Metabolism of FRUCTOSE in human body.

1. A PRESENTATION ON
‘’ METABOLISM OF FRUCTOSE IN LIVER’’
Presented By :
Sunil Kumar Sahoo
Enrolment No-CUSB1703132020
First Semester, L.Sc.-553

2. CONTENTS –
• INTRODUCTION
• PATHWAY OF FRUCTOSE METABOLISM
• DISORDERS RELATED TO IT’S METABOLISM
• IMPORTANCE OF FRUCTOSE
• REFERENCE

3. INTRODUCTION-
 Fructose is present in fruit juices & honey.
 Chief dietary source is sucrose which is a disaccharide composed
of ‘‘glucose & fructose” joined by α(1,2) bond.
 Sucrose is hydrolysed in the intestine by the enzyme sucrase.
 Fructose is mostly absorbed in the small intestine through GLUT-5
transporter mediated faciliated transport & taken by portal blood
to liver.

4. PATHWAY OF FRUCTOSE METABOLISM

5. DISORDERS RELATED TO FRUCTOSE
METABOLISM
Essential Fructosuria –
* Deficiency of the enzyme fructokinase.
* Fructose is not converted to fructose-1-phosphate.
* Excretion of fructose in urine.
Hereditary Fructose intolerance –
* Deficiency of enzyme Aldolase-B.
* Fructose-1-phosphate can not be converted to dihydroxy -
acetone phosphate & glyceraldehyde so it accumulates.
*Results in inhibition of fructokinase & impared clearance of fructose
from the blood.

6. BIOMEDICAL IMPORTANCE OF FRUCTOSE
Frutose is easily metabolized & a good source of
energy.
Seminal fluid is rich in fructose & spermatozoa
utilizes fructose for energy.
In diabetics , fructose metabolism through
sorbitol pathway may account for the
development of cataract.