Consider miRNA target sites, How do these compare to transcription fa.pdf

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Consider miRNA target sites, How do these compare to transcription factor binding sites? Imagine that both miRNA target sites and transcription factor binding sites were dispersed randomly in the genome ? Which would be likely to appear more frequent? Solution mRNA localization: mRAN location is critical for regulation of gene expression by allowing spatially regulated protein production. Through mRAN localization protein are transcribed in their intended target site of the cell. This is especially important during early developement when rapid cell cleavages give different cells various combinations of mRNA which can then lead to drastically different cell fates.RBPs are critical in the location of this mRNA that insures protein are only transcribed in ttheir intended regions. One of these proteins is ZBp1 binds to beta- actin mRNA at the site of transcription and moves with mRNA into the cytoplasm. It then localizes this mRNA to the lamella region of several asymmetric cell types where it can then be translated. FMRP is another RBP involved in RNA localization. It was shown thatt in addition to other functions for FMRP in RNA metabolism, FMRP is involved in the stimulus-induced localization of several dendritic mRNAs in neuronal dendrites. Transcription factors binding site: Transcrption factors bind to either enhancer or promoter regions of DNA adjacent gene is either up- regulated. Transcription factors use a varity of mechanisms for the regulation of gene expression. These mechanisms include: Histone acetyltransferase (HAT) activity - acetylates histone proteins, which weakens the association of DNA with histones, which make the DNA more accessible to transcription, thereby up- regulating transcription. Hiestone deacetylase (HDAC) activity - deacetylates histone proteins, which strengthens the asociation of DNA with histones, which make the DNA less accessible to transcription, thereby down- regulating transcription. Activation: trancsription factors may be activated (or deactivated) through their signal- sensing domain by a number of mechanism including:.

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Money and Our Monetary System The monetary system in any economy facilitates trade and allows people to trade more efficiently, as compared to a barter economy. In the United States, the monetary authority is the Federal Reserve System (also referred to as the Federal Reserve, or informally, as the “Fed”.) For this use the Fed’s website (http://www.federalreserve.gov/) when addressing the questions below. What are the requirements for something to be considered money? Why does the dollar have value? What does the money supply consist of and what are the respective amounts in the total money supply for the United States? What are the primary functions of the Fed? What role does the Federal Open Market Committee (FOMC) play in our economy? What role do the financial institutions (commercial banks and other institutions) play in our financial system? What is meant by the term “fractional-reserve banking” in our system? What are the implications for consumers? What are the tools available to the FED for controlling the money supply? Which are used most often? Which are most effective? How does the money multiplier help to determine the effects of monetary policy? What are the pros and cons of using monetary policy, as opposed to the use of fiscal policy, for implementing economic policies and practices? Solution Money is basically medium of exchange so for anything to be consideredd money there are three eligibility criterias It is a currency which is backed by a stable and sound government, other than that dollar has value because it fulfills all the three criteria mentioned above. It is widely accepted which provides good strength to its value. It consist of M1 and M2(the definitions and details are copied from fedreserve site) Money Stock Measures. Billions of dollars. There are four primar functions of Fed The role of FOMC is to make monetary policy for federal reserve stsrem which it could implement in the U.S. The most basic role of financial institutions is to provide circulate money in the economy and facilitate liquidity. It enables the flow of economic activities and helps in spreading the effects of implemented monetary policies.Table 1 Money Stock Measures. Billions of dollars.DateSeasonally adjustedNot seasonally adjustedM1 1M2 2M1 1M2 2Jan. 20142,688.411,033.82,697.511,058.9Feb. 20142,712.911,098.92,701.711,110.3Mar. 20142,746.111,153.52,768.711,235.4Apr. 20142,770.911,212.32,805.211,288.7May 20142,790.511,281.82,777.711,231.9June 20142,820.811,335.32,820.211,293.7July 20142,836.811,402.02,837.411,348.7Aug. 20142,807.411,438.72,786.111,379.9Sept. 20142,869.611,476.62,831.111,430.4Oct. 20142,874.011,528.62,860.411,496.4Nov. 20142,884.711,566.72,856.011,572.2Dec. 20142,927.311,636.42,985.211,717.4Jan. 20152,937.911,703.52,944.611,723.7Feb. 20152,985.111,800.12,976.111,812.2Mar. 20152,990.211,835.13,019.611,921.3Apr. 20152,995.611,888.03,032.411,970.7May 20152,989.811,923.92,973.111,873.0June 20153,015.311,970.63,017.011,926.7July 2015.

Money and Our Monetary SystemThe monetary system in any economy fa.pdf

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JAVA For the code in which I implemented most of the quick select algorithm. Quick select is a O(n) time algorithm to find the nth smallest value in an (unordered list). The following recursive algorithm finds thenth smallest element with an index bewtween left and right in list: Code: Solution A multi-year effort to prevent hackers from altering computers while they boot up has largely failed because of lax application of preventive steps, researchers say, despite disclosures that flaws are being actively exploited. In the latest sign that the problem persists, researchers at the federally funded MITRE lab said this week that many customers of Intel still had not adopted revised security designs Intel distributed in March after the MITRE team found new vulnerabilities in the start-up process. That could mean many newer Windows computers remain exposed, the MITRE team said ahead of a presentation at the Black Hat security conference in Las Vegas next week. Intel’s point person on the issue, Bruce Monroe, said he did not know how many suppliers and computer makers had followed Intel’s recommendations. “We’re not privy to whether they’ve fixed it or not,” Monroe said. “We asked them to let us know.” The glitches illustrates how well-funded spying programs as those exposed by former National Security Agency contractor Edward Snowden can continue to succeed against targets that depend on a complex supply chain. Long before Snowden’s documents began appearing in the media, professional technicians and US officials were concerned about the vulnerabilities that left computers severely exposed as they are turned on. Years ago, then-US National Security Agency Director Keith Alexander privately urged the chief executives of major American technology companies to do something about the boot-up procedure known as the Basic Input/Output System, or BIOS..

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Investigators are conducting a cohort study to determine whether women exposed to high levels of exposure to electromagnetic fields are more likely to be depressed. Low socioeconomic status is associated with 1) living near power lines and 2) depression. What type of bias or error is most likely to result? a. Selection bias b. Nondifferential misclassification c. Ecologic fallacy d. Confounding e. Random error Solution c. ecologic fallacy.

Investigators are conducting a cohort study to determine whether wom.pdf

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In the class we extensively discussed a node class called IntNode in which each linked list node contains an integer and each node is linked forward to the next element in the list. Implement a node class called DoublyIntNode in which each node contains an integer number and each node is linked not only forward to the next element in the list but also backward to the previous element in the list. Your implementation of DoublyIntNode should adapt and implement all the methods of IntNode including the following methods: Constructor for DoublyIntNode addNodeAfter, removeNodeAfter getData, setData getForeLink, setForeLink getBackLink, setBackLink listCopy listCopyWithTail listLength listPart listPosition listSearch IntNode and Node classes: public class IntNode{ private int data; private IntNode link; // methods here } public class Node { private E data; private Node link; // methods here } Solution program #include using namespace std; struct list { struct list *prev; int data; struct list *next; } *node = NULL, *first = NULL, *last = NULL, *node1 = NULL, *node2 = NULL; class Dlist { public: void insert_beg() { list *addBeg = new list; cout << \"Enter value for the node:\" << endl; cin >> addBeg->data; if(first == NULL) { addBeg->prev = NULL; addBeg->next = NULL; first = addBeg; last = addBeg; cout << \"Linked list Created!\" << endl; } else { addBeg->prev = NULL; first->prev = addBeg; addBeg->next = first; first = addBeg; cout << \"Data Inserted at the beginning of the Linked list!\" << endl; } } void insert_end() { list *addEnd = new list; cout << \"Enter value for the node:\" << endl; cin >> addEnd->data; if(first == NULL) { addEnd->prev = NULL; addEnd->next = NULL; first = addEnd; last = addEnd; cout << \"Linked list Created!\" << endl; } else { addEnd->next = NULL; last->next = addEnd; addEnd->prev = last; last = addEnd; cout << \"Data Inserted at the end of the Linked list!\" << endl; } } void display() { node = first; cout << \"List of data in Linked list in Ascending order!\" << endl; while(node != NULL) { cout << node->data << endl; node = node->next; } node = last; cout << \"List of data in Linked list in Descending order!\" << endl; while(node != NULL) { cout << node->data << endl; node = node->prev; } } void del() { int count = 0, number, i; node = node1 = node2 = first; for(node = first; node != NULL; node = node->next) cout << \"Enter value for the node:\" << endl; count++; display(); cout << count << \" nodes available here!\" << endl; cout << \"Enter the node number which you want to delete:\" << endl; cin >> number; if(number != 1) { if(number < count && number > 0) { for(i = 2; i <= number; i++) node = node->next; for(i = 2; i <= number-1; i++) node1 = node1->next; for(i = 2; i <= number+1; i++) node2 = node2->next; node2->prev = node1; node1->next = node2; node->prev = NULL; node->next = NULL; node = NULL; } else if(number == count) { node = last; last = node->prev; last->next = NULL; node = NULL; } else cout << \"Invalid node.

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In January of 2012, the second stop for a Republican to get votes toward the presidential nomination was at the New Hampshire Primary. The following exhibit shows the votes several candidates received from registered Republicans and Independents. Party Affiliation Mitt Romney Ron Paul Jon Huntsman Others Republicans 62645 16792 12733 27610 Not Republican 34887 40056 29212 24550 Source: ABC News What is the probability that a randomly selected voter voted for Ron Paul? Given that a randomly selected voter is not a Republican, what is the probability that he/she voted for Ron Paul? If a randomly selected voter voted for Jon Huntsman, what is the probability he is a Republican? Party Affiliation Mitt Romney Ron Paul Jon Huntsman Others Republicans 62645 16792 12733 27610 Not Republican 34887 40056 29212 24550 Solution.

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I need some help answering these three questions listed below. 1. An application requires users to either select one of the predefined names Alice, Bob, and Cindy or input a new name. Which Swing component is the most suitable? Provide a code fragment illustrating the creation of that component, with proper initialization. 2. In an interface that includes several buttons, how may an event-handling method determine which button triggered the event? Provide a code fragment to illustrate your answer. 3. An application that displays a computationally intensive animation would benefit from disabling the animation when the main application window is iconified. How may this feature be implemented? Provide a code fragment to illustrate your answer. Solution 1. Editable JCombo Box can be used. The editable combo box, features a text field with a small button abutting it. The user can type a value in the text field or click the button to display a drop- down list. Implementation 2. The event handler is tied to the button, hence it is possible to differentiate between multiple buttons. Implementation 3. When using a JFrame, we can detect window minimization with a windowStateListener(). Implementation.

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hi i need to produce a 300 word report on the construction of structures aligned to the railway infrastructure and explaine the impact of track engineering construction. and my report should include examples from the following tunnels, side bridges, sea defences, platforms, operatinal bulidings, platform awnings, mast and towers. iv started to answer the report but im not to sure if iv stuck to rigth path of the question. so i wounder if any one called help me. Solution Railway is like a lifeline to a country. Most.of the people and goods are transported through railways. As railway runs mostly on land , in order to make it accessible to most part of the land supporting structures are made. Some of them are discussed below. Tunnels- These structures are mainly made when the terrain are rough or they are at very high altitude. At very high altitude it becomes difficult to travel and if travelling is done it is done at very low speed. It is basically carried out in hilly areas. So to overcome this problem tunnels are being constructed in the hills. This solve 2 main purposes. Firstly it reduces the travel time and secondly it connects the places. Side bridges- They are mainly constructed in order to connect the places divided by a water , valley etc. Sea Defences- They are mostly constructed along the sea shore. When a railway passes through sea , it is very likely that it will get affected by its tides. In order to neutralize it sea defences are made to avoid water coming on the tracks and also to avoid soil erosion beneath the tracks. Platform Awnings- Thes structures are mainly above the platforms. These are basically shed type of structures. They can solve many purposes. Firstly they provide shed and shelter to people beneath. Then they lower the temperature from around 5-8 . Installation of solar panels above them can lead to generation of electricity. Platforms- They serve the purpose of people boarding in and out of train. They also act as waiting area for passengers. They are designed according to train length and height. A busy station has more no of platform compared to less busy one as more no of persons are arriving and departing at a busy station compared to less busy one. Mast- They are constructed to hold the electric cables. These cables provide electricity for the train to run. Towers- They are constructed basically for signaling system..

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How does multicore differ from a classic multiprocessing environment? Solution Multicore is differ from Multi processing because A multiprocessor systems having more than one central processing unit and allowing them to work in parallel. This is known as Simultaneous Multiprocessing. A multicore central processing unit has many execution cores on one CPU it means different things depending on the correct design but basically it means that a definite subset of the CPU\'s components is duplicate so multiple cores can work in parallel on separate operations. This is known as Chip level Multiprocessing..

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How the non-dense index works? How the non-dense index works? Solution Dense Index: An index record appears for every search key value in file. This record contains search key value and a pointer to the actual record. This makes searching faster but requires more space to store index records itself. Index records contain search key value and a pointer to the actual record on the disk. A non-dense index has: One entry for each block One entry for each different value Sparse Index is non-dense index In sparse index, index records are not created for every search key. An index record here contains a search key and an actual pointer to the data on the disk. To search a record, we first proceed by index record and reach at the actual location of the data. If the data we are looking for is not where we directly reach by following the index, then the system starts sequential search until the desired data is found..

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Given below is the response of several types of temperature sensors. Which type of temperature sensor has (a) highest sensitivity at low temperatures, (b) best linearity, (c) applicable for high temperatures? What does Fourier analysis of signals mean? What information can one extract once the analysis has been performed? How is this information useful to engineers? Solution Best linearity is of RTD Thermocouple is capable for higher temperatues Thermistor has highest sensitivity at low temperatures.

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For every one NADH molecule oxidized at complex I, how many TOTAL hydrogen ions are pumped across all of the complexes from the mitochondrial matrix to the inner membrane space? A:1 B:10 C:12 -An explanation would be appreciated! Solution Answer is B: NADH is the rich source of electron and it possess high reduction potential. So it transfer electrons (2e-) to oxygen through various complexes of Electron Transport Chain of Mitochondria. Those are Complex-I ----> Complex-III & Complex-IV. During electron transfer, 4:2:4 protons pumped form mitochondrial matrix to peri mitochondrial space via Complex-I, Complex-III & Complex-IV respectively.

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explain as specifically as possible how each of the following helps to enhance safety in the microbiology lab. Explain whether each is necessary in all instances. Negative air flow (i.e., air flows into laboratory rather than out Solution 29 Equipments every microbiology laboratory should have General Concepts : The clinical presentation of an infectious disease reflects the interaction between the host and the microorganism. This interaction is affected by the host immune status and microbial virulence factors.Sings and symptomes vary according to the site and severity of infection. Diagnosis requires a composite of information, including history, physical examination, radiographic findings, and laboratory data. In fections may be caused by bacteria, viruses, fungi, and parasites. The pathogen may be exogenous(acquired form environmental or animal sources or from other persons) or endogenous (from the normal flora)..

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Each of the following lymphatic structures in the correct category based on their location. Solution Cisterna Chyll- loated in THORACIC DUCT. it is a sac in which intestinal and two lumber lymphatic trunk flow. TONSILS- located in NECK. it is near the throat made of soft lymphoid tissue. THYMUS- location THORAX. here T lymphocytes mature. THORACIC DUCT- located in thorax. it is extended in chest area at C7 vertebra. MEDIASTINAL LYMPH NODE- loated in thorax. it is placed between lungs in thoracic cavity. SPLEEN- located in abdomen. it is to the left of stomach and recycles RBC..

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Answer the following questions from the Article below: Exercise #1. Read the following article and then answer the following questions in paragraph form. 1. How has DNA changed the study of biology over the past 50 years? Explain whether scientists have shifted to a molecular level in the various subdisciplines of biology. Also, do you believe any trend to the molecular level will continue far into the future? 2. Explain the role of DNA in the development of an organisms. Does DNA fully provide a blueprint to create an individual? Can DNA by itself propagate itself or does it require other molecular machines? 3. In modern biology, which is the role of physics in the study of organisms and their molecules? Has physics moved to the forefront or does it play an ancillary role? As described in the article, why are the molecular forces of very low energy in an organism? Historians have the luxury of looking back at human endeavor over long periods of time, but most scientists are too busy working in the present and thinking anxiously about the future and have no time to view their work in the context of what has gone before. I once remarked that all graduate students in biology divide history into two epochs: the past 2 years and every- thing else before that, where Archimedes, Newton, Darwin, Mendel—even Watson and Crick—inhabit a time-compressed universe as uneasy contemporaries. It seems remark- able that historians once thought that science progressed by the steady addition of knowledge, building the edifice of scientific truth, brick by brick. In his 1962 book The Struc- ture of Scientific Revolutions, Thomas Kuhn argued that progress occurs in revolutionary steps by the introduction of new paradigms, which may be new theories—new ways of looking at the world—or new technical methods that enhance observation and analysis. Between Kuhn’s revolutions, scientif ic knowledge does advance by accretion, as there is much to do to consolidate the new science. But then, inevitably, unsolved problems accumulate and, in many cases, the inconsis- tencies have been put to one side and every- body hopes that they will quietly go away. The edifice becomes rickety; some of its founda- tions are insecure and many of the bricks have not been well-baked. This is when a new revolutionary wave in the form of new ideas or new techniques appears, which allows us to condemn and demolish the unsafe or corrupt parts of the edifice and rebuild truth. Often there is great resistance to the new wave, but as Max Planck pointed out, it succeeds because the opponents grow old and die. The process is then repeated: The radicals become liberals, the liberals become conservatives, the conservatives become reactionaries, and the reactionaries disappear. Students of evolu- tion will recognize this process in the theory of punctuated equilibrium: Organisms stay much the same for very long periods of time; this is interrupted by bursts of change when novelty appears, f.

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All answers are in the form of True/False with a explantion as to why: 1) An ideal band-pass filter centered (at ± 0) can be created by just multiplying the sinc function by cos(0t) in the the time domain. 2) Nyquist theorem deals with windowing of a signal in the time domain, which is translated into leakage in the frequency domain. 3) The global frequency response of an LTI system composed of two LTI systems in parallel with each other is simply the addition of the individual frequency responses of the systems. 4) We can find the H(j) of an unknown LTI system by stimulating it with a impulse and taking the Fourier Transform of its response. Another more realistic way is to stimulate the LTI system with a unit step function (signal), take the Fourier Transform of its response, multiply it by (j) for every 0 and divide it by pi at =0. ^I believe that one is true, but I am needing help forming an explanation. 5) A first step towards sampling an unknown analog signal without aliasing is to low-pass filter the signal. Solution 1) False Because fourier transform of sinc function is rectanctangular function in frequency domain, and fourier transform of cos function is impuse function. So when when multiply in time domain that means convoution in frequency domain. And if ve convolude rectangular function with impulse function then it would be rectangular pulse train. Which is not ideal band paas filter at w=0. 2) False It would be either window or leakage in time domain or frequency domain. 3) TRUE It is simply understand by block reduction method in control system. When there is another forward block we add both maid forward block with secondry forward block. OR LTI is linear in nature so add in parallel and multiply in series. 4) TRUE Its because the response or tansfer function of any system is called impulse response. It means when the input is Impuse function what is the output of that system. Same as the relation between unit imulse response and impuse respone in just fouries tranfer of unit step function. Because the fourier transform of impulse is unity. so if input is unit step function multiply it by (j) for every 0 and divide it by pi at =0.(1/(i)+(),) 5)FALSE Low paas filter use after sampling to recover the original signal..

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Anaerobic Respiration & Fermentation (Microbiology) What are the bubbles in fermented medium made of? Describe the process that they come from. Solution Answer: The bubbles in the fermented medium is made of carbon dioxide and hydrogen. Microbes ferment glucose/dextrose to produce gases such as carbon dioxide and hydrogen. The medium most commonly used is phenol red glucose broth and is composed of 0.5-1.0% glucose. As the broth gets fermented, acidic end products are produced. This reduces the pH of the media which can be detected as the phenol red changes its colour from red to yellow. Inverted tubes called Durham tubes can be attched to the tubes of the broth which trap any carbon dioxide produced as a result of fermentation..

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4. Pick out any text-mining tool that impressed you the most and discuss an overview of its text mining process, sentimental & speech analytics. Solution LanguageWare is a natural language processing (NLP) technology developed by ibm, which allows applications to process natural language text. It comprises a set of Java libraries which provide a range of nlp functions: language identification, text segmentation/tokenization, normalization, entity and relationship extraction, and semantic analysis and disambiguation. The analysis engine uses Finite state machine approach at multiple levels, which aids its performance characteristics, while maintaining a reasonably small footprint. Speech analytics: Speech analytics allows users to analyse and extract information from both live and recorded conversations. It is being used effectively to gather intelligence for security purposes, to enhance the presentation and utility of rich media applications, and perhaps most significantly, to deliver quantitative business intelligence through the analysis of the millions of recorded calls . Sentiment analysis: Sentiment analysis is a branch of speech analytics that focuses specifically on assessing the emotional states displayed in a conversation. One common use of sentiment analysis within contact centres is to provide insight into a customer’s feelings about an organisation, its products, services, customer service processes, as well as its individual agent behaviours..

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