Blood brain barrier is called BBB in short. The blood brain barrier is formed by the endothelium of blood vessels that supply the brain and the spinal cord. Normally, endothelium of blood vessels has junctions that allow diapedesis of cells and seepage of ions and molecules. However, the junctions of endothelial cells of brain vasculature have tight junctions which do not allow passage of molecules. They have transendothelial transport systems, enzymes, and mechanisms to regulate passage/permeation of immune cells. The brain and the spinal cord are the control centers of the body. They process the sensory inputs, regulate motor output, generate signals to control several sensory and motor function, and coordinate individual and concerted activities of the body parts. For effective control of all these, they use either in isolation or in combination chemical and electrical signals. To ensure homeostasis and effective function, it is essential for the brain to maintain a stable internal environment. This is due to the fact that brain uses ions to generate its chemical signals. The concentrations of these ions are crucial to send signals in the form of nerve impulses. Even a slight change in the ion concentration may affect its functions. Solution Blood brain barrier is called BBB in short. The blood brain barrier is formed by the endothelium of blood vessels that supply the brain and the spinal cord. Normally, endothelium of blood vessels has junctions that allow diapedesis of cells and seepage of ions and molecules. However, the junctions of endothelial cells of brain vasculature have tight junctions which do not allow passage of molecules. They have transendothelial transport systems, enzymes, and mechanisms to regulate passage/permeation of immune cells. The brain and the spinal cord are the control centers of the body. They process the sensory inputs, regulate motor output, generate signals to control several sensory and motor function, and coordinate individual and concerted activities of the body parts. For effective control of all these, they use either in isolation or in combination chemical and electrical signals. To ensure homeostasis and effective function, it is essential for the brain to maintain a stable internal environment. This is due to the fact that brain uses ions to generate its chemical signals. The concentrations of these ions are crucial to send signals in the form of nerve impulses. Even a slight change in the ion concentration may affect its functions..