Surgery Resident clinical seminar on the management of a 60yr old male with upper gastrointestinal bleeding presented to the department of surgery, Niger Delta University Teaching Hospital, Okolobiri, Bayelsa State
3. • Upper Gastrointestinal Bleeding (UGIB)
Diagnosis
• Bleeding from a gastrointestinal source
proximal to the ligament of Treitz
Definition:
• Life threatening medical/surgical emergency
• common cause of hospitalization
UGIB
• Variceal
• Non – variceal
Categorized
Introduction
4. Clinical significance
Common, life threatening emergency
Impact on the patient, relatives, society and
the hospital
In-hospital mortality rate
• 5 – 10%
• Rises to 33%
• when bleeding is first observed in patients who
are hospitalized for other reasons
5. Epidemiology
•According to Antunes C. et al
- 80 – 150/100,000 per year
•Male:Female - 2:1
•Prevalence increases with
age (>60years)
Incidence
6. Causes of UGIB
•Esophageal varices
•Esophagitis
•Esophageal ulcer
•Esophageal cancer
•Mallory-Weiss
tear
Esophageal
10. Causes in Nigeria
• 37%
• Duodenal ulcer – 75%
Peptic Ulcer
• 18.75%
Esophageal varices and gastritis
• 15.6
Gastric cancer
• 9.3%
No obvious pathology
11. Common presentations
• Coffee-ground – indicate slower rate of bleeding
• Fresh blood – indicates rapid bleeding
Hematemesis
• Black tarry offensive stools
• Indicates that blood has been present in the GI tract for
at least 14hours
Melena
• Usually represent a lower GI source
• Can occur in massive brisk bleeding
Hematochezia
12. Management
Preferably co-managed with the physicians
Most UGIB will stop, albeit temporarily while in
a few instances, bleeding with not stop
Principles of management
• Prompt resuscitation
• Investigation to urgently to determine the cause of the
bleeding.
• Definitive treatment
Instances where bleeding does not stop
• Resuscitation, diagnosis and treatment should be carried out
13. Resuscitation
History, examination, resuscitation and relevant
investigations be done simultaneously
Brief History to assess for
• Hx to determine quantity of bleeding and presence of shock
• Hematemesis – duration
• Colour of the vomitus (bright red vs coffee –ground)
• Number of episodes and quantity per episode
• Presence of clots in the vomitus
• History of melena or hematochezia
• Shock
• History of dizziness, generalized weakness, fainting attack,
and dyspnea
14. Assess for signs of shock via examination
and vital signs measurement
• Cold clammy extremities
• Restlessness, confusion, drowsiness or stupor
• Hypotension
• Bradycardia or tachycardia etc
Secure 2 wide bore IV canulla
Group and cross-match blood and
transfusion if urgent PCV is <= 21%
Resuscitation contd
15. Resuscitation contd
Insert urethral catheter to monitor hourly
urinary output
Insert a NG tube to aspirate and do a cold saline
lavage
There is no evidence for the use of intravenous
proton pump inhibitors prior to endoscopy
IV tranexamic acid
Intranasal O2 @ 2L/min
16. • History dyspepsia,
• Epigastric pain with or without radiation to
the back
• smoking
PUD
• Weight loss and epigastric swelling
Gastric cancer
• Prolong vomiting and retching prior to onset
of hematemesis
Mallory Weiss tear
History suggestive of underlying cause
17. • Chronic alcoholism, jaundice and previous
history of liver disease
Esophageal varices
• History of surgery, trauma, burns, severe
sepsis or renal failure
Stress ulcers
• Previous history of aortic surgery with sudden
massive hematemesis +- fainting attack
Aorto-enteric fistula
• Chronic NSAID, aspirin, corticosteriods,
anticoagulant use
Drug history
18. Physical examination
Do a thorough general examination
Examine the systems for possible cause of the
bleeding
Abdomen
• tenderness in the epigastrium, suggestive of peptic ulcer
• hepatosplenomegaly, ascites or spider naevi, suggestive of
oesophageal varices;
• epigastric tumour, suggestive of gastric cancer;
• expansile; pulsating mass suggestive of aorto-enteric fistula.
• DRE
• Fresh blood, melena stool
19. Examination contd
• Palmer erythema – esophageal varices
due to liver cirrhosis
MSS
• Purpura/ecchymosis – bleeding disorders
• Other systemic examination to assess for
comorbid state
Skin
20. Investigation
FBC + differential
• May be normal due to hemoconcentration at presentation
and should be repeated after fluid resuscitation
• Values <=7g/dl should be transfused with red blood cells
Clotting profile
• If features suggest bleeding disorders
Liver function test
Electrolyte Urea and Creatinine
Urinalysis
21. Investigation contd
• Serology or Urea breath test
• If features suggest PUD as the cause of UGIB
H. Pylori
• Rule out perforation and other comobidity
(HHD, COPD etc)
• Secondary tumours in the lung
CXR
22. Investigation contd
• Done after resuscitation and within 24hours of
admission
• Infusion of a prokinetic like erythromycin
• Establish diagnosis and treatment
Endoscopy (Esophagogastroduodenoscopy)
• Double contrast where endoscopy is not available
• Features
• Mucosal defect (Ulcer crater)
• Edematous ring around the ulcer crater (ulcer collar)
• Radiating folds of mucosa away from the ulcer
Barium meal
23.
24.
25.
26. Treatment
Depends on the etiology of the
bleeding
PUD
• Treatment is medical, endoscopic
intervention and surgical
• A comprehensive clinical guideline for the
bleeding ulcer was formulated by ACG in
2020
• Summary of the guideline is as follows
27. Endoscopic therapy is recommended for ulcers with
active spurting or oozing and for non bleeding visible
vessels
Endoscopic therapy with bipolar electrocoagulation,
heater probe, and absolute ethanol injection is
recommended,
hemostatic powder spray TC-325 is suggested for actively
bleeding
low- to very-low-quality evidence also supports clips,
argon plasma coagulation, and soft monopolar
electrocoagulation
ulcers and over-the-scope clips for recurrent ulcer
bleeding after previous successful hemostasis
28. After endoscopic hemostasis, high-dose PPI
therapy is recommended continuously or
intermittently for 3 days, followed by twice-
daily oral proton pump inhibitor for the first 2
weeks of therapy after endoscopy.
Repeat endoscopy is suggested for recurrent
bleeding, and if endoscopic therapy fails,
transcatheter embolization is suggested
Epinephrine only should not be used as an
hemostatic agent
29. •Eradication therapy with triple
therapy
•PPI + Clarithromycin or
Metronidazole + Amoxicillin
•Duration of treatment
•14days
For H. pylori positive
30. Surgery for PUD
• Massive hemorrhage
• Continues hemorrhage
• Significant rebleed after endoscopic
intervention and transcatheter embolisation
• Associated perforation
Indications
• stop the bleeding,
• prevent a recurrence and,
• if possible, cure the underlying cause
Aim of surgery
31. •Often from the gastroduodenal
artery
•Under-run the vessel with a non-
absorbable suture
•Where a giant ulcer destroys the
duodenum, making primary closure
impossible, distal gastrectomy with
roux-en-y reconstruction be done
Bleeding duodenal ulcer
32. •Anterior gastrostomy with
under running of the vessel in
the ulcer bed
•Biopsy of the edges done to
exclusive malignancy
•PPI therapy
Bleeding gastric ulcer
33. Historic procedures for PUD
Vagotomy
• truncal vagotomy and drainage (pyloroplasty
and gastrojejunostomy)
• Selective and Highly selective
Vagotomy + antrectomy
Bilroth I and Bilroth II
No longer widely practice due
• Complications and introduction of effective
acid lowering medications (PPI, H2RA)
34. • 90% bleeding stops spontaneously
• Suture under running is all that is required
Mallory-Weiss tear
• Sclerosant injection and endoscopic clips
• Local excision
Dieufolay’s disease
• Partial gastrecromy is performed if possible.
Gastric Carcinoma
35. • Vasoconstrictor therapy with octreotide
and/or vasopressin
• Propranalol also lowers portal pressure
and be given to prevent rebleed
• Sclerosant injection
• Band ligation
• Balloon tamponade with Sengstaken-
Blakemore tube
• Transjugular intrahepatic portosystemic
stent shunt
Esophageal/gastric varices
39. Treatment contd
• Bleeding often stops spontaenously
• Treated conservative with stopping the
offending agent and in giving PPI and
Gastric erosion
• Conservatively with PPI but if numerous,
vagotomy with hemi-gastrectomy can be
performed
Stress Ulcer
43. Conclusion
UGIB is a surgical/medical emergency with high mortality rate
Most cases of UGIB can stop temporarily and the investigation
of choice is an upper GI endoscopy
The principles of management include resuscitation,
investigation to determine cause and institution of definitive
treatment
In most instances, medical and endoscopic intervention will
cause the bleeding to stop
Where the above fails surgical intervention can be done
depending on the cause
44. References
Normal S. Williams, P. Ronan O’Connell, Andrew W. McCaskie
‘Bailey & Love Short Practice of Surgery’ 27th Edition
Laine et al. ACG Clinical Guideline: Upper Gastrointestinal and
Ulcer Bleeding. Am J Gastroenterol 2021;116:899–917.
https://doi.org/10.14309/ajg.0000000000001245
Blatchford O, Murray W.R., Blatchford M. (2000). A risk score to
predict need for treatment for upper-gastrointestinal
haemorrhage. Lancet (London, England), 356(9238), 1318-1321.
Sung J.J, Chan F.K., Chen M., et al. (2011). Pacific working group
consensus on non-variceal upper gastrointestinal bleeding. GUT
(60): 1170-1177.
Badoe, Archampong, Jaja: Principles and Practice of Surgery
including pathology in the Tropics. 5th Edition
Editor's Notes
From the question, this patient has upper gastrointestinal bleeding (UGIB)
Hematemesis – vomiting of blood which can be bright red or coffee-ground.
Impact on the patient, relatives, society and the hospital
Article UGIB published in National Library of Medicine in 2022
Congenital and acquired
Dieulafoy’s disease (arterovenous malformation) that possess a diagnostic challenge for endoscopist as there lesions often have a normal overlying mucosa
According to the 27th Edition of Bailey and Love’s Short practice of Short pg 1127
The picture is not different in Nigeria.
According to the article – Epidemiology of UGIB in a Nigeria Teaching Hospital by Charles A. A. Et al
In 2002 – 2003 involving 731 patients
IV tranexamic acid @ 10mg/kg slowly over 20mins and then 1mg/kg/hr continuous infusion for 6 – 10hrs
If the patient has had an operation, injury, burns or severe sepsis or is in renal failure, stress ulceration is suspected although the bleeding may be due to re-activation of a chronic peptic ulcer
signs that may suggest a possible cause of the bleeding: tenderness in the epigastrium, suggestive of peptic ulcer; hepatosplenomegaly, ascites or spider naevi, suggestive of oesophageal varices; epigastric tumour, suggestive of gastric cancer; telangiectasia of the mouth or lip, suggestive of hereditary telangiectasia and an expansile; pulsating mass suggestive of aorto-enteric fistula.
PT – 13sec, aPTT – 30 – 40secs, INR – 1.1
There are two methods a) non-invasive and b) invasive.
a) Non-invasive
i) Serological test: This gives only 90% sensitivity and
specificity.
ii) Urea breath test (UBT): After ingestion of carbon isotope-labelled urea, the abundant urease enzyme produced by the organism breaks the urea down to co2 which is detected in the expired air. The test is used to monitor rreatment.
iii) Stool antigen test: It has a higher false positive rate and takes longer to become negative after treatment.
b) Invasive
Multiple biopsies are taken at endoscopy (because the infection is patchy) from the antrium and subjected to i) rapid urease test giving a colour change and
ii) histological staining for H.pylori, H&R, Genta stain, Di ff-Quick stain or El-Zimaity. It has been shown that H. pylori deregulates the control of acid secretion by interfering with somatostin function.
Areas of active bleeding
Areas of recent bleeding
Non bleeding lesions
Risk of rebleeding and indication for endoscopic intervention
Score range from 0 – 23
0-1 low risk (managed on outpatient basis)
>1 (should be admitted and managed accordingly)
Endoscopic therapy is recommended for ulcers with active spurting or
oozing and for nonbleeding visible vessels. Endoscopic therapy with bipolar electrocoagulation, heater probe, and
absolute ethanol injection is recommended, and low- to very-low-quality evidence also supports clips, argon plasma
coagulation, and soft monopolar electrocoagulation; hemostatic powder spray TC-325 is suggested for actively bleeding
ulcers and over-the-scope clips for recurrent ulcer bleeding after previous successful hemostasis. After endoscopic
hemostasis, high-dose proton pump inhibitor therapy is recommended continuously or intermittently for 3 days, followed
by twice-daily oral proton pump inhibitor for the first 2 weeks of therapy after endoscopy. Repeat endoscopy is suggested
for recurrent bleeding, and if endoscopic therapy fails, transcatheter embolization is suggested
80mg IV bolous followed by 8mg/hr continuous infusion for 72hrs, then oral 40mg bd for 2/52
A patient who has required more than six units of blood in general needs surgical treatment
through a transpyloric gastroduodenostomy
Bearing in mind that most patients nowadays are elderly and unfit, the minimum surgery that stops the bleeding is probably optimal
Complications
Gastric arterial venous malformation If it can be seen while bleeding, all that may be visible is profuse bleeding coming from an area of apparently normal
Mucosa.
Octreotide 50mg/hr infusion
Vasopressin 20units in 250ml of 5% dextrouse over 30mins, 4hourly
To prevent coronary vasoconstriction – nitroglycerin should be given
Sengstaken-Blakemore tube
Stress Ulcer: Vagotomy with hemi-gastrectorny is performed
if the erosions are numerous. If the erosions are few,
they may be oversewn
Rockall Score
Scores > 8 High risk of death
Score < 3 Excellent prognosis