5th UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014

5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014
11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR
Page1
5th
UM-NUS-CU TRILATERAL MINI SYMPOSIUM
AND SCIENTIFIC MEETING 2014
PROGRAMME AND
ABSTRACTS
DEPARTMENT OF CHEMISTRY,
FACULTY OF SCIENCE,
UNIVERSITY OF MALAYA, 50603 KUALA LUMPUR

Welcome
Page2
Table of Contents
Page
Welcome note 3
Organizing committee 5
Delegation from Chulalongkorn University 6
Delegation from National University of Singapore 7
Scientific programme 8
Abstracts of invited speakers 11
Abstracts of poster presentations 24
Sponsors 114

Welcome
Page3
Welcome note
Prof. Dr. Mhd. Radzi Abas
Welcome to the 5th UM-NUS-CU Trilateral Mini Symposium and Scientific Meeting
2014!! We are especially proud to be given the opportunity to organize this
symposium in the Department of Chemistry, UM this year.
Since the initiation of this symposium in 2009 in Bangkok, Thailand, we have strived
both to focus and broaden the scope of the symposium. The focus has been to
establish collaborative research and networking among the academics from the top
research universities in Malaysia, Singapore, and Thailand.
This year, the symposium is held on the 11th
and 12th
February 2014. The program
on the first day of the event is packed with oral presentations by 12 distinguished
speakers from the three univeristies. As before, the symposium is structured to allow
close interaction among the participants; hence together with the formal
presentations, there will be social occasions such as dinner at Eastin Hotel, where
the academics and attendees will get together and know each other better to
enhance opportunities for scientific intercourse. Besides, we have also arranged a
short tour for our guests to Rimba Ilmu, which means Forest of Knowledge in the
malay language. Rimba Ilmu is a tropical botanical garden, set up in the University of
Malaya campus in Kuala Lumpur. It is modelled after a rain forest garden concept
rather than a formal flower garden. It emphasises the flora of the Asean region with
living collections of over 1,600 species. The Rimba Ilmu also houses the University of
Malaya herbarium (acronym KLU) and has its own Environmental Education
Programme.
An administrative or annual meeting between the three institutes has also been
arranged and it will be held on the second day of this event to discuss matters
associated to research student exchange, collaboration, MoU, etc. With all these
programs in line, I greatly hope that we can make full use of our time and resources
in the next two days to discuss and deliberate on research issues, and at the same
time paving the way towards a more sustainable and resilient research
collaborations.

Welcome
Page4
To our friends from Singapore and Thailand, the Department of Chemistry, UM
welcomes you, encourages you to visit and stay with us and hope that this trilateral
seminar will bond us even more strongly for our mutual benefit. I hope you will enjoy
yourself in the sympossium and have a wonderful time!!
Prof. Dr. Mhd. Radzi Abas,
Chairman of the Organizing Committee,
5th UM-NUS-CU Trilateral Mini Symposium 2014
Department of Chemistry,
University of Malaya.

Organisers
Page5
Members of Organising Committee
Patron : Prof. Dato’ Dr. Mohd. Sofian Azirun
Dean, Faculty of Science, Univeristy of Malaya
Advisor : Prof. Dr. Sharifuddin Md. Zain
Chairman : Prof. Dr. Mhd. Radzi Abas
Secretary : Dr. Cheng Sit Foon
Treasurer : Dr. Teo Yin Yin
Liason officer : Dr. Cheng Sit Foon (UM – NUS)
Assoc. Prof. Dr. Vannajan Sanghiran Lee (UM – CU)
Members
(i) Dr. Desmond Ang Teck Chye
(ii) Dr. Low Kah Hin
(iii) Dr. Noraini Ahmad
(iv) Dr. Siti Nadiah Abdul Halim
(v) En. Mohd. Azli Ishak
(vi) En. Hashim Mohammad Salleh
(vii) En. Norafandi Tamar
(viii) En. Nor Mazni bin Jahari
(ix) En. Saifulrullah Abd. Rahim
(x) En. Yusriadie Mohd. Azmi
(xi) Pn. Norhaida Mohd. Nor
(xii) Pn. Norzainariah bt. Mat Zaid
(xiii) Pn. Siti Alimah Makmon
(xiv) Pn. Zailawati Mohamad Zakaria

CU Delegates
Page6
Honorable Delegation from Chulalongkorn University
Assoc. Prof. Dr. Vudhichai Parasuk
Assoc. Prof. Dr. Paitoon Rashatasakhon
Assist. Prof. Dr. Worawan Bhantumnavin
Prof. Dr. Orawon Chailapakul
Assist. Prof. Dr. Sumrit Wacharasindhu
Dr. Numpon Insin
Assist. Prof. Dr. Viwat Vchirawongwin
Assist. Prof. Dr. Fuangfa Unob
Dr. Puttaruksa Varanusupakul
Dr. Rojrit Rojanathanes
Dr. Pannee Leeladee
Assist. Prof. Dr. Soamwadee Chaianansutcharit
Dr. Kanet Wongravee
Dr. Prompong Pienpinijtham

NUS Delegates
Page7
Honorable Delegation from National University of Singapore
Prof. Dr. Chang Young Tae
Assoc. Prof. Dr. Valiyaveettil Suresh
Assoc. Prof. Dr. Kang Hway Chuan
Assoc. Prof. Dr. Chen Wei

Programme
Page8
Scientific Programme
Day 1 - 11th February 2014
Activity : Oral and poster presentations
Venue : D112 (Oral) and Dataran Kimia (Poster)
8.30 – 9.30 a.m. Registration
9.30 a.m. Opening ceremony
9.30 – 9.45 a.m. Welcoming remarks and Briefing
Prof. Dr. Sharifuddin Md. Zain
Head, Department of Chemistry, Faculty of Science,
University Malaya, Malaysia
9.45 – 10.00 a.m. Speech and Briefing
Prof. Dr. Chang Young Tae
Head of Delegation,
National University of Singapore
10.00 – 10.15 a.m. Speech and Briefing
Assoc. Prof. Dr. Vudhichai Parasuk
Head, Department of Chemistry,
Chulalongkorn University, Thailand
10.15 – 10.30 a.m. Welcoming and Opening Speech
Prof. Dato’ Dr. Mohd. Sofian Azirun
Dean, Faculty of Science, University Malaya
10.30 – 10.40 a.m. Group photography session
All delegates
10.40 – 11.00 a.m. Coffee break and poster presentation
Venue: Dataran Kimia
11.00 a.m. Session 1
Chairperson : Prof. Dr. Chang Young Tae
11.00 –11.20 a.m. Speaker 1
Prof. Dr. Rauzah Hashim (UM)
Guerbet Glycoside: The New Lipid in Town
11.20 – 11.40 a.m. Speaker 2
Assoc. Prof. Dr. Chen Wei (NUS)
Atomic-Scale Interface Controlled Two-Dimensional Molecular
Dipole Dot Arrays
11.40 – 12.00 p.m. Speaker 3
Prof. Dr. Orawon Chailapakul (CU)
The Novel Electrochemical Systems For Environmental And
Clinical Applications
12.00 – 12.20 p.m. Speaker 4 UM
Prof. Dr. Khalijah Awang (UM)
Bioactive Phytochemicals From The Malaysian Flora And

Programme
Page9
Medicinal Plants
12.20 – 12.40 p.m. Speaker 5
Assoc. Prof. Dr. Kang Hway Chuan (NUS)
Conductance And Electronic Structure Across Graphene
Nanoribbon Junctions
12.40 – 1.00 p.m. Speaker 6
Assist. Prof. Dr. Sumrit Wacharasindhu (CU)
Direct Synthesis of Acetylenic Compounds from Calcium
Carbide: a New Sustainable Chemical Feedstock
1.00 – 2.00 p.m. Lunch
Venue: Multipurpose room
Poster presentation
2.00 p.m. Session 2
Chairperson: Assoc. Prof. Dr. Paitoon Rashatasakhon
2.00 – 2.20 p.m. Speaker 7
Dr. Sharifah Mohamad (UM)
Application of β-cyclodextrin Functionalized With Ionic Liquid
For Extraction And Separation Of Organic Compounds
2.20 – 2.40 p.m. Speaker 8
Assoc. Prof. Dr. Valiyaveettil Suresh (NUS)
Understanding The Environmental Impact And Developing A
Remediation Method For Nanopollutants
2.40 – 3.00 p.m. Speaker 9
Dr. Numpon Insin (CU)
Surface Modifications and Environmental Applications of
Magnetic Nanoparticles and Quantum Dots
3.00 – 3.20 p.m. Speaker 10
Dr. Woi Pei Meng (UM)
Development of Non-Enzymatic Portable Body Metabolites
Sensor
3.20 - 3.40 p.m. Speaker 11
Prof. Dr. Chang Young Tae (NUS)
Caffeine Sensor and Bioimaging Probe Development
3.40 – 4.00 p.m. Speaker 12
Assist. Prof. Dr. Viwat Vchirawongwin (CU)
Evaluations of Vibration Spectra from Molecular Dynamics
Simulation of Hydrated Sulfoxy Anions
4.00 p.m. End of mini sympossium
Light refreshment
8.00 p.m. Dinner at Eastin Hotel (by invitation)

Programme
Page10
Day 2 – 12th February 2014
Activity : Scientific meeting and discussion
Venue : Rimba Ilmu and K017
8.30 – 9.45 a.m. Rimba Ilmu tour
9.45 –12.15 noon Discussion on academic staff exchange programme
Discussion on student exchange programme for
undergraduates and postgraduates
Venue: K017
12.15 – 12.30 p.m. Closing ceremony
12.30 p.m. Lunch
Venue: Multipurpose room

Abstract - Speakers
Page11
ABSTRACTS OF
ORAL PRESENTATIONS
(Content unedited)

Abstract - Speakers
Page12
Guerbet Glycoside: The New Lipid in Town
Rauzah Hashim
Chemistry Department, University of Malaya, Kuala Lumpur, Malaysia
*Email: rauzah@um.edu.my
Abstract
Here, we discuss some results from the study of self-assembly phenomena on a special class
of poly-hydroxy sugar surfactant, the branched chain Guerbet glycoside (BCGG). Surfactants
from this class of material are also classified as amphitropic liquid crystals since they exhibit
both thermotropic and lyotropic liquid crystalline properties. Hence the potential applications
of these non-ionic surfactants are far wider than the conventional lyotropic liquid crystals
encompassing both areas of high-technology industry and life science. From uniting the
approaches in experiment, theory and computation, we have developed some basic
understanding of the phase behavior. In turn, the self-assembly property may be manipulated
using external factors to give rise many innovative ideas. This review covers the effect of
stereochemical diversity of the sugar on the thermotropic/lyotropic phases formed. The
structure to property relationship compares different chain designs and other popular
polyhydroxy compounds, such as monooleins and alkylpolyglucosides. The structural
advantages of these Guerbet glycosides due to large chain hydrophobicity, tunable, chiral,
asymmetric and stable ether linking group are discussed with respect to their self-assembly
organization and potential applications, such as drug delivery, protein crystallization and
membrane mimetic study.
Keywords: Glycolipid, Guerbet Glycoside, Lyotropic, Non-ionic surfactant
Speaker 1

Abstract - Speakers
Page13
Atomic-Scale Interface Controlled Two-Dimensional Molecular Dipole Dot
Arrays
Wei CHEN1,2*
1
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore,
117543
2
Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore,
117542
*E-mail: chmcw@nus.edu.sg
Abstract
Creation of well-ordered functional molecular arrays at the nanometer scale is one of the key
issues in the development for future molecular- or nano-electronic devices, solid-state
quantum computation, single-electron devices, and biosensors. Molecular self-assembly on
surfaces or surface nanotemplates via selective and directional covalent or non-covalent
interactions offers a promising bottom-up approach to fabricating molecular nanostructure
arrays with desired functionalities over macroscopic areas. The directionality and selectivity
of intermolecular hydrogen bonding, metal-ligand interactions as well as covalent bonding
can facilitate the formation of ordered supramolecular assemblies with good structural
stability. In this talk, we highlight our recent progress in the fabrication of self-assembled
molecular nanostructures on surface and surface nanotemplates, as investigated by in-situ
scanning tunneling microscopy, with particular emphasis on the fabrication of 2D molecular
dipole dot arrays, as well as the reversible switching of individual dipole molecule in
hydrogen-bonded 2D networks.
Keywords: Single Molecule, STM, Self-Assembly
Speaker 2

Abstract - Speakers
Page14
The novel electrochemical systems for environmental and clinical
applications
Orawon Chailapakul1,*
, Thara Nurak1
, Narong Praphairaksit1
, Nipapan Ruecha2
, Nadnudda
Rodthongkum3
, Ratthapol Rangkupan3
1
Electrochemistry and Optical Spectroscopy Research Unit (EOSRU), Department of
Chemistry, Faculty of Science, Chulalongkorn University,10330, Thailand
2
Program in Macromolecular Science, Faculty of Science, Chulalongkorn University, 10330,
Thailand
3
Metallurgy and Materials Science Research Institute, Chulalongkorn University, 10330,
Thailand
*Email: corawon@chula.ac.th
Abstract
Our research topic focuses on a development of new electrochemical systems for the
detection of elemental species and biomakers of interest for the environmental and clinical
applications. The first project, we report a spraying method with lacquer developed for a
novel fabrication of paper-based devices. The paper-based devices were used to determine
nickel using anodic stripping voltammetry. Cu-enhancer solution was employed to increase
sensitivity of nickel determination with the optimal concentration of 4.5 ppm. Under the
optimal conditions, linear range was found to be in the range of 1 to 50 ppm with a coefficient
of determination of 0.9971. The limit of detection (LOD) and the limit of quantitation (LOQ)
were found to be 0.5 and 1.97 ppm, respectively. Moreover, these paper-based
electrochemical devices were applied to determine nickel in waste water from a jewelry
factory.
The second project, graphene-polymer nanodroplets are developed and used to modify
paper-based electrode for electrochemical detection of cholesterol. Nanodroplets of
Graphene-polymer were fabricated using electrospraying technique to increase the electrode
surface. The modified electrode was characterized for morphology and electroactivity by
using scanning electron microscope and cyclic voltammetry. This proposed method has been
used to detect cholesterol using chronoamperometry.
Keywords: Electrochemical sensor, Anodic stripping voltammetry, Amperometry, heavy
metal, biomarker
Speaker 3

Abstract - Speakers
Page15
Bioactive Phytochemicals from the Malaysian flora and medicinal plants
Khalijah Awang
Department of Chemistry, Faculty of Science, University Malaya,
50603 Kuala Lumpur
Abstract
Since the dawn of civilisation, plants have been used as medicine and until today there are still the
main source for therapeutic agents especially the anti cancer drugs such as taxol and the indole
alkaloids vinblastine and vincristine. Malaysia is the home to one of the oldest and most diverse
flora in the world. It is the host of more than 15,000 plant species. Therefore, the Malaysian flora
is an excellent resource for bioactive and rare phytochemicals that could be potential candidates
for drug development. In view of the these factors, our laboratory is focussing our research on
bioactive natural products. Our findings on phytochemicals from various plant species shall be
presented. Examples of bioactive compounds possessing complex skeletons from plant families
such as Annonaceae, Apocynaceae, Meliaceae, Guttifereae shall be presented. In addition,
Malaysia is also rich with its traditional medicine heritage from three different cultures: Malay,
Chinese and Indian. Findings from the traditional medicinal plants studied in our laboratory shall
also be discussed briefly.Since the dawn of civilisation, plants have been used as medicine and
until today there are still the main source for therapeutic agents especially the anti cancer drugs
such as taxol and the indole alkaloids vinblastine and vincristine. Malaysia is the home to one of
the oldest and most diverse flora in the world. It is the host of more than 15,000 plant species.
Therefore, the Malaysian flora is an excellent resource for bioactive and rare phytochemicals that
could be potential candidates for drug development. In view of the these factors, our laboratory is
focussing our research on bioactive natural products. Our findings on phytochemicals from
various plant species shall be presented. Examples of bioactive compounds possessing complex
skeletons from plant families such as Annonaceae, Apocynaceae, Meliaceae, Guttifereae shall be
presented. In addition, Malaysia is also rich with its traditional medicine heritage from three
different cultures: Malay, Chinese and Indian. Findings from the traditional medicinal plants
studied in our laboratory shall also be discussed briefly.
Speaker 4

Abstract - Speakers
Page16
Conductance and electronic structure across graphene
nanoribbon junctions
Kang Hway Chuan
Department of Chemistry, NUS
Division of Science, Yale-NUS College
Abstract
The antiferromagnetic electronic structure of zig-zag graphene nanoribbons is well-known,
leading to possible spin-polarized electron transport with a transverse electric field. We
explore an alternative way of achieving spin-polarized electron transport through a junction
consisting of zig-zag graphene nanoribbon leads and a small molecular link such as polyenes
and cumulenes. We will present our results discuss the effects on conductance of the
adsorption position for the linker molecule, edge decoration and relative rotations of the
graphene-nanoribbon leads.
Speaker 5

Abstract - Speakers
Page17
Direct Synthesis of Acetylenic Compounds from Calcium Carbide: a New
Sustainable Chemical Feedstock
Sumrit Wacharasindhu, Padon Chuentragool, Nopparat Thavornsin, Narongpol
Kaewchangwad and Mongkol Sukwattanasinitt
Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330
*Email: sumrit.w@chula.ac.th
Abstract
Acetylenic compounds are important building blocks for natural products,
pharmaceuticals and molecular materials. At the start of our research program, we explored
one of well-known acetylenenic derivatives: polydiacetylene (PDA) in sensor application. The
success of these works led to the development of point of care colorimetric sensors for
detecting temperature anionic surfactants and volatile organic compounds. To promote wider
adoption of PDA-based materials, we aim to develop a more cost efficient and safer method
to synthesize acetylenic derivatives in the second part of our project. In this presentation, we
demonstrated the use of calcium carbide, which is a low price primary feedstock from heavy
chemical industry for the synthesis of acetylenic compounds such as diarylethynes, poly-
phenyleneethylene and arylpyroles in one step fashion. The processes provide high yields of
acetylenic derivatives in comparable or better yield than conventional methods. It is also less
complicate and cheaper to carry out. The optimization and scope of the reaction will be
discussed in this presentation.
Keywords: Sonogashira, acetylene, conjugated polymer and calcium carbide
Speaker 6

Abstract - Speakers
Page18
Application of β-cyclodextrin functionalized with ionic liquid for extraction
and separation of organic compounds.
Sharifah Mohamad*, Mhd Radzi Abas, Nor Kartini Abu Bakar, Tay Kheng Soo, Nur
Nadhirah binti Mohamad Zain, Muggundha Raoov a/L Ramachandran, Tay Kheng Soo
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603,
Malaysia
*Email: sharifahm@um.edu.my
Abstract
The growing interest in cyclodextrin (CD) and ionic liquid (IL) in separation study, has
allowed us to combine these two domains of research to apply in extraction and separation of
organic compounds. In the first part of the presentation, I will focus on how the combination
of properties offered by both domains may be combined usefully for extraction and separation
of organic compounds. Cyclodextrin offer hydrophobic in nature can entrap different kinds of
compounds including organic, inorganic, organometallic and metaloorganic, while ionic
liquids offer unique properties such as negligible volatility, thermal stability, and non-
ﬂammability make them acceptable as new green solvents. Owing to the properties of
cylcodextrin and ionic liquid, the functionalization of β-CD with IL has fostered our interest
in preparing a new generation of material that may demonstrate some interesting phenomena
in extraction and separation studies. In this paper, synthesize and characterization of β-
cyclodextrin functionalized with ionic liquid (β-CD-IL) will be presented and the application
of (β-CD-IL) in extraction and separation of organic compounds will be discussed.
Keywords: Cyclodextrin, Ionic Liquid, Extraction, Separation
Speaker 7

Abstract - Speakers
Page19
Understanding the environmental impact and developing a remediation
method for nanopollutants
Suresh Valiyaveettil
Department of Chemistry, Faculty of Science,
National University of Singapore,
3 Science Drive 3, Singapore, 117543.
E-mail: chmsv@nus.edu.sg
Abstract
Nanoscience and nanotechnologies are expected to revolutionize our life in the coming years.
Engineered nanomaterials are already present in many consumer products such as cosmetics,
biomedical materials, detergents, antimicrobial paints, surface modifiers, food additives and
packaging materials, to name a few. Such increased usage of nanomaterials has caused
concerns from various quarters of our society, including government organizations and public
in general. The main reason for such concern involves the lack of our knowledge on the fate
of such nanomaterials inside the living organism. Recent studies have shown that metallic
nanoparticles are toxic to living systems. We have been examining such adverse impact of
nanomaterials in human cell lines and zebrafish models. On the other hand, if the
environments are contaminated with nanomaterials, there must be efficient materials and
methods to remove such pollutants from environment, especially potable water. Recently, we
tried to develop new renewable adsorbents for water purification. The current presentation
will give full details on environmental impact of nanomaterials and also look a t the future
remediation of contaminated environment.
Keywords: Nanotoxicity, zebrafish, metal nanoparticles, Water purification
Acknowledgement: The authors thank the Environment and Water Industry Programme
Office (EWI) under the National Research Foundation of Singapore (PUBPP 21100/36/2,
NUS WBS no. R-706-002-013-290, R-143-000-458-750, R-143-000-458-731) for the
financial support of the work. The authors also thank Faculty of Science, Department of
Chemistry, NUS Environmental Research Institute (NERI) for funding and technical support.
Speaker 8

Abstract - Speakers
Page20
Surface Modifications and Environmental Applications of
Magnetic Nanoparticles and Quantum Dots
Numpon Insin
Department of Chemistry, Faculty of Science, Chulalongkorn University
Email: Numpon.i@chula.ac.th
Abstract
Magnetic nanoparticles (MNPs) and semiconductor quantum dots (QDs) are two classes of
inorganic nanomaterials with unique properties. MNPs exhibit superparamagnetism, the
phenomenon of nanoscale ferromagnetic and ferrimagnetic materials that can stay colloidal
stable with strong response in presence of magnetic fields. QDs are known for their intense
and tunable fluorescence with broad range of excitation wavelength. In this presentation, we
will discuss about various surface modification processes that have been studied in our lab in
order to use these nanomaterials to solve and prevent some environmental problems.
Pollutants such as oil, heavy metals, and organic dyes were removed from water by
superparamagnetic sorbents. Moreover, QDs were used to monitor the level of some heavy
metals in waste water. From these studies, we found that these nanomaterials, after undergone
suitable surface modification processes, show their potential to be used in many applications
efficiently.
Keywords: Magnetic nanoparticles, superparamagnetic, quantum dots, fluorescent, pollutants
Speaker 9

Abstract - Speakers
Page21
Development of Non-Enzymatic Portable Body Metabolites Sensor
Pei Meng Woi,1,*
Ahmad Nazmi bin Rosli,1,2
, Yatimah Alias1
and Mohd Rais Ahmad2
1
Department of Chemistry, Faculty of Science, University of Malaya, 50603 Lembah Pantai,
Kuala Lumpur, Malaysia.
2
NEMS & Photonics Laboratory, MIMOS Berhad, Technology Park Malaysia, 57000
Kuala Lumpur, Malaysia.
*E-mail: pmwoi@um.edu.my
Abstract
Our research relates to prototype construction of molecular sensing devices of bio-chemical
nanosensors for bio-medical and health applications. This nanosensor can be used to monitor
health conditions by monitoring binding affinity of the metabolites thus possessing recognitive
ability geared towards ionic metabolites such as potassium, sodium, ammonium, hydrogen ions,
chloride, phosphate and carbonate of medical interest [1,2]
. Similarly, biomolecule recognising
substituents are of importance for glucose and living body fluid such as blood and uric acid
determination. Our nanosensors can be used to monitor health conditions by monitoring the
calcium and magnesium level, with preferable selectivity towards calcium. This prototype which
is an integrated miniaturised sensor array along with readout circuitry and microcontroller on the
same platform provides fast and accurate measurement of the targeting analytes via potentiometric
method. The prototype we have here is based on nano-electrodes which are fabricated using
chemical vapour deposition (CVD) method, through selective deposition, nano-lithography and
etching. Alternatively, carbonised polymeric poles, carbon nano-tubes and graphenes can be
grown to function as electrodes [3]
. This is an added advantage compared to other available
sensors on the market in terms of lifetime/reliability, accuracy, mobility, cost and manufactured
ability.
Keywords: Bio-chemical nanosensor, portable detection kit, USB terminal, functionalized
monomer
Suggested Reading:
1. Apodaca, D.C.; Pernites, R.B.; Ponnapati, R.R.; Del Mundo, F.R.; Advincula, R.C. ACS Applied Materials
& Interfaces, 2011 3(2), 191-203.
2. Workman, J.; Lavine, B.; Chrisman, R.; Koch, M. Anal. Chem., 2011, 83(12), 4557-4578.
3. Nayagam, D.A.X.; Williams, R.A.; Irwin, J.; Tan, J.; Innis, P.; Leung, R.T.; Finch, S.; Williams, C.E.;
Clark, G.M.; Wallace, G.G. Small 2011, 7 (8), 1035.
Speaker 10

Abstract - Speakers
Page22
Caffeine Sensor and Bioimaging Probe Development
Young-Tae Chang
National University of Singapore
Department of Chemistry
*Email: chmcyt@nus.edu.sg
Abstract
The conventional bioprobe design has been carried out by so-called hypothesis-driven
approach. The basic assumption of hypothesis-driven approach is that the scientist “knows
the target” in advance, and then design the recognition motif for it. An alternative approach is
diversity-driven approach, in which a broad range of fluorescence molecules in a library
format are constructed by combinatorial chemistry, as a tool box for unbiased screening.
Among several diversity sources, “Diversity Oriented Fluorescence Library Approach
(DOFLA)” using fluorophore core with diverse recognition motives around has been the most
fruitful in novel bioprobe generations. Using DOFLA, various sensors including caffeine
orange, and also colorful bioimaing probes from stem cells to Neurons will be demonstrated.
Keywords: Fluorescence, Sensor, Bioimaging, Probe
Speaker 11

Abstract - Speakers
Page23
Evaluations of Vibration Spectra from Molecular Dynamics Simulation of
Hydrated Sulfoxy Anions
Viwat Vchirawongwin
Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road,
Patumwan, Bangkok 10330, Thailand
*Email: Viwat.V@Chula.ac.th
Abstract
The sulfoxy anions consist of sulfur and oxygen atoms utilized in ubiquitous chemical
processes, resulting contamination in freshwater environments as evidence of water pollution
and in atmospheric aerosol particles. The aqueous solutions of sulfate, bisulfate, sulfonate and
thiosulfate anions were simulated by the ab initio quantum mechanical charge field molecular
dynamics (QMCF MD) formalism. The evaluation of vibration spectra from the trajectory of
simulations is a challenge to verify the dynamics property comparison with the experimental
data. This process uses the normal vector analysis on the molecular solute and the velocity
autocorrelation function (VACF) coupling with Fourier transformation, converting the MD
results into the power spectra. This evaluation provided the positions and patterns of
calculated spectra in very good agreements with available IR and Raman data, which can
confirm the appropriation of the selected theoretical level in the simulation protocol to acquire
the properties of these hydrated anions.
Keywords: Molecular Dynamics, Sulfoxy anion, Velocity autocorrelation function, Vibration
spectra
Speaker 12

Abstract -Poster
Page24
ABSTRACTS OF
POSTER PRESENTATION
(CONTENT UNEDITED)

Abstract -Poster
Page25
Index
Abstracts of Posters
Section Author Title Designation
Inorganic
Chemistry
Fadhil Lafta Faraj, Hapipah
Mohd Ali, Hamid Khaledi and
Noraini Ahmad
A meso-substituted β-
dialdiminate-bis(phenolate)
ligand in Mn
III
, Co
III
, Co
II
,, Ni
II
and Cu
II
complexes
INORG 1
Nurul Azimah Ikmal Hisham,
Hamid Khaledi, and Hapipah
Mohd Ali
Di- and trinuclear metal
complexes derived from
pyrazolylindolenine
INORG 2
Ainnul Hamidah Syahadah
Azizan, Nurfarhanim Abu
Bakar, Teh Kai Ni, Gwaram
Nura Suleiman, Hapipah Mohd
Ali and Hamid Khaledi
Reduction of carbon-carbon
double bonds of Chalcone
using phenylsulfonyl
hydrazide
INORG 3
Mok Piew Heng, Kong Wai
Tan, Seik Weng Ng, Yoke
Kqueen Cheah, Sabrina
Sukardi
Synthesis and
characterization of nickel (II)
complex bearing a Schiff
base with a testosterone
moiety and its biological
properties
INORG 4
Farhatun Najat Maluin,
Sharifah Mohamad, Ninie S. A.
Manan
Ionic Liquid as the
morphology template for
polyaniline/ nano-hematite
composite
INORG 5
Subathra Sinniah, Sharifah
Mohamad, Ninie S.A. Manan
Synthesis and
Characterization of Fe3O4
Nanoparticles Coated with β-
CD-IL
INORG 6
Norbani Abdullah and Noha
Said A. Bedowr
Single-molecule magnet and
magnetic coordination
polymers with mesogenic
properties
INORG 7
Abeer Abduljaleel Ibrahim,
Hapipah Mohd Ali, Hamid
Khaledi
Spectroscopic and X-ray
crystallographic studies on
Pd
+2
and Pt
+2
complexes of
flexidentate Schiff base
ligand derived from indole-7-
thiosemicarbazone and their
anticancer activity
INORG 8
Shin Thung Chew, Kong Mun
Lo and Kong Wai Tan
Synthesis, Structural
Characterization And
Biological Properties Of
Copper Complexes With
Ligands Containing
Phosphonium Substituents
INORG 9
Sze Koon Lee, Kong Wai Tan,
Hoi Ling Seng
Zinc (II) Complex Bearing A
Cationic Schiff Base With A
Bromomethyl Group:
INORG 10

Abstract -Poster
Page26
Synthesis, Spectroscopic
Characterizations And
Biological Study On E.Coli
Topoisomerase I Activity
Hana Bashir Shawish, Mohd
Jamil Maah
Synthesis and
Characterization of Nickel
complexes - New Insights
into the Structure and
Bonding of Thiourea Diamine
Derivatives
INORG11
Ishak, D. H. A., Ooi, K. K., Ang,
K. P., Akim, A. M., Cheah, Y.
K., Nordin, N., Halim, S. N. A.,
Seng, H. L. & Tiekink, E. R. T.1
A bismuth
diethyldithiocarbamate
compound promotes
apoptosis in HepG2
carcinoma, cell cycle arrest
and inhibits cell invasion
through modulation of the
NF-κB activation pathway
INORG12
Kit May Chow and Kong Mun
Lo
Organometallic Chemistry
INORG13
Pannee Leeladee, Guy N. L.
Jameson, Maxime Siegler and
David Goldberg
A High-Valent Iron Imido
Corrolazine: Generation and
Evidence of NR Group
Transfer
INORG14
Richard C.S. Wong and Mei
Lee Ooi
Isolation And
Characterisation Of Novel
Organometallic Derivatives
Of Multidentate Phosphine
Bis[(o-
methylthio)phenyl]phenylpho
sphine and Tris[(o-
methylthio)phenyl]phosphine
INORG15
Wang Chunyan and Suresh
Valiyaveettil
Study of cytotoxic effects of
green synthesized silver
nanoparticles with different
capping agents on tumor
cells
INORG16
Aina Mardia Akhmad Aznan,
A. P. Safwan, Zanariah
Abdullah, Trupta Kaulgud,
Hadi D. Arman, Matthew
Mahindaratne, Laurie E.
McNeil, and Edward R. T.
Tiekink
Supramolecular metathesis:
cation exchange in salts
derived from the sulfa-drug,
sulfathiazole
INORG17

Abstract -Poster
Page27
Organic /
Natural
products
Nur Atiqah Mohd Nasuha and
Yeun-Mun Choo
Dyes From Natural
Resources
ORG 1
Katrina Mohamad Khidzir, Sit
Foon Cheng and Cheng Hock
Chuah
Volatile Components of
Fresh Jasminum sambac
Buds and the Potential
Antioxidant Activities of its
Methanolic Extract
ORG 2
Chun Hui Ang, Sit Foon
Cheng, Chavasiri Warinthorn
and Cheng Hock Chuah
Antioxidant Potential of
Tannin-rich n-Butanol Extract
from Elaeis guineensis Leaf
ORG 3
Wei Seng Ng, Sit Foon Cheng,
Choy Sin Lee and Cheng Hock
Chuah
Synthesis of Palm Oil-Based
Polyester Polyols
ORG 4
Wai-Ming Kok, Sit-Foon Cheng
and Cheng-Hock Chuah
Long Chain Saturated
Structured Lipids via
Enzymatic Interesterification
using Lipase Rhizomucor
miehei (Lipozyme RM IM)
ORG 5
Lim Jun Lee, Gan Chew Yan,
Low Yun Yee, Lim Siew Huah
and Kam Toh Seok
Alkaloid from Alstonia
rostrata
ORG 6
Rojrit Rojanathanes, Kobkun
Saepang, Supakit
Seawpakorn, Patchanita
Thamyongkit, and Wittawat
Keawsongsang
Pyridine-Based Molecular
Pincer for Transition Metal
Complexation
ORG 7
Shah Bakhtiar Nasir and
Noorsaadah Abd Rahman
Aza Diels-Alder Rection of
Cyclic Imine with
Danishefsky’s Diene
ORG 8
Chun Keng Thy, Chin Fei Chee
and Noorsaadah Abd Rahman
Total Synthesis of (±)-
Cyclollicinone
ORG 9
Jia Ti Tee, Chin Fei Chee and
Noorsaadah Abd Rahman
Total synthesis of (+)-
Morusalbanol A and (+)-
Sorocein B
ORG 10
Nurul Izzatil Aisya Asri, Issha
Nadirah Ismail, Hairul Anuar
Tajuddin, and Zanariah
Abdullah
Preparation and
Fluorescence Behaviour Of
Coumarin Terminated
Monolayer On Silver Particle
ORG11
Mohd Helmi Hussaini Dullah,
Zanariah Abdullah, Hairul
Anuar Tajuddin
Synthesis and Fluorescence
Characterization Of Azo-
Coumarin And Azo-Naphthol
ORG12
Issha Nadirah Ismail, Nurul
Izzatil Aisya Asri, Hairul Anuar
Tajuddin, and Zanariah
Abdullah.
Alkyl Disulfide as an
Alternative Absorbate for
Monolayer Formation on
Silver Particles
ORG13

Abstract -Poster
Page28
Physical /
Polymer /
Composites /
Material
chemistry
Nirosa Raman, Kavirajaa
Pandian Sambasevam and
Phang Sook Wai
Comparison studies of
polyaniline nanocomposite
with & without TiO2 for
hydrazine detection
PHY 1
Misni Misran, Teo Yin Yin,
Woo Juin Onn, Vicit Rizal Eh
Suk, and Yew Han Choi
Fatty acid nanoparticle for
topical and oral delivery
applications
PHY 2
T. H. Ali, R. S. D. Hussen and
T. Heidelberg
Y-shaped Carbohydrate
Surfactants by ‘Click
Chemistry’ for Oil-in-Water
Emulsions
PHY 3
Nurshafiza Shahabudin,
Rosiyah Yahya and Seng
Neon Gan
Preparation of microcapsules
containing alkyd resin as
core
PHY 4
M.S. Nusari and A. Mainal
Adsorption of Methylene blue
onto Chitosan-Based
Activated Carbon: Isotherm
and Kinetic Studies
PHY 5
Vannajan Sanghiran Lee,
Vertika Gautam, Wei Lim
Chong, Sharifuddin M. Zain,
Noorsaadah Abd. Rahman
Hot-Spot Motif
Characterization of Interface
between a Designed Ankyrin-
Repeat Protein and Its Target
Kinase
PHY 6
Pedram Azari, Haris Akram,
Gan Seng Neon, Rosiyah
Yahya, Wong Chiow San,
Belinda-Pingguan Murphy
An in vitro biological
evaluation of electrospun
poly(3-hydroxybutyrate) and
bovine hydroxyapatite
composite scaffold for bone
tissue engineering
PHY 7
Pameswari Subramani,Yeong
Siang Chiam, Seng Neon Gan,
Sook Wai Phang
Synthesis, Characterization
And Application Of
Polyaniline (PAni) Optical
Sensor For pH Detection
PHY 8
Zahrabatoul Mosapour Kotena,
Reza Behjatmanesh–Ardakani,
Rauzah Hashim
Hydrogen bonds formation in
α/β-D-mannose and n-octyl-
α/β-D-mannopyranoside
using AIM and NBO analyses
PHY 9
Abbas Abdulameer Salman
and Thorsten Heidelberg
Bio-Functionalization of
Inorganic Nanoparticles
PHY 10
Vannajan Sanghiran Lee,
Kanchanok Kodchakorn,
Jitrayut Jitonnom, Piyarat
Nimmanpipug, Prachya
Kongtawelert, Bhusana
Premanode, Wei Lim Chong,
Sharifuddin M. Zain,
Noorsaadah Abd. Rahman
Exploration on the Role of
Metal Cofactors and Water
on the Catalytic Mechanism
of Creatininase-Creatinine in
Aqueous Solution from
Molecular Dynamics
Simulation/Quantum Study
PHY11
Shabnam Bakhshaei, Sharifah
Mohamad, Sharifuddin Md
Zain
Synthesis and
characterization of of new
sol–gel titanium(IV)
butoxide–
cyanopropyltriethoxysilane in
cooperated with imidazolium-
based ionic liquids
PHY12
Naimah Haron, Nor Asrina
Sairi, Mohamed Kheireddine
Aroua, Yatimah Alias
Effect of Water Concentration
on the Structural and
Diffusion Properties of
PHY13

Abstract -Poster
Page29
Guanidinium
Trifluoromethanesulfonate
Ionic Liquid− Mixture
Nor Asrina Sairi, Mohd Azlan
Kassim, Rozita Yusoff,
Mohamed Kheireddine Taieb
Aroua
CO2 Capture in Ionic Liquid:
A review on mixed solvent
systems
PHY14
Zati Ismah Ishak, Nor Asrina
Sairi, Yatimah Alias, Mohamed
Kheireddine Taieb Aroua
Transesterification reaction:
Facile reaction by ionic
liquids as catalyst – A review
PHY15
Wan Melissa Diyana Wan
Normazlan, Vijaya
Ranganathan, Usman Ali
Rana, Nor Asrina Sairi,
Yatimah Alias and Douglas
MacFarlane
The Role of Hydrogen
Bonding by New Protic Ionic
Liquids in Driving Phase
Separation or Phase
Miscibility in UCST Ternary
Mixtures.
PHY16
Prompong Pienpinijtham, Xiao
Xia Han, Sanong Ekgasit, and
Yukihiro Ozaki
A Fabrication of Surface-
Enhanced Raman Scattering
(SERS) Substrate Using an
Ionic Surfactant-Mediated
Langmuir-Blodgett Method
PHY17
Supamas Kanjanakunthon,
Nipaka Sukpirom and
Puttaruksa Varanusupakul
Electrospun Titanium Dioxide
Fibers as Stationary Phase in
Thin Layer Chromatography
PHY18
Anucha Koedtruad, Koichiro
Mitsuke and Soamwadee
Chaianansutcharit
Effects of Sintering
Temperature on Conductivity
and Oxygen Permeation of
La0.3Sr0.7Co0.9Fe0.1O3
Perovskite
PHY19
Norazlinaliza Salim, Rauzah
Hashim and Noraini Ahmad
Formation of Branched-Chain
Glycolipids Nano-Emulsions
for Topical Drug Delivery
Systems
PHY20
Faheem Ahmed Qaid, Abdul
Hamid bin Yahaya and
Rosiyah binti Yahya
Kinetic and isotherm
adsorption of phenol from
wastewater using activated
carbons prepared from
jatropha seed husks by KOH
activation
PHY21
Yee Ting Chong, Norazilawati
Muhamad Sarih, Sie Tiong Ha,
Rezaul Karim Sheikh
Synthesis and Mesomorphic
Properties of Schiff’s Base
Ester with Terminal Methoxy
Substituent
PHY22
Olla .H.Sharhan, Abdul Hamid
Yahaya and Mohamed
Mahmoud Nasef
Preparation and
characterization of poly (3-
hydroxybutyric
acid)/poly(vinyl acetate) thin
films
PHY23
Sung-Jin Park, Nam-Young
Kang, Anandhkumar Raju,
Xiao Wei Emmiline Ang,
Animesh Samanta, Seong-
Wook Yun and Young-Tae
Chang
Development of in vivo
Inflammation Imaging Probes
PHY24
Nam-Young Kang, Sung-Chan
Lee, Sung-Jin Park, Seong-
Development of in vivo
imaging probes for
PHY25

Abstract -Poster
Page30
Wook Yun, and Young-Tae
Chang
pancreatic islets by Diversity
Oriented Fluorescence
Library Approach (DOFLA)
Young-Tae Chang and Seong-
Wook Yun
Fluorescent chemical
imaging probes for live stem
cells
PHY26
Animesh Samanta,Kaustabh
Kumar Maiti, U. S. Dinish and
Young-Tae Chang
Near-Infrared Raman
Reporters for SERS-based in
vivo Cancer detection
PHY27
Wan Hamdah Wan Ahmad
Effect Of Pure Cationic
Micelle ([Ctabr]T On The Rate
Of Alkaline Hydrolysis Of N-
(2-Aminophenyl)Phthalimide
PHY28
Norazizah A. Razak, Nor
Saadah M. Yusof and M. Niyaz
Khan
Quantitative Correlation
Between Counterion (X)
Affinity to Cationic Micelles
and X-Induced Micellar
Growth for X = 2,6-
Dichlorobenzoate Ions
PHY29
Ashok Keerthi, Yeru Liu, Qing
Wang, Suresh Valiyaveettil
Multidonor Substituted
Perylene Dyes through
Unusual Bromination of
Perylene Monoimide
PHY30
Perakassh veloo, Yen Nee
Koh, Sook Wai Phang
Morphology Studies of
Doped Polyaniline
Nanocomposites Containing
TiO2 Nanoparticles and
Graphene Nanoplatelets
PHY31
Muhammad Adil Mansoor,
Muhammad Mazhar and
Zainudin Artfin.
Development of
Photosensitive Ceramic Thin
Films for Photovoltaic
Applications
PHY32

Abstract -Poster
Page31
Analytical /
Environmental
Adam Henry Sivapatham,
Nadiya Taha Darwish, Mai Mai
Khoo and Sook Mei Khor
Development of a Reusable
Biosensor for Small
Molecules
AN-EV 1
Mehwish Jamil Noor,
Muhammad Aqeel Ashraf,
Mushtaq Ahmad,Amber latif,
Sonia Fatima
Identification and Evaluation
of Air Pollution Tolerance
Index of Plant Species under
the Impacts of Marble
Industry Pollutants of
AN-EV 2
Rizwana Naureen, Imran
Hashmi, Mohd, Jamil Maah,
Ismail Yusoff, Muhammad
Aqeel Ashraf
Biodegradation Studies of
Dichlorvos under Different
Sets of Conditions
AN-EV 3
Shiau Yi Tan and Kah Hin Low
Prediction of cetirizine
hydrochloride content in
medication tablet using ATR-
FTIR and PLS
AN-EV 4
Mehrnaz Ashrafi, Sharifah
Mohamad, Ismail Yusoff,
Fauziah Shahul Hamid
Remediation of Heavy Metal
Contaminated Soil Using
Banana Stem as the Organic
Fixing Additive
AN-EV 5
Fathiah Zubaidi, Guan Huat
Tan, Choo Yeun Mun
Development and Validation
of Liquid Chromatography
Tandem Mass Spectrometer
(LCMSMS) for the
Simultaneous Determination
of Common Drugs of Abuse
in Forensic Cases in
Malaysia: Application to
Dried Blood Stain (DBS)
AN-EV 6
Ummi Noor Salhah Masseren,
Tay K.S, Abas M.R.B
Preliminary Result On
Screening Of
Pharmaceuticals In Hospital
Sungai Buloh Wastewater
Treatment Plant
AN-EV 7
Jarinya Sittiwong, Fuangfa
Unob
Detection of creatinine in
urine samples by gold
nanoparticles
AN-EV 8
Kanet Wongravee, Tewalak
Parnklang, Yukihiro Ozaki,
Chuchaat Thammacharoen,
Sanong Ekgasit
Chemometric Analysis of
Spectroscopic Data on
Shape Evolution of Silver
Nanoparticles Induced by
Hydrogen Peroxide
AN-EV 9
H.H. Mohammad, Khalisanni
Khalid, Kheng Soo Tay,
Sharifuddin Md. Zain, Rashid
Atta Khan
The Influence of Triton-X on
the Evaporation Rate of
Methanol- An analysis using
Reversed-Flow Gas
Chromatography (RF-GC)
Methodologies
AN-EV 10
Ramakrishna Mallampati, Ong
Pin Jin, Suresh Valiyaveettil
Efficient removal of
engineered nanoparticles
from water using renewable
resources
AN-EV11

Abstract -Poster
Page32
UM
Undergraduate
poster
Final Year
Project
and
Internship
Mak Oi Wei, Maheswari D/O
Paliyanny
Multi-residue Analysis of β-
Agonists in Tissues by LC-
MS/MS
UP 1
Ong Pei Pei and Dr. Ng Mei
Han
Extraction Of Phytonutrients
From Crude Palm Oil And
Red Palm Oil Using Ionic
Liquid
UP 2
Su-Han Ng and Toh-Seok
Kam
Alkaloids from Alstonia sp. UP 3
Sim-Yee Cha, Bonnie Yen-
Ping Tay, and Pei-Meng Woi
Analysis of Compound P, A
By-Product of Palm-Based
Ester
Using HPLC-MWD
UP 4

Abstract -Poster
Page33
A meso-substituted β-dialdiminate-bis(phenolate) ligand in Mn
III
, Co
III ,
Co
II
, Ni
II
and Cu
II
complexes
Fadhil Lafta Faraj*, Hapipah Mohd Ali, Hamid Khaledi and Noraini Ahmad
Department of Chemistry, Faculty of Science, University of Malaya,
Kuala Lumpur 50603, Malaysia
E-mail: fadhil_960@yahoo.com
Abstract
Copper, nickel, manganese and cobalt complexes have been synthesized from a new ligand
derived from condensation reaction of 2-aminophenol and 2-(3,3-dimethylindolin-2-ylidene)
malonaldehyde. The structures of ligand and complexes were characterized by FT-IR, UV–
Vis, TGA,
1
H and
13
C-NMR spectroscopy and magnetic susceptibility measurements,
elemental analysis and X-ray crystallographic analysis.
Keywords: 2-(3,3-dimethylindolin-2-ylidene) malonaldehyde, 2-aminophenol, complexes
INORG 1

Abstract -Poster
Page34
Di- and trinuclear metal complexes derived from pyrazolylindolenine
Nurul Azimah Ikmal Hisham*, Hamid Khaledi, and Hapipah Mohd Ali.
1
Department of Chemistry University of Malaya, 50603 Kuala Lumpur,Malaysia
*Email: nurulaziemahikmal@gmail.com
Abstract
Reactions of the 2,3,3-trimethylindolenine with Vilsmeier reagent (DMF/POCl3) produced
aminomethylene-malonaldehyde which reacted with hydrazine to obtain the corresponding
pyrazolylindolenine. The heterocycle was used in the synthesis of a series of di- and
trinuclear metal complexes. The structures were characterized by single crystal X-ray
diffraction and magnetic susceptibility.
Keywords: Dinuclear, Trinuclear, Metal complexes, Pyrazolylindolenine
Suggested Reading :
1. R. M. Aghdam, M. M. Baradarani & A. Afghan, Curr. Chem. Lett. 2 (2013) 13.
2. J.E. Cosgriff, G.B. Deacon, Angew. Chem., Int. Ed. 37 (1998) 286.
3. O. Kahn, Molecular Magnetism, Wiley-VCH, Weinheim, 1993.
INORG 2

Abstract -Poster
Page35
Reduction of carbon-carbon double bonds of Chalcone using phenylsulfonyl
hydrazide
Ainnul Hamidah Syahadah Azizan*, Nurfarhanim Abu Bakar, Teh Kai Ni, Gwaram Nura
Suleiman, Hapipah Mohd Ali and Hamid Khaledi
Department of chemistry, Faculty of Science, University of Malaya.
*Email: nura_suleiman@yahoo.com
Abstract
The reactions of substituted chalcones with phenylsulfonyl hydrazide in ethanol resulted in
the reduction of the carbon-carbon double bond of the chalcones. While in the presence of
sodium acetate, the reactions gave the corresponding ketones as the sole product, in acidic
conditions, along with the ketones, sulfones were generated. The reactions were also carried
out in solvent-free conditions were the ketones were obtained as the sole-products. The
products were all characterized by IR and NMR spectroscopy and also X-ray crystallographic
analysis.
Keywords: Chalcones, Phenylsulfonyl hydrazide, carbon-carbon reduction
Suggested Reading:
1. Smit C., Fraaije M.W. and Minnaard A. J. (2008). Reduction of Carbon−Carbon Double Bonds Using
Organocatalytically Generated Diimide, J. Org. Chem., 73, 9482–9485
2. Li, J.P.; Zhang, Y.X.; Ji, Y. (2008). Selective 1,4-reduction of chalcones with Zn/NH4Cl/C2H5OH/ H2O. J.
Chin. Chem. Soc., 55, 390–393.
INORG 3

Abstract -Poster
Page36
Synthesis and characterization of nickel (II) complex bearing a Schiff base
with a testosterone moiety and its biological properties
Mok Piew Heng1,2
, Kong Wai Tan2
, Seik Weng Ng2
, Yoke Kqueen Cheah1
, Sabrina Sukardi1
1
Department of Biomedical Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
2
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Email: mokpiew@gmail.com
Abstract
A Schiff base ligand L was prepared by refluxing equimolar amount of testosterone and
thiosemicarbazide in boiling ethanol with continuous stirring for 6 hours. Crystal of L was
obtained from slow evaporation ethanol at room temperature. Its nickel (II) complex 1 were
synthesized and precipitated upon addition of nickel acetate into ethanolic solution of L.
Complex 1 was recrystallized from mixture of DMF:methanol (3:8).
These compounds sythesized were characterized by using FTIR, CHN, 1
H-NMR, and X-ray
crystallography. These spectroscopic methods confirmed the formation of L from
condensation of testosterone and thiosemicarbazide. Besides, X-ray study also proved that
complex 1 is in a slightly distorted square planar environment. L acts as a bidentate OS-donor
ligand, whereby a mononuclear complex 1 is coordinated to 2 L via 2 imine nitrogens and 2
tautomeric thiol sulfurs.
The inhibitory effects of L and 1 on E. coli topoisomerase I were evaluated by agarose gel
electrophoresis. However, both compounds failed to inhibit topoisomerase I even at high
compound concentration (500 µM). The DNA binding ability of these compounds were
determined by UV-vis spectroscopy and the intrinsic binding constants (Kb) for the interaction
of the compounds with calf thymus DNA were determined by employing Wolfe-Shimmer
equation. Complexation with nickel dramatically increased the binding ability.
Keywords: Testosterone, Thiosemicarbazide, Nickel, Schiff base, DNA binding
INORG 4

Abstract -Poster
Page37
Ionic Liquid as the morphology template for polyaniline/ nano-hematite
composite
Farhatun Najat Maluin*, Sharifah Mohamad, Ninie S. A. Manan
Department of Chemistry, University Malaya, 50603 Kuala Lumpur.
*Email: farha.naj@siswa.um.edu.my
Abstract
The synthesis and morphology of polyaniline/hematite(α-Fe2O3) was explored using an
imidazolidium base ionic liquids (ILs). A series of ILs with different length of alkyl chain
with several types of anions (Cl, BF4, PF6 and NTf2) have been tested. A direct chemical
synthesis of polyaniline-ferric oxide was prepared via interface polymerization. This
polymerization occurs between the layer of ionic liquid and immiscible solvent. The reactions
were simple and fast as the green thin layer of polyaniline in the interface can be observed
immediately. The composite were subjected to the structural characterization by Infrared
spectroscopy (FT-IR), X-ray Diffraction (XRD) and UV spectroscopy. The FT-IR result
confirmed the formation of polyaniline in the composite while the XRD result confirmed the
presence of hematite in the composite. The morphology of the nanocomposites was confirmed
with Field Emission Scanning Microscopy (FESEM) and Transmission Electron Microscopy
(TEM). The size, shape and distribution of nanoparticle of hematite loading in nanocomposite
of polyaniline-ferric oxide were determined. In addition, the magnetic susceptibility of
polyaniline/nano-hematite composite has been investigated by using Guoy balance
magnetometer.
Keywords: Ionic Liquid, Polyaniline, nano-hematite
INORG 5

Abstract -Poster
Page38
Synthesis and Characterization of Fe3O4 Nanoparticles Coated
with β-CD-IL
Subathra Sinniah*, Sharifah Mohamad, Ninie S.A. Manan
Department of Chemistry, Faculty of Sciences,
University Malaya, 50603 Kuala Lumpur, Malaysia
*Email: suba_28@yahoo.com
Abstract
Beta Cyclodextrin-Ionic liquid (β-CD-IL) coated with iron oxide nanoparticles (FeNPs) were
synthesized by chemical co-precipitation method. The structure and morphology of prepared
complex was characterized using X Ray Diffaction (XRD), Tramission Electron Microscope
(TEM), Fourier Transform Infrared Spectroscopy (FT-IR), Thermal Gravimetric Analysis
(TGA) and Field Emission Scanning Electron Microscopy (FESEM). The results of analysis
confirmed the proposed complex as the product. The FESEM showed β-CD-IL-FeNPs have
mean diameter (between 10 to 30nm).
Keywords: Beta Cyclodextrin, Ionic liquid, Fe3O4 Nanoparticles
INORG 6

Abstract -Poster
Page39
Single-molecule magnet and magnetic coordination polymers with
mesogenic properties
Norbani Abdullah and Noha Said A. Bedowr*
Chemistry Department, University of Malaya, 50603 Kuala Lumpur, Malaysia
*Email: e.m.t.p1432@gmail.com
Abstract
Single molecule magnets and magnetic coordination polymers are examples of advanced low-
dimensional materials, especially for spintronic applications. They may be constructed from
copper(II) ion and ditopic ligands, such as 2,2’-bipyridine and 4,4’-bipyridine. This paper
reports the synthesis and characterization of a single molecule magnet,
[Cu2(ɳ2
-(OOCR)2(ɳ1
-(OOCR)2(2,2'-bpy)].H2O (1), and a coordination polymer,
{[Cu2(ɳ2
-(OOCR)2(ɳ1
-(OOCR)2(2,2'-bpy)(4,4'-bpy)].H2O}n (2), where R = CH3(CH2)14.
These complexes were characterized by elemental analyses, FTIR and UV-vis spectroscopies,
magnetic susceptibility, differential scanning calorimetry (DSC) and optical polarized
microscopy (OPM). Both complexes showed weak antiferromagnetic interactions between the
square pyramidal Cu(II) centres, and exhibit mesomorphisms.
Keywords: Cu(II), Single molecule magnet, Coordination polymer, Magnetic,
Mesomorphism
INORG 7

Abstract -Poster
Page40
Spectroscopic and X-ray crystallographic studies on Pd+2
and
Pt+2
complexes of flexidentate Schiff base ligand derived from indole-7-
thiosemicarbazone and their anticancer activity
Abeer Abduljaleel Ibrahim*
, Hapipah Mohd Ali, Hamid Khaledi
Chemistry Department, Faculty of science, University of Malaya,
50603 Kuala Lumpur, Malaysia
*Email : marwa2002@siswa.um.edu.my
Abstract
A new indolyl-imine ligand was synthesized by the condensation reaction of indole-7-
carbaldehyde with thiosemicabazide . This ligand was reacted with Pd+2
and Pt+2
. The
chemical structures and purities of the complexes were evaluated by 1
HNMR and X-ray
crystalloghraphy. In the palladium complex, the Schiff base molecule acts as a tridantate-
N,N,S ligand to chelate the metal center via its indole and azomethine nitrogens and thiolate
sulfur atoms to afford a complex of the type 2:1 (ligand/metal ratio) in square planner
coordination geometry. Also,the Schiff base coordinates Pt+2
ion as a tridentate ligand via
N,N,S atoms to form a complex of the type 1:1(ligand/metal) in square planner geometry.
Anticancer activity of the ligand and its complexes are investigated in vitro assay.
Suggested Pathway:
Keywords: Thiosemicarbazone, Platinum complex, Palladium complex, Crystal structure,
Anticancer assay
INORG 8

Abstract -Poster
Page41
Synthesis, Structural Characterization And Biological Properties Of
Copper Complexes With Ligands Containing Phosphonium Substituents
Shin Thung Chew*, Kong Mun Lo and Kong Wai Tan
Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur,
Malaysia
* E-mail: shinthung@live.com.my
Abstract
The interaction between anticancer drugs and nucleic acids has attracted much attention in
molecular pharmacology, pharmaceutical chemistry and biological chemistry. It is commonly
believed that DNA is one of the main target of many antitumor agents. In this connection, a
series of copper complexes containing phosphonium substituted hydrazones was synthesized
and further reacted with diamine ligands. All the compounds were characterized by elemental
analysis and spectroscopic methods (FT-IR, NMR and UV-Vis) and in the case of crystalline
products by X-ray crystallography. In addition, the DNA binding and nucleolytic properties
of these Schiff base complexes were evaluated by using spectroscopic methods and gel
electrophoresis. The topoisomerase I inhibition was also carried out in an attempt to
investigate the ability of complexes to inhibit the topoisomerase I enzyme.
Keywords: Hydrazones, DNA binding, topoisomerase I inhibitor, copper complexes
INORG 9

Abstract -Poster
Page42
Zinc (II) Complex Bearing A Cationic Schiff Base With A Bromomethyl
Group: Synthesis, Spectroscopic Characterizations And Biological Study
On E.Coli Topoisomerase I Activity
Sze Koon Lee, Kong Wai Tan, Hoi Ling Seng
Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur,
Malaysia.
Email: Louiskoon@gmail.com
Abstract
A new cationic schiff base (STB) was synthesized by refluxing (3-Formyl-4-hydroxybenzyl)
triphenylphosphonium chloride with 2-bromoethylamine.HBr. The ligand treated with zinc
acetate salts in 1:1 molar ratios afforded the new metal complex, ZnSTB. Schiff base and its
zinc complex formation have been confirmed by using IR, NMR, CHN and x-ray diffraction
analysis. STB can be dissolved in most of the polar solvent, whereas ZnSTB only dissolve in
DMF and DMSO. X-ray diffraction study shows that ZnSTB is four coordinated and the
coordination geometry around zinc (II) is tetrahedral. Two bromine atoms are attached to the
central zinc in cis-position and the singly deprotonated STB acts as an ON-donor ligand. The
inhibition effect of STB and ZnSTB on E.coli topoisomerase I have been evaluated by gel
electrophoresis. Results show that the inhibitory effect of STB is further enhanced upon
complexation with zinc.
Figure 1: Structure of STB
INORG 10

Abstract -Poster
Page43
Figure 2: Structure of ZnSTB
Figure 3: Effect of various concentrations of STB on the inhibition of E.coli topoisomerase I
activity
Figure 4: Effect of various concentrations of ZnSTB on the inhibition of E.coli
topoisomerase I activity
Keywords: Zinc, cationic, schiff base, triphenylphosphine, topoisomerase

Abstract -Poster
Page44
Synthesis and Characterization of Nickel complexes - New Insights into the
Structure and Bonding of Thiourea Diamine Derivatives
Hana Bashir Shawish*, Mohd Jamil Maah
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
* Email: shawishhana@yahoo.com
Abstract
Three series of nickel(II) complexes with thiourea ligands have been synthesized. Complexes
of the formula [Ni(RNHCSNHRR̀ )2] and [Ni2(RNHCSNHRR̀ )2(NN)2]X where R= phenyl,
R̀ = o-phenylamine, p-phenylamine and o-aminopyridine, NN= N,N bidentate ligand, X= NO3
-
; Cl-
, have been characterized by elemental analysis, UV-Vis, IR, NMR spectroscopic studies
as well as single crystal X-ray diffraction. Thiourea diamine ligands have been coordinated to
nickel(II) and the differing binding modes of the ligands in the absence and presence of co-
ligands have been investigated. The crystal structures of the complexes show that the reaction
of thiourea ligands with nickel(II) salts yields mononuclear diamagnetic complexes with
thiourea ligand coordinates as bidentate NS donors, while the reaction of nickel salts with the
thiourea ligands in the presence of 1,10-phenanthroline or 2,2-bipyridine affords binuclear
paramagnetic complexes with the thiourea ligands coordinate as tridentate NNS donors. The
ligands and their nickel complexes were subjected to test their DNA topoisomerase I
inhibition efficiency.
Keywords: Nickel(II) complexes, Thiourea, Diamine Derivatives, Binuclear complexes,
DNA Topoisomerase I
INORG 11

Abstract -Poster
Page45
A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2
carcinoma, cell cycle arrest and inhibits cell invasion through modulation of
the NF-κB activation pathway
Ishak, D. H. A.1
, Ooi, K. K.2
, Ang, K. P.2
, Akim, A. M.2*
, Cheah, Y. K.2
, Nordin, N.3
, Halim,
S. N. A.1
, Seng, H. L.1
& Tiekink, E. R. T.1**
1
Department of Chemistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.
2
Department of Biomedical Science, Faculty of Medicine and Health Sciences, University
Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
3
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences,
University Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
*Email: abdah@upm.edu.my
**Email: Edward.Tiekink@um.edu.my
Abstract
The compound with R = CH2CH3 in Bi(S2CNR2)3 (1) is highly cytotoxic against a range of
human carcinoma, whereas that with R = CH2CH2OH (2) is considerably less so. Both 1 and
2 induce apoptosis in HepG2 cells with some evidence for necrosis induced by 2. Based on
DNA fragmentation, caspase activities and human apoptosis PCR-array analysis, both the
extrinsic and intrinsic pathways of apoptosis have been shown to occur. While both
compounds activate mitochondrial and FAS apoptotic pathways, compound 1 was also found
to induce another death receptor-dependent pathway by induction of CD40, CD40L and TNF-
R1 (p55). Further, 1 highly expressed DAPK1, a tumour suppressor, with concomitant down-
regulation of XIAP and NF-κB. Cell cycle arrest at the S and G2/M phases correlates with the
inhibition of the growth of HepG2 cells. The cell invasion rate of 2 is 10-fold higher than that
of 1, a finding correlated with the down-regulation of survivin and XIAP expression by 1.
Compounds 1 and 2 interact with DNA through different binding motifs with 1 interacting
with AT- or TA-specific sites followed by inhibition of restriction enzyme digestion; 2 did not
interfere with any of the studied restriction enzymes.
Keywords: Bismuth, Apoptosis, Metallopharmaceuticals, Cell cycle, NF-κB
INORG 12

Abstract -Poster
Page46
Organometallic Chemistry
Kit May Chow* and Kong Mun Lo
University Malaya, Faculty of Science, Department of Chemistry,
Kuala Lumpur, 50603, Malaysia.
*Email: kitmaychow@siswa.um.edu.my
Abstract
Organotin(IV) complexes have received considerable attention because of their biological
properties, particularly antitumor, antibacterial and antifungal activity. An important class of
organotin(IV) complexes with potential biological activities are those derived from ligands
containing nitrogen and oxygen donor atoms. The easily accessibility and structural features
made them the target of numerous biological and catalytic studies. New diorganotin(IV) and
monoorganotin(IV) complexes have been synthesized from the reaction of the corresponding
diorganotin(IV) dichloride or diorganotin(IV) dibromide with tridentate ligands such as (E)-
4-chloro-N’-(2-hydroxy-4-methoxybenzylidene)benzohydrazide and (E)-4-chloro-N’-(3,5-
dichloro-2-hydroxybenzylidene)benzohydrazide in methanol. All the complexes were
characterized by elemental analysis, IR and NMR (1
H and 13
C) spectroscopic studies, and
their molecular structures have been confirmed by single crystal X-ray diffraction analysis.
Keywords: Organotin Compounds (OTCs), Mononuclear organotin(IV) complexes, Crystal
structure
INORG 13

Abstract -Poster
Page47
A High-Valent Iron Imido Corrolazine: Generation and Evidence of NR
Group Transfer
Pannee Leeladee1,3
, Guy N. L. Jameson2
, Maxime Siegler1
and David Goldberg1,
*
1
Department of Chemistry, The Johns Hopkins University, Baltimore, 21218, USA
2
Department of Chemistry and MacDiarmid Institute for Advanced Materials and
Nanotechnology, University of Otago, Dunedin 9054, New Zealand
Present Address: 3
Department of Chemistry, Faculty of Science, Chulalongkorn University,
Bangkok 10330, Thailand
*Email: pannee.l@chula.ac.th
Abstract
Iron-nitrogen multiply bonded compounds have been postulated as key intermediates in
biological transformation (e.g. dinitrogen reduction in nitrogenase) and industrial processes
(e.g. Haber-Bosch process). However, synthesis and characterization of such species remains
challenging. Herein, generation of a new high-valent Fe-imido corrolazine complex is
reported. Reaction of FeIII
(TBP8Cz) (TBP8Cz = octakis(4-tert-butylphenyl)corrolazinato) and
commercially available chloramine-T afforded a new species assigned as
[FeIV
(TBP8Cz+•
)(NTs)] (Ts = 4-toluenesulfonyl) at room temperature. This new compound
was characterized by UV-vis, EPR (X-band (15 K), g = 2.10, 2.00) and Mössbauer ( = -0.05
mm s-1
, EQ = -2.95 mm s-1
) spectroscopies. [FeIV
(TBP8Cz+•
)(NTs)] was shown to perform
stoichiometric and catalytic NTs transfer to triphenylphosphine (PPh3) giving the phospharane
product, Ph3P=NTs, monitored by 31
P-NMR. Kinetic data were also consistent with the
proposed NTs transfer mechanism. The reaction mixture of FeIII
(TBP8Cz) + chloramine-T +
PPh3 gave two new Fe corrolazine compounds i.e. [FeIV
(TBP8Cz)(NPPh3)] and
[FeIII
(TBP8Cz)(OPPh3)], which were determined by X-ray crystallography. Full
characterization of the [FeIII
(TBP8Cz)(OPPh3)] structure was obtained by independently
preparing the compound from FeIII
(TBP8Cz) and OPPh3. This pure [FeIII
(TBP8Cz)(OPPh3)]
offers a benchmark for spectroscopic study on FeIII
corrolazine in a structurally defined
compound.
INORG 14

Abstract -Poster
Page48
Isolation And Characterisation Of Novel Organometallic Derivatives Of
Multidentate Phosphine Bis[(o-methylthio)phenyl]phenylphosphine
and Tris[(o-methylthio)phenyl]phosphine
Richard C.S. Wong* and Mei Lee Ooi
*E-mail: richard@um.edu.my
Abstract
Multidentate phosphine ligands containing thiolaryl groups have been in the limelight in
recent years because of its lability towards soft metal complexes via its σ-donor and π-
acceptor properties. Phosphine complexes are common in a variety of catalytic reactions, and
the ability to control cis/trans isomerism via attractive interactions opens up possibilities for
controlling the mechanisms of homogeneous catalytic reactions.
In this work, we report the reactivity of bis(o-methylthiophenyl)phenylphosphine and tris(o-
methylthiophenyl)phenylphosphine, acting as bidentate, tridentate and tetradentate ligands,
respectively. Herein, we reported the syntheses and isolation of 8 novel complexes which
were fully characterized by 1
H, 13
C and 31
P NMR, I.R. spectroscopy and single crystal X-ray
crystallography.
Keywords: multidentate, thioaryl, lability, synthesis, isolation.
INORG 15

Abstract -Poster
Page49
Study of cytotoxic effects of green synthesized silver nanoparticles with
different capping agents on tumor cells
Wang Chunyan and Suresh Valiyaveettil*
Department of Chemistry, Faculty of Science, 3 Science Drive 3,
National University of Singapore, Singapore 117543
Abstract
Metal nanoparticles (NPs) have been found in a wide range of commercially available
consumer products ranging from cosmetics to household detergents. This is especially true for
silver (Ag) NPs, which showed antimicrobial effects. Recently, various green approaches have
been used for preparing Ag NPs, as they may reduce or eliminate the toxic effects towards the
environment and ultimately to human being. In our study, we explore preparation of Ag NPs
using ginger, coffee and mint extracts at room temperature. The as-synthesized nanostructures
were characterized using transmission electron microscopy and UV spectroscopy. The toxicity
of Ag NPs with respective capping agents was studied using human cervical cancer cells
(HeLa) and hepatocellular carcinoma cells (HepG2). Furthermore, the level of toxicity was
evaluated using changes in cell morphology, cell viability and oxidative stress. Toxicity of Ag
NPs is dependent on both concentration and chemical nature of capping agents. Ag-mint NPs
induced significant toxicity as competed to the other three NPs, with a viability of only 30%
at a concentration of 25 µg/ml. The poster will discuss the synthesis, characterization and
toxicity studies of AgNPs in detail.
Acknowledgement: The authors acknowledge the support from Department of Chemistry,
National University of Singapore for funding and technical support. WC thanks the National
University for a graduate scholarship.
INORG 16

Abstract -Poster
Page50
Supramolecular metathesis: cation exchange in salts derived from the sulfa-
drug, sulfathiazole
Aina Mardia Akhmad Aznan,a
A. P. Safwan,a
Zanariah Abdullah,a
Trupta Kaulgud,b
Hadi D.
Arman,b
Matthew Mahindaratne,b
Laurie E. McNeil,c
and Edward R. T. Tiekink*a
a
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
b Department of Chemistry, The University of Texas at San Antonio, San Antonio,
Texas 78249-0698, USA
c Department of Physics and Astronomy, University of North Carolina at Chapel Hill,
Chapel Hill, North Carolina 27599-3255, USA
*E-mail: Edward.Tiekink@gmail.com; Fax: +60 3 79674204; Tel: +60 3 7967 6775
Abstract
Co-crystallisation of equimolar quantities of sulfathiazole (STL) with each of 1,4-
diazabicyclo[2.2.2]octane (DABCO) and piperazine (PIP) lead to the facile formation of salts
[DABCOH][STL_H] (1) and [PIPH][STL_H] (2), respectively. Crystallography shows the
formation of aniline-N–H...O(sulfonyl) hydrogen bonds between anions to form undulating
and zig-zag layers, respectively, with the cations being connected to these by charge-assisted
N–H...N(thioazole) interactions. The salts were also investigated by 1
H NMR, IR and Raman
spectroscopies as well as by DSC. Solid-state grinding competition experiments were
monitored by PXRD. When 2 was ground with an equimolar amount of DABCO,
substitution of the PIPH+
cation by DABCOH+
was proven, i.e. supramolecular metathesis
had occurred, an observation correlated with the more efficient crystal packing observed in 1
cf. 2.
INORG 17

Abstract -Poster
Page51
Dyes From Natural Resources
Nur Atiqah Mohd Nasuha* and Yeun-Mun Choo
Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia
*Email: atiqah_nasuha@siswa.um.edu.my
Abstract
Roots of Morinda citrifolia (Mengkudu, Engkudu, or Noni) have been used traditionally by
Iban community from Sarawak, Malaysia as a natural dye to produce yellow-orange shades.
M. citrifolia is known to have a broad range of therapeutic effects due to its antioxidant
activities. These include antiviral, antibacterial, anticancer activities as well as analgesics
effects. In the present study, the chemical components were separated using various
chromatographic methods. The structures were established by spectroscopic methods,
particularly 2D NMR and MS.
Keywords: Morinda citrifolia; Anthraquinones; Antioxidants
ORG 1

Abstract -Poster
Page52
Volatile Components of Fresh Jasminum sambac Buds and the Potential
Antioxidant Activities of its Methanolic Extract
Katrina Mohamad Khidzir, *Sit Foon Cheng and Cheng Hock Chuah.
Unit of Research on Lipids, Department of Chemistry, Faculty of Science, University of
Malaya,50603, Kuala Lumpur, Malaysia.
* E-mail: sfcheng@um.edu.my
Abstract
We report on the volatile components of the methanolic extract from the fresh buds of
Jasminum sambac which is categorized under the olive family, Oleaceae. A headspace solid -
phase micro extraction (HS-SPME) method was utilized for profiling the volatile compounds
released from fresh buds of Jasminum sambac. A 100 µm polydimethylsiloxane fibre was
used to absorb and desorb the volatile compounds from the equilibrium headspace generated
by the fresh buds. A gas chromatography-mass spectrometry coupled with the HS-SPME was
employed for the confirmation of identity and quantification of volatiles extracted. Volatile
components found include farnesene, linalool, cadiene and muurolene. The antioxidant
properties of the methanolic extract at different concentrations (50, 100, 250, 500 and 1000
ppm) were then examined by estimating the capability to scavenge DPPH free radicals. It was
interestingly found that the methanolic extract has an IC50 value of 208.33 µg/mL compared
to Butylated hydroxytoluene (BHT) which is 13.67 µg/mL.
Keywords: Jasminum sambac, buds, solid phase micro extraction, antioxidant
ORG 2

Abstract -Poster
Page53
Antioxidant Potential of Tannin-rich
n-Butanol Extract from Elaeis guineensis Leaf
Chun Hui Ang1
, *Sit Foon Cheng1
, Chavasiri Warinthorn2
and Cheng Hock Chuah1
1
Unit of Research on Lipids, Department of Chemistry, Faculty of Science, University of
Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia
2
Natural Products Research Unit, Department of Chemistry, Faculty of Science,
Chulalongkorn University, Bangkok 10330, Thailand
*Email: sfcheng@um.edu.my
Abstract
Aqueous fraction partitioned from methanolic extract of fresh Elaeis guineensis leaf
was found to exhibit antioxidant activity in various in-vitro bioactivity evaluation
assays including DPPH radical-scavenging activity assay, lipid peroxidation (LPO)
inhibition assay and beta-carotene bleaching assay, as compared to butylated
hydroxytoluene (BHT) as standard. This active aqueous fraction was subjected to
further fractionation to gain n-butanol tannin-rich sticky solid, then purified
chromatographically by Sephadex LH-20 and RP C-18 silica gel columns.
Phytochemical screening on these purified fractions suggested that Elaeis guineensis
leaf has great potential to be used as natural antioxidant and worthy of further
investigations.
Keywords: Elaeis guineensis, antioxidant, tannins, n-butanol
ORG 3

Abstract -Poster
Page54
Synthesis of Palm Oil-Based Polyester Polyols
Wei Seng Ng1
, *
Sit Foon Cheng1
, Choy Sin Lee2
and Cheng Hock Chuah1
1
Unit of Research on Lipids (URL), Department of Chemistry, Faculty of Science, University
of Malaya, 50603 Kuala Lumpur, Malaysia.
2
Department of Pharmaceutical Chemistry, School of Pharmacy and Health Sciences,
International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
Abstract
Palm oil-based polyester polyols were prepared from palm oil-based glycerol monostearate
(GMS) and glutaric acid in a solvent free and non-catalyzed condition. The effect of
temperature and effect of ratio of functionality (OH:COOH) were studied. This reaction
involved esterification reaction with evolving water. Deacidification of GMS was carried out
before proceeding to synthesis of polyester polyol. The acid value and hydroxyl value of
polyester polyol were measured according to AOCS Official Method Te 2a-64 and AOCS
Official Method Cd 13-60 (1993) respectively. From the study of the effect of
temperature, the acid value decreased from 163.67 to 28.38 mg NaOH/g sample at the
temperature of 190℃. Further decrement of acid value to 24.19 mg NaOH/g sample was
recorded at the temperature of 200℃. Hydroxyl values of polyester polyols were
measured in the range of 82 to 225 mg KOH/g sample. The polyester polyol were also
characterized with 1
H & 13
C NMR, FTIR, GPC, LCMS and HPLC. Polyester polyol
exhibited the characteristic peaks at about 3550 and 1732 cm-1
which attributed to -OH & -
C=O stretching of ester group, respectively, confirming the formation of polyester polyols.
The molecular weights of polyester polyols were recorded in the range of 560 to 34039
Dalton.
Keywords: dicarboxylic acid; palm oil-based monoglyceride; polyester polyol
Suggested Reading:
1. Lee, C. S., Lee, S. C. (2011). Preparation of polyester polyol from epoxidized palm olein. Chinese Journal
of Chemistry, 29(4), 840-846.
2. Abdel Hakim, A. A., Mosa Nassar, Aisha Emam, Maha Sultan. (2011). Preparation and
characterization of rigid polyurethane foam prepared from sugar-cane bagasse polyol. Materials Chemistry
and Physics, 129, 301-307.
3. Lin, S., Zhou, J.,Chen, J. (2009). Microwave synthesis of polyester polyol used for polyurethane soles.
Faming Zhuanli Shenqing, CN 101538358 A 20090923.
ORG 4

Abstract -Poster
Page55
Long Chain Saturated Structured Lipids via
Enzymatic Interesterification using Lipase Rhizomucor miehei (Lipozyme
RM IM)
Wai-Ming Kok, *Sit-Foon Cheng. and Cheng-Hock Chuah.
Unit of Research on Lipids (URL), Department of Chemistry, Faculty of Science, University
of Malaya.
Abstract
There were several reports relating positional fatty acid distributions and fatty acids
composition of triacyglycerols with obesity. Unsaturated fatty acid at sn-2 position is
absorbed through intestinal mucosa in the form of monoacyglycerol, while the free saturated
fatty acids from sn-1 and sn-3 positions are hardly absorbed and easily excreted. That is
especially evidenced for long and saturated fatty acids. In the present study, structured lipids
of long and saturated fatty acids were synthesized. High oleic sunflower oil (HOS) and
behenic acid ethyl ester were interesterified using sn-1,3-specific lipase (10 m/m% of total
substrates), Rhizomucor miehei (Lipozyme RM IM), at 65°C for 2 hours. The synthesized
structured lipids were characterized and quantified using 13
C NMR as containing 65.1 mol%
of SFA, 28.7 mol% of MUFA, 6.2 mol% of PUFA at sn-1,3 positions and 81.8% of MUFA,
18.2% of PUFA at sn-2 position. Overall, there were 42.9 mol% of SFA, 46.8 mol% of
MUFA and 10.2 mol% of PUFA at sn-1,2,3 positions.
Keywords: Enzymatic interseterification, lipase, triacyglycerols, qCNMR.
ORG 5

Abstract -Poster
Page56
Alkaloid from Alstonia rostrata
Lim Jun Lee1,
*, Gan Chew Yan2
, Low Yun Yee1
, Lim Siew Huah1
and Kam Toh Seok1
1
Department of Chemistry, Faculty of Science, University Malaya,
50603 Kuala Lumpur, Malaysia.
2
University Malaysia of Computer Science & Engineering, Ground Floor, Menara Z10, No.2,
Jalan Alamanda 2, Presint 1, 62000 Putrajaya, Wilayah Persekutuan, Malaysia.
*Email: junlee1988@um.edu.my
Abstract
A total of 20 alkaloids were isolated and characterized from the bark extract of Malayan
Alstonia Rostrata (Apocynaceae), including six leuconolam-rhazinilam alkaloids, four
strychnan alkaloids, two vallesiachotaman alkaloids, a corynanthean alkaloid, an
asipidospermatan alkaloid, an uleine alkaloid, a vallesamine alkaloid, an akuammiline
alkaloid, two skythantine alkaloids and a 2,7-napthiridine alkaloid. The structures were
determined using NMR and MS analysis.
Keywords: Alstonia Rostrata; Apocynaceae; Alkaloids
ORG 6

Abstract -Poster
Page57
Pyridine-Based Molecular Pincer for Transition Metal Complexation
Rojrit Rojanathanes*1
, Kobkun Saepang2
, Supakit Seawpakorn2
, Patchanita Thamyongkit1
,
and Wittawat Keawsongsang1
1
Department of Chemistry, Faculty of Science, Chulalongkorn University
2
Program in Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn
University
*Email: rojrit@hotmail.com
Abstract
Two novel molecular pincers was successfully synthesized from chelidamic acid. Both
molecular pincers contains 5 nitrogen atoms forming two different pocket sizes. The
nitrogen-rich cavities are designed for complexation with some transition metal ions.
Carboxylic group was introduced onto the 4- position of the central pyridine core as a linker
for further application in solar cell technology. The carboxylic group was successfully
fabricated by two different methods, chromate oxidation and copper-free Sonogashira
coupling.
Keywords: pincer, chelidamic, picolinic, complexation
ORG 7

Abstract -Poster
Page58
Aza Diels-Alder Rection of Cyclic Imine with Danishefsky’s Diene
Shah Bakhtiar Nasir and Noorsaadah Abd Rahman
Department of Chemistry, Faculty of Science, University of Malaya
*Email: shah_bakhtiar85@yahoo.com, noorsaadah@um.edu.my
Abstract
Danishefsky’s diene is a diene with a formal name trans-1-methoxy-3-trimethylsilyloxy-1,3-
butadiene. It has been known for its efficiency in Diels-Alder reactions. Calculation of the
energy for the reaction between cyclic imine derivatives and Danishefsky’s Diene were
carried out to determine the energy level and the selectivity for the Aza Diels-Alder reaction.
The calculation used density functional theory (DFT) basis set to discern the selectivity and
the transition state of the reactions. This information then will further use for the total
synthesis of Mitraphylline.
Keywords: Aza Diels-Alder, Danishefsky’s Diene, Density Functional Theory (DFT)
ORG 8

Abstract -Poster
Page59
Total Synthesis of (±)-Cyclollicinone
Chun Keng Thy, Chin Fei Chee and Noorsaadah Abd Rahman
E-mail: ckthy1984@yahoo.com
Abstract
Cycloillicinone and illicarborene A were isolated from the Illicium anisatum1 and Illicium
arborescens2. This compound belongs to the class of phytoquinoids which are known for their
antitumor and cytotoxic activities. In this presentation, the total synthesis of a racemic
cycloillicinone is described. The key step is Diels-Alder cycloaddition reaction between a β-
trans-ocimene and a racemic illicinone A. A chiral Corey-Bakshi-Shibata (CBS)
oxazaborolidine was used as catalyst in the reaction. The β-trans-ocimene is commercially
available and the racemic illicinone A was prepared in 4 steps from commercially available
sesamol via alkylation, Claisen rearrangement, prenylation and finally prenyl migration3. In
summary, the (±)-cyclollicinone was prepared in 5 steps with a total yield of 19.0%
ORG 9

Abstract -Poster
Page60
Keywords: cycloillicinone; illicarborene A; Diels-Alder cycloaddition reaction
References
1. Kubo, M., Shima, N., Harada, K., Hioki, H., & Fukuyama, Y. (2011). New prenylated C6-C3 compounds from
the twigs of Illicium anisatum. Chemical and Pharmaceutical Bulletin, 59, 898-901.
2. Liaw, C. C., Chen, Y. C., Fazary, A. E., Hsieh, J. L., Chen, S. Y., & Chien, C. T. (2013). A novel prenylated
C6-C3 compound with estrogen-like activity from the fruits of Illicium arborescens. Phytochemistry letters, 6,
397-402.
3. Lei, X., Dai, M., Hua, Z., & Danishefsky, S. J. (2008). Biomimetic total synthesis of tricycloillicinone and
mechanistic studies toward the rearrangement of prenyl phenyl ethers. Tetrahedron Letters, 49, 6383-6385.

Abstract -Poster
Page61
Total synthesis of (+)-Morusalbanol A and (+)-Sorocein B
Jia Ti Tee, Chin Fei Chee and Noorsaadah Abd Rahman
Chemistry Department, Faculty of Science, University of Malaya, 68100,
Kuala Lumpur, MALAYSIA.
*Email: jennytee12302um.edu.my
Abstract
Morusalbanol A and sorocein B are biologically active oxabicyclic compounds which appear to
originate from an intramolecular cyclisation /ketalisation of a cis-trans mulberry Diels-Alder
adduct (i.e. 1 & 2). Due to its sparse distribution of its natural plant source, there has been no
report on the synthesis of these compounds since its first isolation in 1991.
Our work involved the synthesis of Morulsalbanol A (1) and Sorocein (2). In this presentation,
we describe the synthesis of the key intermediates (3) and (4) leading to Morulsalbanol A (1) and
Sorocein (2), respectively through the Diels-Alder reaction (DA) (Scheme 1). To investigate the
effect of different substituents on the DA reaction, model studies have been carried out using
various chalcones containing hydroxy (OH), methoxy (OMe) and ethoxymethoxy (EOM) groups.
The presence of hydroxyl group at C2’ position was found to be essential for the intermolecular
cycloaddition reaction. However, the low yield of product was obtained when the hydroxyl group
at C2’ position was replaced with a methoxy group and no product observed for the one without
hydroxyl group at C2’ position.
Further efforts toward the total synthesis of morusalbanol A and Sorecein B are underway.
Keywords: Diels-Alder reaction, Morusalbanol A, Sorocein B
ORG 10

Abstract -Poster
Page62
Preparation and Fluorescence Behaviour Of Coumarin Terminated
Monolayer On Silver Particle
Nurul Izzatil Aisya Asri*, Issha Nadirah Ismail, Hairul Anuar Tajuddin, and Zanariah
Abdullah
Chemistry Department, Faculty of Science, University of Malaya,
*
Corresponding author: izzatilaisya@siswa.um.edu.my
Abstract
Coumarin and their derivatives are known fluorescent compounds potentially used for
chemical sensors and biosensors. In this work, self-assembled monolayer with coumarin
terminated was successfully prepared from chemisorptions of (1) onto silver particles. The
method was applied according to Brust et.al with minor modification. The adsorbate structure
(1) was purified and confirmed under 1
H NMR, 13
C NMR, FTIR and LCMS. The formation
of the monolayer was investigated using FTIR, UV-visible and Fluorescence Spectrometers.
The size of the particle suspension was determined at around 141.7 nm. The fluorescence of
the monolayer was similar to with the emission of adsorbate in Ethanol indicates that
monolayer of coumarin successfully formed on the silver surface.
O OO
S
O OO
S
(1)
Keywords: coumarin, self-assembled monolayer, fluorescence.
ORG 11

Abstract -Poster
Page63
Synthesis and Fluorescence Characterization Of
Azo-Coumarin And Azo-Naphthol
Mohd Helmi Hussaini Dullah, Zanariah Abdullah, Hairul Anuar Tajuddin
Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur
Email: helmihussaini@ymail.com
Abstract
Azo compounds are widely used as dyes and colorants. They are also used as laser dyes,
optical brighteners and fluorescent. In this work, azo-coumarin and azo-naphthol have been
synthesized by coupling of 7-hydroxycoumarin and 2-naphthol with diazonium salts
intermediate. The products were purified and confirmed by 1
H NMR, 13
C NMR, FTIR, UV-
visible absorption and elemental analysis. The presence of IR transmission at 1470-1508 cm-1
indicates the formation of -N=N- in both products. Their absorption and fluorescence
behavior were also characterized. Absorption occurred between 320-350 nm either in ethanol
or chloroform suggesting that the products are chromophores. Azo linkages was found as
reliable way to modify both naphthol and coumarin including their fluorescence character.
Keywords: azo-coumarin, azo-naphthol, diazotization, fluorescence
ORG 12

Abstract -Poster
Page64
Alkyl Disulfide as an Alternative Absorbate for Monolayer Formation on
Silver Particles
Issha Nadirah Ismail, Nurul Izzatil Aisya Asri, Hairul Anuar Tajuddin, and Zanariah
Abdullah.
Chemistry Department , Faculty of Science, University of Malaya,
Email: issha89@siswa.edu.my
Abstract
Two types of self-assembled monolayers on silver particles have been derived from alkyl
disulfides with methyl and hydroxyl terminals. Both alkyl disulfides were synthetically
prepared and purified before further analyzed using spectroscopic methods. Silver particles
were then prepared from reduction of silver nitrate using phase transfer method in the
presence of the alkyl disulfides. The products were purified either by solvent extraction or
filtration with copious amount of solvents. Alkyl disulfide with hydroxyl terminal produced
highly hydrophilic monolayer protected silver particles and the other absorbate with methyl
terminal produced highly hydrophobic monolayer. The similar method was repeated with
common alkyl thiols for background experiment. All samples were analyzed from FTIR and
UV-visible absorption. The presence of strong -CH2- band indicated the formation of organic
monolayers. Broad signal for alkyl disulfide with hydroxyl terminal was observed at around
3100 cm-1
, evident of hydroxyl terminated monolayer that consistent with our prediction and
the background experiment. The formation of silver particles was indicated from absorption
band above 400 nm. The results suggesting that disulfide group is also practical for anchoring
group for the formation of self-assembled monolayer on silver particles.
ORG 13

Abstract -Poster
Page65
Comparison studies of polyaniline nanocomposite with & without TiO2 for
hydrazine detection
Nirosa Raman*, Kavirajaa Pandian Sambasevam and Phang Sook Wai
Department of Chemistry, Faculty of Science, University of Malaya
*Email: pinkyphang@gmail.com
Abstract
This work presents the comparison of PANI and PANI/TiO2 nanocomposite chemical sensors
for hydrazine detection. The PANI and PANI/TiO2 films were prepared by chemical oxidative
polymerization of aniline by ammonium persulfate in the presence of dioctyl sulfosuccinate
sodium salt (AOT) as a dopant. The polymers were characterized by UV-Vis, FT-IR, FESEM
and conductivity study. Besides, the response of the chemical sensors in terms of conductivity
was measured at room temperature by using four point probe method. PANI and PANI/TiO2
sensor response for hydrazine detection was evaluated based on the wavelength shift of
conducting and non-conducting states of PANI upon exposure to hydrazine at different
concentrations. PANI/TiO2 exhibited better performance compared to PANI due to the
complementary behaviour of TiO2 nanoparticles. As conclusion, PANI/TiO2 nanocomposite
can be potentially applied for hydrazine detection.
Keywords: Polyaniline, TiO2, Hydrazine, Nanocomposite
Suggested Reading:
1. Yuzhen Li et. al., Applied Surface Science 273 (2013) 135-143.
2. E. Subramanian et. al., Indian Journal of Engineering & Material Sciences 19 (2012) 237-244.
3. M. Nagaraja et. al., Synthetic Metals 159 (2009) 718-722.
PHY 1

Abstract -Poster
Page66
Fatty Acid Nanoparticle For Topical and Oral Delivery Applications
Misni Misran*, Teo Yin Yin, Woo Juin Onn, Vicit Rizal Eh Suk, Yew Han Choi
Colloid and Surface Laboratory,
Department of Chemistry,
University of Malaya,
50603 Kuala Lumpur
Contact: +603-79676776/4079
Abstract
Fatty acid nanoparticle is nano-sized colloidal system that has extensively been investigated
for controlled drug delivery, cosmetic and pharmaceutical application. Fatty acid
nanoparticles are prepared using fatty acids which possesses negligible toxicity,
biocompatible and avoids the use of organic solvents in the preparation makes them as
promising delivery system. In this work, a cost effective fatty acid nanoparticles with a wide
range of particle size (from 50 nm to 500 nm) were developed for topical and oral
applications.
Figure 1: TEM micrograph (left) and confocal laser scanning micrograph (right) of fatty acid
nanoparticles
The TEM micrograph of fatty acid nanoparticles showed that they were spherical shape and
laser confocal laser scanning micrograph revealed that lipophilic dye was successfully
incorporated into the solid matrix of nanoparticles. Fatty acid nanoparticles with high
encapsulation efficiency had successfully been developed by modified its composition with
liquid fatty acid. High actives loaded fatty acid nanoparticles was then incorporated into base
cream to evaluate its in vitro release using Franz Diffusion Cell. Fatty acid nanoparticles
enriched cream demonstrated a controlled release for the period of 24 hours. Our finding
PHY 2

Abstract -Poster
Page67
suggests that the fatty acid nanoparticles prepared could be a promising delivery system for
the enhancement of the therapeutic efficacy in the topical and oral application.
Figure 2: Fatty acid nanoparticles prepared with different mean particle size
Keywords: Fatty acid, Nanoparticle, Topical delivery, Oral delivery
Patent Filled No.: PI2013002585

Abstract -Poster
Page68
Y-shaped Carbohydrate Surfactants by ‘Click Chemistry’ for Oil-in-Water
Emulsions
T. H. Ali, R. S. D. Hussen* and T. Heidelberg
Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur
*Email: r_syahila@um.edu.my
Abstract
A series of Y-shaped, sugar-based surfactants varying in the linkage between two hydrophilic
glucose units and a hydrophobic hydrocarbon chain were prepared by copper(I) assisted
azide-alkyne cycloaddition (CuAAC). The compounds were obtained in moderate overall
yields of 23-39% based on 6-7-step processes involving a chromatographic purification. The
chemical structures were confirmed by proton nuclear magnetic resonance spectroscopy, and
the physical-chemical properties, i.e. self-assembly, Kraftt and cloud temperatures, air-water
interface behaviour as well as oil-in-water emulsions, were studied. While one compound
displayed a cubic phase, all others exclusively formed micellar solutions. All Krafft
temperatures were below 10 °C and no clouding was observed up to 80 °C. The air-water
interface investigations revealed an influence of the linkage on the critical micelle
concentration (CMC). Besides, the linkage also affected the emulsion behaviour.
Keywords: Non-ionic surfactants, Carbohydrate surfactants, Y-shaped surfactants, Wedges
shaped surfactants, Click chemistry synthesis
PHY 3

Abstract -Poster
Page69
Preparation of microcapsules containing alkyd resin as core
Nurshafiza Shahabudin, Rosiyah Yahya and Seng Neon Gan
Chemistry Department, Science Faculty, University of Malaya, 50603 Kuala Lumpur,
Malaysia
*Email: shafizashah@siswa.um.edu.my
Abstract
This work reports the preparation of poly(urea-melamine-formaldehyde) (PUMF)
microcapsules with a core of palm oil-based alkyd resin and the PUMF as the shell.
Poly(vinyl alcohol) (PVA) and ethylene maleic anhydride (EMA) were used as a viscosity
modifier. The effect of various parameters on the microencapsulation of the PUMF-alkyd
microcapsules was studied, these include dispersed phase to continuous phase ratio, agitation
rate and surfactants concentration. The microcapsules obtained were inspected using digital
microscopy, optical microscopy (OM) and also scanning electron microscopy (SEM). The
alkyd core content and the PUMF shell materials was verified using Fourier transform
infrared (FTIR) and differential scanning calorimetry (DSC). Thermal analysis by TGA has
shown that the core and shell materials have different thermal stabilities. The resultant
microcapsules appear white-yellowish and free-flowing, and have a rough, porous shell which
was formed by PUMF nanoparticles. Their diameters range from 500 to 150 microns. The
size of the microcapsules is controllable by the agitation rate and the ratio of the dispersed
phase to continuous phase.
Keywords: poly(urea-melamine-formaldehyde), alkyd, microcapsule, polymerization,
surfactant
Suggested Reading:
1. BROWN, E. N., KESSLER, M. R., SOTTOS, N. R. & WHITE, S. R. 2003. In situ poly(urea-formaldehyde)
microencapsulation of dicyclopentadiene. Journal of Microencapsulation, 20, 719-730.
2. SURYANARAYANA, C., RAOB, K. C. & KUMARA, D. 2008. Preparation and characterization of
microcapsules containing linseed oil and its use in self-healing coatings. Progress in Organic Coatings, 63,
72-78.
3. THEN, S., GAN S. N. & KASIM, N. H. A. 2011. Performance of Melamine Modified Urea–Formaldehyde
Microcapsules in a Dental Host Material. Journal of Applied Polymer Science, 122, 2557-2562.
PHY 4

5th UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014

5th UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014

Recommended

Recommended

More Related Content

Viewers also liked

Viewers also liked (7)

Similar to 5th UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014

Similar to 5th UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 (20)

More from Mohammad Hafiz Bin Hamzah, M. Sc.

More from Mohammad Hafiz Bin Hamzah, M. Sc. (15)

Recently uploaded

Recently uploaded (20)

5th UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014