Cure for common cold gets a step closer

1. Cure for common cold gets a
step closer
Experts Spot Hidden System That Incubates Infection, May Be Able To
Snuff It Out
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2. Contd..
A breakthrough made by British scientists
could be the first major step towards curing
the common cold. The researchers have
cracked a code that governs infections by a
major group of viruses, including the common
cold and polio.
Rhinovirus (which causes the common cold)
accounts for more infections every year than
all other infectious agents put together (about
one billion cases), while emergent infections
such as chikungunya and tick-borne
encephalitis are from the same ancient family.
Other single-stranded ribonucleic acid (RNA)
viruses include the hepatitis C virus, HIV and
the winter vomiting bug norovirus.
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3. Contd..
Until now, scientists had not noticed the code, which
had been hidden in plain sight in the sequence of the
RNA that makes up this type of viral genome. But
scientists from the varsities of Leeds and York have
unlocked its meaning and demonstrated that jamming
the code can disrupt virus assembly and prevent
disease.
“If you think of this as molecular warfare, these are the
encrypted signals that allow a virus to deploy itself
effective ly,“ said Professor Peter Stockley of the
University of Leeds, who led the study . “Now, for this
whole class of viruses, we've found the `Enigma
machine' -the coding system that was hiding these
signals from us. We've shown that not only can we read
these messages but we can jam them and stop the virus'
deployment.“
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4. Contd..
This breakthrough was the result of three
stages of research. In 2012, researchers at
the University of Leeds published the first
observations at a single-molecule level of
how the core of a single-stranded RNA virus
packs itself into its outer shell. The next
challenge for researchers was to find out how
the viruses did this, which they did through
specially-devised mathematical algorithms .
In this latest study, the two groups have
unlocked the code. Said Dr Roman Tuma
from the University of Leeds, “It’s like finding
a secret message within an ordinary news
report and then being able to crack the
whole coding system behind it.”
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