Diploma second year final annual exam paper question no 6bis based on Special give reasons ,this totally question are
Summer 2018, summer 2017,or summer 2019 and other important given reason
3. 1] why Acetylcholine is not used in clinically
1] It is rapidly metabolized in GIT enzymes
2] on parentrals administration itis the destroyed in the plasma by enzyme
PSEDOCHOLINE EASTERAGE At the site of action by enzyme True
choline easterage
3] Being The quaternay ammonium compounds it does not cross Blood
Brain Barrier
4] HEANCE it inffeactive for CNS action
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4. 2] Multidrug Therapy is effective in the treatment
of TB
1] The singal dose is develop the resistance to TB
2] Combination drug are better resistance bacteria
3] combination drug is produced SYNERJUSTIC
effects
4] combination drug reduces side effects
5] It is various advantages so it is used in combination
therapy
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5. 3] Antibiotics are given in
combination
1]Generally, antibiotics are given in combination to
have more advantages
2]It produces SYNERJUSTIC effects
3]It is used for various mixed infection like
Pneumonia
4]To avoid the delopment of resistance
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6. 4]Sulphonamides are not used in now a days
1]Sulphonamides are various side effects
2]Sulpha drugs are produced Fever, skin rash, joint pain, anemia,
etc
3]Bacterial resistance is much more low of Sulpha drugs
4]In market other better drugs are available in various
preparations
5] This is that really reason to now a days Sulpha drugs are not used
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7. 5]Toxicity of Digitalis is increased by Chlorthiazide
1]Chlorthiazide is diuretics drug
2]Chlorthiazide is depress the sodium transportation
3]Thiazide also increase potassium excretion a
considerable extent.
4]It is used in treatment of CHF with details Allready
excess potassium loss I. E=Hypokalemia......
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8. 6] Levodopa is given in combination
with carbidopa1]This is Antiparkinsonium drugs
2]Levodopa is PREACOUR OF Dopamine, while carbidopa is
decarboxylase inhibitor
3]Levodopa is metabolized to dopamine By enzyme
decarboxylase
4]If Levi's converter into dopamine in blood itself
5]Dopamine can't cross BBB
6]Carbidopa is can't cross BBB,BUT it inhibits decarboxylase
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9. 7] Insulin is not given in orally?
1]Insuline produced by B-cells of iselate offer langrance in panacrease
2]It also secondary sources is pig or cattle
3]orally administration of insulin degradation of enzyme
, gastri-acid ,OR HCL other fluid
4]orally insulin are affected
5]It degradation 9f HCL in gastro intestine tract
6]so, the insulin is given in parental
7] it also affect on Pharmacokinetically of drug
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10. 8] Tincture of opium used in
diarrhoea?1]Tincture of opium is against of morphine Or codine
2]Diarrheoa is condition which loss of fluid ,which
increasing Intestinal muscles tone also increase
peristalsis
3] The tincture of opium is Reduce intestinal muscle tone
or reduce peristalsis
4]Heance , tincture of opium is used
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11. 9] Atropine produce photophobia?
1]Atropine is a antimuscarnic drug which wide range of used in
eye, which inhibits Mascarnic receptar this causes mydrasis
2] The capillary smooth muscle is paralyzed & person increase
the focal length.
3] The individual the percon see the object only long distance ,
This term is called cyclopegia or spam of accommodation
4] cyclopegia or mydrasis is the condition which that the person
fall
Response to bright light this is called PHOTOPHOBIA.
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12. 10] Tetracycline is not given in small children?
1] Tetracycline is aslo deposited in growing teeth
2]children also shows brown staining at teeth if
tetracycline ate administration
3]Tetracycline is stained growth of human bones
4[The nail also becomes stained by Tetracycline
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13. 11] Cheese or butter is contraindication during MOA
inhibitor therapy
1i Banana,chocklets ,cheese ,Bitter contain
THYRAMINE
2] THYRAMINE is not metabolized in liver by enzyme
MONOAMONO OIIDASE
3]MAO is metabolized by THRYAMINE
4] Thrymaine is not metabolized & they are
Accumulated in the body
5] It produces sympathomimetics stimulation to increase
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14. 1] It is used to compare to therapeutically index of toxic Dose
2] It is a statement relatively to safety
3] It is the ratio of dose
4] It produces desired therapeutic respond to toxic response
5] The common TI to toxic response 50% Dose response
It incluid TD50 & ED 50
6] It safety of margin uselly calculated toxic Dose ratio to 1%
population. TD=01% ED=99%
TD= THERAPEUTICDOSE, ED= EFFECTIVE DOSE
12] Higher therapeutic index safer will be drug justifies the
statement
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15. 13] Asprine is not given in peptic ulcer?
1] Asprine is not given in peptic ulcer because it
administered after food
2] postaglandin control Acid secreation
3] Asprine inhibits postaglandin &COX enzyme
Synthesis
4] To avoid the side effects Of asprine it
administered in after food
5] It gives increases, ulceration. yo.gesh954
16. ]
14]Penicillin is life saving drug as well as treating drug
1] Penicillin is a antibiotic
2] It is widely use different diseases like syphilis, gonorrhea, fever,,
etc
So this is the reason it is called life saving drug
3] penicillin dose are administered on parentrals without checking it's
Produce sever allergy
4] It produces analephetic shocks
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17. 15] Use of purgative is essential with
piprizine1]Antihelmitics are eighter vermicidal or vermifungal action
2] They are killing verms or fungal
3] Vermicidal killing water they are expal out form intestin or
body with out
Affect on host.
4] combined drugs are produced SYNERJUSTIC effects
5]It reduced side effects & produces advantage
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18. 16] StrEptomycine is Not Given in
orally
1] Strwptomycine absorption rate is slow
2] pharmacological action is slow of Strwptomycine
3] It does not used in emergency
4] Can not used in uncooperative patient
5] Irritation offer GIT track
6] Nausea ,vomiting are produce
7] It destroyed on gastrointestinal track
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19. 17] Digatilis is called Cardiotonic
1] Increased force of contraction
2] Digatilis is increases cardiac output
3] Digatilis is increases contratility not a
rate of heart beat
4] working capacity Of heart is increased
5] Digatilis is also called as a cardiac
glycoside
20. 118] Atropine is given in neostigamine Mystheniia
gravis
1] Neostigamine is a antimuscarnic drug
2] Neostigamine is a reverseable anticholinestrage
3] Neostigamine is parasympathomimytic drugs
4] It's action with both Mascarnic or nicotinic receptors
5] Mystheniya gravis is a only Nicotinic receptor action only
6] It suppress Mascarnic effect hence Atropine gives along
with Neostigamine
21. 19] ADRANALIN is always present in emergency k
1]Adranalin is a sympathetic drug .it produces agonist action of ACH
2] ADRANALIN IS also usefully in emergency treatment, so
physician are
Save the adranalin in kit box
3] It used in sever hemorrhage
4] It is used in also vasodilation
5] It is used in dental practices to time of bleeding
6] It used in Bronch asthma
7]It IA also used of ANALEPTIC SHOVK
So, generally or regularally ADRANALIN is very helpful. So it is
used kit of emergency
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22. 20] Dextrose is given by IV drip?
1] Dextrose is a volume expander
2] clinically, it is higher molecular weight
3] D5 & D10 dextrosep repration Given orally, but it
degrenate in Intestine
4] It gives in IV or IM route is slowly pharmacologicl action
5] Dextrose is present in blood circulation it maintain Blood
pressure
HEANCE, For maintaining blood volume to gives
INTRAVENOUS drip
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23. 21] Antihypertensive is give along with diuretics?
1]Mtihypertansive is used in Hypertension
2] It reduces the blood pressure
3] Diuretics are used in excretion of electrolyte or urine
along with water
4] Sodium level are increased in Hypertension
5] Diureticsare loss the electrolyte, like sodium it lead to
decrease hypertension
6] to produce SYNERJUSTIC effects
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24. 22] why combination of phynotoin & phenobarbital is given in Grandamal
epilepsy
1] Grandamal epilepsy is Generalized epilepsy causing ironic as well
as clonic
Convulsions
2] phynotoin is sodium cenal blocker while phenobarbitone is GABA
AGONIST
3] combination of phynotoin & phenobarbitone producing
SYNERJUSTIC effects & control generalized seizure by increasing
conc. Of GABA inbrain
4] HEANCE, combination is given preferable on
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25. 23] why BZD (BENZODIAZIPINE) are popular than Barbichurate?
1] BZN is higher therapeutic Index, Ever 20 hypnotics doses do not
Dangerous
2] Do not affect in cardiavascular & respiratory systems
3] No affect on other body functions or systems
4] Drug depends is less marked
5] Do not induces microsomal enzymes
6] Specific antitode like FLUMAZENIL (0.2MG IV) is avalible
Heanc bzdis are more popular than Barbichurates
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26. 24] Combination of Atropine & eighter is given in
GENERAL ANAESTHETIC?
1]Eather is a drug of general anaesthetic
2] The eather is produced irritation vapours to respiratory tract
3] This irritation causes secretion of normal respiration as well
as with Anesthetic process
4] To avoid this effect Atropine is given or used
5] Atropine is Antisecratory drug which leads to reduce
secreations
6] Atropine block secretion & assist in the anaesthesia
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27. 25] Morphine is contraindication in Brain injury
1] morphine is increases Interacramial pressure &
wornes Bleeding condition in head injuries
2] It depresses respiration, produce Moises & mental
clouding or causes complications in head injuries
HEANCE morphine is contraindication in head injury
28. 26] Barbichurates are Develops tolerance &
automation1] Barbichurates induce microzomal enzyme
system In liver while in activates Barbichurate
2] The inactivation increase in repated
admination, this develops tolerance
3] In repated admination of barbiturate also
causes mental confusioN & Forgetfulne
because of which person is unable to fall sleep
To takes pills making poisons him produce drug
automatism,
4] HEANCE Barbichurates developes tolerance
& automatism
29. 1] Morphine is opioid AGONIST it action on smooth muscle of GIT
& action is comtraction, decrease tone of intestinal & reduced
peristalsis
2] Morphine is also refuse sensitivety offer intestinal muscle to
deflection reflexes
3] This causes The stagnation if food material, resulting in
maximum absorption of water, makes stool dred & heard to
frequency & output of
Deflection is reduced
4] The above action of morphine is resulting into constipation
27] Morphine causes
constipation ?
30. 27] Morphine causes Addition?
1] Morphine is indicated for many disorder like Pani, cough,
diarrhea ,
Myocardial infarction, etc
2] Morphine improve above condition also In turn cause
Euphoria.
I. E= state Of mind well being
3] To positive state of mind Individual continuous the drug on
its own
With out therapeutic indication
4] This develops tolerance & storage degree of physiological
drug dependence which in true cause addition
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