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Presentation
Given by;.
DR, Zulqarnain
Course name;.
Introduction to Bioinformatics
To present;.
Mutation and types of mutation
Prepared by;.
Muhammad Afnan
Course outlines
Mutation
Cause of mutation
Types of mutation
Mutation
 The change in genetic material (DNA) of an organisms
The causes of mutations
 1. DNA fails to copy accurately
Most of the mutations that we think matter to evolution are
"naturally-occurring." For example, when a cell divides, it
makes a copy of its DNA — and sometimes the copy is not
quite perfect. That small difference from the original DNA
sequence is a mutation.
 2. External influences can create mutations
Mutations can also be caused by radiation. These agents cause the DNA to break
down. This is not necessarily unnatural. when the cell repairs the DNA, it might not
do a perfect e repair. So the cell would end up with DNA slightly different than the
original DNA and hence, a mutation
Types of Mutation
Mutations can occur in two
different types of cells:
1. Somatic (body) cells
2. Gamete (sex) cells
Mutation in Somatic Cell
 Mutations that occur in
somatic (body) cells usually
result in killing that body
cell only.
An exception to this is if the
mutation occurs to the DNA
that controls regulation of
the cell cycle. This can result
in cancer.
 Somatic mutations usually
do not affect the individual.
 Somatic mutations can NOT
be passed on to the next
generation.
Mutation in Gamete Cells
 Mutations that occur in gamete (sex) cells means that
every cell of the developing fetus/baby will have that
mutation.
 Gamete mutations usually do affect the individual with
some genetic disorder.
 Gamete mutations can be passed on to the next
generation
Two types of mutation in gamete cell
1. Gene Mutations
2. Chromosomal Mutations
Type of Single Gene Mutations -
Point
.
It’s a point mutation and type of single gene
mutation
Chromosomal Mutations
Types of Chromosomal Mutations
 Deletion
 Duplication
Deletion
 Involves the loss of all or part of a chromosome
Duplication
 Involves the production of extra copies of parts of the
chromosome

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Presentation

  • 1. Presentation Given by;. DR, Zulqarnain Course name;. Introduction to Bioinformatics To present;. Mutation and types of mutation Prepared by;. Muhammad Afnan
  • 2. Course outlines Mutation Cause of mutation Types of mutation
  • 3. Mutation  The change in genetic material (DNA) of an organisms
  • 4. The causes of mutations  1. DNA fails to copy accurately Most of the mutations that we think matter to evolution are "naturally-occurring." For example, when a cell divides, it makes a copy of its DNA — and sometimes the copy is not quite perfect. That small difference from the original DNA sequence is a mutation.  2. External influences can create mutations Mutations can also be caused by radiation. These agents cause the DNA to break down. This is not necessarily unnatural. when the cell repairs the DNA, it might not do a perfect e repair. So the cell would end up with DNA slightly different than the original DNA and hence, a mutation
  • 5. Types of Mutation Mutations can occur in two different types of cells: 1. Somatic (body) cells 2. Gamete (sex) cells
  • 6. Mutation in Somatic Cell  Mutations that occur in somatic (body) cells usually result in killing that body cell only. An exception to this is if the mutation occurs to the DNA that controls regulation of the cell cycle. This can result in cancer.  Somatic mutations usually do not affect the individual.  Somatic mutations can NOT be passed on to the next generation.
  • 7. Mutation in Gamete Cells  Mutations that occur in gamete (sex) cells means that every cell of the developing fetus/baby will have that mutation.  Gamete mutations usually do affect the individual with some genetic disorder.  Gamete mutations can be passed on to the next generation
  • 8. Two types of mutation in gamete cell 1. Gene Mutations 2. Chromosomal Mutations
  • 9. Type of Single Gene Mutations - Point . It’s a point mutation and type of single gene mutation
  • 10. Chromosomal Mutations Types of Chromosomal Mutations  Deletion  Duplication
  • 11. Deletion  Involves the loss of all or part of a chromosome
  • 12. Duplication  Involves the production of extra copies of parts of the chromosome