The document summarizes Mendel's laws of inheritance based on his experiments with pea plants. It discusses Mendel's discovery of the laws of dominance, segregation, and independent assortment through monohybrid and dihybrid crosses. The law of dominance states that one trait will mask the other in hybrid offspring. The law of segregation explains that alleles separate during gamete formation so each gamete contains one allele. The law of independent assortment says that allele pairs assort independently, resulting in multiple allele combinations in offspring. Mendel's laws explained inheritance of traits for the first time.
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INTRODUCTION:
Inheritance is the acquiring of genetic characteristics or traits from parents by their offspring.
In the year 1860, Gregor Johann Mendel, the father and founder of genetics unlocked the
mystery of genetics.
He conducted many experiments on the pea plants (Pisum sativum) and observed their pattern
of inheritance from one generation to the next generation.
His investigation led to the discovery of three laws of inheritance, famously known as Mendel’s
Laws of Inheritance.
Mendel’s laws of inheritance
1. The Law of Dominance, 2. Law of Segregation and 3. Law of Independent
Assortment
These laws came into existence by the experiments on pea plants (Pisum
sativum) in a variety of differing traits.
Mendel started his research with monohybrid cross.
Mendel observed that traits which were absent in the F1 generation had
reappeared in the F2 generation.
These observations led to the formulation of the Law of Dominance and the
Law of Segregation.
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Mendel’s law of dominance states that:
“When parents with pure, contrasting traits are crossed
together, only one form of trait appears in the next generation.
The hybrid offsprings will exhibit only the dominant trait in the
phenotype.”
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Law of dominance is known as the first law of inheritance. In this law, each
character is controlled by distinct units called factors, which occur in pairs. If
the pairs are heterozygous, one will always dominate the other.
Law of dominance explains that in a monohybrid cross between a pair of
contrasting traits, only one parental character will be expressed in the F1
generation and both parental characters will be expressed in the F2 generation
in the ratio 3:1.
The one which is expressed in the F1 generation is called the dominant trait
and the one which is suppressed is called a recessive trait. In simple words,
the law of dominance states that recessive traits are always dominated or
masked by the dominant trait. This law can be described by Mendel’s
experiment.
A monohybrid cross is a cross between the two monohybrid traits (TT and tt).
Here plants which have the same characters, but differ in only one character
were crossed.
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This is a first law of inheritance.
If your two alleles are different (heterozygous, e.g. Bb),
the trait associated with only one of these will be visible
(Dominant) while the other will be hidden (Recessive).
For example B is Dominant & b is Recessive.
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Law of Dominance:
In a hybrid union, the allele which expresses itself
phenotypically is the Dominant allele while the other
allele which fails to express itself phenotypically is the
Recessive allele.
The hybrid individual shows phenotypically only the
Dominant character.
The law of Dominance is often described as Mendel’s First
law of inheritance.
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Mendel’s law of segregation states that:
“During the formation of gamete, each gene separates from each
other so that each gamete carries only one allele for each gene.”
Law of segregation is the second law of inheritance.
This law explains that the pair of alleles segregate from each other
during meiosis cell division (gamete formation) so that only one allele will
be present in each gamete.
In a monohybrid cross, both the alleles are expressed in the F2 generation without
any blending. Thus, the law of segregation is based on the fact that each gamete
contains only one allele.
This law is based on four basic concepts:
•A gene exists in more than one form of an allele.
•When gametes are produced by meiosis, the allelic pairs separate,
leaving each gamete with a single allele.
•Every organism inherits two alleles for each trait.
•The two alleles of a pair are different, i.e., one is dominant and one is
recessive.
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Mendel’s law of segregation:
a) Factors (genes) for a particular trait occur in pairs.
b)For each trait, an organism inherits two genes, one from each
parent
1.One trait is controlled by one gene.
2.Each gene is found in two alleles.
3.During Gamete formation each allele is
segregated in one gamete.
The limitations of the law of segregation
Law of segregation applies only to traits that completely
control a single gene pair in which one of the two alleles is
overriding the other. Therefore, the law of segregation does
not apply to incompletely dominant or co-dominant alleles.
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States that each pair of alleles segregates independently of the other pairs and
all possible combinations of allele can occur in the resulting gametes.
When a dihybrid (or a polyhybrid) forms gametes,
(i) Each gamete receives one allele from each allelic pair and
(ii) The assortment of the alleles of different traits during the
gamete formation is totally independent of their original
combinations in the parents.
In other words, each allele of any one pair is free to combine with
any allele from each of the remaining pairs during the formation for
the gametes.
This is known as the law of independent Assortment of characters.
It is also referred to as Mendel’s third law of heredity
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Explanation of the law of independent Assortment
The principle of independent assortment was explained by Mendel with the help
of a dihybrid cross involving characters of cotyledon colour (yellow/round) and
seed shape (round/wrinkled).
Mendel’s Law of INDEPENDENT ASSORTMENT
Thus, the yellow round parent has the genotype (YYRR) and the green
wrinked parent (yyrr).
Since each parent is homozygous for both characters (colour and
shape), each will produce only one type of gametes.
The (YYRR) parent will produce all (YR) type gametes and the (yyrr)
will produce all (yr) type gametes.
Mendel crossed a true breeding variety of pea having yellow cotyledons (YY) and
round seeds (RR) with another true breeding variety having green cotyledons (yy)
and wrinked seeds (rr)
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All F1 dihybrids resulting from the fusion of these gametes would be double
heterozygous with (YyRr) genotype and appear yellow round.
This indicated that in the dihybrid cross also in each pair, the alleles behaved exactly
in the same way as in the monohybrid cross.
Both the dominants (Y and R) expressed themselves in F1 while both the recessive
alleles (y and r) remained hidden.
Mendel’s Law of INDEPENDENT ASSORTMENT
Types of Gametes formed by F 1 Dihybrid:
According to Mendel, during gamete formation by the F 1 dihybrid,
the alleles in both pairs Y-y and R-r first segregate from each other
(Law of Segregation).
Each pair segregates independently of the pair. Then the alleles enter
the gametes. A gametes can receive only one allele from each pair,
i.e. Y or y and R or r.
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Similarly, a gamete that receives a factor (gene) for colour must also
receive factor for shape (a factor for every character must be present
in each gamete).
Thus, a gamete that receives Y for colour may receive R or r for shape.
This would result in (YR) and (Yr) types of gamets. Simolarly, a gamete
that receives y for colour may receive R or r for shape.
Mendel’s Law of INDEPENDENT ASSORTMENT
This would give (yR) and (yr) types of gametes. In other
words, the F 1 dihybrid would produce four types of
gametes (YR), (Yr), (yR) and (yr) in equal proportions. This
is the principle of independent assortment of characters.
There will be four types of male gametes and four types
of female gametes formed by the F 1 dihybrid.
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1)The inheritance of each trait is determined by “units AA” or “factors
AA” (now called genes) that are passed on to descendants unchanged.
2) An individual inherits one such unit from each parent for each trait.
MENDEL CAME TO FOUR IMPORTANT CONCLUSIONS
FROM THESE EXPERIMENTAL RESULTS:
3) A trait may not show up in an individual but can
still be passed on to the next generation.
4) The genes for each trait segregate themselves
during gamete production.
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Exception of law of dominance:
1. Incomplete dominance: - In incomplete dominance when a red snapdragon flowered
plant is crossed with a white flowered plant an intermediate phenotype appears in the F1
hybrid instead of a parental phenotype.
2. Codominance: - Unlike dominance in codominance when a A (IAIAIAIA) blood group
individual mates with B (IBIBIBIB) blood group individual the offsprings have blood group
AB (IAIBIAIB) instead of A or B.
EXCEPTION TO MENDEL’S LAW
Exception of law of segregation:
1. Nondysjunction: - During meiosis homologous chromosomes/sister
chromatids and hence genes may move to a common gamete violating
law of segregation.
Exception of law of independent assortment:
1. Linkage:- When genes are present on the same chromosome they tend
to remain together and enter into the same gamete. This is the reason
behind deviation of dihybrid test cross ratio from 1:1:1:1 and occurrence
of parental combination in high frequencies.