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Contraception
I MWEENE
• DEFINITION
• TYPES
• MECHANISM OF ACTIONS
• SIDE EFFECTS
• ADVANTAGES AND DISADVANTAGES
2
“Outercourse”
• Can be primary or temporary means of preventing
pregnancy
• Can also be used when it’s not advisable to have
intercourse for other reasons, such as after childbirth or
abortion
• No undesirable contraceptive side effects
• Does not eliminate chances of spreading STDs, especially
if it involves oral or anal sex
…is to prevent
pregnancy, not to
protect against
STI’s
3
Definition
• The prevention of an unwanted pregnancy
using a contraceptive which acts by preventing
fertilization of the ovum by spermatozoa
4
Unmet need for FP
• family planning (FP) (any method) has
improved to 21 % of currently married
women from 27% with 14 percent having an
unmet need for spacing and 7 percent having
an unmet need for limiting family size.
5
Factors affecting choice of method
Whether or not a method:
• is permanent or reversible
• is effective
• is inexpensive
• is perceived to be safe
• is easy to obtain
• is easy to use and
discontinue
• has frequent or undesirable
side effects
6
Factors affecting choice cont’d
• can be used while b/feeding
• protects against STIs
• requires partner
cooperation
• must be used each time the
couple have sexual
intercourse
7
‘Contraceptive Method Mix’
• Refers to the variety of contraceptives
available to clients through a family planning
programme
8
Hormone-based contraceptives
5 types
1) Oral contraceptives (pills)
2) Vaginal ring
3) Transdermal patch
4) Injected hormones
5) Hormonal IUDs
6)implants
9
Methods available
• Barrier Withdrawal
• Natural
• Sterilization
10
Combined oral contraceptives (COCs)
• Consists of oestrogen (E) and progestin (P)
– Low dose
– Ultra low dose
• Monophasic pills - same dose of E/P all through the course
• Biphasic pills - fixed dose or E/P & more P in the last 14/7
• Triphasic pills - variable dose of E/P
• Sequential pills - fixed dose of E, No P for first 7/7 then P for 14/7
11
Other of oral contraceptives
• Progestin-only pill
– Low dose of progestin and no estrogen
– For women who should not take estrogen (breastfeeding, high b.p., at
risk for blood clots, smoke)
12
How hormonal
contraceptives
work
FSH & LH trigger
ovulation
Gonadotropin releasing
hormone (GnRH) triggers
release of gonadotropins
FSH & LH
Estrogen & progesterone in
hormonal contraceptives
inhibit LH, FSH, and GnRH
secretion, preventing ovulation

Progesterone also:
•thickens cervical mucus to prevent
Passage of sperm into the uterus
•changes uterine lining to inhibit implantation

13
Mechanism of action
- COCs
• Prevents ovulation by inhibiting
gonadotrophin secretion via an effect on both
pituitary and hypothalamic centres
• The progestin suppresses LH secretion (& thus
prevents ovulation, while the oestrogenic
agent suppresses FSH secretion (& thus
prevents the selection and emergence of a
dominant follicle)
14
Efficacy of COC
• Typical usage is associated with a 3.0% failure
rate during the first year of use
• Efficacy decreases significantly when the
oestrogen component is removed
15
WHO Categories for Temporary
Methods
• The scientific meetings classified known
medical conditions that might affect eligibility
for the use of a contraceptive method into
one of the four following categories
16
WHO Categories for Temporary
Methods
• WHO 1 Can use the method. No restriction on
use.
• WHO 2 Can use the method. Advantages
generally outweigh theoretical or proven
risks. Category 2 conditions could be
considered in choosing a method. If the client
chooses the method, more than usual follow-
up may be needed
17
WHO Categories for Temporary
Methods cont
• WHO 3 Should not use the method unless a
doctor or nurse makes a clinical judgement
that the client can safely use it. Theoretical or
proven risks usually outweigh the advantages
of the method. Method of last choice, for
which regular monitoring will be needed.
18
WHO Categories for Temporary
Methods cont
• WHO 4 Should not use the method. Condition
represents an unacceptable health risk if
method is used.
19
Absolute contraindications to COC use
• thrombophlebitis,
thromboembolic disorders,
CVA, coronary occlusion
• markedly impaired liver
function
• known or suspected breast
cancer
• undiagnosed abnormal
vaginal bleeding
• known or suspected
pregnancy
• smokers over the age of 35
years
20
Relative contraindications to COC use
• Migraine headaches
• Hypertension
• H/O gestational diabetes
• Elective surgery
• Epilepsy
• H/O obstructive jaundice in
pregn
• Sickle cell disease or sickle C
disease
• Diabetes mellitus
• Gall bladder disease
21
Clinical problems associated with COCs
• Breakthrough bleeding
• Amenorrhoea
• weight gain
• Acne
• Ovarian cysts
• Drugs that affect efficacy
• Migraine headaches
22
Non-Contraceptive Benefits of OCs
These can broadly be grouped into two main
categories:
• Benefits that incidentally accrue when OC is
specifically utilized for contraception &;
• Benefits that result from the use of OCs to
treat problems or disorders
23
Non contraceptive incidental benefits
of OCs
• less endometrial cancer
• less ovarian cancer
• fewer ectopic pregns.
• more regular menses
• less PID
• less rheumatoid arthritis
• increased bone density
• ~ less endometriosis
• ~ less benign breast disease
• ~ fewer ovarian cysts
24
OC as treatment
• DUB
• dysmenorrhoea
• endometriosis prophylaxis
• acne & hirsutism
• hormone therapy for
hypothalamic amenorrhoea
• control of bleeding
• ~ functional ovarian cysts
• ~ premenstrual syndrome
25
Pill taking
• Effective contraception is present during the
first cycle of pill use, provided the pills are
started no later than the 5th day of the cycle
and no pills are missed
26
Missed Pills
• If a woman misses 1 pill, she should take that
pill as soon as she remembers and take the
next pill as usual. No back-up is needed.
• If she misses 2 pills in the first two weeks, she
should take two pills on each of the next two
days, and back-up for the next 7 days
27
Missed pills cont’d
• If 2 pills are missed in the third week, or if
more than 2 active pills are missed at any
time, another form of contraception should be
used as back-up immediately and for 7 days or
start a new pack with back-up for 7 days
without taking the iron tablets
28
The Progestin-Only Pill (POP) Minipill
• The minipill contains a small dose of
progestational agent (25% of that in COC) and
must be taken daily, in a continuous fashion
29
Mechanism of Action - POP
The contraceptive effect is more dependent
upon endometrial and cervical mucus effects,
since the gonadotrophins are not consistently
suppressed
• The endometrium involutes and becomes
hostile to implantation and the cervical mucus
becomes thick and impermeable
30
POP cont’d
• There are no significant metabolic effects
(lipid levels, CHO metabolism and coagulation
factors remain unchanged)
• There is an immediate return to fertility upon
discontinuation
• Failure rates range form 1.1 to 9.6% per 100
women in the first year of use
31
POP cont’d
Pill taking
• The minipill should be started on the first day of
menses and a back-up method must be used for
the first 7 days
• The pill should be taken at the same time of the
day
• If more than 3 hours late in taking a pill, a back-
up method should be used for 48 hours
32
Problems associated with POP
POP have unpredictable effect
on ovulation
• 40% of patients can expect
to have normal ovulatory
cycles
• 40% short irregular cycles
• 20% total lack of cycles
ranging from irregular
bleeding to spotting and
amenorrhoea
• development of functional
cysts
• levonorgestrel minipill may
be associated with acne
33
POP
There are two situations where excellent
efficacy is achieved:
• In lactating women, the contribution of the
minipill is combined with prolactin-induced
suppression of ovulation adding up to very
effective protection
• In women over age 40, reduced fecundity
adds to the minipill’s effects.
34
Other hormonal methods
(contain both estrogen and progestin)
• Vaginal ring (Nuvaring)
– 2” ring inserted into the vagina during period
– Worn for 3 weeks, removed for 1 week, then
replaced with new ring
– Cost per year: $580
– Pros: no daily pill; spontaneity
– Cons: no STD protection, not effective for women
over 198 lbs.
• Transdermal patch (Ortho Evra)
– Patch is placed on buttock, abdomen, outer upper
arm, or upper torso
– Replaced weekly for 3 weeks, then a patch-free
week
– Cost per year: $420
– Pros: no daily pill; spontaneity
– Cons: no STD protection, skin irritation
35
Implant contraception - jadelle
• Progestin circulating at levels 1/4 to 1/10th of
those in COC, prevents conception by
suppressing ovulation and thickening cervical
mucus to inhibit sperm penetration
• Side effects include changes in menstrual
patter, weight gain, headache, and effects on
mood
36
37
What is JADELLE®
Two Silastic rods
containing 75 mg of
levonorgestrel (LNG)
which are inserted
just under the skin
(subdermal) of a
woman’s upper arm.
Jadelle description
• Two rods containing 75mg LNG crystals embedded in a
coplolymer and encased in silastic tubing
• Rods are 43mm long and 2.5mm wide
• Lasts for 5 years
• Rods are easier and more convenient to insert and remove
• Norplant and Jadelle are bioequivalent over 5 years of use
38
39
JADELLE®: Mechanisms of Action
Suppress ovulation
Decrease tubal motility
Change endometrium
Thicken cervical mucus
40
JADELLE®: Contraceptive Benefits
• Highly effective (0.051,2 pregnancies per 100
women during the first year of use)
• Rapidly effective (< 72 hours)
• Pelvic examination not required prior to use
• Does not interfere with intercourse
• Does not affect breastfeeding
1 Perfect-use estimate is equal to typical-use estimate.
2 Trussell et al 1998.
41
JADELLE®: Noncontraceptive Benefits
• Decreases ectopic pregnancy
• May decrease menstrual cramps
• May decrease menstrual bleeding
• May improve anemia
• Protects against endometrial cancer
• Decreases benign breast disease
• Protects against some causes of PID
Disadvantages
• disruption of bleeding
patterns in up to 80% of
users
• implants must be inserted
and removed in a surgical
procedure by trained
personnel
• implants can be visible
under the naked eye
• does not protect against
STI/HIV
• acne
• 30% of pregnancies are
ectopic
42
Absolute contraindications
• active thrombophlebitis or
thromboemboilc
phenomena
• undiagnosed genital
bleeding
• acute liver disease
• benign or malignant liver
tumours
• known or suspected breast
cancer
43
IMPLANON
• A single implant 4 cm long contains 60 mg of
3-keto desogestrel
• The hormone is released at a rate of about 60
micro grams per day
• Is designed to be provide contraception for 2-
3 years
• Efficacy and side effects are similar to those of
JADELLE
44
Injectable Contraception:
Depo-Provera
• Comes as microcrystals, suspended in an
aqueous solution
• Correct dose is150 mg IM (gluteal or deltoid)
every 3 months
• Relies on higher peaks of progestin to inhibit
ovulation and thicken cervical mucus. The
progestin level is high enough to block the LH
surge
45
Depo-Provera
cont’d
• The injection should be given within the first 5
days of the current menstrual cycle, otherwise
a back-up method is necessary for 2 weeks
• The injection must be given deeply in muscle
46
Depo-Provera
Advantages
• easy to use, no daily or
coital acton required
• safe no serious health
effects
• effective as sterilization,
IUCD & implant
contraception
• free from eostrogen related
problems
• private use not detectable
• enhances lactation
• has noncontraceptive
benefits
47
Depo-Provera
Disadvantages
• irregular menstrual
bleeding
• breast tenderness
• weight gain
• depression
• can’t be removed
• return to fertility is delayed
• regular injections required
• no STI/HIV protection
48
Depo-Provera
Absolute contraindications
• Pregnancy
• Unexplained genital bleeding
49
Intrauterine Devices (IUDs)
• Small plastic objects inserted into
uterus
• 2 types
– Hormone-releasing (progesterone)
– Copper-releasing
• Have fine strings threads attached
that hang in hang slightly out of
cervix into vagina for removal
• Very high continuation rate (how many women are still
using it one year after starting) compared w/other
methods
progesterone
50
Intrauterine Contraception
Types of IUDS
• Unmedicated IUDs -Lippes Loop
• Copper IUDs - TCu-380A, Tcu-220C, Nova T,
Mulitload-375
51
IUD Mechanisms of Action
Levonorgestrel-Releasing IUD
(LNG-IUS, Mirena®)
– Inhibits fertilization
– Thickens cervical mucous
– Inhibits sperm function
– Thins and suppresses the
endometrium
Jonsson B, et al. Contraception. 1991;43:447-458; Videla-Rivero L, et al. Contraception.
1987;36:217-226; Kulier R, et al. Cochrane Database Syst Rev. 2006;3: CD005347.
Copper-Releasing IUD
(ParaGard® T380A)
– Inhibits fertilization
– Releases copper ions (Cu2+)
that reduce sperm motility
– May disrupt the normal
division of oocytes and the
formation of fertilizable ova
52
Efficacy of IUDS
• The actual failure rate in the first year is
approximately 3%, with a 10% expulsion rate,
and a 15% rate of removal, mainly for
bleeding and pain.
• The non medicated IUDs never have to be
replaced
53
Timing of IUD insertion
• An IUD can be safely inserted at any time after
delivery, abortion or during the menstrual
cycle
• The IUD can also be inserted at Caesarean
section
– Postplacental
– Immediate postpartum
54
IUD Use
and Medical conditions
• a woman with a H/O
ectopic pregn can use a
copper IUD or the
Levonorgestrel IUD
• a progestin releasing IUD
should be considered for
women with bleeding
disorder
• women at risk of bacterial
endocarditis should receive
prophylactic antibiotics at
insertion & removal
• current, recent, or recurrent
PID is a contraindication for
IUD use
55
Pregnancy with IUD in situ
• Spontaneous abortion - 40-50%, IUDs should be
removed if pregnancy is diagnosed and the
strings are visible
• Septic abortion - there is no evidence that there
is an increased risk of septic abortion if pregn
occurs, other than with the Dalkon Shield
• Pre-term labour and birth - incidence is
increased 4-fold
56
Barrier methods
Have been the most widely used contraceptive
technique throughout recorded history.
• Spermicides - 21% failure rate
• Cervical cap - 18-28%
• Sponge - 18%
• Diaphragm - 18%
• Condom - 12%
57
Condoms (male)
• Sheath that fits over the erect penis
• The only temporary method of birth control for men
• Only form of contraception that effectively reduces
STI transmission
• Made of thin latex, polyurethane, or natural membrane
– Natural membrane (from sheep intestines) condoms can permit passage of viruses,
incl. those that cause AIDS, herpes, hepatitis, HPV
• Many varieties
– Different features, shapes, textures, colors, flavors
– Some “extended pleasure” types have a desensitizing agent on the inside to delay
ejaculation
– Lubricated or nonlubricated
• Note: average shelf life of condoms is 5 years; don’t store latex condoms
in hot places (glove compartment, back pocket) b/c heat can deteriorate the
latex
58
How to use the (male) condom
• Pinch reservoir tip or twist tip of nonreservoir tip condom before unrolling
condom over the penis to leave room for ejaculate--reduces chance of
condom breaking
• Unroll condom over erect penis before any contact between the penis and
vulva occurs
– Common error: putting on a condom after vaginal penetration but before
ejaculation--increases risk of pregnancy & STI transmission
• Use a water-based lubricant to reduce risk of condom breaking (oil-based
lubricants deteriorate condom)
• Hold condom at the base of the penis before withdrawing from the vagina
to avoid spilling semen inside vagina
59
Female condom
• Consists of two flexible polyurethane rings and a soft,
loose-fitting polyurethane sheath
– One ring at closed end fits loosely against cervix; other ring at
open end encircles the labial area
• Can be inserted before sexual activity; don’t need to
remove it immediately following ejaculation
60
Costs, pros, & cons of condoms
• Costs
– Male condoms, about $0.75-$1 each
– Female condoms, about $3 each
• Advantages
– STI protection!
– Available w/o prescription or medical intervention
• Disadvantages
– Can reduce sensation
• Polyurethane transmits heat well, so some say that the female condom has less
reduction in sensation
– Interruption of sexual experience (though some couples find sensual
ways of incorporating condoms into foreplay)
– Note: female condom can be inserted several hours before intercourse
61
Vaginal spermicides
• Include: foam, sponge, suppositories, creams, film
• Spermicide: chemical that kills sperm (nonoxynol-
9)
• Cost: $0.85 per application
• Advantage: no prescription necessary
• Disadvantages:
– Interruption of sexual experience (except for the
sponge)
– Skin irritation (which can increase susceptibility
to STI infection)
– No protection from STIs
– Not effective enough to be used w/o a condom
or other method
62
Cervical barrier devices
• Covering the cervix is one of the
oldest methods in contraceptive history
– Casanova (18th century Europe) promoted
using squeezed-out lemon half; European
women shaped beeswax to cover cervix
• Cervical cap: covers cervix only
• Diaphragm: covers upper vaginal wall
behind cervix underneath pubic bone
• FemCap & Lea’s shield have removal straps
• Lea’s Shield allows a one-way flow of fluid from cervix to
vagina
• Method is usually combined w/spermicide
diaphragm Cerv cap
Lea’s shield
FemCap
63
How to use cervical barrier devices
• Diaphragm & cervical cap: need to be fitted (may need to be refitted
w/weight gain or loss >10 lbs.)
• FemCap & Lea’s Shield do not have to be fitted, but still require a
prescription in the U.S.
• Use diaphragm & cervical cap only with water-based lubricants b/c they are
latex (FemCap & L.S. are silicone)
• Can insert up to 6-8 hr. before intercourse; should leave in at least 8 hr after
64
Placement of cervical barrier devices
(& FemCap)
65
Periodic abstinence
• Is keyed to the observation of naturally
occurring signs and symptoms of the fertile
phase of the menstrual cycle.
• It takes into account the viability of sperm in
the female reproductive tract and the life span
of the ovum
66
Fertility Awareness Methods
• Standard days method
– For women w/cycles btwn 26 & 32 days
– Couples avoid unprotected intercourse btwn days 8-19 of each
menstrual cycle
– Highest rate of effectiveness of natural family planning methods
• Mucus method: based on cyclical changes
– Vaginal secretions change throughout cycle; woman learns to “read”
these changes and keeps a daily chart
• Calendar method: self- knowledge of fertility
– After charting cycles for some time (preferably 1 year), a woman
estimates the time she is ovulating based on the calendar
• Basal body-temperature
– Based on changes in body temperature around ovulation
• Often, some combination of these methods will be used
67
Standard Days Method (w/Cyclebeads)
Arevalo M et al., Contraception, 2002;65:333-338.
On WHITE bead days
you can get pregnant.
Avoid unprotected
intercourse to prevent
a pregnancy.
On the day you start your
your period, move the
ring to the RED bead.
Every morning
move the ring
to the next
bead.
Always move
the ring from
the narrow to
the wide end.
1
2
Also, mark this date
on your calendar
When you start your
next period, move the
ring directly to red
bead and begin again.
On BROWN bead
days you can
have intercourse
with very low
probability of
pregnancy.
If you have not started
your period by the day
after you put the ring on
the last brown bread,
contact your provider.
If you start
your period
before you put
the ring on the
darker brown
bead, contact
your provider.
(may not be a good
method for you)
68
Basal Body Temperature Method
• BBT=body temp in resting state on waking
• Slight drop immediately before ovulation
• After ovulation, release of progesterone causes slight
increase in temperature
69
Cervical Mucus Method
Stanford JB, et al. Obstet Gynecol. 2003;101:1285-1293.
•Slight amount
•Thick
•White
•Sticky
•Holds its shape
•Increasing
amounts
•Thinner
•Cloudy
•Slightly stretchy
•Profuse
•Thin
•Transparent
•Stretchy
Early
Mucus
Transitional
Mucus
Highly Fertile
Mucus
no unprotected
intercourse
70
Periodic abstinence
Periodic abstinence is associated with good
efficacy when used correctly and consistently
and the following rules are observed:
• No intercourse during mucus days
• No intercourse within 3days after peak
fecundity
• No intercourse during times of stress
71
calendar
• Based on studying cycle length for 6months to
one year
– Subtract 18 from short cycle and 11 from long
cycle
– Avoid intercourse during this interval
72
Calendar or Rhythm Method
Low-risk Days
Egg may still
be present Ovulation
These days may be
unsafe if 28-day cycle
varies as much as 8-9
days between shortest
and longest cycles.
Intercourse on these days
may leave live sperm to
fertilize egg.
8
Billings JJ. Med J Aust. 1978;2:436.
Byer/Shainberg/Galliano. Dimensions of Human Sexuality,
5e. 1999, The McGraw-Hill Companies, Inc.
73
Withdrawal
• Involves removal of the penis from the vagina
before ejaculation takes place
• 1st year failure rate - 18%
• Some sperm may be released before
ejaculation
• Is a better method than using no method at all
74
Lactational Amennorrhoea Method
(LAM)
• High concentrations of prolactin work at both
central and ovarian sites to produce
lactational amenorrhoea and anovulation
• Elevated levels of prolactin inhibit the
pulsatile secretion of GnRH
75
LAM
• Only amenorrhoeic women who exclusively
breastfeed at regular intervals, including at
nighttime, during the first 6 months have the
contraceptive protection equivalent to the
provided by oral contraception
76
LAM
• With menstruation or after 6 months, the risk
of ovulation increases
• Supplemental feeding increases the risk of
ovulation (and pregnancy) even in
amenorrheic women
• Total protection against pregnancy is achieved
by exclusively b/feeding for 10 weeks
77
B/feeding and Contraception
The rule of 3s
• In the presence of FULL b/feeding, a
contraceptive method should be used
beginning in the 3rd postpartum month
• With PARTIAL b/feeding or NO b/feeding, a
contraceptive method should begin during the
3rd postpartum week
78
B/feeding and Contraception
• Oral contraception even in low doses
diminishes the quantity and quality of breast
milk
• Depo-provera does not affect breast feeding
79
B/feeding and Contraception cont’d
• Periodic abstinence cannot be used with a
great deal of confidence
• Barrier methods are an excellent choice for
motivated couples
• IUDs can be inserted after vaginal or C/S
80
Female Sterilization
• Unipolar coagulation
• Postpartum tubal excision
• Silastic (Falope or Yoon) ring
• Interval tubal excision
• Bipolar coagulation
• Hulka-Clemens clip/Filshie clip
81
Ex. of female sterilization procedure
• Laparoscope: narrow, lighted viewing instrument that is inserted
into abdomen to locate the fallopian tubes 82
Advantages of female sterilization
• Very effective-failure one in 200
• Permanent
• Nothing to remember
• No interference with sex
• Increased enjoyment-no worries
• No effect on milk
• No health reisks
• Can be done soon after birth
83
Disadvantages
• Painful for few days
• Uncommon complications of surgery
– Infection
– Internal infection and bleeding
– anaesthetic risks
– Death
– Ectopic
– Requires trained staff
– Reversal difficult and expensive
– No protection against STI
– No method of proving effectiveness
84
Male Sterilization
• Standard vasectomy
• “No scalpel” technique
85
Ex. of male sterilization procedure
• Vas deferens on each
side is cut; small
section is removed,
and the ends are tied
off or cauterized
86
Advantages of vasectomy
• Very effective-failure 1/700
• Permanent
• Nothing to remember after 20 ejaculations or
3 months
• No interference with sex
• Increased enjoyment
• No apparent longterm health risks
87
• Easier to perform,less expensive
• Able to test for effectiveness at any time
88
disadvantages
• Complications of surgery
– Discomfort for 2-3 days
– Pain in scrotum
– Brief feeling of faintness
– Bleeding
– Blood clots in scrotum
• Requires someone trained
• Not immediately effective-unless after 20 ejaculations or 3/12
89
• Reversal expensive
• No STI protection
90
Reversal of Sterilization
• Pregnancy rates correlate with the length of
remaining tube, a length of 4 cm or more is
optimal
• Pregnancy rates are lowest with
electrocoagulation, and reach 70-80% with
clips, rings and surgical methods such as the
Pomeroy
• About 2 per 1000 women will eventually
undergo tubal anastomosis
91
counselling
• Consider reason for request
• Age
• Permanent
• Irreversible
• Explain procedure
• Failure rate
92
Medical methods for the Male
• Hormonal contraception is inherently a
difficult physiological problem, because unlike
cyclic ovulation in the female,
spermatogenesis is continuous
93
Medical methods for the Male
• Sex steroids reduce testosterone synthesis
which leads to loss of libido and development
of female 2o sexual characteristics. Sperm
counts are not reduced adequately
• GnRH analogues also decrease endogenous
synthesis of testosterone, and supplemental
testosterone must be provided
94
Medical methods for the Male
• Gossypol a derivative of cotton seed oil,
effectively decreases sperm counts to
contraceptive levels, by incapacitating the
sperm producing cells
• The pills are taken daily for 2 months until
sperm are no longer observed in the ejaculate,
and then weekly
• Fertility returns to normal 3 months after
discontinuation
95
Emergency Contraception
• Emergency contraception methods can
prevent pregnancy after unprotected
intercourse, method failure or incorrect
method use
• Can help reduce unplanned pregnancies,
many of which result in unsafe abortion
96
Emergency contraception methods
• Combined oral contraceptive pills
• Progestin only pills
• Intra uterine contraceptive device
• mifepristone
97
Oral contraceptive pills
• Emergency contraceptive pills use the same
ingredients as regular contraceptives
• Should be initiated ideally within 5 days (120
hours) of unprotected intercourse
• Should be taken in two doses 12 hours apart
98
COC
• Each of the two doses of COC should contain
at least 100 ug (0.10 mg) Ethinyl Estradiol (EE)
and 500 ug (0.50 mg) Levonorgestrel
99
COC
PC-4, Eugoynon 50, Neogynon, Noral, Nordiol,
Ovidon, Ovral, Ovran
• Two tablets per dose: each tablet contains 50
ug EE & either 0.25mg or 0.50 mg
levonorgestrel
100
COC
LoFemenal, Microgynon 30, Nordette, Ovral L,
Rigevidon
• Four tablets per dose: each tablet contains 30
ug EE & either 0.15 mg or 0.30 mg
Levonorgestrel
101
POP
• Each of the two doses of POP contraceptives
should contain at least 0.75 mg Levonorgestrel
102
POP
• Ovrette - 20 tablets per dose, each tablet
contains 0.0375 mg Levonorgestrel
• Microlut, Microval, Norgestron - 25 tablets per
dose, each tablet contains 0.03mg
Levonorgestrel
103
IUCDs
• Copper T and others
• Insertion within 120 hours (five days) of
unprotected intercourse
104
End
Any questions?

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Contraception_Lecture_i mweene.pptx

  • 2. • DEFINITION • TYPES • MECHANISM OF ACTIONS • SIDE EFFECTS • ADVANTAGES AND DISADVANTAGES 2
  • 3. “Outercourse” • Can be primary or temporary means of preventing pregnancy • Can also be used when it’s not advisable to have intercourse for other reasons, such as after childbirth or abortion • No undesirable contraceptive side effects • Does not eliminate chances of spreading STDs, especially if it involves oral or anal sex …is to prevent pregnancy, not to protect against STI’s 3
  • 4. Definition • The prevention of an unwanted pregnancy using a contraceptive which acts by preventing fertilization of the ovum by spermatozoa 4
  • 5. Unmet need for FP • family planning (FP) (any method) has improved to 21 % of currently married women from 27% with 14 percent having an unmet need for spacing and 7 percent having an unmet need for limiting family size. 5
  • 6. Factors affecting choice of method Whether or not a method: • is permanent or reversible • is effective • is inexpensive • is perceived to be safe • is easy to obtain • is easy to use and discontinue • has frequent or undesirable side effects 6
  • 7. Factors affecting choice cont’d • can be used while b/feeding • protects against STIs • requires partner cooperation • must be used each time the couple have sexual intercourse 7
  • 8. ‘Contraceptive Method Mix’ • Refers to the variety of contraceptives available to clients through a family planning programme 8
  • 9. Hormone-based contraceptives 5 types 1) Oral contraceptives (pills) 2) Vaginal ring 3) Transdermal patch 4) Injected hormones 5) Hormonal IUDs 6)implants 9
  • 10. Methods available • Barrier Withdrawal • Natural • Sterilization 10
  • 11. Combined oral contraceptives (COCs) • Consists of oestrogen (E) and progestin (P) – Low dose – Ultra low dose • Monophasic pills - same dose of E/P all through the course • Biphasic pills - fixed dose or E/P & more P in the last 14/7 • Triphasic pills - variable dose of E/P • Sequential pills - fixed dose of E, No P for first 7/7 then P for 14/7 11
  • 12. Other of oral contraceptives • Progestin-only pill – Low dose of progestin and no estrogen – For women who should not take estrogen (breastfeeding, high b.p., at risk for blood clots, smoke) 12
  • 13. How hormonal contraceptives work FSH & LH trigger ovulation Gonadotropin releasing hormone (GnRH) triggers release of gonadotropins FSH & LH Estrogen & progesterone in hormonal contraceptives inhibit LH, FSH, and GnRH secretion, preventing ovulation  Progesterone also: •thickens cervical mucus to prevent Passage of sperm into the uterus •changes uterine lining to inhibit implantation  13
  • 14. Mechanism of action - COCs • Prevents ovulation by inhibiting gonadotrophin secretion via an effect on both pituitary and hypothalamic centres • The progestin suppresses LH secretion (& thus prevents ovulation, while the oestrogenic agent suppresses FSH secretion (& thus prevents the selection and emergence of a dominant follicle) 14
  • 15. Efficacy of COC • Typical usage is associated with a 3.0% failure rate during the first year of use • Efficacy decreases significantly when the oestrogen component is removed 15
  • 16. WHO Categories for Temporary Methods • The scientific meetings classified known medical conditions that might affect eligibility for the use of a contraceptive method into one of the four following categories 16
  • 17. WHO Categories for Temporary Methods • WHO 1 Can use the method. No restriction on use. • WHO 2 Can use the method. Advantages generally outweigh theoretical or proven risks. Category 2 conditions could be considered in choosing a method. If the client chooses the method, more than usual follow- up may be needed 17
  • 18. WHO Categories for Temporary Methods cont • WHO 3 Should not use the method unless a doctor or nurse makes a clinical judgement that the client can safely use it. Theoretical or proven risks usually outweigh the advantages of the method. Method of last choice, for which regular monitoring will be needed. 18
  • 19. WHO Categories for Temporary Methods cont • WHO 4 Should not use the method. Condition represents an unacceptable health risk if method is used. 19
  • 20. Absolute contraindications to COC use • thrombophlebitis, thromboembolic disorders, CVA, coronary occlusion • markedly impaired liver function • known or suspected breast cancer • undiagnosed abnormal vaginal bleeding • known or suspected pregnancy • smokers over the age of 35 years 20
  • 21. Relative contraindications to COC use • Migraine headaches • Hypertension • H/O gestational diabetes • Elective surgery • Epilepsy • H/O obstructive jaundice in pregn • Sickle cell disease or sickle C disease • Diabetes mellitus • Gall bladder disease 21
  • 22. Clinical problems associated with COCs • Breakthrough bleeding • Amenorrhoea • weight gain • Acne • Ovarian cysts • Drugs that affect efficacy • Migraine headaches 22
  • 23. Non-Contraceptive Benefits of OCs These can broadly be grouped into two main categories: • Benefits that incidentally accrue when OC is specifically utilized for contraception &; • Benefits that result from the use of OCs to treat problems or disorders 23
  • 24. Non contraceptive incidental benefits of OCs • less endometrial cancer • less ovarian cancer • fewer ectopic pregns. • more regular menses • less PID • less rheumatoid arthritis • increased bone density • ~ less endometriosis • ~ less benign breast disease • ~ fewer ovarian cysts 24
  • 25. OC as treatment • DUB • dysmenorrhoea • endometriosis prophylaxis • acne & hirsutism • hormone therapy for hypothalamic amenorrhoea • control of bleeding • ~ functional ovarian cysts • ~ premenstrual syndrome 25
  • 26. Pill taking • Effective contraception is present during the first cycle of pill use, provided the pills are started no later than the 5th day of the cycle and no pills are missed 26
  • 27. Missed Pills • If a woman misses 1 pill, she should take that pill as soon as she remembers and take the next pill as usual. No back-up is needed. • If she misses 2 pills in the first two weeks, she should take two pills on each of the next two days, and back-up for the next 7 days 27
  • 28. Missed pills cont’d • If 2 pills are missed in the third week, or if more than 2 active pills are missed at any time, another form of contraception should be used as back-up immediately and for 7 days or start a new pack with back-up for 7 days without taking the iron tablets 28
  • 29. The Progestin-Only Pill (POP) Minipill • The minipill contains a small dose of progestational agent (25% of that in COC) and must be taken daily, in a continuous fashion 29
  • 30. Mechanism of Action - POP The contraceptive effect is more dependent upon endometrial and cervical mucus effects, since the gonadotrophins are not consistently suppressed • The endometrium involutes and becomes hostile to implantation and the cervical mucus becomes thick and impermeable 30
  • 31. POP cont’d • There are no significant metabolic effects (lipid levels, CHO metabolism and coagulation factors remain unchanged) • There is an immediate return to fertility upon discontinuation • Failure rates range form 1.1 to 9.6% per 100 women in the first year of use 31
  • 32. POP cont’d Pill taking • The minipill should be started on the first day of menses and a back-up method must be used for the first 7 days • The pill should be taken at the same time of the day • If more than 3 hours late in taking a pill, a back- up method should be used for 48 hours 32
  • 33. Problems associated with POP POP have unpredictable effect on ovulation • 40% of patients can expect to have normal ovulatory cycles • 40% short irregular cycles • 20% total lack of cycles ranging from irregular bleeding to spotting and amenorrhoea • development of functional cysts • levonorgestrel minipill may be associated with acne 33
  • 34. POP There are two situations where excellent efficacy is achieved: • In lactating women, the contribution of the minipill is combined with prolactin-induced suppression of ovulation adding up to very effective protection • In women over age 40, reduced fecundity adds to the minipill’s effects. 34
  • 35. Other hormonal methods (contain both estrogen and progestin) • Vaginal ring (Nuvaring) – 2” ring inserted into the vagina during period – Worn for 3 weeks, removed for 1 week, then replaced with new ring – Cost per year: $580 – Pros: no daily pill; spontaneity – Cons: no STD protection, not effective for women over 198 lbs. • Transdermal patch (Ortho Evra) – Patch is placed on buttock, abdomen, outer upper arm, or upper torso – Replaced weekly for 3 weeks, then a patch-free week – Cost per year: $420 – Pros: no daily pill; spontaneity – Cons: no STD protection, skin irritation 35
  • 36. Implant contraception - jadelle • Progestin circulating at levels 1/4 to 1/10th of those in COC, prevents conception by suppressing ovulation and thickening cervical mucus to inhibit sperm penetration • Side effects include changes in menstrual patter, weight gain, headache, and effects on mood 36
  • 37. 37 What is JADELLE® Two Silastic rods containing 75 mg of levonorgestrel (LNG) which are inserted just under the skin (subdermal) of a woman’s upper arm.
  • 38. Jadelle description • Two rods containing 75mg LNG crystals embedded in a coplolymer and encased in silastic tubing • Rods are 43mm long and 2.5mm wide • Lasts for 5 years • Rods are easier and more convenient to insert and remove • Norplant and Jadelle are bioequivalent over 5 years of use 38
  • 39. 39 JADELLE®: Mechanisms of Action Suppress ovulation Decrease tubal motility Change endometrium Thicken cervical mucus
  • 40. 40 JADELLE®: Contraceptive Benefits • Highly effective (0.051,2 pregnancies per 100 women during the first year of use) • Rapidly effective (< 72 hours) • Pelvic examination not required prior to use • Does not interfere with intercourse • Does not affect breastfeeding 1 Perfect-use estimate is equal to typical-use estimate. 2 Trussell et al 1998.
  • 41. 41 JADELLE®: Noncontraceptive Benefits • Decreases ectopic pregnancy • May decrease menstrual cramps • May decrease menstrual bleeding • May improve anemia • Protects against endometrial cancer • Decreases benign breast disease • Protects against some causes of PID
  • 42. Disadvantages • disruption of bleeding patterns in up to 80% of users • implants must be inserted and removed in a surgical procedure by trained personnel • implants can be visible under the naked eye • does not protect against STI/HIV • acne • 30% of pregnancies are ectopic 42
  • 43. Absolute contraindications • active thrombophlebitis or thromboemboilc phenomena • undiagnosed genital bleeding • acute liver disease • benign or malignant liver tumours • known or suspected breast cancer 43
  • 44. IMPLANON • A single implant 4 cm long contains 60 mg of 3-keto desogestrel • The hormone is released at a rate of about 60 micro grams per day • Is designed to be provide contraception for 2- 3 years • Efficacy and side effects are similar to those of JADELLE 44
  • 45. Injectable Contraception: Depo-Provera • Comes as microcrystals, suspended in an aqueous solution • Correct dose is150 mg IM (gluteal or deltoid) every 3 months • Relies on higher peaks of progestin to inhibit ovulation and thicken cervical mucus. The progestin level is high enough to block the LH surge 45
  • 46. Depo-Provera cont’d • The injection should be given within the first 5 days of the current menstrual cycle, otherwise a back-up method is necessary for 2 weeks • The injection must be given deeply in muscle 46
  • 47. Depo-Provera Advantages • easy to use, no daily or coital acton required • safe no serious health effects • effective as sterilization, IUCD & implant contraception • free from eostrogen related problems • private use not detectable • enhances lactation • has noncontraceptive benefits 47
  • 48. Depo-Provera Disadvantages • irregular menstrual bleeding • breast tenderness • weight gain • depression • can’t be removed • return to fertility is delayed • regular injections required • no STI/HIV protection 48
  • 50. Intrauterine Devices (IUDs) • Small plastic objects inserted into uterus • 2 types – Hormone-releasing (progesterone) – Copper-releasing • Have fine strings threads attached that hang in hang slightly out of cervix into vagina for removal • Very high continuation rate (how many women are still using it one year after starting) compared w/other methods progesterone 50
  • 51. Intrauterine Contraception Types of IUDS • Unmedicated IUDs -Lippes Loop • Copper IUDs - TCu-380A, Tcu-220C, Nova T, Mulitload-375 51
  • 52. IUD Mechanisms of Action Levonorgestrel-Releasing IUD (LNG-IUS, Mirena®) – Inhibits fertilization – Thickens cervical mucous – Inhibits sperm function – Thins and suppresses the endometrium Jonsson B, et al. Contraception. 1991;43:447-458; Videla-Rivero L, et al. Contraception. 1987;36:217-226; Kulier R, et al. Cochrane Database Syst Rev. 2006;3: CD005347. Copper-Releasing IUD (ParaGard® T380A) – Inhibits fertilization – Releases copper ions (Cu2+) that reduce sperm motility – May disrupt the normal division of oocytes and the formation of fertilizable ova 52
  • 53. Efficacy of IUDS • The actual failure rate in the first year is approximately 3%, with a 10% expulsion rate, and a 15% rate of removal, mainly for bleeding and pain. • The non medicated IUDs never have to be replaced 53
  • 54. Timing of IUD insertion • An IUD can be safely inserted at any time after delivery, abortion or during the menstrual cycle • The IUD can also be inserted at Caesarean section – Postplacental – Immediate postpartum 54
  • 55. IUD Use and Medical conditions • a woman with a H/O ectopic pregn can use a copper IUD or the Levonorgestrel IUD • a progestin releasing IUD should be considered for women with bleeding disorder • women at risk of bacterial endocarditis should receive prophylactic antibiotics at insertion & removal • current, recent, or recurrent PID is a contraindication for IUD use 55
  • 56. Pregnancy with IUD in situ • Spontaneous abortion - 40-50%, IUDs should be removed if pregnancy is diagnosed and the strings are visible • Septic abortion - there is no evidence that there is an increased risk of septic abortion if pregn occurs, other than with the Dalkon Shield • Pre-term labour and birth - incidence is increased 4-fold 56
  • 57. Barrier methods Have been the most widely used contraceptive technique throughout recorded history. • Spermicides - 21% failure rate • Cervical cap - 18-28% • Sponge - 18% • Diaphragm - 18% • Condom - 12% 57
  • 58. Condoms (male) • Sheath that fits over the erect penis • The only temporary method of birth control for men • Only form of contraception that effectively reduces STI transmission • Made of thin latex, polyurethane, or natural membrane – Natural membrane (from sheep intestines) condoms can permit passage of viruses, incl. those that cause AIDS, herpes, hepatitis, HPV • Many varieties – Different features, shapes, textures, colors, flavors – Some “extended pleasure” types have a desensitizing agent on the inside to delay ejaculation – Lubricated or nonlubricated • Note: average shelf life of condoms is 5 years; don’t store latex condoms in hot places (glove compartment, back pocket) b/c heat can deteriorate the latex 58
  • 59. How to use the (male) condom • Pinch reservoir tip or twist tip of nonreservoir tip condom before unrolling condom over the penis to leave room for ejaculate--reduces chance of condom breaking • Unroll condom over erect penis before any contact between the penis and vulva occurs – Common error: putting on a condom after vaginal penetration but before ejaculation--increases risk of pregnancy & STI transmission • Use a water-based lubricant to reduce risk of condom breaking (oil-based lubricants deteriorate condom) • Hold condom at the base of the penis before withdrawing from the vagina to avoid spilling semen inside vagina 59
  • 60. Female condom • Consists of two flexible polyurethane rings and a soft, loose-fitting polyurethane sheath – One ring at closed end fits loosely against cervix; other ring at open end encircles the labial area • Can be inserted before sexual activity; don’t need to remove it immediately following ejaculation 60
  • 61. Costs, pros, & cons of condoms • Costs – Male condoms, about $0.75-$1 each – Female condoms, about $3 each • Advantages – STI protection! – Available w/o prescription or medical intervention • Disadvantages – Can reduce sensation • Polyurethane transmits heat well, so some say that the female condom has less reduction in sensation – Interruption of sexual experience (though some couples find sensual ways of incorporating condoms into foreplay) – Note: female condom can be inserted several hours before intercourse 61
  • 62. Vaginal spermicides • Include: foam, sponge, suppositories, creams, film • Spermicide: chemical that kills sperm (nonoxynol- 9) • Cost: $0.85 per application • Advantage: no prescription necessary • Disadvantages: – Interruption of sexual experience (except for the sponge) – Skin irritation (which can increase susceptibility to STI infection) – No protection from STIs – Not effective enough to be used w/o a condom or other method 62
  • 63. Cervical barrier devices • Covering the cervix is one of the oldest methods in contraceptive history – Casanova (18th century Europe) promoted using squeezed-out lemon half; European women shaped beeswax to cover cervix • Cervical cap: covers cervix only • Diaphragm: covers upper vaginal wall behind cervix underneath pubic bone • FemCap & Lea’s shield have removal straps • Lea’s Shield allows a one-way flow of fluid from cervix to vagina • Method is usually combined w/spermicide diaphragm Cerv cap Lea’s shield FemCap 63
  • 64. How to use cervical barrier devices • Diaphragm & cervical cap: need to be fitted (may need to be refitted w/weight gain or loss >10 lbs.) • FemCap & Lea’s Shield do not have to be fitted, but still require a prescription in the U.S. • Use diaphragm & cervical cap only with water-based lubricants b/c they are latex (FemCap & L.S. are silicone) • Can insert up to 6-8 hr. before intercourse; should leave in at least 8 hr after 64
  • 65. Placement of cervical barrier devices (& FemCap) 65
  • 66. Periodic abstinence • Is keyed to the observation of naturally occurring signs and symptoms of the fertile phase of the menstrual cycle. • It takes into account the viability of sperm in the female reproductive tract and the life span of the ovum 66
  • 67. Fertility Awareness Methods • Standard days method – For women w/cycles btwn 26 & 32 days – Couples avoid unprotected intercourse btwn days 8-19 of each menstrual cycle – Highest rate of effectiveness of natural family planning methods • Mucus method: based on cyclical changes – Vaginal secretions change throughout cycle; woman learns to “read” these changes and keeps a daily chart • Calendar method: self- knowledge of fertility – After charting cycles for some time (preferably 1 year), a woman estimates the time she is ovulating based on the calendar • Basal body-temperature – Based on changes in body temperature around ovulation • Often, some combination of these methods will be used 67
  • 68. Standard Days Method (w/Cyclebeads) Arevalo M et al., Contraception, 2002;65:333-338. On WHITE bead days you can get pregnant. Avoid unprotected intercourse to prevent a pregnancy. On the day you start your your period, move the ring to the RED bead. Every morning move the ring to the next bead. Always move the ring from the narrow to the wide end. 1 2 Also, mark this date on your calendar When you start your next period, move the ring directly to red bead and begin again. On BROWN bead days you can have intercourse with very low probability of pregnancy. If you have not started your period by the day after you put the ring on the last brown bread, contact your provider. If you start your period before you put the ring on the darker brown bead, contact your provider. (may not be a good method for you) 68
  • 69. Basal Body Temperature Method • BBT=body temp in resting state on waking • Slight drop immediately before ovulation • After ovulation, release of progesterone causes slight increase in temperature 69
  • 70. Cervical Mucus Method Stanford JB, et al. Obstet Gynecol. 2003;101:1285-1293. •Slight amount •Thick •White •Sticky •Holds its shape •Increasing amounts •Thinner •Cloudy •Slightly stretchy •Profuse •Thin •Transparent •Stretchy Early Mucus Transitional Mucus Highly Fertile Mucus no unprotected intercourse 70
  • 71. Periodic abstinence Periodic abstinence is associated with good efficacy when used correctly and consistently and the following rules are observed: • No intercourse during mucus days • No intercourse within 3days after peak fecundity • No intercourse during times of stress 71
  • 72. calendar • Based on studying cycle length for 6months to one year – Subtract 18 from short cycle and 11 from long cycle – Avoid intercourse during this interval 72
  • 73. Calendar or Rhythm Method Low-risk Days Egg may still be present Ovulation These days may be unsafe if 28-day cycle varies as much as 8-9 days between shortest and longest cycles. Intercourse on these days may leave live sperm to fertilize egg. 8 Billings JJ. Med J Aust. 1978;2:436. Byer/Shainberg/Galliano. Dimensions of Human Sexuality, 5e. 1999, The McGraw-Hill Companies, Inc. 73
  • 74. Withdrawal • Involves removal of the penis from the vagina before ejaculation takes place • 1st year failure rate - 18% • Some sperm may be released before ejaculation • Is a better method than using no method at all 74
  • 75. Lactational Amennorrhoea Method (LAM) • High concentrations of prolactin work at both central and ovarian sites to produce lactational amenorrhoea and anovulation • Elevated levels of prolactin inhibit the pulsatile secretion of GnRH 75
  • 76. LAM • Only amenorrhoeic women who exclusively breastfeed at regular intervals, including at nighttime, during the first 6 months have the contraceptive protection equivalent to the provided by oral contraception 76
  • 77. LAM • With menstruation or after 6 months, the risk of ovulation increases • Supplemental feeding increases the risk of ovulation (and pregnancy) even in amenorrheic women • Total protection against pregnancy is achieved by exclusively b/feeding for 10 weeks 77
  • 78. B/feeding and Contraception The rule of 3s • In the presence of FULL b/feeding, a contraceptive method should be used beginning in the 3rd postpartum month • With PARTIAL b/feeding or NO b/feeding, a contraceptive method should begin during the 3rd postpartum week 78
  • 79. B/feeding and Contraception • Oral contraception even in low doses diminishes the quantity and quality of breast milk • Depo-provera does not affect breast feeding 79
  • 80. B/feeding and Contraception cont’d • Periodic abstinence cannot be used with a great deal of confidence • Barrier methods are an excellent choice for motivated couples • IUDs can be inserted after vaginal or C/S 80
  • 81. Female Sterilization • Unipolar coagulation • Postpartum tubal excision • Silastic (Falope or Yoon) ring • Interval tubal excision • Bipolar coagulation • Hulka-Clemens clip/Filshie clip 81
  • 82. Ex. of female sterilization procedure • Laparoscope: narrow, lighted viewing instrument that is inserted into abdomen to locate the fallopian tubes 82
  • 83. Advantages of female sterilization • Very effective-failure one in 200 • Permanent • Nothing to remember • No interference with sex • Increased enjoyment-no worries • No effect on milk • No health reisks • Can be done soon after birth 83
  • 84. Disadvantages • Painful for few days • Uncommon complications of surgery – Infection – Internal infection and bleeding – anaesthetic risks – Death – Ectopic – Requires trained staff – Reversal difficult and expensive – No protection against STI – No method of proving effectiveness 84
  • 85. Male Sterilization • Standard vasectomy • “No scalpel” technique 85
  • 86. Ex. of male sterilization procedure • Vas deferens on each side is cut; small section is removed, and the ends are tied off or cauterized 86
  • 87. Advantages of vasectomy • Very effective-failure 1/700 • Permanent • Nothing to remember after 20 ejaculations or 3 months • No interference with sex • Increased enjoyment • No apparent longterm health risks 87
  • 88. • Easier to perform,less expensive • Able to test for effectiveness at any time 88
  • 89. disadvantages • Complications of surgery – Discomfort for 2-3 days – Pain in scrotum – Brief feeling of faintness – Bleeding – Blood clots in scrotum • Requires someone trained • Not immediately effective-unless after 20 ejaculations or 3/12 89
  • 90. • Reversal expensive • No STI protection 90
  • 91. Reversal of Sterilization • Pregnancy rates correlate with the length of remaining tube, a length of 4 cm or more is optimal • Pregnancy rates are lowest with electrocoagulation, and reach 70-80% with clips, rings and surgical methods such as the Pomeroy • About 2 per 1000 women will eventually undergo tubal anastomosis 91
  • 92. counselling • Consider reason for request • Age • Permanent • Irreversible • Explain procedure • Failure rate 92
  • 93. Medical methods for the Male • Hormonal contraception is inherently a difficult physiological problem, because unlike cyclic ovulation in the female, spermatogenesis is continuous 93
  • 94. Medical methods for the Male • Sex steroids reduce testosterone synthesis which leads to loss of libido and development of female 2o sexual characteristics. Sperm counts are not reduced adequately • GnRH analogues also decrease endogenous synthesis of testosterone, and supplemental testosterone must be provided 94
  • 95. Medical methods for the Male • Gossypol a derivative of cotton seed oil, effectively decreases sperm counts to contraceptive levels, by incapacitating the sperm producing cells • The pills are taken daily for 2 months until sperm are no longer observed in the ejaculate, and then weekly • Fertility returns to normal 3 months after discontinuation 95
  • 96. Emergency Contraception • Emergency contraception methods can prevent pregnancy after unprotected intercourse, method failure or incorrect method use • Can help reduce unplanned pregnancies, many of which result in unsafe abortion 96
  • 97. Emergency contraception methods • Combined oral contraceptive pills • Progestin only pills • Intra uterine contraceptive device • mifepristone 97
  • 98. Oral contraceptive pills • Emergency contraceptive pills use the same ingredients as regular contraceptives • Should be initiated ideally within 5 days (120 hours) of unprotected intercourse • Should be taken in two doses 12 hours apart 98
  • 99. COC • Each of the two doses of COC should contain at least 100 ug (0.10 mg) Ethinyl Estradiol (EE) and 500 ug (0.50 mg) Levonorgestrel 99
  • 100. COC PC-4, Eugoynon 50, Neogynon, Noral, Nordiol, Ovidon, Ovral, Ovran • Two tablets per dose: each tablet contains 50 ug EE & either 0.25mg or 0.50 mg levonorgestrel 100
  • 101. COC LoFemenal, Microgynon 30, Nordette, Ovral L, Rigevidon • Four tablets per dose: each tablet contains 30 ug EE & either 0.15 mg or 0.30 mg Levonorgestrel 101
  • 102. POP • Each of the two doses of POP contraceptives should contain at least 0.75 mg Levonorgestrel 102
  • 103. POP • Ovrette - 20 tablets per dose, each tablet contains 0.0375 mg Levonorgestrel • Microlut, Microval, Norgestron - 25 tablets per dose, each tablet contains 0.03mg Levonorgestrel 103
  • 104. IUCDs • Copper T and others • Insertion within 120 hours (five days) of unprotected intercourse 104