2. 2014 International Year of Crystallography
In June 1912, Max von Laue, Walter Friedrich and Paul
Knipping demonstrate and confirm the nature of
X-rays as waves by demonstrating their diffraction by
crystals of Copper Sulphate and Zincblende
Max von Laue
source: Wikipedia
After returning to Cambridge, Lawrence Bragg set about
determining an explanation of the different reflective
strengths of diffraction within a crystal of Zincblende. This
work lead to the development of Braggs Law, which is a
cornerstone of X-ray crystallography
3. Although not officially credited with taking part in the
work, Rosalind Franklin had taken X-ray diffraction
images of DNA and suggested the helical structure
prior to the publishing of the work by Watson and
Crick. The images she had taken were shown to Watson
and Crick without her knowledge or approval, and in
fact, Francis Crick later acknowledged that it was her
data that was ‘the data we used’ to develop the
hypothesis
John Kendrew and Max Perutz win the Nobel Prize for
Chemistry for their determination of the structures of
Myoglobin and Haemoglobin using the technique of Xray crystallography.
!
!
!
source: www.rigb.org
10. Biol. Assemb. Disease
SNP:rs28940893 causes Metachromatic leukodystrophy
(lysosomal storage disorder)
!
asym unit
... the exchange of leucine for proline at position 426 increases the susceptibility of
arylsulfatase A to lysosomal cysteine proteinases and results in a severe reduction in
the half-life of the mutant polypeptides
Polten A, Fluharty AL, Fluharty CB, Kappler J, von Figura K, Gieselmann V.
N Engl J Med. 1991 Jan 3;324(1):18-22.
!
!
Lukatela G, Krauss N, Theis K, Selmer T, Gieselmann V, von Figura K, Saenger W.
Biochemistry. 1998 Mar 17;37(11):3654-64.
arylsulfatase A -1AUK
P-L
same structure,
but can’t form octamer
1E33
25. Acknowledgments
Peter Rose
Spencer Bliven
Wolfgang Bluhm
Phil Bourne
Cole Christie
Chunxiao Bi
Ann Kagehiro
Jessie Woo
Kyle Pang
Douglas Myers Turnbull
Roshni
Bhattacharya
!
!
!
!
!
!
David Goodsell
!
Stephen Burley,
Maria Voigt,
Christine Zardecki
!
!
RCSB PDB
26. rcsb.org!•!info@rcsb.org!
The RCSB PDB is
managed by two
members of the RCSB:
The RCSB PDB is
a member of:
Funding:
www.rcsb.org
info@rcsb.org
Find us at:
@buildmodels
/RCSBPDB
/rcsbpdb
/biojava