1) Blow fill seal technology is used to aseptically produce small liquid-filled containers through continuous formation, filling, and sealing processes. 2) Jet injectors administer injections through compressed gas that forms a narrow, high-pressure jet instead of using hypodermic needles. 3) Both technologies offer sterile, safe administration of drugs without using needles and are useful for mass vaccinations.

1. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 1
Presented by
D. Ravi Shankar
(20L81S0403)
Department of Pharmaceutical Quality Assurance
BLOW FILL SEAL TECHNOLOGY
&JET INJECTOR

2. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 2
Contents :
Blow Fill Seal Technology Jet Injector
1. Introduction 1. Introduction
2. Concept & Working
3. Advantages & Applications
 Bibliography
2. Types
3. How it Works
4. Advantages & Uses

3. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 3
• Blow fill seal technology is used to produce small (0.1ml – 99ml) and large
volume (100ml & above) liquid filled containers.
• Rommelag is the master of this technology and market leader in making the
machines that uses this technology.
Introduction

4. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 4
Formation
Filling
Sealing of the containers
Concept and Working

5. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 5
• Rommelag’s BFS bottle pack machine produces
around 3000 bottles of 1000ml in one hour with
six moulds
 BFS include following steps
 Parison extrusion
Container moulding
Container filling
Container sealing
Container discharge

6. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 6
Advantages
•Reduce human intervention
•Produce sterile products
•Cleaning & Sterilization of prefabricated containers and closures is it required
•Make a viable delivery option for injectable products and traditional glasses.
Applications
•Respiratory preparations
•Oral solutions
•Gela and Liquids for rectal and vaginal preparations
•Soft drinks or Milk products

7. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 7

8. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 8
• It is a type of medical injecting syringe that uses a high pressure narrow jet
of the injection liquid instead of a hypodermic needle to penetrate the epidermis.
• It is powered by compressed air / gas, either by a pressure hose from a large
cylinder or from a built in gas catridge or small cylinder.
INTRODUCTION

9. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 9
Types
Ped- O- Jet
Biojector

10. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 10
It create a hair thin jet of fluid that impact the skin surface at 200 m/s
Can penetrate the skin & tissue to a depth of 20 mm
Advantages
• Useful in mass vaccination
• Reduced chance for infections
• Avoid accidental needle pricks
• Patient can use by himself
How it Works

11. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 11
Uses of Jet Injectors
• Plastic surgeons / Reconstructive Surgeons
• Dermatologists
• Otolaryngologists
• Colon – Rectal (Protocology)
• OB/GYN
• Emergency Room Physicians
• Orthopedic Surgeons
• Urologists
• Anesthesioogists

12. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 12
• Hoffman, P.N; R.A Abuknesha; N.J Andrews; D Samuel; J.S Lloyd (2001-07-16). "A model to assess the
infection potential of jet injectors used in mass immunisation. Population risk (Veterans and children) for
another deadly virus, previously known as "non A- non B" or Chronic Hepatitis C "CHC or HCV"". Vaccine.
19 (28–29): 4020–7. doi:10.1016/S0264-410X(01)00106-2. PMID 11427278.
• Brink, P.R.G.; Van Loon, M.; Trommelen, J.C.M.; Gribnau, W.J.; Smale-Novakova, I.R.O. (1985-12-01).
"Virus Transmission by Subcutaneous Jet Injection". J Med Microbiol. 20 (3): 393–7. doi:10.1099/00222615-
20-3-393. PMID 4068027.
• Canter, Jeffrey; Katherine Mackey; Loraine S. Good; Ronald R. Roberto; James Chin; Walter W. Bond;
Miriam J. Alter; John M. Horan (1990-09-01). "An Outbreak of Hepatitis B Associated With Jet Injections in a
Weight Reduction Clinic". Arch Intern Med. 150 (9): 1923–1927. doi:10.1001/archinte.1990.00390200105020.
PMID 2393323.
Bibliography

13. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 13

14. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 14