1. CURRICULUM VITAE
NAME: Aleksandra Stojanovic-Terpo
Phone: (708) 991-7134
Cell: (773) 474-0705
E-mail: astojan@uic.edu
EDUCATION:
1991-1999: -BS and MS Graduated Engineer
College of Technology and Metallurgy, Department of Biochemistry and
Biotechnology, University of Belgrade, Yugoslavia
The requirement for obtaining the Bachelor degree diploma comprised of 38 exams with
the Bachelor’s Thesis work included. Overall GPA was 8.00 out of 10.00.
WORK EXPERIENCE:
2004-curent: Research Specialist in Health Sciences- Department of Pharmacology,
College of Medicine, University of Illinois at Chicago, IL.
Responsibilities as Lab manager:
Writing IRB, IBC, ACC protocols and renewals
Coordination between PI’s and grant and protocol officers
Communication with companies representatives
Ordering, reconciling
Maintenance of lab instruments
Hygiene officer
Prompt response on all ongoing lab and administration problems
Hire, train, develop and manage lab staff
Train and supervise new lab members
Responsibilities as Researcher:
The investigation of signaling pathways involved in the platelet activation
Blood drawing and isolation of platelet from humans and genetic modified mice
The electrochemical measurements of free radicals
In vivo experiments on animals (bleeding time, sepsis models, thrombosis models-
ferry chloride and laser injury); isolation of microphages from mice; isolation of
organs from genetic manipulated mice,
Production of monoclonal and polyclonal antibodies; maintenance of cell and
bacterial cultures, and animal colonies; purification of proteins
Replicate, refine and add/develop new research approaches based on project needs
2. 2002-2004: - Visiting Research Specialist in Health Sciences- Department of
Pharmacology, College of Medicine, University of Illinois at Chicago, IL.
Responsibilities:
Investigation of signaling pathways involved in platelet activation
Drawing blood and isolation of platelet from genetic manipulated mice
Production of monoclonal and polyclonal antibodies
Maintenance of cell and bacterial cultures, and animal colonies
Purification of proteins
Ordering and administrative duties.
2000-2002: - A Senior Research Advisor at Institute of Public Health- Center for
Education and Scientific Research, Information Systems and Public Relations,
Kragujevac.
Responsibilities:
Analyzing of contents of the public water supply, wastewater, pesticides,
pollutants, gas, and food according to stringent standards using various techniques
including chromatography and mass-spectroscopy
Developing of new methods for detection of clinically relevant parameters in
bodily fluids
Developing of new methods for microbiological and chemical control of water and
food.
1996 and 1998: - A Researcher at the Institute of Immunology- Torlak, Belgrade.
Responsibilities: assisting in production of antibodies and vaccines. Produced
Lactobacterial agents intended to prevent both bacterial and yeast infection of the
digestive tract.
COMPUTER SKILLS:
Work in Windows both on PC and Mac (Word, Excel, Power Point,), Adobe, Canvas,
Graph Pad, Instat
PUBLICATIONS:
1. Estevez B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J,
Ruggeri Z, Du X: Signaling-mediated cooperativity between glycoprotein Ib-IX
and protease-activated receptors in thrombin-induced platelet activation, Blood
Nov. 2015
2. Shen B, Zhao X, O’Brien K, Stoanovic-Terpo A, Delaney MK, Kim K, Cho J,
Lam SC, Du X:Selective nhibition of outside-in signaling for platelet integrin
alphaIIbeta3 as a novel and safer anti-thrombotic strategy, Amerivcan Journal of
Hematology, May 2014, 89(6):E10-E11
3. Delaney MK, Liu J, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X:
3. Agonist-induced platelet procoagulant activity requires shear and a Rac1-
dependent signaling mechanism. Blood, July 2014, 124(12).
4. Shen B, Zhao X, O’Brien K, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J,
Lam SC, Du X: A directional switch of integrin siganiling and a new anti-
thrombotic strategy. Nature, Oct. 2013, 503(7474)
5. Rusu L, Andreeva A, Vistntine D, Kim K, Vogel S, Stojanovic-Terpo A, Chernaya
O, Liu G, Bakhshi F, Haberichter S, Iwanari H, Kusono-Arai O, Suzuki N,
Hamakubo T, Kozasa T, Cho J, Du X, Minshall R: G protin-dependant basal and
evoked endothelial cell vWF secretion. Blood, Sep. 2013, 123(3).
6. Yin H, Stojanovic-Terpo A, Xu W, Corken A, Zakharov A, Qien F, Pavlovic S,
Krbanjevic A, Lyubimov A, Wang Z, Ware J, Du X: Role for platelet glycoprotein
Ib-IX and effects of its inhibition in Endotoxemia-induced thrombosis,
thrombocytopenia, and mortality. ATVB, Sep. 2009, 33(11)
Yin H, Stojanovic-Terpo A: These authors contributed equally to this work.
7. Estevez B, Stojanovic-Terpo A, Dealney MK, O’Brien K, Berndt M, Ruan C, Du
X: LIM Kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2
syhtesis, platelet activation, and thrombosis. Blood, Apr. 2013, 121(22)
Estevez B, Stojanovic-Terpo A: These authors contributed equally to this work
8. O’Brien K, Stojanovic-Terpo A, Hay N, Du X: An novel role for Akt3 in platelet
activation and thrombosis. Blood, Aug. 2011, 118(15): 4215-23
9. Starin M, Wu S, Stoajnovic-Terpo A, Du X, Bona R, Liu B, Li Z: Heat-shock
protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V
complex. Blood, May, 2011: 117(26):7136-44
10. Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Clifford LA, Du X: An important
role of the Src family kinase Lyn in stimulating platelet granule secretion, 2009, J
Biol. Chem., Feb. 2010, 285(17):12559-70
11. Senyuk, V, Rinaldi, CR, Li D, Cattaneo F, Stojanovic A, Pane F, Du X, Mahmud
N, Dickstein J, Nucifora G: Consistent Up-regulation of Stat3 Independently of
Jak2 Mutations a New Murine Model of Essential Thrombocythemia. Cancer
Research, 2009, 69(1): 262-271
12. Marjanovic JA, Stojanovic A, Brovkovych VM, Skidgel RA, Du X: Signaling-
mediated Functional Activation of Inducible Nitric-oxide Synthase and Its Role in
Stimulating Platelet Activation, J Biol. Chem., 2008, Oct 24; 283(43): 28827-34
Marjanovic JA, Stojanovic A: These authors contributed equally to this work.
4. 13. Yin H, Stojanovic A, Hay N, Du X: The role of Akt in the signaling pathway of
the glycoprotein Ib-IX induced platelet activation, Blood, 2008, 111(2), 658-665
14. Flevaris P, Stojanovic A, Gong H, Chishti A, Welch E, Du X: A molecular switch
that controls cell spreading and retraction, J Cell Biology, 2007, Nov 5, 179(3),
553-565
15. Xi X, Flevaris P, Stojanovic A, Chishti A, Lam C-T S, Du X: Tyrosine
Phosphorylation of the Integrin β3 Cleavage by Calpain, J Biol. Chem., 2006, Oct
6; 281(40): 29426-30
Xi X, Flevaris P, Stojanovic A: These authors contributed equally to this work.
16. Stojanovic A, Marjanovic JA, Brovkovych V, Peng X, Hay N, Skidgel RA, Du X:
A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in
stimulating platelet secretion and aggregation, J Biol. Chem., 2006 Jun 16;
281(24): 16333-9
17. Marjanovic JA, Li Z, Stojanovic A, Du X: Stimulatory roles of nitric-oxide
synthase 3 and guanylyl cyclase in platelet activation, J Biol. Chem., 2005 Nov 11:
280(45): 37430-8
ABSTRACTS:
1. Stojanovic A, Gorovoy m, Voyno-Yasenetskaya T, Du X: The LIM Kinase-1 in
the Glycoprotein Ib-IX Complex-Mediated Platelet Activation and Thrombus
Formation, American Society of Hematology, Annual Meeting, 2008, Blood
112(11): 48-48
2. Oral presentation
3. O’Brien KA, Stojanovic A, Hay N, Du XP: The Role of AKT3 in Platelet
Activation: American Society of Hematology, Annual Meeting, 2008, Blood
112(11): 985-985
4. Marjanovic JA, Li Z, Stojanovic A, Du X: Nitric Oxide Synthase 3 Place
Stimulatory Role in Platelet Secretion and Aggregation, 12th
Midwest Platelet
Conference, Lexington, KY, 2008
5. O’Brien KA, Stojanovic A, Hay N, Du XP: The Role of AKT3 in Platelet
Activation, 12th
Midwest Platelet Conference, Lexington, KY, 2008
6. Yin H, Stojanovic A, Hay N, Du X: The Roles of Akt1 and Akt2 /GPIb-IX-
mediated Platelet Activation Signaling, American Society of Hematology, Annual
Meeting, 2007, Blood 110(11): 1063A-1063A, Abstract #3635
7. Yin H, Stojanovic A, Hay N, Du X: The Role of Akt in the VWF/GPIb-IX
5. Induced Platelet Activation, Gordon Research Conference in Cell Biology of
Megakaryocytes and Platelets, 2007
8. Flevaris P, Stojanovic A, Burleigh M, Welch E, Du X: A Novel Calpain-
Dependent Mechanism that Control the Direction of β3 Integrin Outside-In
Signaling, Gordon Research Conference in Cell Biology of Megakaryocytes and
Platelets, 2007
9. Stojanovic A, Marjanovic JA, Brovkovych V, Skidgel R, Hay N, Du X: Akt
Mediates Platelet Activation by Stimulating Nitric Oxide Synthesis and cGMP
Elevation, 11th
Midwest Platelet Conference, Chicago, IL, 2006
10. Stojanovic A, Xi X, Flevaris P, Chishti A, Lam C-T S, Du X: Tyrosine
Phosphorylation of the Integrin β3 Cleavage by Calpain, American Society of
Hematology, Annual Meeting, 2006
11. Oral Presentation
12. Stojanovic A, Marjanovic JA, Brovkovych V, Skidgel R, Hay N, Du X: Akt
Mediates Platelet Activation by Stimulating Nitric Oxide Synthesis and cGMP
Elevation, American Society of Hematology, Annual Meeting, 2005, Blood
106(11): Abstract #: 1652
13. Marjanovic JA, Stojanovic A, Brovkovych V, Skidgel R, Du X: Inducible Nitric
Oxide Synthase Place Stimulatory Role in Platelet Activation, American Society
of Hematology, Annual Meeting, 2005, Blood 106(11): Abstract #: 1650
14. Marjanovic JA, Li Z, Stojanovic A, Du X: Nitric Oxide Synthase 3 Place
Stimulatory Role in Platelet Secretion and Aggregation, 10th
Midwest Platelet
Conference, Milwaukee, WI, 2004
15. Marjanovic JA, Li Z, Stojanovic A, Du X: Stimulatory Role of Nitric Oxide
Synthase 3 and Soluble Guanylyl Cyclase in Platelet Activation, Gordon Research
Conference in Hemostasis, 2004
16. Marjanovic JA, Li Z, Stojanovic A, Du X: Stimulatory Role of Nitric Oxide
Synthase 3 and Soluble Guanylyl Cyclase in Platelet Activation, American Society
of Hematology, Annual Meeting, 2003, Blood 102(11): Abstract #: 2865
6. Induced Platelet Activation, Gordon Research Conference in Cell Biology of
Megakaryocytes and Platelets, 2007
8. Flevaris P, Stojanovic A, Burleigh M, Welch E, Du X: A Novel Calpain-
Dependent Mechanism that Control the Direction of β3 Integrin Outside-In
Signaling, Gordon Research Conference in Cell Biology of Megakaryocytes and
Platelets, 2007
9. Stojanovic A, Marjanovic JA, Brovkovych V, Skidgel R, Hay N, Du X: Akt
Mediates Platelet Activation by Stimulating Nitric Oxide Synthesis and cGMP
Elevation, 11th
Midwest Platelet Conference, Chicago, IL, 2006
10. Stojanovic A, Xi X, Flevaris P, Chishti A, Lam C-T S, Du X: Tyrosine
Phosphorylation of the Integrin β3 Cleavage by Calpain, American Society of
Hematology, Annual Meeting, 2006
11. Oral Presentation
12. Stojanovic A, Marjanovic JA, Brovkovych V, Skidgel R, Hay N, Du X: Akt
Mediates Platelet Activation by Stimulating Nitric Oxide Synthesis and cGMP
Elevation, American Society of Hematology, Annual Meeting, 2005, Blood
106(11): Abstract #: 1652
13. Marjanovic JA, Stojanovic A, Brovkovych V, Skidgel R, Du X: Inducible Nitric
Oxide Synthase Place Stimulatory Role in Platelet Activation, American Society
of Hematology, Annual Meeting, 2005, Blood 106(11): Abstract #: 1650
14. Marjanovic JA, Li Z, Stojanovic A, Du X: Nitric Oxide Synthase 3 Place
Stimulatory Role in Platelet Secretion and Aggregation, 10th
Midwest Platelet
Conference, Milwaukee, WI, 2004
15. Marjanovic JA, Li Z, Stojanovic A, Du X: Stimulatory Role of Nitric Oxide
Synthase 3 and Soluble Guanylyl Cyclase in Platelet Activation, Gordon Research
Conference in Hemostasis, 2004
16. Marjanovic JA, Li Z, Stojanovic A, Du X: Stimulatory Role of Nitric Oxide
Synthase 3 and Soluble Guanylyl Cyclase in Platelet Activation, American Society
of Hematology, Annual Meeting, 2003, Blood 102(11): Abstract #: 2865