3. INTRODUCTION
Ventilation is moving in and out of gases into the
lungs through the airways
Respiration is process of gas exchange within the
lungs(external) or at the tissue level(internal)
5. BASIC TERMINOLOGIES
Fi𝑶𝟐 ∶ fraction of oxygen in inspired air
21%-100%
Peak Inspiratory Pressure(PIP):
highest pressure in inspiratory cycle
opens up alveoli
PIP α R/C
Positive End Expiratory Pressure:
pressure at the end of expiration in the lungs
prevents collapse of recruited alveoli
6. Mean Airway Pressure(Paw)
average pressure attained during the respiratory
cycle
𝑃𝑎𝑤 =
𝑘 𝑃𝐼𝑃×𝑇𝑖 +(𝑃𝐸𝐸𝑃×𝑇𝑒)
𝑇𝑖+𝑇𝑒
I:E Ratio:
ratio of inspiratory to expiratory time
inspiratory or expiratory time should not be below
Tc
7. Tidal Volume:
volume going in and out of lungs in each cycle
newborns: 4-6 ml/kg
older children: 5-8 ml/kg
Rate/Frequency:
number of breaths per minute ventilator delivers
affects minute ventilation
Flow Rate:
flow of gas through the circuit
minimum of twice the minute ventilation
8. OXYGENATION
Addition of oxygen to the blood through gaseous
exchange
Takes place at alveolar capillary membrane
9. Factors on which oxygenation depends:
Oxygenation(paO2) α MAP × FiO2
MAP increases with increase in:
Peak inspiratory pressure
Positive end expiratory pressure
I:E ratio
Flow rate
10. Oxygenation Indices:
useful to quantify oxygenation and track the course
of the disease
Alveolar arterial pO2 difference(A-a) pO2
paO2/FiO2 ratio
Oxygenation index: MAP × FiO2 × 100/paO2
11. VENTILATION
Exchange of gases between the lungs and
atmosphere
Mainly eliminates carbon-di-oxide from the lungs
Ventilation α (tidal volume – dead space) × R.R
Tidal volume α delta p (PIP-PEEP)
Ventilation increases by:
increasing tidal volume
increasing PIP
decreasing PEEP
increasing frequency/rate
12. BASIC MODES OF VENTILATION
Variables on which modes depends:
Control variables
Phase variables
Control variables: remains constant as the ventilator
load changes
They include pressure, volume, flow and time.
14. Phase Variables: respiratory cycle can be divided
into four phases based on these phase variables
Trigger: variable used to initiate inspiration
triggered by ventilator( time cycled)
triggered by patient(flow or pressure)
Limit variable: ventilator cannot go beyond the limit
during inspiration
inspiration need not be terminated
15. Cycle variable: termination of inspiration
time, pressure, flow, volume
Baseline variable: variable controlled during
expiratory phase such as PEEP
Mandatory breath: breath is triggered and cycled by
ventilator
Spontaneous breath: breath is triggered and cycled
by patient