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Thyroid & parathyroid
• Capsule
• Connective septa
• Lobule
• Parenchyam of the
thyroid is formed by –
thyroid follicle; (para
follicular cells)
Thyroid follicle
• Functional unit of the thyroid
• Spherical/cystic
• Central colloid core
• Single layered epithelium
• Connective tissue around Follicular
cells contain – fenestrate capillary
plexus,
lymph plexus and
sympathetic nerve fibers
Thyroid follicle at different levels
of activity
State of the
follicle
Lining epithelium Amount of colloid
Inactive/ resting Squamous Abundant
Active Cuboidal Moderate
Highly active Low columnar Scanty
C(clear) cells or parafollicular cells
• Polyhedral cells with oval
nucleus
• Paler & larger than thyroid
follicular cells
• present between basement
membrane and the follicular cell
• Secrets : Thyrocalcitonin which
lowers the blood calcium level.
Parathyroid gland
• Capsule
• Parenchyma of the
gland consist of two
types of cells
• Chief (principal )cells
• Oxyphil cells(stained
with acid dye)
Chief cells:
• Most numerous
• Shape: polygonal and
centrally placed nucleus
• Size: smaller
• Slightly eosinophilic
• Synthesizes: PTH
Oxyphil cells:
• Appear s just before puberty
• Less numerous than chief
cells.
• Larger than the chief cells
• Deeply acidophilic
• Function is not known.
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Thyroid and Parathyroid Anatomy and Functions

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  • 6. • Capsule • Connective septa • Lobule • Parenchyam of the thyroid is formed by – thyroid follicle; (para follicular cells)
  • 7. Thyroid follicle • Functional unit of the thyroid • Spherical/cystic • Central colloid core • Single layered epithelium • Connective tissue around Follicular cells contain – fenestrate capillary plexus, lymph plexus and sympathetic nerve fibers
  • 8. Thyroid follicle at different levels of activity State of the follicle Lining epithelium Amount of colloid Inactive/ resting Squamous Abundant Active Cuboidal Moderate Highly active Low columnar Scanty
  • 9. C(clear) cells or parafollicular cells • Polyhedral cells with oval nucleus • Paler & larger than thyroid follicular cells • present between basement membrane and the follicular cell • Secrets : Thyrocalcitonin which lowers the blood calcium level.
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  • 12. Parathyroid gland • Capsule • Parenchyma of the gland consist of two types of cells • Chief (principal )cells • Oxyphil cells(stained with acid dye)
  • 13. Chief cells: • Most numerous • Shape: polygonal and centrally placed nucleus • Size: smaller • Slightly eosinophilic • Synthesizes: PTH
  • 14. Oxyphil cells: • Appear s just before puberty • Less numerous than chief cells. • Larger than the chief cells • Deeply acidophilic • Function is not known.