Cerebrospinal liquid (CSF) assortment is a test to check out at the liquid that encompasses the cerebrum and spinal string. CSF goes about as a pad, safeguarding the mind and spine from injury. The liquid is typically clear. It has a similar consistency as water. The test is likewise used to quantify strain in the spinal liquid.
2. Abstract:
● Sampling of cerebrospinal fluid (CSF) is an
essential step for early-phase drug development
studies, and particularly for studies in neurology.
● In addition, CSF biomarkers are vital for
indicating pharmacodynamic action of CNS drugs in
clinical trials, as well as providing an excellent
basis for go/no go decisions in the drug
development process.
4. What CHDR Offers?
● Extensive experience in early-phase clinical trials
involving healthy volunteers and patients with a variety
of conditions, especially neurodegenerative diseases
● Capacity to conduct numerous lumbar punctures (~300 single
punctures per year) in our Clinical Research Unit
● Excellent quality of CSF collection with high success rate
and less than 2% post-puncture headache
● An experienced and highly-trained team of physicians and
two in-house neurologists assisted by dedicated nursing
staff
● Expertise and support from the department of
anaesthesiology of our partner hospital, the Leiden
University Medical Center
● 24/7 pharmacy and bioanalytical laboratory facilities
5. CSF sampling
techniques applied
at CHDR
CHDR has experience with
intrathecally
administered drugs and
long-term CSF sampling
in healthy subjects and
patient populations.
7. 1.Single lumbar puncture:
- Performed under local
anaesthesia
- Used for direct PK and/or
PD assessments in the CNS
compartment, as well as for
intrathecal drug
administration
2.Continuous sampling with
spinal catheter:
- Performed under local
anaesthesia
- Used when serial CSF
sampling is needed for
pharmacokinetic and/or
pharmacodynamic profiling
8. Infectious diseases:
Viruses, bacteria, fungi, and parasites can all
infect the CNS. Certain infections can be found by
CSF analysis. Common CNS infections include:
● meningitis
● encephalitis
● tuberculosis
● fungal infections
● west Nile virus
● eastern equine encephalitis virus (EEEV)
9. Interpreting your test results
Normal results mean that nothing abnormal was found in
the spinal fluid. All measured levels of CSF components
were found to be within normal range.
Abnormal results may be caused by one of the following:
● a tumor
● metastatic cancer
● hemorrhaging
● encephalitis, which is an inflammation of the brain
● an infection
● inflammation
