There are various subtypes of peripheral T-cell lymphoma, such as AITL (angioimmunoblastic T-cell lymphoma), PCALCL (primary cutaneous anaplastic large cell lymphoma), and MF (mycosis fungoides). These are the most frequent subtypes of PTCL. Let’s have a look at all types of PTCL.

2. Angioimmunoblastic T-Cell
Lymphoma (AITL)
About 2% of all NHL (non-Hodgkin lymphoma) cases are attributed to AITL. This
subtype is usually aggressive (fast-growing), but, at times, it can have a
spontaneous regression. It commonly occurs in the lymph nodes and can affect the
patient’s liver or spleen.

3. Primary Cutaneous Anaplastic
Large Cell Lymphoma (PCALCL)
PCALCL usually affects the skin and falls in the group of slow-growing (indolent)
lymphoma. Even with a good prognosis, it is ALK-negative.

4. Nasal, Natural Killer (NK)/T-Cell
Lymphoma
This lymphoma subtype affects the nasal area and some areas behind the nose and
cheeks, which are the paranasal sinus areas. Although, it does not mean that it can
only occur in those areas. Its occurrence can also be in the skin, testes, and
gastrointestinal tract. Less than 1.5% of all NHL cases in the US come from this
subtype, making it a rare disease.

5. Peripheral T-Cell Lymphoma, Not
Otherwise Stated (PTCL-NOS)
It is the most common type of Peripheral T-cell Lymphoma, containing a group of
diseases that can not fit into any other PTCL subtype. In PTCL-NOS there are nodal
as well as extranodal sites. The subtype is aggressive in nature most of the time.

6. Anaplastic Large Cell Lymphoma
This subtype is also pretty rare in adults, with a constitution of 3% of all NHL cases.
The percentage of cases in children is much higher, making it more common in
children. It can be further divided into ALK-positive and ALK-negative. The division
is due to the absence or presence of anaplastic lymphoma kinase (ALK), which is a
protein.

7. Blastic NK-Cell Lymphoma
Blastic NK-cell lymphoma is a subtype of PTCL which is hard to treat, rare, and
grows very fast. Often, the patients in this category take part in clinical trials after
discussing it with their medical team.

8. Precursor T-Cell Acute Lymphoblastic
Lymphoma Or Leukemia
This condition can be diagnosed as leukemia or lymphoma, or even both of them.
You can find this subtype more commonly in adolescents and male adults.
However, it can also exist in children and other adults.

9. Enteropathy-Associated Lymphoma
Celiac disease is usually associated with this subtype. Celiac disease is a chronic
disorder caused in the intestine due to being hypersensitive to gluten proteins. The
common symptoms of enteropathy-associated lymphoma are weight loss, stomach
pain, gastrointestinal bleeding, etc.

10. Hepatosplenic Lymphoma
It is an extremely aggressive and rare disease. You can find it commonly in young
adults under 30 years. The patients of this subtype experience it first in their spleen
or liver.

11. Subcutaneous Panniculitis-Like Lymphoma
This subtype is the rarest and is also the worst when it comes to well-defined
lymphomas. It occurs in the subcutaneous fat tissues and forms nodules. Some of
its symptoms include fever, weight loss, chills, and oral mucosal ulcers. They can be
either aggressive or indolent.

12. Adult T-Cell Acute Lymphoblastic
Lymphoma Or Leukemia
This type is more common in Japan and the Caribbean and is associated with the
HTLV-1 virus. The transmission of HTLV-1 (Human T-cell Leukemia Virus-1) can be
through blood transfusions, sexual intercourse, childbirth, breast milk, etc.
Apart from these subtypes, there are categories of PTCL that the WHO recognizes.
Even though PTCL is already a type of cancer with subtypes, it also has these
categories.
• Nodal
• Extranodal
• Leukemic

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