1) Road traffic crashes are a leading cause of death among young people in the region. 2) A regional strategic framework is proposed to progressively reduce road traffic deaths and serious injuries with a vision of a region free of road traffic deaths and serious injuries. 3) The framework calls for establishing structural foundations for road safety, implementing key programs and policies, and monitoring outcomes to improve the regional approach to road safety during the Decade of Action for Road Safety 2021-2030.