Vizbi 2014 Multiscale Visualization of Protein Assemblies

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visualizing molecular data across multiple scales

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Vizbi 2014 Multiscale Visualization of Protein Assemblies

  1. 1. Multiscale Visualization of Protein Assemblies Andreas Prlić www.rcsb.org @andorsch
  2. 2. 2014 International Year of Crystallography In June 1912, Max von Laue, Walter Friedrich and Paul Knipping demonstrate and confirm the nature of X-rays as waves by demonstrating their diffraction by crystals of Copper Sulphate and Zincblende Max von Laue source: Wikipedia After returning to Cambridge, Lawrence Bragg set about determining an explanation of the different reflective strengths of diffraction within a crystal of Zincblende. This work lead to the development of Braggs Law, which is a cornerstone of X-ray crystallography
  3. 3. Although not officially credited with taking part in the work, Rosalind Franklin had taken X-ray diffraction images of DNA and suggested the helical structure prior to the publishing of the work by Watson and Crick. The images she had taken were shown to Watson and Crick without her knowledge or approval, and in fact, Francis Crick later acknowledged that it was her data that was ‘the data we used’ to develop the hypothesis John Kendrew and Max Perutz win the Nobel Prize for Chemistry for their determination of the structures of Myoglobin and Haemoglobin using the technique of Xray crystallography. ! ! ! source: www.rigb.org
  4. 4. soon: 100k
  5. 5. The Scale of the Molecular World

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