The future of medicines

1. DOSAGE FORM FOR PERSONALIZED
MEDICINE
M.SIMRANA FATHIMA
(M.PHARMACY)

2. INTRODUCTION
 Personalized medicine is a multifaceted to patient care.
 risk assessment.
 Diagnosis, treatment, management.
 Offers right drug to → to the right patient → for the right
disease → at the right time → with the right dosage.
 Relies on patients fundamental biology, DNA, RNA which
helps in disease conformation.

3. Find defected
DNA
mutation
• Eg:breast
cancer, patient
A has HER2
protien (rare)
Identify the
drugs against
mutation
• Trastuzumab
supresses the
protein and
tumour.
treatment
• The patient A is
given
TRASTUZUMAB

4. DEFINITION
Individualized or precision medicine or
genomi
One size does’nt fit all
Personalized medicine is the tailoring of
medical treatment to the individual
characteristics of each patient.

5. Categories of patient for personalized
medicine

6. Age related – eg paediatric patient
TABLETS: bigger size , so
broken into half
CAPSULE: opened
mixed/dissolved with
food or liquids
Loss of efficacy,
irritation in stomach,
improper dosing, bad
taste.
Minitablets
Orodispersible
dosage form.

7. Disease related - eg cancer
ANTILEUKEMIA
DRUG (6-
mercaptopurine)
Drug gets
metabolized
quickly so dose
is increased
Metabolise the
drug slowly and
need less dose
Most normal
people
Other
people
metabolizes the
drug poorly, so
fatal, minimum
dose
Small
portion
Tpmt deficient
Tpmt
normal

8. Genetically determined susceptibility
• After chemotheraphy, patient A was taking
erlotinib. But after 3 yrs the tumour wasn’t at
bay.
• The patient A underwent genetic testing which
resulted ALK (anaplastic lymphoma kinase)
positive.
• Patient A was prescribed with crizotinib which
supresses the ALK positive lung cancer tumour.
• After the clinical trials the tumour was barely
visible

9. Individual physiological status
Similar to the other categories

10. Thank you