)Nuclei of 3rd ,6th&8th -MLF 3)Superior colliculi -descending predorsal bundle 4)Vertical & torsional gaze centres 5)Cerebellum - vestibular nuclei. Free Template from www.brainybetty.com 17
  • 18. UNIQUE CHARACTERS • Only cranial nerve to emerge from dorsal aspect of brain. • Only crossed cranial nerve • Longest Intra cranial course(about 75 mm)& thinnest of all cranial nerves Free Template from www.brainybetty.com 18
  • 19. CLINICAL FEATURES SYMPTOMS: • Ac.onset of double vision, • Difficulty in going downstairs, • Vertigo SIGNS: • Hyperdeviation ,limitation of depression in adduction, • Extorsion, vertical diplopia, • Hypertropia on opposite gaze • Charecteristic head posture-head tilted to opposite side face turned towards opposite side chin depressed Free Template from www.brainybetty.com 19
  • 20. Free Template from www.brainybetty.com 20
  • 21. SPECIAL TESTS Free Template from www.brainybetty.com 21
  • 22. PARK’S 3 STEP TEST: STEP 1: Identify the HYPERTROPIC EYE in primary position. depressors of hypertropic eye- SO,IR. elevators of hypotropic eye-SR,IO. STEP 2: Determine whether hypertropia is greater in Rt or Lt gaze. on Lt gaze Lt SR, Rt.SO on Rt gaze Rt IR, Lt IO Free Template from www.brainybetty.com 22
  • 23. STEP 3: Tilt the head towards each shoulder, look for vertical sqint. BEILSCHOWSKY HEAD TILT TEST: same principle as the 3rd step of PARK TEST Pt fixates, head tilted Rt &Lt of Lt hypertropia on Lt head tilt- Lt SO of Lt hypertropia on Rt head tilt- Lt IR Free Template from www.brainybetty.com 23
  • 24. Free Template from www.brainybetty.com 24
  • 25. DOUBLE MADDOX ROD TEST : For measuring the degree of cyclodeviation. In unilateral palsy – cyclodeviation <10 deg In bilateral palsy – cyclodeviation >10 deg Free Template from www.brainybetty.com 25
  • 26. Free Template from www.brainybetty.com 26
  • 27. Differential Diagnosis of Vertical Binocular Diplopia • Superior Oblique Palsy • Thyroid Ophthalmopathy • Myasthenia Gravis • Brown Syndrome • Orbital fracture with entrapment • Cyclovertical paresis or overaction • Skew Deviation/Ocular Tilt • Dissociated Vertical Deviation Free Template from www.brainybetty.com 27
  • 28. Isolated Superior Oblique Palsy • Most common etiologies are congenital and traumatic • Also vascular; less commonly tumor, demyelinating • In absence of other neurological symptoms and presence of vascular risk factors, reasonable to observe Free Template from www.brainybetty.com 28
  • 29. TREATMENT • CONGENITAL:large hypertropia in PP treated by SO tucking • ACQUIRED: SMALL- ipsilateral IO weakening. MODERATE- ipsilateral IO weakening with ipsilateral SR weakening . PURE EXCYCLOTROPIA: without hypertropia – HARADA- Ito procedure Splitting & ALT OF lateral half of SO tendon. Free Template from www.brainybetty.com 29