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CROHN’S DISEASE
Sanita Libin
Definition
 Regional enteritis / granulomatous
enteritis/Inflammatory bowel disease
 Can affect any part of the GI tract
 Chronic inflammatory bowel disease that
affect the lining of the GI tract.
Commonly affecting ilieum
Causes & Risk factors
 Idiopathic
 Linked probably with immune system
 Risk factors … Family history
 Jewish ancestry
 Smoking
 NSAIDS
Types
Colonic disease
common symptoms are
* Diarrhea
* General malaise
* Anorexia & Weight loss
* Persistent abdominal discomfort
* Pain in lower abdominal quadrant & left side
* Symptoms can mimic diverticulitis
Perianal disease
 Present more than 2/3rd of pt with
crohn,s disease
 Painless & asymptomatic
 It become painful when there is abscess
Small bowel disease
 Present with abdominal pain(Right lower
quadrant)
 Diarrhea
 Anorexia & wt loss
 Peripheral edema with low serum albumin
 Fever
Gastro duodenal crohns disease
 Affecting gastro duodenal region
 Occurs in 5% of people
 Symptoms resembles peptic ulcer
Sign & Symptoms
Main symptoms
 Crampy abdominal pain
 Fever
 Fatigue &general
malaise
 Anorexia & Weight loss
 Pain in passing stool
 Persistent watery
diarrhea
Other symptoms
 Constipation
 Eye inflammation
 Fistula, anal fissure
 Arthritis
 Liver inflammation
 Moth ulcer
 Rectal bleeding
 Skin lump or sore
Diagnostic evaluation
 HC & PE
 Blood test (anemia)
 Barium meal
 X- ray
 Sigmoidoscopy
 Colonoscopy
Management
Depend up on the severity and extend of
disease
 Medical management
Anti inflammation drug
Sulfasalazine
Mesalamine
Cortisone & steroid
Prednisone
Immune system suppressor
Block immune reaction that contribute to
inflammation
Azathioprine
Infliximab (Remicade) to control thhe immune
response
Antibiotic
Ampicillin
sulfonamide
cephalosporin
Anti diarrhoel
loparamide
codeine
Diet & nutrition management
 Balanced diet with sufficient calorie
 Total pare nteral nutrition
Surgical management
Colectomy with Ileostomy
Thank you

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Chrons disease

  • 2. Definition  Regional enteritis / granulomatous enteritis/Inflammatory bowel disease  Can affect any part of the GI tract  Chronic inflammatory bowel disease that affect the lining of the GI tract. Commonly affecting ilieum
  • 3.
  • 4. Causes & Risk factors  Idiopathic  Linked probably with immune system  Risk factors … Family history  Jewish ancestry  Smoking  NSAIDS
  • 5.
  • 6. Types Colonic disease common symptoms are * Diarrhea * General malaise * Anorexia & Weight loss * Persistent abdominal discomfort * Pain in lower abdominal quadrant & left side * Symptoms can mimic diverticulitis
  • 7. Perianal disease  Present more than 2/3rd of pt with crohn,s disease  Painless & asymptomatic  It become painful when there is abscess
  • 8. Small bowel disease  Present with abdominal pain(Right lower quadrant)  Diarrhea  Anorexia & wt loss  Peripheral edema with low serum albumin  Fever
  • 9. Gastro duodenal crohns disease  Affecting gastro duodenal region  Occurs in 5% of people  Symptoms resembles peptic ulcer
  • 10. Sign & Symptoms Main symptoms  Crampy abdominal pain  Fever  Fatigue &general malaise  Anorexia & Weight loss  Pain in passing stool  Persistent watery diarrhea Other symptoms  Constipation  Eye inflammation  Fistula, anal fissure  Arthritis  Liver inflammation  Moth ulcer  Rectal bleeding  Skin lump or sore
  • 11. Diagnostic evaluation  HC & PE  Blood test (anemia)  Barium meal  X- ray  Sigmoidoscopy  Colonoscopy
  • 12. Management Depend up on the severity and extend of disease  Medical management Anti inflammation drug Sulfasalazine Mesalamine Cortisone & steroid Prednisone
  • 13. Immune system suppressor Block immune reaction that contribute to inflammation Azathioprine Infliximab (Remicade) to control thhe immune response Antibiotic Ampicillin sulfonamide cephalosporin Anti diarrhoel loparamide codeine
  • 14. Diet & nutrition management  Balanced diet with sufficient calorie  Total pare nteral nutrition Surgical management Colectomy with Ileostomy