fungal infection and anti fungal drugs

1. FUNGAL INFECTIONS
Presented by;
Saurabh Negi
B.Pharma 4th year
HIPR Dehradun

2. Introduction
Infections disease caused by fungi also called mycoses
Mycoses are the common and a variety of environmental and
physiological condition can contribute to the development of fungal
disease.
 Fungi are eukaryotes grows predominantly by budding ( yeast) or
hyphae(moulds)
Fungal infection are transmitted by spores or hyphae and normally
enter the body through lungs or skin

3. Symptoms
(A)Peeling of skin (b)cracking of skin (c) rashes (d) itching

4. TYPES OF FUNGAL INFECTION
1- SUPERFICIAL MYCOSES – Outer layer of skin ,nail and hair .
eg. – Yeast
(a) Non inflammatory
(b) Inflammatory
2- SUBCUTANEOUS MYCOSES – Deeper layer of skin .
3- SYSTEMIC MYCOSES -mycoses result from breathing in the spores of fungi
Respiratory tract ,vaginal yeast infection

5. Tinea pedis
Also called athlete’s foot
it is fungal infection of the foot
Fungus grows moist or warm environment such as shoes socks swimming
pools
It causes peeling redness itching burning and sometime blisters sores

6. Tinea corporis
Also called ringworm
It is fungal infection of skin
It appear everywhere of the body and appear as a red circular flat sore

7. Anti fungal drugs
Those drugs which are used to treat fungal infections
Anti fungal drugs are used for both superficial(topical) and systemic type
of fungal infections

8. Classification
1 – Antibiotic
(a) – Polyenes – Amphotericin
Nystatin
Hamycin
(b) Echinocandins - Capsofungin
Micafungin
Anidulafungin
(c) Heterocyclic benzofuran – Griseofulvin
2 – Antimetabolite – Flucytosine

9. 3 - Azoles
(A) – Imidazoles
(a) Topical – clotrimazole (b) Systemic - ketoconazole
Econazole
Oxiconazole
(B) Triazoles (systemic) – fluconazole
Itraconazole
Voriconazole
4 – Allylamine - terbinafine
5 –Other topical agent - Benzoic acid
Sod. Thiosulfate
Butenafine

11. Amphoterecin

12. Griseofulvin
Griseofulvin
Intract with microtubules of mitotic spindle and
with cytoplasmic microtubules
Prevent spindle formation and mitosis in fungi
Inhibit the growth of fungi

13. Mechanism of action – Imidazole & Triazoles
Inhibit the fungal cytochrome P450 enzyme lanosterol 14-
demethylase
Impair with ergosterol synthesis
Inhibit fungal cell

14. Mechanism of action – Terbinafine

15. Submitted to
Minakshi Barmola
(Asst. Prof. Pharmacology)