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Disulifram
Phase 0 Phase 1 Phase 2 Phase 3 Phase 4
Pre clinical
Microdosing
Clinical phase Therapeutic
excploratory
Theraptuic
Confirmatory
Post marke
survelliacne
Synonym
Animal Healthy
volunteers
Diseases Disease volunteers Type
10-30 30-300 300-3000 No of
NCE/NME INDA
Investiagonatol
NDA(Branded Non
generic proportiarty
/ANDA(generic /Non
PropRITARY) generic BE
STUDIES NO CLINCAL
TRIALS
imp
Screening Safety Safety and Efficacy Efficacy and safety ADR PV Purpose
CDL:Kolkata
CDRI: Luckhnow
IVRI:Izzatnagar
Grignard
Wolff kishner
Clemmeson
Kolbe
Wurtz
Hoffmann broamide
Fittig
Wurtz fittig
Reimer Tiemann
Primary alchol ALDEHYDE
Secondary Ketone
Tertitrary (Na2cr2o7,k2cr2o7,Kmno4 ,Cro3) Alkene Ketone
Drug Category Subcategroy Chemica Biological Synonym Miscellaneous Use
Aloe Glycosides Anthraquinon
e/C glyco
Aloin
Barbaloin
Mussabar
kumari
Night blindness
Eutetic
• Hygroscopic • Efflorescne • Deliquescent
All tests (Biochem,Cognosy)
Alklaoids Glycosides Flvanaoids Volatiles Resings Carbohydr
ates
proteins Fats Miscellaneous Steroids
Mayer
wagner
Hager
dragender
off
Borntager
Modiefied
brontager
Shinoda
Vanillin
h2so4
Sudan red
3
Tincture
alkana
Vanilin-hCl
Gambier
fluroescie
Umbellifer
one
,Molisch Biuret
Ninhydrin
Sapo
Iodine
acid
Reiche
r
miesee
Polens
ki
Ruthenium red
Phlorgucniol
conc hcl
Cuoxam
PIcirc acid
Liberbman
n
salkwoski
Meconci
acid
Kedde
kller killian
Bnedict Xanthorp
teic
Vitalis
morin
bAlijet Barfoed Hopkin
cole
Murexide Raymond Seliwaniff Millon
Thallequin Legal Fwhling Paulys
Iodine Sagakuch
i
OSazone
Tollen
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Imp GPAT concepts.pptx

  • 2. Phase 0 Phase 1 Phase 2 Phase 3 Phase 4 Pre clinical Microdosing Clinical phase Therapeutic excploratory Theraptuic Confirmatory Post marke survelliacne Synonym Animal Healthy volunteers Diseases Disease volunteers Type 10-30 30-300 300-3000 No of NCE/NME INDA Investiagonatol NDA(Branded Non generic proportiarty /ANDA(generic /Non PropRITARY) generic BE STUDIES NO CLINCAL TRIALS imp Screening Safety Safety and Efficacy Efficacy and safety ADR PV Purpose
  • 4.
  • 5. Grignard Wolff kishner Clemmeson Kolbe Wurtz Hoffmann broamide Fittig Wurtz fittig Reimer Tiemann Primary alchol ALDEHYDE Secondary Ketone Tertitrary (Na2cr2o7,k2cr2o7,Kmno4 ,Cro3) Alkene Ketone
  • 6. Drug Category Subcategroy Chemica Biological Synonym Miscellaneous Use Aloe Glycosides Anthraquinon e/C glyco Aloin Barbaloin Mussabar kumari
  • 8. Eutetic • Hygroscopic • Efflorescne • Deliquescent
  • 9. All tests (Biochem,Cognosy) Alklaoids Glycosides Flvanaoids Volatiles Resings Carbohydr ates proteins Fats Miscellaneous Steroids Mayer wagner Hager dragender off Borntager Modiefied brontager Shinoda Vanillin h2so4 Sudan red 3 Tincture alkana Vanilin-hCl Gambier fluroescie Umbellifer one ,Molisch Biuret Ninhydrin Sapo Iodine acid Reiche r miesee Polens ki Ruthenium red Phlorgucniol conc hcl Cuoxam PIcirc acid Liberbman n salkwoski Meconci acid Kedde kller killian Bnedict Xanthorp teic Vitalis morin bAlijet Barfoed Hopkin cole Murexide Raymond Seliwaniff Millon Thallequin Legal Fwhling Paulys Iodine Sagakuch i OSazone Tollen