This document discusses leprosy (Hansen's disease), including its classification, signs and symptoms, diagnosis, and treatment. It is caused by the bacterium Mycobacterium leprae and primarily affects the skin and peripheral nerves. Symptoms include numb bumps on the skin that do not heal and muscle weakness. Leprosy is diagnosed based on skin lesions and nerve damage and classified using systems like Ridley-Jopling. It is treated with multidrug therapy including dapsone, rifampicin, and clofazimine. While still an issue in some developing areas, leprosy has been largely eliminated worldwide through modern medical treatment.
3. Leprosy is also known as Hansen’s disease, after the
scientist who discovered M. leprae In 1873.
Leprosy is an infectious disease that causes severe,
disfiguring skin sores and nerve damage in the arms and
legs.
Today, about 180,000 people worldwide are infected with
leprosy, according to the World Health Organization, most
of them in Africa and Asia. About 200 people are
diagnosed with leprosy in the U.S. every year.
4. Chronic granulomatous infectious disease
Caused by Mycobacterium leprae
Mainly involves the peripheral nerves and skin
Other organs may involve:
Mucosa of mouth
Upper respiratory tract
Eyes
Bones & Muscles
Testes etc.
Commonly involves every organ except
CNC, Ovary and Lungs
6. Identify the patients likely to develop the deformities and
determine the prognosis
Frame the line of treatment
Helpful in planning and evaluation of leprosy control
activities
Identify the infectious cases-Epidemiological importance-
Principle targets for treatment
7. Three types of classification
1. Indian Classification
2. Ridly and jopling classification
Indeterminate type
Tuberculoid type
Borderline type
Lepromatus type
Pure neuritic type
8. Divides Leprosy cases into five groups according to their
position on an immunohistological scale.
Tuberculoid
Borderline Tuberculoid
Borderline Borderline
Borderline Lepromatous
Lepromatous
9. Large bumps on the skin that do not feel
pain.
Large bumps on the skin that do not heal for
weeks or months.
Muscle weakness .
Disappearance of eyebrows or eyelashes .
10. Mycobacterium leprae multiplies very
slowly.
Symptoms can take as long as 20 years to
appear.
I.
Well defined skin lesions that are numb.
II.
Chronically stuffy nose and many skin lesions and
nodules on both sides of the body.
11. Hypopigmented or reddish skin
lesions with definite loss of sensation
Damage to the peripheral nerves, as
demonstrated by loss of sensation
Weakness of the muscles of hands, feet or face
Positive skin smear
12. Common drugs
I. Dapsone
II. Rifampicin
III. Clofazimine
The combination of these three drugs Is
known as multi drug therapy (MDT)
13. Used all over the world for 30years
1-2mg/kg of body weight
Weakly bactericidal effect
High bactericidal against M.Ieprae
Single dose of 1500mg
3-4 consecutive daily doses of 600mg
Synthesized for treatment of TB
Found to have greater value against M.Ieprae
May give darkish coloration to the skin,urinesweat
14. Fortunately, modern medicine has cured most of the
world of Leprosy
People with Leprosy are being more accepted by
communities around the world
Leprosy still Remains a problem in
undeveloped countries
The World Health Organization is putting a stop to this
If they reach their goal, Leprosy should be eliminated from the
world within 20 years
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