2. WHAT IS A DATABASE ?
• A database is an organized collection of data,
generally stored and accessed electronically from a
computer system. Where databases are more complex
they are often developed using formal design and
modeling techniques.
3. WHAT IS A BIOLOGICAL DATABASE ?
• Biological databases are libraries of life sciences information,
collected from scientific experiments, published literature, high-
throughput experiment technology, and computational analysis.
4. FEATURES OF A BIOLOGICAL DATABASE:-
1.HETEROGENEITY
2.HIGH VOLUME DATA
3.UNCERTAINITY
4.DATA CURATION
5.DATA INTEGRATION
6.DATA SHARING
7.DYNAMICS
5. WHY DO WE NEED BIOLOGICAL DATABASE?
• BIOLOGICAL DATABASES SERVE A CRITICAL PURPOSE IN THE
COLLATION AND ORGANIZATION OF DATA RELATED TO
BIOLOGICAL SYSTEMS.
• THEY PROVIDE A COMPUTATIONAL SUPPORT AND A USER-
FRIENDLY INTERFACE TO A RESEARCHER FOR A MEANINGFUL
ANALYSIS OF BIOLOGICAL DATA.
6. TYPES OF DATABASES:-
1.PRIMARY DATABASES
2.SECONDARY DATABASES
7. PRIMARY DATABASES
• CONTAINS BIO-MOLECULAR DATA IN IT’S ORIGINAL DATA
FORM.
• EXPERIMENTAL RESULTS ARE SUBMITTED DIRECTLY INTO
THE DATABASE BY RESEARCHERS, AND THE DATA ARE
ESSENTIALLY ARCHIVAL IN NATURE.
• ONCE GIVEN A DATABASE ACCESSION NUMBER, THE DATA
IN PRIMARY DATABASES ARE NEVER CHANGED.
• EXAMPLES: GenBank, EMBL and DDBJ for RNA/DNA
sequences, SWISS-PROT and PIR for protein sequences and
8. COMPOSITE DATABASES
• COLLECTION OF VARIOUS PRIMARY DATABASE
SEQUENCES.
• RENDERS SEQUENCE SEARCHING HIGHLY EFFICIENT AS
IT SEARCHES MULTIPLE RESOURCES.
• EXAMPLES:-NDRB(Non-redundant Database),
OWL,MIPSX, SWISS-PROT + Tr EMBL
9.
10. SECONDARY DATABASES
• CONTAINS DATA DERIVED FROM THE RESULTS OF ANALYSING
PRIMARY DATA.
• MANUALLY CREATED OR AUTOMATICALLY GENERATED.
• CONTAINS MORE RELEVANT AND USEFUL INFORMATION
STRUCTURED TO SPECIFIC REQUIREMENTS.
• EXAMPLE:-PROSITE, PRINTS, BLOCKS, Pfam
