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Lectures,Teaching plan, Development
- 1. Dr. Tahir Abbas (Ph.D. Zoology) Major Fields of Interest: Zoology, Toxicology, Teratology, Rehabilitation, Cancer
- 2. 24 days 64days Hypothalamus P.G T.G FSH, LH A.G HRF Th. G Androgen P O Sertoli CellLeydig’s Cell ABP S.T ACTIVIN INHIBIN DHT TESTOSTERONE SPERMATOGONIUM 2n 2n Mitosis Primary Spermatocyte 2n Differentiation Secondary Spermatocytes n First Meiotic Spermatids Second Meiotic n 24days 16 days ClonalExpansionMaturationDifferentiation Spermatidogenesis Spermiogenesis SPERMATOCYTOGENESIS SPERMATOGENESIS Germ line Cell Spermatozoa ACTH Designed by; Dr. Tahir Abbas P 53 mRNA
- 3. CLEAVAGE EMBRYO Cleavage Planes AP VP Meridional Sagittal Equatorial Latitudinal Vertical Transversal Cleavage Patterns HOLOBLASTIC MEROBLASTIC Radial Superimposed Deuterostome Human Bilateral Tunicates Superimposed Spiral Not Superimposed Protostomes Rotational Asynchronous Mammals Discoidal Reptiles Birds Superficial Insects a b c d *a; alecithal b; microlecithal c; macrolecitha d; telolecithal e; mesolecithal f; centrolecithal TYPES OF EGGS … ….…….……. …….……. e f a, b b e, f b, e c e, f Design by; Dr. Tahir Abbas
- 4. P MAT MITOTIC PHASE G1 S Go 9 h 10 h 3.5-5 h 0.5 h Pre-mitosis Check PointPost-mitosis Check Point Cyclin B, CDK 1 Cyclin A, CDK 2 Cyclin A, CDK 1 CDK 2, Cyclin E 53 PAdenyl cyclase cAMP m RNA PTK Glucose INSULUN organizer β-catenin Homeobox genes MPFPrepared by Dr. Tahir Abbas PL-C PIP2 DAG E.R INTERPHASE KARYO KINESIS MITOSIS P; prophase, G; gap, M; metaphase, A; anaphase, T; telophase, S; synthesis, P53; protein forming gene, MPF; maturation promoting factor, PTK; protein tyrosine kinase, PL-C; phospholipase, PIP2; phosphatidyl inositol bisphosphate, DAG; diaceyl glycerol, E.R; endoplasmic reticulum Check Point REGULATION OF CELL CYCLE & CLEAVAGE
- 5. Ovary Egg F Oviduct Ampulla 24 hc Morula 16 cell cavitation Trophoblast b. c Blastocyst ICM (13 C) 64 Cell 50 Cell DIFFERENTIATION FGF ZP hatching Endometrium implantation Decidua EPIBLAST HYPOBLAST Extra-embryonic Endoderm Yolk Sac Embryonic Epiblast Amniotic Epiblast ECTODERM Primitive Streak ENDODERM Mesoderm Embryonic Mesoderm Extra - embryonic Mesoderm Amnion Integumentary Nervous MESODERM Skin, hair, glands as sweat, sebaceous, mammary & nail Anterior Lobe of Pituitary Gland, Eye Lens cell Epithelium of oral cavity & nose, teeth covering BRAIN, SPINAL CORD Posterior Lobe of Pituitary Gland Medulla of Adrenal Gland Sensory, Motor Nerves Intermediate mesodermReproductive System Renal System Lung, Thyroid, Thymus, Trachea Middle Ear , Liver Ovary Uterus Oviduct Vagina Testes, Vas deference Epididymis Dorsal mesoderm Kidney Nephron Muscles Axial Skeleton Lateral mesoderm Pleura Respiratory Parts Cortex of Adrenal Gland Heart Blood Cells Blood Vessels Pericardium Allantois Placenta attach Umbilical cord Prepared by; Dr. Tahir Abbas tahirabbasbloch@gmail.com 5D 7D Haemochorial Placenta 18-20D Chorion * * Extra-Embryonic Layers 30-50D 0D Pharynx, Pancreas, GIT, Parathyroid
- 6. Epiboly Invagination Convergent Extension Ectoderm Spemann’s Organizer Intercalation SHH PKT PL-C PIP E.R Ca ++ Cadherin β-catenin mRNA Animal Hemisphere Blastula Gastrulation Mesoderm Endoderm C A M Bottle Cells NOG NOGGIN 17 Notochord FGF TGF-β Wnt SMAD Growth BMP CHORDIN ACTIVIN Follistatin 7 Muscle GIT Ectoderm E X T E R N A L E C T O D E R M External Skin Hair Nails Epithelium Lens Eye Glands Tooth Enamel Anterior P.G Cornea Receptors Nasal Cavity Dental Optic Nerves Mesenchyme Retina N E U R O E C T O D E R M Neural Tube BRAIN Spinal Cord Neural Crest Skin PigmentsANS V.H Adrenal Medulla Septa Prepared by; Dr. Tahir Abbas tahirabbasbloch@gmail.com DAG
- 7. Spemann’s Organizer PKT PL-C PIP E.R Ca ++ β-catenin mRNA Blastula Gastrulation TF NOGIN 17 FGF TGF-β Wnt BMP CHORDIN 7 Prepared by; Dr. Tahir Abbas tahirabbasbloch@gmail.com A 10 DAG A.Cap Dorsal Ventral V.Cap Dorsal V.P Ventral V.P Dorsal A.P Ventral A.P G.C cAMP Ca 30 Follistatin Dorsal Lip Ventral Lip Gremlin Dorsal Vegetal Cell Nieuwkoop Center Bicoid CADHERIN SIAMOIS AD DBD SSD Ligand MyC SMAD CAM DORSAL VENTRAL A P Blemmyes Megacephaly Conjoin Twin PAX NODAL Glucose G-6-P F-1, 6-BP 3-PG P.A Operon Lac- SHH HOX Activin
- 8. ECTODERM MESODERM ENDODERM MESODERM ENDODERM Neuroectoderm N-Cadherin Neural Crest Somite Neural Fold Notochord Neural Groove Neural Ridges Neural Fold Primary Neurulation Secondary Neurulation Designed by; Dr. Tahir Abbas PROSENCEPHALON MESENCEPHALON RHOMBENCEPHALON Telencephalon Diencephalon Metencephalon Myelencephalon Cerebral Hemisphere Hypothalamus Thalamus Mid Brain Pons Cerebellum Medulla Spinal Cord Neural Tube NeuralEpithelialCell Spina Bifida Neural Progenitor Cells