The document discusses the global market size of drug leads, precursors, and drug discovery outsourcing. It provides insights into market trends such as:
1) The global drug discovery outsourcing market was estimated at $2.19 billion in 2016 and is expected to witness rapid growth due to increased outsourcing and investments in drug discovery R&D.
2) North America dominated the market in 2016, while Asia Pacific is expected to grow the fastest during 2020-2025 due to growth in pharmaceutical industries and less stringent regulations.
3) The beta-carotene market is driven by its use as a natural colorant and precursor to vitamin A to treat deficiencies, and in pharmaceuticals and
Global Drug Discovery and Precursor Markets Insights
1. GLOBAL MARKET SIZE OF :-DRUG LEADS & PRECURSOR
NAME:-SARAF PRIYA MADHAV
FINAL YEAR B.PHARMACY- VIII SEM
ROLL NO-53
SUBECT-NATURAL PRODUCT:COMMERCE,INDUSTRY &
REGULATIONS
GUIDED BY:-MRS.MOHINI UPADHYE MAA’M
2. CONTENT
Global market size of drug lead
Workflow insight
Therapeutic area insight
Drug type insight
Regional insight
Drug Discovery Outsourcing Market Share InsightS
Report scope
opportunities
Outlooks
Global market size of precursor
Beta carotenoid as an example of precusor
References
3. The global drug discovery outsourcing market size was estimated at USD 2.19 billion in 2016.
The pharmaceutical industry has witnessed radical changes in the past two decades, in terms
of a shift toward biologics, patent expiration, and unprecedented downsizing of internal
discovery of big pharmaceuticals.
It is long, costly, Required manpower, financial resources, and infrastructure
A. GLOBAL MARKET SIZE OF DRUG LEAD
4. The iterative process of lead identification, also known as hit-to-lead, is a significant stage in early drug
discovery.
It has historically proven to have improved efficiencies and economies of scale for drug developers.
Introduction of advanced in silico techniques to improve lead identification process, such as Computer-
Aided Drug Discovery (CADD)
It is anticipated to witness rapid growth in the coming years. This is owing to increased adoption of
outsourcing services and high investments in drug discovery R&D.
Need for resources with combinational knowledge of metabolism, analytical chemistry, and computer
software, along with high cost associated with integration of latest computation technology, is enabling
higher outsourcing of lead identification.
As a result, lead identification and candidate optimization accounted for the largest share in terms of
revenue in 2016.
Workflow Insights
5. Therapeutic Area Insights
I. Respiratory systems accounted for largest share in the drug discovery outsourcing market in 2016.
High incidence of respiratory disorders such as lung cancer, bronchitis, tuberculosis, chronic obstructive
pulmonary diseases (COPD), and asthma, coupled with increasing cases of drug resistance, has also influenced
segment growth.
II. Oncology therapeutic area to dominate the drug discovery services market in2019.”
In 2019, oncology therapeutic areas segment accounted for the largest market share in market as the number of
patients who have cancer is on the rise, the subsequent increase in the demand for effective cancer therapies and
the increasing R&D expenditure by pharmaceutical companies in this therapeutic area is fueling the growth of
this segment
III. Antimicrobial resistance is projected to become a global crisis with its high rate in 2018
Resulting in high economic burden. Companies have increased R&D in anti-infective drugs, This is poised to
benefit segment growth
IV. Medicinal chemistry services accounted for the largest market share in 2019.
6. Drug Type Insights
Small molecules pharmaceuticals accounted for the highest number of NDA approvals in 2014 and contributed a
substantial number of new molecular entities.
Increased significance and highly effective components add up to the potential of small molecules in
pharmaceutical portfolio. Owing to this, small molecules held the largest share in the overall market.
• Advantages of small molecules over larger ones
have increased investments in the field,
especially in cancer research.
• Ongoing studies to investigate and develop
novel therapeutics for various indications is
expected to further influence segment growth.
7. Regional Insights
North America dominated the market in 2016 owing to higher adoption of technological advancements,
presence of well-established research infrastructure, presence of key players, and higher investments in
drug discovery R&D. With outsourcing no longer being solely about cost reduction, rising need for
efficiency, quality, and innovation are expected to contribute to market growth.
For instance, China launched the Market Authorization Holder (MAH) pilot program, following which,
investments from venture capital increased in the nation’s biotech and pharmaceutical sector. Initiatives
for economic progress and high investments to raise infrastructure to support R&D further contributes to
growth in the APAC market.
Government initiatives in emerging Asia Pacific (APAC) countries to forge alliances with U.S.
pharmaceutical companies are anticipated to foster regional market growth. In addition, regulatory
changes as well as emerging and promising startups have been attracting API and drug development
outsourcing to countries such as China and India.
8. Regional Insights
“Asia Pacific to grow at the highest rate during the forecast period (2020–2025)”
• Market in Asia Pacific is expected to grow at a high pace in the coming years. the rapid growth in the
pharmaceutical and biopharmaceutical industry, CROs.
• The presence of less-stringent regulations for drug discovery processes and smooth export protocols.
• The North American and European markets will account for a large share due to mature economies and the
presence of significant players in the region.
9. Drug Discovery Outsourcing Market Share Insights
Some of the major players are Albany Molecular Research Inc.; EVOTEC;Laboratory Corporation of
America Holdings; GenScript; Pharmaceutical Product Development, LLC; Charles River;WuXi
AppTec; Merck & Co., Inc.; Thermo Fisher Scientific Inc.; Dalton Pharma Services; Oncodesign;
Jubilant Biosys; DiscoverX Corporation; and QIAGEN.
Events like the UK Trade & Investment (UKTI) further encourage alliances among players.
In addition, pharmaceutical industry , agility becomes vital in the fast-moving drug discovery.
Thus, partnerships with Contract Development and Manufacturing Organizations (CDMOs) are
preferred over Contract Manufacturing Organizations (CMOs).
10. Attribute Details
Base year for estimation 2016
Actual estimates/Historical data 2013 - 2016
Forecast period 2017 - 2025
Market representation Revenue in USD Million & CAGR from 2017 to 2025
Regional scope
North America, Europe, Asia Pacific, Latin America, Middle East
& Africa
Country scope U.S., Canada, U.K., Germany, Japan, China, Brazil, South Africa
Report coverage
Revenue forecast, company share, competitive landscape, growth
factors and trends
15% free customization scope (equivalent to 5 analyst
working days)
If you need specific information, which is not currently within the
scope of the report, we will provide it to you as a part of
customization
Report Scope
11. • The global drug discovery services market is projected to reach USD 19.1 billion by 2025 from USD
10.7 billion in 2020, at a CAGR of 12.1% from 2020 to 2025.
• The emerging economies, such as India, China, and Brazil, are expected to provide a wide range of
opportunities for players in the industry.
• Furthermore, growth in the biologics market and patent expiries will also boost the growth of this
market.
12. Segments Covered in the Report
This report forecasts revenue growth at global, regional, and country levels and provides an analysis on
latest industry trends and opportunities in each of the sub-segments from 2013 to 2025.
Workflow Outlook (Revenue, USD Million, 2013 - 2025
• Other Associated Workflow
• Target Identification & Screening
• Target Validation & Functional Informatics
• Lead Identification & Candidate Optimization
• Preclinical Development
13. Therapeutic Area Outlook
(Revenue, USD Million,
2013 - 2025)
•Respiratory System
•Pain and Anesthesia
•Oncology
•Ophthalmology
•Hematology
•Cardiovascular
•Endocrine
•Gastrointestinal
•Immunomodulation
•Anti-Infective
•Central Nervous System
•Dermatology
•Genitourinary System
14. Regional Outlook (Revenue, USD Million, 2013 - 2025)
North America
• U.S.
• Canada
Europe
• Germany
• U.K.
Asia Pacific
• Japan
• China
Latin America
• Brazil
Middle East and Africa (MEA)
• South Africa
Drug Type Outlook (Revenue, USD Million, 2013 –
2025)
•Small Molecules
•Large Molecules (Biopharmaceuticals
15. Beta-carotenes are naturally occurring chemicals that are responsible for the reddish-yellow color in
various plants.
Due to the presence of high concentration of antioxidants and vitamin A, beta-carotenes also find
application in natural and synthetic cosmetics.
B. GLOBAL MARKET SIZE OF PRECURSOR
PRECURSOR:-
It is biochemical substance such as an intermediate compound in a chain of enzymatic reaction.
It gives more stable product
Example:-beta carotene is precursor of vitamin A
16.
17. Beta-Carotene: Market Drivers
Growing Propensity of Beta-Carotene in Food Processing Industries as a Source of Natural Color
Beta-carotenes are widely used in food processing industries as a source of natural color, which provides
varied versions of red, yellow, and orange.
Thus, the growing consumer awareness regarding the health benefits of natural color sources such as beta-
carotenes in recent years is one of the major driving factors of the global beta-carotene market.
High Prevalence of Vitamin A Deficiencies Leading to a Surge in Demand for Beta-Carotene in
Functional Foods
The increasing prevalence of vitamin A deficiencies and related diseases in developing economies such as
India, Bangladesh, Pakistan, and other South Asian countries has resulted in various public health concerns.
As a precursor of vitamin A, beta-carotene is often utilized as a vital fortification ingredient in functional foods
such as processed grains, fruit extracts, purees, and others, in order to fight vitamin A deficiencies (VADs).
18. Increasing Penetration of Beta-Carotene in Pharmaceuticals
As an organic compound, beta-carotene has greater application in drug development and
carrier medicine processing.
In addition, beta-carotenes are rich in antioxidant which has created a huge demand for
beta-carotenes among drug developers and pharmaceutical manufacturers for developing
cognitive medicines, over the past decade.
Thus, the pharmaceutical consumption of beta-carotene is one of the strong drivers that is
fuelling the growth of the global beta-carotene market.
Dietary Beta-Carotene Reduces Type-2 Diabetes RisK
There have been studies associated with the dietary intake of beta-carotenes and the risk of type-2
diabetes. One such study has revealed that, those who follow a diet comprising beta-carotenes
and alpha-carotenes present reduced risks of type-2 diabetes among generally healthy men and
women.
19. Rising Incidences of Eye Diseases and Cancer to Boost Beta-Carotene Consumption
Cancer has created a significant social as well as economic health burden – around 8.8
million deaths across the world in 2015, and US$ 87.8 billion expenditure in 2014 for the
direct medical cost of cancer treatment in the United States.
The World Health Organization estimates that around 253 million people are living with vision
disabilities, among which, 36 million are blind, and 217 million people suffer from moderate to
severe vision impairment due to vitamin deficiencies.
.The increasing utilization of beta-carotenes in preventing and curing chronic diseases is
likely to escalate its demand in the near future
It is anticipated that the global beta-carotene market would proliferate in terms of volume and
value during the forecast period.