The document provides an overview of articles related to the use of the Crystal16® system in the pharmaceutical and polymer industries. It lists numerous articles from 2010-2008 that describe research using Crystal16® for applications such as crystallization screening, polymorph detection, and studying the effects of solvents on phase behavior and crystallization kinetics in both industry contexts.

1. Journals<br />Below is an overview of article featuring the Crystal16® for use in the pharma industry and the polymer industry.<br />Articles Pharma Industry<br />01.2011Jiang S. and ter Horst J.H. (2010) Crystal Nucleation Rates from Probability Distributions of Induction Times, Cryst. Growth Des., 11 (1), 256-261. Abstract<br />09.2010Fetha M.P., Nagelb N., Baumgartnerb B., Bröckelmannb M., Rigala D., Ottoa B., Spitzenberga M., Schulza M, Beckera B., Fischera F. and Petzoldt C. (2010) Challenges in the development of hydrate phases as active pharmaceutical ingredients - An example, European Journal of Pharmaceutical Sciences, 42 (1-2), 116-129. Abstract<br />08.2010Srisanga S. and ter Horst J.H. (2010) Racemic Compound, Conglomerate, or Solid Solution: Phase Diagram Screening of Chiral Compounds, Cryst. Growth Des., 10 (4), 1808-1812. Abstract<br />07.2010Habgood M., Deij, M.A., Mazurek J., Price S.L. and ter Horst J.H. (2010) Carbamazepine Co-crystallization with Pyridine Carboxamides: Rationalization by Complementary Phase Diagrams and Crystal Energy Landscapes, Cryst. Growth Des., 10 (2), 903-912. Abstract<br />06.2010Tulashie S.K., von Langermann J., Lorenz H. and Seidel-Morgenstern A. (2010) Chiral Task-Specific Solvents for Mandelic Acid and Their Impact on Solution Thermodynamics and Crystallization Kinetics, Cryst. Growth Des. Abstract<br />05.2010Kadam S.S., van der Windt E, Daudey P.J. and Kramer H.J.M. (2010) A Comparative Study of ATR-FTIR and FT-NIR Spectroscopy for In-Situ Concentration Monitoring during Batch Cooling Crystallization Processes, Cryst. Growth Des., 10 (6), 2629-2640. Abstract<br />04.2010Billot P., Couty M. and Hosek P. (2010) Application of ATR-UV Spectroscopy for Monitoring the Crystallisation of UV Absorbing and Nonabsorbing Molecules, Org. Process Res. Dev., 14 (3), 511-523. Abstract<br />03.2010Sistla A,Wu Y, Khamphavong P and Liu J (2010) Medium-throughput hydrate screening using the Crystal 16(TM)., Pharmaceutical development and technology, 1- 8. Abstract<br />02.2010Sistla V. S., von Langermann J., Lorenz H. and Seidel-Morgenstern A. (2010) Application of Classical Resolution for Separation of DL-Serine, Chemical Engineering & Technology, 33, 780-786. Abstract<br />01.2010Boyd S., Back K.,Chadwick K.,Davey R.J. and Seaton C.C. (2010) Solubility, metastable zone width measurement and crystal growth of the 1:1 benzoic acid/isonicotinamide cocrystal in solutions of variable stoichiometry, Journal of Pharmaceutical Sciences, 99, 3779-3786. Abstract<br />05.2009Dickens J., Swinney K. and Stockbroekx S. (2009) Crystallization: The Broad Perspective, American Pharmaceutical Review. Click here to request a paper copy<br />04.2009Howard K.S., Nagy Z.K., Saha B., Robertson A.L., Steele G. and Martin D. (2009) A Process Analytical Technology Based Investigation of the Polymorphic Transformations during the Antisolvent Crystallization of Sodium Benzoate from IPA/Water Mixture, Cryst. Growth Des., 9 (9), 3964-3975. Abstract<br />03.2009Argentine M.D., Braden T.M., Czarnik J., Conder E.W., Dunlap S.E., Fennell J.W., LaPack M.A., Rothhaar R.R., Scherer R.B., Schmid C.R., Vicenzi J.T., Wei J.G. and Werner J (2009) The Role of New Technologies in Defining a Manufacturing Process for PPAR? Agonist LY518674, Org. Process Res. Dev., 13 (2), 131-143.<br />02.2009Howard K. S.,Nagy Z.K., Saha B,Robertson A.L. and Steele G (2009) Combined PAT-Solid State Analytical Approach for the Detection and Study of Sodium Benzoate Hydrate, Org. Process Res. Dev., 13 (3), 590-597. Abstract<br />01.2009ter Horst J.H.,Deij M.A. and Cains P.W. (2009) Discovering New Co-Crystals, Cryst. Growth Des., 9 (3), 1531-1537. Abstract<br />01.2008ter Horst J.H. and Cains P.W. (2008) Co-Crystal Polymorphs from a Solvent-Mediated Transformation, Cryst. Growth Des., 8 (7), 2537-2542. Abstract<br />02.2007ter Horst J.H., Cains P.W. and van Rosmalen G.M. (2007) Co-crystallization of Carbamazepine and Isonicotinamide: Two New Co-crystal Forms?, BIWIC 2007, 143-152. Article<br />01.2007Kumara L., Amina A. and Bansal A.K. (2007) An overview of automated systems relevant in pharmaceutical salt screening, Drug Discovery Today, 12 (23-24), 1046-1053. Abstract<br />01.2006Smith A.A.,McKay B., Damen E.W.P., Darphorn-Hooijschuur S.,Ras E., and Verspui G. (2006) Prediction of Maximum Yield in the Crystallization of Multicomponent Isomeric Systems, Org. Process Res. Dev., 10 (6), 1132-1143. Article<br />01.2005Birch M., Fussell S.J., Higginson P.D.,McDowall N. and Marziano I. (2005) Towards a PAT-Based Strategy for Crystallization Development, Org. Process Res. Dev., 9 (3), 360-364. Abstract<br />Articles Polymer Industry<br />01.2011Lambermont-Thijs H.M.L., Heuts J.P.A., Hoeppener S., Hoogenboom R. and Schubert U.S. (2011) Selective partial hydrolysis of amphiphilic copoly(2-oxazoline)s as basis for temperature and pH responsive micelles, Polymer Chemistry, Advance Article. Article<br />09.2010Hoogenboom R., Becer C.R., Guerrero-Sanchez C, Hoeppener S. and Schubert U.S. (2010) Solubility and Thermoresponsiveness of PMMA in Alcohol-Water Solvent Mixtures, Australian Journal of Chemistry, 63(8) 1173-1178. Abstract<br />08.2010Becer C. R., Kokado K., Weber C., Can A., Chujo Y. and Schubert U. S. (2010) Metal-free synthesis of responsive polymers: Cloud point tuning by controlled quot;
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reaction., Journal of Polymer Science Part A: Polymer Chemistry, 48, 1278-1286. Abstract<br />07.2010Lambermont-Thijs H.M.L, van der Woerdt F.S., Baumgaertel A., Bonami L.,Du Prez F.E., Schubert U.S. and Hoogenboom R. (2010) Linear Poly(ethylene imine)s by Acidic Hydrolysis of Poly(2-oxazoline)s: Kinetic Screening, Thermal Properties, and Temperature-Induced Solubility Transitions, Macromolecules, 43 (2), 927-933. Abstract<br />06.2010Bloksma M.M., Rogers S., Schubert U.S.and Hoogenboom R. (2010) Secondary structure formation of main-chain chiral poly(2-oxazoline)s in solution, Soft Matter, 6, 994-1003. Abstract<br />05.2010Weber C., Becer C.R., Guenther W., Hoogenboom R. and Schubert U.S. (2010) Dual Responsive Methacrylic Acid and Oligo(2-ethyl-2-oxazoline) Containing Graft Copolymers, Macromolecules, 43 (1), 160-167. Abstract<br />04.2010Popescu D., Hoogenboom R., Keul H. and Moeller M. (2010) Thermoresponsive polyacrylates obtained via a cascade of enzymatic transacylation and FRP or NMP, Polymer Chemistry, 1, 878-890. Article<br />03.2010Lambermont-Thijs H.M.L., Bonami L., Du Prez F.E. and Hoogenboom R. (2010) Linear poly(alkyl ethylene imine) with varying side chain length: synthesis and physical properties, Polymer Chemistry, 1, 747-754. Abstract<br />02.2010Steinhauer W., Hoogenboom R., Keul H and Moeller M. (2010) Copolymerization of 2-Hydroxyethyl Acrylate and 2-Methoxyethyl Acrylate via RAFT: Kinetics and Thermoresponsive Properties, Macromolecules, 43 (17), 7041-7047. Abstract<br />01.2010Bloksma M. M., Bakker D. J., Weber C., Hoogenboom R. and Schubert U. S. (2010) The Effect of Hofmeister Salts on the LCST Transition of Poly(2-oxazoline)s with Varying Hydrophilicity, Macromolecular Rapid Communications, 31, 724-728. Abstract<br />04.2009Ott C., Hoogenboom R., Hoeppener S., Wouters D., Gohyb J. and Schubert U.S. (2009) Tuning the morphologies of amphiphilic metallo-supramolecular triblock terpolymers: from spherical micelles to switchable vesicles, Soft Matter, 5, 84-91. Abstract<br />03.2009Hoogenboom R., Popescu D., Steinhauer W., Keul H. and Möller M. (2009) Nitroxide-Mediated Copolymerization of 2-Hydroxyethyl Acrylate and 2-Hydroxypropyl Acrylate: Copolymerization Kinetics and Thermoresponsive Properties, Macromolecular Rapid Communications, 30, 2042-2048. Abstract <br />02.2009Weber C., Becer C.R., Hoogenboom R. and Schubert U.S. (2009) Lower Critical Solution Temperature Behavior of Comb and Graft Shaped Poly[oligo(2-ethyl-2-oxazoline)methacrylate]s, Macromolecules, 42 (8), 2965-2971. Article<br />01.2009Lambermont-Thijs H.M.L, Hoogenboom R., Fustin C., Bomal-D'Haese C., Gohy J. and Schubert U.S. (2009) Solubility behavior of amphiphilic block and random copolymers based on 2-ethyl-2-oxazoline and 2-nonyl-2-oxazoline in binary water-ethanol mixtures, Journal of Polymer Science Part A: Polymer Chemistry, 47, 515-522. Abstract<br />04.2008Eggenhuisen T.M., Becer C.R., Fijten M.W.M, Eckardt R., Hoogenboom R. and Schubert U.S. (2008) Libraries of Statistical Hydroxypropyl Acrylate Containing Copolymers with LCST Properties Prepared by NMP, Macromolecules, 41 (14), 5132-5140. Abstract<br />03.2008Hoogenboom R., Thijs H.M.L., Wouters D., Hoeppener S. and Schubert U.S. (2008) Tuning solution polymer properties by binary water-ethanol solvent mixtures, Soft Matter, 4, 103-107. Article<br />02.2008Chiper M., Fournier D., Hoogenboom R. and Schubert U.S. (2008) Thermosensitive and Switchable Terpyridine-Functionalized Metallo-Supramolecular Poly(N-isopropylacrylamide), Macromolecular Rapid Communications, 29 (20), 1640-1647. Abstract<br />01.2008Becer R.C., Hahn S., Fijten M.W.M., Thijs H.M.L., Hoogenboom R. and Schubert U.S. (2008) Libraries of methacrylic acid and oligo(ethylene glycol) methacrylate copolymers with LCST behavior, Journal of Polymer Science Part A: Polymer Chemistry, 46 (21), 7138-7147. Article<br />