2. El hepatoblastoma es el tumor hepático maligno más frecuente en la infancia. Afecta sobre todo a niños
menores de 3 años. Se trata de un tumor infrecuente, cuya incidencia parece aumentar en los últimos
años. Puede aparecer de forma aislada o integrarse en el contexto de un síndrome de predisposición.
DEFINICIÓN
3. EPIDEMIOLOGÍA
El hepatoblastoma (HB) supone el
79% de los tumores hepáticos
malignos pediátricos, pero solo el
2% de todos los tumores malignos
infantiles
01
La etiología se desconoce,
aunque se han descrito
factores de riesgo como la
prematuridad y un muy bajo
peso al nacer (< 1.500 g)
02
03
El promedio de edad en el
momento del diagnóstico varía
de 12 a 21 meses. El 4%
corresponde a formas
congénitas. La incidencia es
más elevada en los niños
portadores de anomalías
congénitas
04
La proporción en función del
sexo (varones/mujeres) es de
alrededor de 1,5 y la incidencia
se estima en 0,5-1,5 casos por
millón
6. SIGNOS CLINICOS
El signo revelador suele ser un
aumento de volumen del abdomen sin
otros signos asociados, salvo en los
tumores muy voluminosos (trastornos
del tránsito o dolor)
El diagnóstico puede
sospecharse en caso de
pubertad precoz con
secreción anormal de -HCG
(subunidad de la
gonadotropina coriónica
humana)
Puede manifestarse por una
ruptura tumoral o una
hemorragia intraabdominal
causante de un síndrome
abdominal agudo
La fiebre, el dolor, la ictericia
y la alteración del estado
general
Se han descrito varios
casos de asociación con
una osteoporosis
generalizada con fracturas.
8. Venus has a beautiful
name and is the second
planet from the Sun
VENUS
Concentración sérica de alfa-fetoproteína
La AFP es un marcador
muy sensible, pero
inespecífico de los tumores
hepáticos. Su
concentración debe
interpretarse en función de
la edad, porque existe una
secreción fisiológica en
recién nacidos
En todos los casos de
secreción no tumoral,
la concentración no es
tan elevada como en
los hepatoblastomas,
donde la
concentración sérica
media es mayor de 1,1
× 104ng/ml en el 90%
de los casos
9. Se puede observar una gran masa en el hígado
y áreas de hemorragia interna dentro del
tumor.
Ecografía abdominal
tomografía computarizada
(TC)
multifásica o la resonancia magnética nuclear (RMN).
10. BIOPSIA
HEPATICA
Aunque el diagnóstico de HB es muy
probable basándose en la asociación
de un tumor hepático con el aumento
de la AFP por encima de 104ng/ml,
la biopsia es necesaria para precisar
la biología del tumor y avanzar en
las posibilidades terapéuticas, al
permitir una mejor estratificación de
los pacientes antes de cualquier
tratamiento. La biopsia con aguja de
tipo Tru-Cut bajo anestesia general y
guiada por ecografía es el método
de elección. Debe realizarse a través
del hígado sano, dando prioridad al
método coaxial para evitar el riesgo
de diseminación tumoral
intraperitoneal
El diagnóstico histológico
de una muestra de tumor
es esencial, aunque
algunos investigadores
creen que la biopsia
puede no ser necesaria
en niños muy pequeños
(6 meses a 3 años) y así
evitar la probabilidad de
crecimiento o
diseminación del tumor
11. CLASIFICACION PRETEX
En Europa el Childhood Liver
Tumor Study Group de la Sociedad
Universal de Oncología Pediátrica
(SIOPEL) ha desarrollado la
evaluación preoperatoria del
sistema de estadificación de la
expansión tumoral (PRETEXT), que
parece ser un instrumento preciado
para la estratificación del peligro.
22. “This is a quote, words full of
wisdom that someone
important said and can
make the reader get
inspired.”
—SOMEONE FAMOUS
23. CLINICAL TRIAL
PRECLINICA
L
Mars is a actually a
very cold place
Human safety
PHASE 1
Venus is the
second planet from
the Sun
Expanded safety
PHASE 2
Mercury is the
smallest planet
Efficacy & safety
PHASE 3
Lab studies
24. TRIAL TIMELINE
1
Mercury is the closest
planet to the Sun and the
smallest one in the Solar
System
RESEARCH
2
Despite being red, Mars is
actually a cold place. It's
full of iron oxide dust
EXPERIMENTAL
3
Venus has a beautiful
name and is the second
planet from the Sun. It’s
terribly hot
RESULTS
4
Neptune is the farthest
planet from the Sun. It's
also the fourth-largest
object
CONCLUSIONS
25. 80%
PHASE 1
20%
MERCUR
Y
It’s the closest
planet to the
Sun
80%
MARS
Mars is a very
cold place
Success rate
Despite being red, Mars is
actually a cold place. It's
full of iron oxide dust
RESULTS
Young healthy people
20 - 80 Participants
26. TREND
PHASE 1
Despite being red, Mars is a
cold place. It's full of iron oxide
dust
PHASE 2
Neptune is the farthest planet
from the Sun. It's really cold
there
PHASE 3
Saturn is a gas giant. It’s
composed of hydrogen and
helium
Follow the link in the graph to modify its data and then paste
the new one here. For more info, click here
27. RESULTS
OUTCOME
TREATME
NT
123 42 397
GROUP 1 256 - 423
GROUP 2 90 89 190
GROUP 3 - 245 99
EXPERIMENT A
OUTCOME
TREATME
NT
- 36 93
GROUP 1 315 70 150
GROUP 2 777 - -
GROUP 3 375 - 36
EXPERIMENT B
29. RESULTS ANALYSIS
JUPITER
Jupiter is the biggest planet in
the entire Solar System
15%
Venus has a
very beautiful
name
30%
Mercury is the
smallest planet
55%
Mars is a very
cold place
SATURN
Saturn is a gas giant and is
composed of hydrogen and
helium
EARTH
Earth is the third planet from
the Sun and the only one with
life
30. SUCCESS RATE
Neptune is the farthest
planet from the Sun. It's
really cold there
NEPTUNE
10%
Despite being red, Mars
is actually a cold place.
It's full of iron oxide
dust
MARS
30%
Jupiter is the biggest
planet in the Solar
System. It’s a gas giant
JUPITER
60%
31. Do you know what helps you make
your point clear?
Lists like this one:
● They’re simple
● You can organize your ideas
clearly
● You’ll never forget to buy milk!
And the most important thing: the
audience won’t miss the point of your
presentation
CONCLUSIONS
32. You can replace the
image on the screen with
your own work. Just right-
click on it and select
“Replace image”
VISIT OUR
WEBSITE!
33. CREDITS: This presentation template was created by
Slidesgo, including icons by Flaticon and infographics &
images by Freepik
DO YOU HAVE ANY
QUESTIONS?
youremail@freepik.com
+91 620 421 838
yourcompany.com
THANKS!
Please keep this slide for attribution
36. Here’s an assortment of alternative resources whose style fits the one of this template
VECTORS
● Flat world health day illustration
PHOTOS
● Crop medic measuring pressure to patient
● Young medic with papers
ALTERNATIVE RESOURCES
37. Did you like the resources on this template? Get them for free at our other websites:
VECTORS
● Hand drawn world hepatitis day illustration
PHOTOS
● A female doctor with stethoscope around her neck using laptop on desk
● Doctors in masks with documents
ICON
● Icon Pack: Healthcare and Medical
RESOURCES
38. In order to use this template, you must credit Slidesgo by keeping the Thanks slide.
You are allowed to:
- Modify this template.
- Use it for both personal and commercial projects.
You are not allowed to:
- Sublicense, sell or rent any of Slidesgo Content (or a modified version of Slidesgo Content).
- Distribute Slidesgo Content unless it has been expressly authorized by Slidesgo.
- Include Slidesgo Content in an online or offline database or file.
- Offer Slidesgo templates (or modified versions of Slidesgo templates) for download.
- Acquire the copyright of Slidesgo Content.
For more information about editing slides, please read our FAQs or visit Slidesgo School:
https://slidesgo.com/faqs and https://slidesgo.com/slidesgo-school
Instructions for use
39. As a Premium user, you can use this template without attributing Slidesgo or keeping the "Thanks" slide.
You are allowed to:
● Modify this template.
● Use it for both personal and commercial purposes.
● Hide or delete the “Thanks” slide and the mention to Slidesgo in the credits.
● Share this template in an editable format with people who are not part of your team.
You are not allowed to:
● Sublicense, sell or rent this Slidesgo Template (or a modified version of this Slidesgo Template).
● Distribute this Slidesgo Template (or a modified version of this Slidesgo Template) or include it in a database or in
any other product or service that offers downloadable images, icons or presentations that may be subject to
distribution or resale.
● Use any of the elements that are part of this Slidesgo Template in an isolated and separated way from this
Template.
● Register any of the elements that are part of this template as a trademark or logo, or register it as a work in an
intellectual property registry or similar.
For more information about editing slides, please read our FAQs or visit Slidesgo School:
https://slidesgo.com/faqs and https://slidesgo.com/slidesgo-school
Instructions for use (premium users)
40. This presentation has been made using the following fonts:
Lilita One
(https://fonts.google.com/specimen/Lilita+One)
Roboto Slab
(https://fonts.google.com/specimen/Roboto+Condensed)
#330404 #ffffff #ffd300 #ffaa00
#d5dee5 #db3737 #ff5d5d #5ab9eb
#4a7999
#2e93bf
Fonts & colors used
41. Create your Story with our illustrated concepts. Choose the style you like the most, edit its colors, pick
the background and layers you want to show and bring them to life with the animator panel! It will boost
your presentation. Check out How it works.
Pana Amico Bro Rafiki Cuate
Storyset
42. You can easily resize these resources without losing quality. To change the color, just ungroup the resource
and click on the object you want to change. Then, click on the paint bucket and select the color you want.
Group the resource again when you’re done. You can also look for more infographics on Slidesgo.
Use our editable graphic resources...
43.
44.
45. JANUARY FEBRUARY MARCH APRIL MAY JUNE
PHASE 1
PHASE 2
Task 1
Task 2
Task 1
Task 2
JANUARY FEBRUARY MARCH APRIL
PHASE 1
Task 1
Task 2
51. You can resize these icons without losing quality.
You can change the stroke and fill color; just select the icon and click on the paint bucket/pen.
In Google Slides, you can also use Flaticon’s extension, allowing you to customize and add even more icons.
...and our sets of editable icons
58. Add the title here
Text 1 Text 2 Text 3
Text 4 Text 5 Text 6
2016 2017 2018 2019 2020
“Despite being red,
Mars is actually a
very cold place”
“Mercury is closest
planet to the Sun
and the smallest”
“Neptune is the
farthest-known
planet from the Sun”
“Saturn is a gas
giant and has
several rings”
“Venus has a
beautiful name and
is the second planet”
Premium infographics
59. “Mercury is closest
planet to the Sun
and the smallest”
TITLE 1
75% “Mercury is closest
planet to the Sun
and the smallest”
“Mercury is closest
planet to the Sun
and the smallest”
“Mercury is closest
planet to the Sun
and the smallest”
75%
Premium infographics
