When comparing the R groups of these to amino acids, isoleucine has a non polar tail, which would hinder the solubility in water of the molecule because it can\'t Hydrogen bond with water molecules. Arginine, however, has three strongly electrophilic N atoms which each will be able to Hydrogen bond with the Hydrogen atoms of several water molecules, thus increasing the solubility. Solution When comparing the R groups of these to amino acids, isoleucine has a non polar tail, which would hinder the solubility in water of the molecule because it can\'t Hydrogen bond with water molecules. Arginine, however, has three strongly electrophilic N atoms which each will be able to Hydrogen bond with the Hydrogen atoms of several water molecules, thus increasing the solubility..

1. When comparing the R groups of these to amino acids, isoleucine has a non polar
tail, which would hinder the solubility in water of the molecule because it can't Hydrogen bond
with water molecules. Arginine, however, has three strongly electrophilic N atoms which each
will be able to Hydrogen bond with the Hydrogen atoms of several water molecules, thus
increasing the solubility.
Solution
When comparing the R groups of these to amino acids, isoleucine has a non polar
tail, which would hinder the solubility in water of the molecule because it can't Hydrogen bond
with water molecules. Arginine, however, has three strongly electrophilic N atoms which each
will be able to Hydrogen bond with the Hydrogen atoms of several water molecules, thus
increasing the solubility.