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Pentose phosphate pathway
- 1. Glucose 6-phosphate→ Glucose 6-phosphate Under anaerobic condition Hexose monophosphate shunt 20/03/2013 Yared Alemayehu (PhD) 1 By: Yared Alemayehu (PhD) 20/03/2013 Pentose phosphate pathway or Occur in the cytosol
- 2. Pentose phosphate pathway Also called hexose monophosphate shunt More complex than glycolytic pathway Three molecules of glucose 6-phosphate give rise to three molecules of CO2 and three five- carbon sugars. As in glycolysis, oxidation is achieved by dehydrogenation; but NADP+ and not NAD+ is the hydrogen acceptor. 20/03/2013 Yared Alemayehu (PhD) 2
- 3. 20/03/2013 Yared Alemayehu (PhD) 3 Glucose 6- phosphate Glucose 6- phosphate Glucose 6- phosphate 6-phosphogluconate 6-phosphogluconate 6-phosphogluconate Glucose 6- phosphate dehydrogenase Glucose 6- phosphate dehydrogenase Glucose 6- phosphate dehydrogenase NADPH + H+ NADP+ H20 NADPH + H+ NADP+ H20 NADPH + H+ NADP+ H20 1 1 1
- 4. 20/03/2013 Yared Alemayehu (PhD) 4 6-phosphogluconate Ribulose 5-phosphate Ribulose 5-phosphate Ribulose 5-phosphate 6-phosphogluconate dehydrogenase 6-phosphogluconate dehydrogenase 6-phosphogluconate dehydrogenase NADPH + H+ NADP+ NADPH + H+ NADP+ NADPH + H+ NADP+ 6-phosphogluconate 6-phosphogluconate CO2 CO2 CO2 2 2 1
- 5. 20/03/2013 Yared Alemayehu (PhD) 5 Ribulose 5- phosphate Xylulose 5-phosphate Ribose 5-phosphate Xylulose 5-phosphate 3-Epimerase Keto isomerase 3-Epimerase Ribulose 5- phosphate Ribulose 5- phosphate 3 3 3
- 6. 20/03/2013 Yared Alemayehu (PhD) 6 Xylulose 5- phosphate Glyceraldehyde 3- phosphate Sedoheptulose 7- phosphate Glyceraldehyde 3- phosphate Transketolase Transketolase Transketolase Ribose 5- phosphate Xylulose 5- phosphate Required for synthesis of nucleotide, RNA and DNA 4 4 4
- 7. 20/03/2013 Yared Alemayehu (PhD) 7 Glyceraldehyde 3- phosphate Fructose 6- phosphate Erythrose 4- phosphate ½ Fructose 1, 6- bisphosphate Transaldolase Transaldolase Aldolase or Phosphotriose isomerase Sedoheptulose 7- phosphate Glyceraldehyde 3- phosphate 5 5 5
- 8. 20/03/2013 Yared Alemayehu (PhD) 8 Fructose 6- phosphate Glucose 6- phosphate Fructose 6- phosphate ½ Fructose 6- bisphosphate Phosphohexose isomerase Transketolase Fructose 1, 6- bisphosphatase Erythrose 4- phosphate ½ Fructose 1, 6- bisphosphate 6 6 6
- 9. 20/03/2013 Yared Alemayehu (PhD) 9 Glucose 6- phosphate ½ Glucose 6- bisphosphate Phosphohexose isomerase Phosphohexose isomerase Fructose 6- phosphate ½ Fructose 6- bisphosphate 7 7
- 10. 20/03/2013 Yared Alemayehu (PhD) 10 Thank You Very Much