Call Girls Ludhiana Just Call 9907093804 Top Class Call Girl Service Available
TGL METABOLISM
1.
2. Site:
Liver & adipose tissue.
TAG synthesis in adipose tissue is for storage
of energy.
In liver it is mainly secreted as VLDL & is
transported.
TAG is synthesized by esterification of fatty
acyl CoA with either glycerol 3-phosphate or
DHAP.
3. The glycerol is derived from metabolism of
glucose.
DHAP is an intermediate of glycolysis.
Glycerol 3-phosphate is formed by
phosphorylation of glycerol or by reduction of
DHAP.
NOTE:
In adipose tissue, glycerol kinase is deficient &
major source is DHAP derived from glycolysis.
4. In liver, glycerol kinase is active.
The fatty acyl CoA transfer the fatty acid to the
hydroxyl groups of glycerol by the specific
enzyme –acyl transferases.
In the intestinal mucosal cells the TAG
synthesis occurs by the MAG pathway.
2-MAG absorbed is re-esterified with fatty acyl
CoA to form TAG.
5. Esterification of fatty acyl CoA with glycerol
phosphate to form triacylglycerol occurs at a
rapid rate during the fed state.
Under fasting state, synthesis of TAG occurs side
by side with lipolysis, since free fatty acid level
is high in plasma.
The glycerol phosphate is derived from the
metabolism of glucose in fed state by
channeling DHAP, intermediate in glycolysis.
6. In the fasting state, the glycerol phosphate is
derived from DHAP formed during
gluconeogenesis.
The activity of PEPCK is enhanced in liver &
adipose tissue during fasting.
Glycerol phosphate is available to esterify &
store excess fatty acid mobilized.
