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1. KYRGYZ STATE MEDICAL UNIVERSITY FACULTY
CHEMISTRY AND BIOCHEMISTRY DEPARTMENT 1ST COURSE
GUIDED BY- A.J ABDURASHITOVA (MAM)
Disha Vishal Modak
Group-7
Course- 1
Para-aminobenzoic acid and its derivatives
with a local anesthetic
action: an aesthesin (benzocaine),
novocaine.
TOPIC

2. PARA-AMINOBENZOIC ACID
 • P-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA because the two functional
groups are attached to the benzene ring across from one another in the para position) is an organic
compound with the formula H2NC6H4CO2H.
 • PABA is a white solid, although commercial samples can appear gray
 •It is slightly soluble in water. It consists of a benzene ring substituted with amino and carboxyl groups.
 •The compound occurs extensively in the natural world.

3. STRUCTURE OF PABA

4. AMINOBENZOIC ACID DERIVATIVE
 •The PABA derivative, octyldimethyl-p-aminobenzoate (OD-PABA, tradename Padimate-O) was also
subsequently deemed undesirable as a sunscreen ingredient due to its structural similarity to a radical
initiator used for polymerisation, ethyl-4-dimethylaminobenzoate [14], although OD-PABA is still in use
today.
 •PABA derivatives are commonly used in sunscreens as ultraviolet B (UVB) filters.
 •PABA is the chemical foundation for a group of local anaesthetic agents. These include butethamide,
benzocaine, procaine, tetracaine, propoxycaine, and butacaine.
 •Benzocaine is the most notorious sensitizer.

5. ANAESTHESIN (BENZOCAINE)
 • Benzocaine is an ester local anesthetic that acts by preventing
transmission of impulses along nerve fibers and at nerve endings.4 It
is commonly used for local anesthesia in many over the counter
products.13,14,15 Ben zocain was first used for local anesthesia in
dentistry.
 •used for the temporary relief of pain and itching associated with
minor burns, sunburn, scrapes and insect bites or minor skin
irritations. Benzocaine is an ester local anesthetic that acts by
preventing transmission of impulses along nerve fibers and at nerve
endings
 • Benzocaine is the most notorious sensitizer.

6. MECHANISM OF ACTION
 • Mechanism of action
 Benzocaine diffuses into nerve cells where it binds to sodium channels, preventing the channels from
opening, and blocking the influx of sodium ions.2,3,4 Nerve cells unable to allow sodium into cells
cannot depolarize and conduct nerve impulses.3,4

7. NOVOCAINE
•Novocaine, also called procaine, is an injectable anesthetic that prevents pain by numbing a small, localized area. It was previously frequently
used in dental or skin procedures, though lidocaine is more commonly used now. Generally speaking, the word “novocaine” is used to describe
various types of local anesthesia.
•Novocaine causes numbness in a localized area for a brief amount of time. It is used for procedures that don’t require a longer-lasting
anesthetic. It’s also used when people are allergic to amide-based drugs (a group of local anesthetic compounds).
• side effects: Cold sweats (diaphoresis)
Dizziness
Paleness or “loss of color” (pallor)
Heart palpitations
Nausea
Vomiting
Trembling, shaking
Asthma symptoms
Difficulty breathing
Anaphylaxis symptoms (serious, life-threatening allergic reaction)
Seizures (convulsions)

8. ACTION MECHANISM NOVOCAINE
 Novocain stabilizes the neuronal
membrane and prevents the initiation
and transmission of nerve impulses,
thereby effecting local anesthesia.
Novocain lacks surface anesthetic
activity.

9. BIBLIOGRAPHY
 • textbook
 •https://www.sciencedirect.com/topics/medicine-and-dentistry/aminobenzoic-acid-
derivative#:~:text=p%2DAminobenzoic%20acid%20(PABA),photosensitizers%20as%20well%20as%20sen
sitizers
 •https://www.verywellhealth.com/novocaine-5220252
 •https://en.m.wikipedia.org/wiki/4-Aminobenzoic_acid
 •https://en.m.wikipedia.org/wiki/Benzocaine

10. Thank you