1. Publications
1.
Inhibitionof toll-like receptor2 (TLR-2)-mediatedresponseinhumanalveolarepithelialcellsbymycolic
acidsand Mycobacteriumtuberculosismce1operonmutant.
SequeiraPC,Senaratne RH,RileyLW.
PathogDis.2014 Mar;70(2):132-40. doi:10.1111/2049-632X.12110. Epub 2013 Dec 16.
2.
Posttreatmentreactivationof tuberculosisinmice causedbyMycobacteriumtuberculosisdisruptedin
mce1R.
CheighCI,Senaratne R,Uchida Y, Casali N,Kendall LV,RileyLW.
J InfectDis.2010 Sep1;202(5):752-9. doi:10.1086/655224.
3.
Attenuationof Mycobacteriumtuberculosisfunctionallydisruptedinafattyacyl-coenzyme A synthetase
gene fadD5.
DunphyKY, Senaratne RH,Masuzawa M, Kendall LV,RileyLW.
J InfectDis.2010 Apr15;201(8):1232-9. doi:10.1086/651452.
4.
Attenuatedactivationof macrophage TLR9by DNA fromvirulentmycobacteria.
KiemerAK,Senaratne RH,HoppstädterJ,Diesel B,RileyLW,TabetaK, BauerS, BeutlerB,Zuraw BL.
J Innate Immun.2009;1(1):29-45. doi:10.1159/000142731. Epub 2008 Jul 2.

2. 5.
Mycobacteriumtuberculosisstrainsdisruptedinmce3andmce4 operonsare attenuatedinmice.
Senaratne RH,SiddersB,SequeiraP,SaundersG,DunphyK,Marjanovic O,ReaderJR, LimaP, ChanS,
Kendall S,McFaddenJ,RileyLW.
J Med Microbiol.2008 Feb;57(Pt2):164-70. doi: 10.1099/jmm.0.47454-0.
6.
Enhancedmortalitydespitecontrol of lunginfectioninmice aerogenicallyinfectedwitha
Mycobacteriumtuberculosismce1operonmutant.
Lima P,SiddersB,Morici L, ReaderR, Senaratne R, Casali N,RileyLW.
MicrobesInfect.2007 Sep;9(11):1285-90. Epub 2007 Jun9.
7.
Vaccine efficacyof anattenuatedbutpersistentMycobacteriumtuberculosiscysHmutant.
Senaratne RH,Mougous JD,ReaderJR, WilliamsSJ,ZhangT,Bertozzi CR,RileyLW.
J Med Microbiol.2007 Apr;56(Pt4):454-8.
8.
5'-Adenosinephosphosulphate reductase(CysH) protectsMycobacteriumtuberculosisagainstfree
radicalsduringchronicinfectionphase inmice.
Senaratne RH,De SilvaAD,WilliamsSJ,MougousJD,ReaderJR,Zhang T, ChanS, SiddersB,Lee DH, Chan
J, Bertozzi CR,RileyLW.
Mol Microbiol.2006 Mar;59(6):1744-53.
9.
A sulfatedmetabolite producedbystf3negativelyregulatesthe virulence of Mycobacterium
tuberculosis.

3. MougousJD, Senaratne RH,PetzoldCJ,JainM, Lee DH, Schelle MW,Leavell MD,Cox JS,Leary JA,Riley
LW, Bertozzi CR.
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4258-63. Epub2006 Mar 6.
10.
Identification,functionandstructure of the mycobacterial sulfotransferase thatinitiatessulfolipid-1
biosynthesis.
MougousJD, PetzoldCJ,Senaratne RH,Lee DH, AkeyDL,Lin FL, Munchel SE, PrattMR, RileyLW,Leary
JA,BergerJM, Bertozzi CR.
Nat Struct Mol Biol.2004 Aug;11(8):721-9. Epub2004 Jul 18.
11.
Trehalose isrequiredforgrowthof Mycobacterium smegmatis.
Woodruff PJ,CarlsonBL, SiridechadilokB,PrattMR, Senaratne RH,MougousJD, RileyLW,WilliamsSJ,
Bertozzi CR.
J Biol Chem.2004 Jul 9;279(28):28835-43. Epub 2004 Apr 21.
12.
Discoveryof sulfatedmetabolitesinmycobacteriawithagenetic andmassspectrometricapproach.
MougousJD, Leavell MD,Senaratne RH,LeighCD, WilliamsSJ,RileyLW,LearyJA,Bertozzi CR.
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17037-42. Epub2002 Dec 13.
13.
5'-adenosinephosphosulfate liesatametabolicbranchpointinmycobacteria.
WilliamsSJ,Senaratne RH,MougousJD,RileyLW,Bertozzi CR.
J Biol Chem.2002 Sep6;277(36):32606-15. Epub 2002 Jun 18.

4. 14.
Mechanismsof pyrazinamide resistanceinmycobacteria:importance of lackof uptake inadditionto
lack of pyrazinamidase activity.
RaynaudC, Lanéelle MA,Senaratne RH,DraperP,Lanéelle G,Daffé M.
Microbiology.1999 Jun;145 ( Pt 6):1359-67.
15.
Expressionof agene fora porin-like proteinof the OmpA familyfromMycobacteriumtuberculosis
H37Rv.
Senaratne RH,Mobasheri H, PapavinasasundaramKG,JennerP,LeaEJ, Draper P.
J Bacteriol.1998 Jul;180(14):3541-7.