DETAIL INFORMATION ABOUT ANTACID.

1. ANTACIDS
Mr.ROHIT CHAUDHARI
(F.Y.B.PHARMACY STUDENT)
K.K.Wagh College of Pharmacy,Panchavati Nashik.

2.  CONTENT- 1.DEFINATION OF ANTACID
2.CHARACTERISTICS OF ANTACID
3.INFORMATION- A. ALUMINIUM HYDROXIDE
GEL
B.ALUMINIUM PHOSPHATE
C.CALCIUM CARBONATE

3. 1.DEFINATION- AN ANTACID IS A SUBSTANCE WHICH
NEUTRALIZES STOMACH ACIDITY AND IS USED TO RELIEVE
HEARTBURN, INDIGESTION OR AN UPSET STOMACH.
THEY COME AS A LIQUID OR CHEWABLE TABLETS AND CAN BE
BOUGHT FROM PHARMACIES AND SHOPS WITHOUT A
PRESCRIPTION.

4. 2.CHARACTERISTICS OF ANTACID
1.IT SHOULD NOT BE ABSORBED IN SYSTEMIC CIRCULATION.
2.IT SHOULD NOT CAUSE SYSTEMIC ALKALOSIS.
3.IT SHOULD INHIBIT PEPSIN.
4.IT SHOULD BE PALATABLE AND INEXPENSIVE.
5.IT SHOULD PRODUCE RAPID AND LONG LASTING EFFECT.
6.IT SHOULD NEITHER BE A CONSTIPATIVE NOR LAXATIVE.

5. 3.INFORMATION
A. ALUMINIUM HYDROXIDE GEL –
MOLECULAR FORMULA- AL(OH)3,M.WT-78.
IT IS A HYBRATE SUSPENSION OF ALUMINIUM OXIDE WITH VARIABLE AMOUNTS OF BASIC
ALUMINIUM CARBONATE.IT CONTAIN NOT LESS THAN 3.5% AND NOT MORE THAN
4.4%W/W AL2O3.
PREPARATION-
IT IS PREPARED BY ADDITION OF HOT SOLUTION OF POTASH ALUM TO HOT SOLUTION OF SODIUM
CARBONATE.
3NA2CO3+ KAL(SO₄)₂+3H2O--> 3NA2 SO₄+K2 SO₄+3CO2+2AI(OH)3
APPLICATIONS-
1.USED AS SLOW ACTING ANTACID TO TREAT HYPERACIDITY.
2.EFFECTIVE FOR USE IN TREATMENTS OF ULCERS AND HYPERCHLORHYDRIA.

6. DOSE-
AROUND 7.5 ML, 4-6 TIMES A DAY. THIS 7.5 ML TO 15 ML AMOUNTS TO APPROXIMATELY 150-
300MG OF ALUMINIUM HYDROXIDE.
SOME MARKETED PREPARATION-

7. B.ALUMINIUM PHOSPHATE –
MOLECULAR FORMULA-AIPO4,M.WT. 122
IT CONSISTS MAINLY OF ABOUT 80% OF HYDRATE ALUMINIUM
ORTHOPHOSPHATE.
PREPARATION-
BY INTERACTION BETWEEN AQUEOUS ALUMINIUM CHLORIDE AND SODIUM
PHOSPHATE.
ALCL3+NA3PO4--> ALPO4+3NACL
APPLICATION-
USED AS A MILD ACTING ANTACID HAVING HALF THE ACID NEUTRALIZING
CAPACITY OF ALUMINIUM HYDROXIDE GEL.

8. DOSE-
5-15 ML(1 TEASPOONFUL TO 1 TABLESPOONFUL)
SOME MARKETED PREPARATION-

9. C. CALCIUM CARBONATE-
ALSO CALLED AS PRECIPITATED CHALK.
MOLECULAR FORMULA-CACO3, M.WT- 100.09
IT CONTAIN NOT LESS THAN 98% AND NOT MORE THAN 100.5% CACO3 CALCULATED ON DRIED BASIS.
PREPARATION-
1.PREPARED BY MIXING SOLUTIONS OF CALCIUM CHLORIDE AND SODIUM CARBONATE.
CACL2+NA2CO3--> CACO3+2NACL
2.IT CAN ALSO BE PREPARED BY PASSING CARBON DIOXIDE THROUGH LIME WATER.
CAO+CO2--> CACO3

10. APPLICATION-
1.USED AS A FAST ACTING NON-SYSTEMIC ANATACID.
2.AS A SUPPLEMENT FOR CALCIUM DEFICIENCY.
3.AS DENTRIFIES DUE TO MILD ABRASIVE PROPERTY AND IN COSMETICS.
SOME MARKETED PREPARATION-

11. GUIDENCE BY – PROF.D.V.JAIN
REFRNCES-1.WWW.GOOGLE.COM
2.WWW.YOUTUBE.COM
3.WWW.HEALTHLINE.COM
4.PIC (NIRALI PUBLICATION) BOOK

12. THANK YOU