Pharmacology of Penicillin for Physiotherapy Students

1. PENICILLIN
DR VISHAL DEEP (PT)
PHYSIOTHERAPY INCHARGE
GMCH,MIRAJ

2. Introduction
 Antibiotic: Any substance that inhibits the growth and replication of a bacterium
or kills it outright.
 Penicillin:Obtained from Fungus Penicillium Chrysogenum
 Discovered by Sir Alexander Fleming in 1928.
 One of the most important group of antibiotics.

3. Mechanism of Action

4. Penicillin
Bind (PBP) on the cell wall of susceptible bacteria
Inhibits transpeptidation
Prevents peptidoglycan synthesis
Cell wall deficient forms spheroplasts & filamentous forms
Autolysis
Cell death (bactericidal action)

5. Classification
Penicillin
Natural Semi Synthetic
Penicillin G
(Benzyl Penicillin)

6. Semi Synthetic
Acid Resistant Penicillase Resistant Beta Lactamase Extended Spectrum
-Penicillin V - Methicillin - Tazobactum
- Cloxacillin - Clavulanic Acid
Aminopenicillin Carboxypenicillin Ureidopenicillin
- Ampicillin -Carbenicillin -Piperacillin
- Amoxicillin

7. Theraputic uses
1. Streptococcal Infection
 Pharyngitis
 Scarlett Fever
 Rheumatic Fever
 Endocarditis
2. Pneumococcal Infection
 Lobar Pneumonia

8. 3. Meningcoccal Infection
 Menengitis
4. Gonococcal Infection
 Opthalmia Neonatorum

9. 5. Syphillis
 Drug of Choice
6. Leptospirosis

10. 7. Anaerobic Infection
 Pulmonary Infection and Brain Abscess
8. Tetanus and Gas Gangrene
 Gas Gangrene Treatment of Choice

11. Adverse Effect
1. Local Injury and Direct Toxicity
 Pain at injection site
 Nausea
 Shivering
 Fever
 Myalgia

12. 2. Hypersensitivity
 1-10%
 Allergic to drugs
 Rash,Itching,Fever
 Anaphylaxis
3. Bleeding
 Due to interference in platelet function

13. 4. Brain Toxicity
 Mental Confusion
 Muscular Twitching
 Convulsions
 Coma

14. Doubts

15. Thank You