Deoxyribonucleic acid is the fundamental building block of life it contains just four bases guanine, cytosine, adenine, thymine, which pair up by hydrogen bonding in only 2 combinations G-c, or A-c to form a double stranded helix the DNA is coiled to form nucleosomes which coil again to form chromosomes. The DNA is packaged into 22 pairs of autosomal chromosomes and two sex chromosomes xx in females and xy in males. There are some historical scientific experiments with significance that proved DNA was the genetic material. Experiment 1: Hershey and chase were help to confirm that DNA is genetic material, they examined different parts of phages they isolated the phage subsections they inserted the radioactive elements into bacteriophages by adding the isotopes to separate media, in that they allow to grow bacteria for 4 hours, before bacteria phase introduction the bacteriophages infected the bacteria progeny contained the radioactive isotopes in there structures. same procedure they performed on the sulphur labelled phage and phosphorus labelled phages. The labelled progeny where they allowed to insert the unlabeled bacteria the phage coat remind on the outside of the bacteria while genetic material entered thus, the hershey chase experiment confirmed that it is not a protein, it is a genetic material. Experiment 2: DNA is not a protein it is a genetic material proven by some simple experiments and observations with bacteria and viruses.the bacteria diplococcus pneumonia it is also known as pneumoconiosis in mammals. Frederick Griffiths observed that there are two strains of D pneumonia one that forms smooth colonies (s strain) protected by a capsules and another that forms irregular R string without Capsule. When grown on a suitable medium in Petri dish when injected in to mice, only S cells produced the disease not the R cells when the heat killed S cells were mixed with the live K cells and then injected the disease was produced. at last he found that the DNA isolated from the heat killed S cells. When added to R cells changed their surface character. Thus, DNA was proved to be the genetic material. Experiment 3: Avery, macleod and mc carty they used biochemical purification of cellular fractions to determine that DNA and not RNA protein was the transforming principle. transformation: the alteration of phenotype by the addition of foreign DNA. Solution Deoxyribonucleic acid is the fundamental building block of life it contains just four bases guanine, cytosine, adenine, thymine, which pair up by hydrogen bonding in only 2 combinations G-c, or A-c to form a double stranded helix the DNA is coiled to form nucleosomes which coil again to form chromosomes. The DNA is packaged into 22 pairs of autosomal chromosomes and two sex chromosomes xx in females and xy in males. There are some historical scientific experiments with significance that proved DNA was the genetic material. Experiment 1: Hershey and chase were help to confirm that DNA is gene.