it isabout hodgkin"s lymphoma

1. Ahmed salim

2. WHAT IS LYMPHOMA?
LYMPHOMA
is the term applied to a heterogeneous
collection of diseases characterised by the
presence of malignant lymphoid cells.
i.e.
Cancer of the Lymphatic System

3. LYMPHOMA
Traditionally 2 main Types of Lymphoma
Non-Hodgkin’s Lymphoma Hodgkin’s Lymphoma
6th
Most Common Cancer Much less common
4.1% of cancers in Australia 0.5% of cancers
3500 new cases / year 400 new cases / year
Incidence increases with age Peak incidence in
Many different subtypes Adolescence and >50

5. What causes Lymphoma?
 In most cases we do not know
 It is likely that several factors are
important
e.g. Genetic predisposition
plus infection
(bacteria or virus)
plus chemicals
plus ????
 But in some cases we know some risk
factors

6. Types of lymphocytes
B cells: humoral immunity
• antibody production
T cells: cellular immunity
• cytotoxicity against virus, fungus
• B cell help
Most lymphomas are of B cell type (80%)

7. B cell malignancies
Pre-B acute lympho-
blastic leukaemia
B cell lymphoma Chronic lympho-
cytic leukaemia
Multiple myeloma
Progressive B lymphocyte maturation
Bone marrow
Lymph node,
lymph, blood,
bone marrow
Lymph node,
lymph, blood,
bone marrow
Bone marrow
Lymphoid stem cell Maturing B cell
many stages
Mature B cell Plasma cell

8. How does lymphoma
present?
 Patient notices lumps in
neck, under arms, in groin
(lymphadenopathy)
 Lymphadenopathy noted
during examination for
other reason eg. check up
Abnormal blood findings
unusual (cf. leukaemia)

9. Making the diagnosis
• blood
•Lymph node excision biopsy
•Chest x-ray
•CT of thorax abdominal
•Petuis and bone marrow biopsy

10. Making the diagnosis
nodular (follicular) diffuse
small cell large cell
Indolent Aggressive

11. Hodgkin’s lymphoma
(HL)
 Accounts for ~ 30% of all malignant lymphomas
 Composed of two different disease entities:
Lymphocyte-predominant Hodgkin’s (LPHL),
making up ~ 5% of cases and
Classical HL, representing
~ 95% of all HLs.
A common factor of both HL types is that
neoplastic cells constitute only a small minority of
the cells in the affected tissue, often corresponding
to < 2% of the total tumour

12. Features of Classical Hodgkin Lymphoma
 Fever
 Weight loss
 Loss appetite
 Night sweats
 pruritus

13. Hodgkin’s Lymphoma - Management
1 – radio therapy and short course of
chemotherapy
2- radio therapy and long course of
chemotherapy
3 – high dose of chemotherapy and stem
cell

15. REFFERNCE
 http://
www.mayoclinic.org/diseases-conditions/hodgkin
 http://www.merckmanuals.com/professio
nal/hematology-and-
oncology/lymphomas/hodgkin-
lymphoma
 http://www.cancernetwork.com/leukemia
-lymphoma/hodgkins-lymphoma-elderly-
different-disease-patients-over-60