5th UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014

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Welcome to the 5th UM-NUS-CU Trilateral Mini Symposium and Scientific Meeting 2014!! We are especially proud to be given the opportunity to organize this symposium in the Department of Chemistry, UM this year.
Since the initiation of this symposium in 2009 in Bangkok, Thailand, we have strived both to focus and broaden the scope of the symposium. The focus has been to establish collaborative research and networking among the academics from the top research universities in Malaysia, Singapore, and Thailand.
This year, the symposium is held on the 11th and 12th February 2014. The program on the first day of the event is packed with oral presentations by 12 distinguished speakers from the three univeristies. As before, the symposium is structured to allow close interaction among the participants; hence together with the formal presentations, there will be social occasions such as dinner at Eastin Hotel, where the academics and attendees will get together and know each other better to enhance opportunities for scientific intercourse. Besides, we have also arranged a short tour for our guests to Rimba Ilmu, which means Forest of Knowledge in the malay language. Rimba Ilmu is a tropical botanical garden, set up in the University of Malaya campus in Kuala Lumpur. It is modelled after a rain forest garden concept rather than a formal flower garden. It emphasises the flora of the Asean region with living collections of over 1,600 species. The Rimba Ilmu also houses the University of Malaya herbarium (acronym KLU) and has its own Environmental Education Programme.
An administrative or annual meeting between the three institutes has also been arranged and it will be held on the second day of this event to discuss matters associated to research student exchange, collaboration, MoU, etc. With all these programs in line, I greatly hope that we can make full use of our time and resources in the next two days to discuss and deliberate on research issues, and at the same time paving the way towards a more sustainable and resilient research collaborations.

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5th UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014

  1. 1. 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page1 5th UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 PROGRAMME AND ABSTRACTS DEPARTMENT OF CHEMISTRY, FACULTY OF SCIENCE, UNIVERSITY OF MALAYA, 50603 KUALA LUMPUR
  2. 2. Welcome 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page2 Table of Contents Page Welcome note 3 Organizing committee 5 Delegation from Chulalongkorn University 6 Delegation from National University of Singapore 7 Scientific programme 8 Abstracts of invited speakers 11 Abstracts of poster presentations 24 Sponsors 114
  3. 3. Welcome 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page3 Welcome note Prof. Dr. Mhd. Radzi Abas Welcome to the 5th UM-NUS-CU Trilateral Mini Symposium and Scientific Meeting 2014!! We are especially proud to be given the opportunity to organize this symposium in the Department of Chemistry, UM this year. Since the initiation of this symposium in 2009 in Bangkok, Thailand, we have strived both to focus and broaden the scope of the symposium. The focus has been to establish collaborative research and networking among the academics from the top research universities in Malaysia, Singapore, and Thailand. This year, the symposium is held on the 11th and 12th February 2014. The program on the first day of the event is packed with oral presentations by 12 distinguished speakers from the three univeristies. As before, the symposium is structured to allow close interaction among the participants; hence together with the formal presentations, there will be social occasions such as dinner at Eastin Hotel, where the academics and attendees will get together and know each other better to enhance opportunities for scientific intercourse. Besides, we have also arranged a short tour for our guests to Rimba Ilmu, which means Forest of Knowledge in the malay language. Rimba Ilmu is a tropical botanical garden, set up in the University of Malaya campus in Kuala Lumpur. It is modelled after a rain forest garden concept rather than a formal flower garden. It emphasises the flora of the Asean region with living collections of over 1,600 species. The Rimba Ilmu also houses the University of Malaya herbarium (acronym KLU) and has its own Environmental Education Programme. An administrative or annual meeting between the three institutes has also been arranged and it will be held on the second day of this event to discuss matters associated to research student exchange, collaboration, MoU, etc. With all these programs in line, I greatly hope that we can make full use of our time and resources in the next two days to discuss and deliberate on research issues, and at the same time paving the way towards a more sustainable and resilient research collaborations.
  4. 4. Welcome 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page4 To our friends from Singapore and Thailand, the Department of Chemistry, UM welcomes you, encourages you to visit and stay with us and hope that this trilateral seminar will bond us even more strongly for our mutual benefit. I hope you will enjoy yourself in the sympossium and have a wonderful time!! Prof. Dr. Mhd. Radzi Abas, Chairman of the Organizing Committee, 5th UM-NUS-CU Trilateral Mini Symposium 2014 Department of Chemistry, University of Malaya.
  5. 5. Organisers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page5 Members of Organising Committee Patron : Prof. Dato’ Dr. Mohd. Sofian Azirun Dean, Faculty of Science, Univeristy of Malaya Advisor : Prof. Dr. Sharifuddin Md. Zain Chairman : Prof. Dr. Mhd. Radzi Abas Secretary : Dr. Cheng Sit Foon Treasurer : Dr. Teo Yin Yin Liason officer : Dr. Cheng Sit Foon (UM – NUS) Assoc. Prof. Dr. Vannajan Sanghiran Lee (UM – CU) Members (i) Dr. Desmond Ang Teck Chye (ii) Dr. Low Kah Hin (iii) Dr. Noraini Ahmad (iv) Dr. Siti Nadiah Abdul Halim (v) En. Mohd. Azli Ishak (vi) En. Hashim Mohammad Salleh (vii) En. Norafandi Tamar (viii) En. Nor Mazni bin Jahari (ix) En. Saifulrullah Abd. Rahim (x) En. Yusriadie Mohd. Azmi (xi) Pn. Norhaida Mohd. Nor (xii) Pn. Norzainariah bt. Mat Zaid (xiii) Pn. Siti Alimah Makmon (xiv) Pn. Zailawati Mohamad Zakaria
  6. 6. CU Delegates 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page6 Honorable Delegation from Chulalongkorn University Assoc. Prof. Dr. Vudhichai Parasuk Assoc. Prof. Dr. Paitoon Rashatasakhon Assist. Prof. Dr. Worawan Bhantumnavin Prof. Dr. Orawon Chailapakul Assist. Prof. Dr. Sumrit Wacharasindhu Dr. Numpon Insin Assist. Prof. Dr. Viwat Vchirawongwin Assist. Prof. Dr. Fuangfa Unob Dr. Puttaruksa Varanusupakul Dr. Rojrit Rojanathanes Dr. Pannee Leeladee Assist. Prof. Dr. Soamwadee Chaianansutcharit Dr. Kanet Wongravee Dr. Prompong Pienpinijtham
  7. 7. NUS Delegates 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page7 Honorable Delegation from National University of Singapore Prof. Dr. Chang Young Tae Assoc. Prof. Dr. Valiyaveettil Suresh Assoc. Prof. Dr. Kang Hway Chuan Assoc. Prof. Dr. Chen Wei
  8. 8. Programme 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page8 Scientific Programme Day 1 - 11th February 2014 Activity : Oral and poster presentations Venue : D112 (Oral) and Dataran Kimia (Poster) 8.30 – 9.30 a.m. Registration 9.30 a.m. Opening ceremony 9.30 – 9.45 a.m. Welcoming remarks and Briefing Prof. Dr. Sharifuddin Md. Zain Head, Department of Chemistry, Faculty of Science, University Malaya, Malaysia 9.45 – 10.00 a.m. Speech and Briefing Prof. Dr. Chang Young Tae Head of Delegation, National University of Singapore 10.00 – 10.15 a.m. Speech and Briefing Assoc. Prof. Dr. Vudhichai Parasuk Head, Department of Chemistry, Chulalongkorn University, Thailand 10.15 – 10.30 a.m. Welcoming and Opening Speech Prof. Dato’ Dr. Mohd. Sofian Azirun Dean, Faculty of Science, University Malaya 10.30 – 10.40 a.m. Group photography session All delegates 10.40 – 11.00 a.m. Coffee break and poster presentation Venue: Dataran Kimia 11.00 a.m. Session 1 Chairperson : Prof. Dr. Chang Young Tae 11.00 –11.20 a.m. Speaker 1 Prof. Dr. Rauzah Hashim (UM) Guerbet Glycoside: The New Lipid in Town 11.20 – 11.40 a.m. Speaker 2 Assoc. Prof. Dr. Chen Wei (NUS) Atomic-Scale Interface Controlled Two-Dimensional Molecular Dipole Dot Arrays 11.40 – 12.00 p.m. Speaker 3 Prof. Dr. Orawon Chailapakul (CU) The Novel Electrochemical Systems For Environmental And Clinical Applications 12.00 – 12.20 p.m. Speaker 4 UM Prof. Dr. Khalijah Awang (UM) Bioactive Phytochemicals From The Malaysian Flora And
  9. 9. Programme 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page9 Medicinal Plants 12.20 – 12.40 p.m. Speaker 5 Assoc. Prof. Dr. Kang Hway Chuan (NUS) Conductance And Electronic Structure Across Graphene Nanoribbon Junctions 12.40 – 1.00 p.m. Speaker 6 Assist. Prof. Dr. Sumrit Wacharasindhu (CU) Direct Synthesis of Acetylenic Compounds from Calcium Carbide: a New Sustainable Chemical Feedstock 1.00 – 2.00 p.m. Lunch Venue: Multipurpose room Poster presentation Venue: Dataran Kimia 2.00 p.m. Session 2 Chairperson: Assoc. Prof. Dr. Paitoon Rashatasakhon 2.00 – 2.20 p.m. Speaker 7 Dr. Sharifah Mohamad (UM) Application of β-cyclodextrin Functionalized With Ionic Liquid For Extraction And Separation Of Organic Compounds 2.20 – 2.40 p.m. Speaker 8 Assoc. Prof. Dr. Valiyaveettil Suresh (NUS) Understanding The Environmental Impact And Developing A Remediation Method For Nanopollutants 2.40 – 3.00 p.m. Speaker 9 Dr. Numpon Insin (CU) Surface Modifications and Environmental Applications of Magnetic Nanoparticles and Quantum Dots 3.00 – 3.20 p.m. Speaker 10 Dr. Woi Pei Meng (UM) Development of Non-Enzymatic Portable Body Metabolites Sensor 3.20 - 3.40 p.m. Speaker 11 Prof. Dr. Chang Young Tae (NUS) Caffeine Sensor and Bioimaging Probe Development 3.40 – 4.00 p.m. Speaker 12 Assist. Prof. Dr. Viwat Vchirawongwin (CU) Evaluations of Vibration Spectra from Molecular Dynamics Simulation of Hydrated Sulfoxy Anions 4.00 p.m. End of mini sympossium Light refreshment Venue: Dataran Kimia 8.00 p.m. Dinner at Eastin Hotel (by invitation)
  10. 10. Programme 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page10 Day 2 – 12th February 2014 Activity : Scientific meeting and discussion Venue : Rimba Ilmu and K017 8.30 – 9.45 a.m. Rimba Ilmu tour 9.45 –12.15 noon Discussion on academic staff exchange programme Discussion on student exchange programme for undergraduates and postgraduates Venue: K017 12.15 – 12.30 p.m. Closing ceremony 12.30 p.m. Lunch Venue: Multipurpose room
  11. 11. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page11 ABSTRACTS OF ORAL PRESENTATIONS (Content unedited)
  12. 12. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page12 Guerbet Glycoside: The New Lipid in Town Rauzah Hashim Chemistry Department, University of Malaya, Kuala Lumpur, Malaysia *Email: rauzah@um.edu.my Abstract Here, we discuss some results from the study of self-assembly phenomena on a special class of poly-hydroxy sugar surfactant, the branched chain Guerbet glycoside (BCGG). Surfactants from this class of material are also classified as amphitropic liquid crystals since they exhibit both thermotropic and lyotropic liquid crystalline properties. Hence the potential applications of these non-ionic surfactants are far wider than the conventional lyotropic liquid crystals encompassing both areas of high-technology industry and life science. From uniting the approaches in experiment, theory and computation, we have developed some basic understanding of the phase behavior. In turn, the self-assembly property may be manipulated using external factors to give rise many innovative ideas. This review covers the effect of stereochemical diversity of the sugar on the thermotropic/lyotropic phases formed. The structure to property relationship compares different chain designs and other popular polyhydroxy compounds, such as monooleins and alkylpolyglucosides. The structural advantages of these Guerbet glycosides due to large chain hydrophobicity, tunable, chiral, asymmetric and stable ether linking group are discussed with respect to their self-assembly organization and potential applications, such as drug delivery, protein crystallization and membrane mimetic study. Keywords: Glycolipid, Guerbet Glycoside, Lyotropic, Non-ionic surfactant Speaker 1
  13. 13. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page13 Atomic-Scale Interface Controlled Two-Dimensional Molecular Dipole Dot Arrays Wei CHEN1,2* 1 Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 2 Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore, 117542 *E-mail: chmcw@nus.edu.sg Abstract Creation of well-ordered functional molecular arrays at the nanometer scale is one of the key issues in the development for future molecular- or nano-electronic devices, solid-state quantum computation, single-electron devices, and biosensors. Molecular self-assembly on surfaces or surface nanotemplates via selective and directional covalent or non-covalent interactions offers a promising bottom-up approach to fabricating molecular nanostructure arrays with desired functionalities over macroscopic areas. The directionality and selectivity of intermolecular hydrogen bonding, metal-ligand interactions as well as covalent bonding can facilitate the formation of ordered supramolecular assemblies with good structural stability. In this talk, we highlight our recent progress in the fabrication of self-assembled molecular nanostructures on surface and surface nanotemplates, as investigated by in-situ scanning tunneling microscopy, with particular emphasis on the fabrication of 2D molecular dipole dot arrays, as well as the reversible switching of individual dipole molecule in hydrogen-bonded 2D networks. Keywords: Single Molecule, STM, Self-Assembly Speaker 2
  14. 14. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page14 The novel electrochemical systems for environmental and clinical applications Orawon Chailapakul1,* , Thara Nurak1 , Narong Praphairaksit1 , Nipapan Ruecha2 , Nadnudda Rodthongkum3 , Ratthapol Rangkupan3 1 Electrochemistry and Optical Spectroscopy Research Unit (EOSRU), Department of Chemistry, Faculty of Science, Chulalongkorn University,10330, Thailand 2 Program in Macromolecular Science, Faculty of Science, Chulalongkorn University, 10330, Thailand 3 Metallurgy and Materials Science Research Institute, Chulalongkorn University, 10330, Thailand *Email: corawon@chula.ac.th Abstract Our research topic focuses on a development of new electrochemical systems for the detection of elemental species and biomakers of interest for the environmental and clinical applications. The first project, we report a spraying method with lacquer developed for a novel fabrication of paper-based devices. The paper-based devices were used to determine nickel using anodic stripping voltammetry. Cu-enhancer solution was employed to increase sensitivity of nickel determination with the optimal concentration of 4.5 ppm. Under the optimal conditions, linear range was found to be in the range of 1 to 50 ppm with a coefficient of determination of 0.9971. The limit of detection (LOD) and the limit of quantitation (LOQ) were found to be 0.5 and 1.97 ppm, respectively. Moreover, these paper-based electrochemical devices were applied to determine nickel in waste water from a jewelry factory. The second project, graphene-polymer nanodroplets are developed and used to modify paper-based electrode for electrochemical detection of cholesterol. Nanodroplets of Graphene-polymer were fabricated using electrospraying technique to increase the electrode surface. The modified electrode was characterized for morphology and electroactivity by using scanning electron microscope and cyclic voltammetry. This proposed method has been used to detect cholesterol using chronoamperometry. Keywords: Electrochemical sensor, Anodic stripping voltammetry, Amperometry, heavy metal, biomarker Speaker 3
  15. 15. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page15 Bioactive Phytochemicals from the Malaysian flora and medicinal plants Khalijah Awang Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur Abstract Since the dawn of civilisation, plants have been used as medicine and until today there are still the main source for therapeutic agents especially the anti cancer drugs such as taxol and the indole alkaloids vinblastine and vincristine. Malaysia is the home to one of the oldest and most diverse flora in the world. It is the host of more than 15,000 plant species. Therefore, the Malaysian flora is an excellent resource for bioactive and rare phytochemicals that could be potential candidates for drug development. In view of the these factors, our laboratory is focussing our research on bioactive natural products. Our findings on phytochemicals from various plant species shall be presented. Examples of bioactive compounds possessing complex skeletons from plant families such as Annonaceae, Apocynaceae, Meliaceae, Guttifereae shall be presented. In addition, Malaysia is also rich with its traditional medicine heritage from three different cultures: Malay, Chinese and Indian. Findings from the traditional medicinal plants studied in our laboratory shall also be discussed briefly.Since the dawn of civilisation, plants have been used as medicine and until today there are still the main source for therapeutic agents especially the anti cancer drugs such as taxol and the indole alkaloids vinblastine and vincristine. Malaysia is the home to one of the oldest and most diverse flora in the world. It is the host of more than 15,000 plant species. Therefore, the Malaysian flora is an excellent resource for bioactive and rare phytochemicals that could be potential candidates for drug development. In view of the these factors, our laboratory is focussing our research on bioactive natural products. Our findings on phytochemicals from various plant species shall be presented. Examples of bioactive compounds possessing complex skeletons from plant families such as Annonaceae, Apocynaceae, Meliaceae, Guttifereae shall be presented. In addition, Malaysia is also rich with its traditional medicine heritage from three different cultures: Malay, Chinese and Indian. Findings from the traditional medicinal plants studied in our laboratory shall also be discussed briefly. Speaker 4
  16. 16. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page16 Conductance and electronic structure across graphene nanoribbon junctions Kang Hway Chuan Department of Chemistry, NUS Division of Science, Yale-NUS College Abstract The antiferromagnetic electronic structure of zig-zag graphene nanoribbons is well-known, leading to possible spin-polarized electron transport with a transverse electric field. We explore an alternative way of achieving spin-polarized electron transport through a junction consisting of zig-zag graphene nanoribbon leads and a small molecular link such as polyenes and cumulenes. We will present our results discuss the effects on conductance of the adsorption position for the linker molecule, edge decoration and relative rotations of the graphene-nanoribbon leads. Speaker 5
  17. 17. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page17 Direct Synthesis of Acetylenic Compounds from Calcium Carbide: a New Sustainable Chemical Feedstock Sumrit Wacharasindhu, Padon Chuentragool, Nopparat Thavornsin, Narongpol Kaewchangwad and Mongkol Sukwattanasinitt Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330 *Email: sumrit.w@chula.ac.th Abstract Acetylenic compounds are important building blocks for natural products, pharmaceuticals and molecular materials. At the start of our research program, we explored one of well-known acetylenenic derivatives: polydiacetylene (PDA) in sensor application. The success of these works led to the development of point of care colorimetric sensors for detecting temperature anionic surfactants and volatile organic compounds. To promote wider adoption of PDA-based materials, we aim to develop a more cost efficient and safer method to synthesize acetylenic derivatives in the second part of our project. In this presentation, we demonstrated the use of calcium carbide, which is a low price primary feedstock from heavy chemical industry for the synthesis of acetylenic compounds such as diarylethynes, poly- phenyleneethylene and arylpyroles in one step fashion. The processes provide high yields of acetylenic derivatives in comparable or better yield than conventional methods. It is also less complicate and cheaper to carry out. The optimization and scope of the reaction will be discussed in this presentation. Keywords: Sonogashira, acetylene, conjugated polymer and calcium carbide Speaker 6
  18. 18. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page18 Application of β-cyclodextrin functionalized with ionic liquid for extraction and separation of organic compounds. Sharifah Mohamad*, Mhd Radzi Abas, Nor Kartini Abu Bakar, Tay Kheng Soo, Nur Nadhirah binti Mohamad Zain, Muggundha Raoov a/L Ramachandran, Tay Kheng Soo Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia *Email: sharifahm@um.edu.my Abstract The growing interest in cyclodextrin (CD) and ionic liquid (IL) in separation study, has allowed us to combine these two domains of research to apply in extraction and separation of organic compounds. In the first part of the presentation, I will focus on how the combination of properties offered by both domains may be combined usefully for extraction and separation of organic compounds. Cyclodextrin offer hydrophobic in nature can entrap different kinds of compounds including organic, inorganic, organometallic and metaloorganic, while ionic liquids offer unique properties such as negligible volatility, thermal stability, and non- flammability make them acceptable as new green solvents. Owing to the properties of cylcodextrin and ionic liquid, the functionalization of β-CD with IL has fostered our interest in preparing a new generation of material that may demonstrate some interesting phenomena in extraction and separation studies. In this paper, synthesize and characterization of β- cyclodextrin functionalized with ionic liquid (β-CD-IL) will be presented and the application of (β-CD-IL) in extraction and separation of organic compounds will be discussed. Keywords: Cyclodextrin, Ionic Liquid, Extraction, Separation Speaker 7
  19. 19. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page19 Understanding the environmental impact and developing a remediation method for nanopollutants Suresh Valiyaveettil Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, Singapore, 117543. E-mail: chmsv@nus.edu.sg Abstract Nanoscience and nanotechnologies are expected to revolutionize our life in the coming years. Engineered nanomaterials are already present in many consumer products such as cosmetics, biomedical materials, detergents, antimicrobial paints, surface modifiers, food additives and packaging materials, to name a few. Such increased usage of nanomaterials has caused concerns from various quarters of our society, including government organizations and public in general. The main reason for such concern involves the lack of our knowledge on the fate of such nanomaterials inside the living organism. Recent studies have shown that metallic nanoparticles are toxic to living systems. We have been examining such adverse impact of nanomaterials in human cell lines and zebrafish models. On the other hand, if the environments are contaminated with nanomaterials, there must be efficient materials and methods to remove such pollutants from environment, especially potable water. Recently, we tried to develop new renewable adsorbents for water purification. The current presentation will give full details on environmental impact of nanomaterials and also look a t the future remediation of contaminated environment. Keywords: Nanotoxicity, zebrafish, metal nanoparticles, Water purification Acknowledgement: The authors thank the Environment and Water Industry Programme Office (EWI) under the National Research Foundation of Singapore (PUBPP 21100/36/2, NUS WBS no. R-706-002-013-290, R-143-000-458-750, R-143-000-458-731) for the financial support of the work. The authors also thank Faculty of Science, Department of Chemistry, NUS Environmental Research Institute (NERI) for funding and technical support. Speaker 8
  20. 20. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page20 Surface Modifications and Environmental Applications of Magnetic Nanoparticles and Quantum Dots Numpon Insin Department of Chemistry, Faculty of Science, Chulalongkorn University Email: Numpon.i@chula.ac.th Abstract Magnetic nanoparticles (MNPs) and semiconductor quantum dots (QDs) are two classes of inorganic nanomaterials with unique properties. MNPs exhibit superparamagnetism, the phenomenon of nanoscale ferromagnetic and ferrimagnetic materials that can stay colloidal stable with strong response in presence of magnetic fields. QDs are known for their intense and tunable fluorescence with broad range of excitation wavelength. In this presentation, we will discuss about various surface modification processes that have been studied in our lab in order to use these nanomaterials to solve and prevent some environmental problems. Pollutants such as oil, heavy metals, and organic dyes were removed from water by superparamagnetic sorbents. Moreover, QDs were used to monitor the level of some heavy metals in waste water. From these studies, we found that these nanomaterials, after undergone suitable surface modification processes, show their potential to be used in many applications efficiently. Keywords: Magnetic nanoparticles, superparamagnetic, quantum dots, fluorescent, pollutants Speaker 9
  21. 21. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page21 Development of Non-Enzymatic Portable Body Metabolites Sensor Pei Meng Woi,1,* Ahmad Nazmi bin Rosli,1,2 , Yatimah Alias1 and Mohd Rais Ahmad2 1 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Lembah Pantai, Kuala Lumpur, Malaysia. 2 NEMS & Photonics Laboratory, MIMOS Berhad, Technology Park Malaysia, 57000 Kuala Lumpur, Malaysia. *E-mail: pmwoi@um.edu.my Abstract Our research relates to prototype construction of molecular sensing devices of bio-chemical nanosensors for bio-medical and health applications. This nanosensor can be used to monitor health conditions by monitoring binding affinity of the metabolites thus possessing recognitive ability geared towards ionic metabolites such as potassium, sodium, ammonium, hydrogen ions, chloride, phosphate and carbonate of medical interest [1,2] . Similarly, biomolecule recognising substituents are of importance for glucose and living body fluid such as blood and uric acid determination. Our nanosensors can be used to monitor health conditions by monitoring the calcium and magnesium level, with preferable selectivity towards calcium. This prototype which is an integrated miniaturised sensor array along with readout circuitry and microcontroller on the same platform provides fast and accurate measurement of the targeting analytes via potentiometric method. The prototype we have here is based on nano-electrodes which are fabricated using chemical vapour deposition (CVD) method, through selective deposition, nano-lithography and etching. Alternatively, carbonised polymeric poles, carbon nano-tubes and graphenes can be grown to function as electrodes [3] . This is an added advantage compared to other available sensors on the market in terms of lifetime/reliability, accuracy, mobility, cost and manufactured ability. Keywords: Bio-chemical nanosensor, portable detection kit, USB terminal, functionalized monomer Suggested Reading: 1. Apodaca, D.C.; Pernites, R.B.; Ponnapati, R.R.; Del Mundo, F.R.; Advincula, R.C. ACS Applied Materials & Interfaces, 2011 3(2), 191-203. 2. Workman, J.; Lavine, B.; Chrisman, R.; Koch, M. Anal. Chem., 2011, 83(12), 4557-4578. 3. Nayagam, D.A.X.; Williams, R.A.; Irwin, J.; Tan, J.; Innis, P.; Leung, R.T.; Finch, S.; Williams, C.E.; Clark, G.M.; Wallace, G.G. Small 2011, 7 (8), 1035. Speaker 10
  22. 22. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page22 Caffeine Sensor and Bioimaging Probe Development Young-Tae Chang National University of Singapore Department of Chemistry *Email: chmcyt@nus.edu.sg Abstract The conventional bioprobe design has been carried out by so-called hypothesis-driven approach. The basic assumption of hypothesis-driven approach is that the scientist “knows the target” in advance, and then design the recognition motif for it. An alternative approach is diversity-driven approach, in which a broad range of fluorescence molecules in a library format are constructed by combinatorial chemistry, as a tool box for unbiased screening. Among several diversity sources, “Diversity Oriented Fluorescence Library Approach (DOFLA)” using fluorophore core with diverse recognition motives around has been the most fruitful in novel bioprobe generations. Using DOFLA, various sensors including caffeine orange, and also colorful bioimaing probes from stem cells to Neurons will be demonstrated. Keywords: Fluorescence, Sensor, Bioimaging, Probe Speaker 11
  23. 23. Abstract - Speakers 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page23 Evaluations of Vibration Spectra from Molecular Dynamics Simulation of Hydrated Sulfoxy Anions Viwat Vchirawongwin Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand *Email: Viwat.V@Chula.ac.th Abstract The sulfoxy anions consist of sulfur and oxygen atoms utilized in ubiquitous chemical processes, resulting contamination in freshwater environments as evidence of water pollution and in atmospheric aerosol particles. The aqueous solutions of sulfate, bisulfate, sulfonate and thiosulfate anions were simulated by the ab initio quantum mechanical charge field molecular dynamics (QMCF MD) formalism. The evaluation of vibration spectra from the trajectory of simulations is a challenge to verify the dynamics property comparison with the experimental data. This process uses the normal vector analysis on the molecular solute and the velocity autocorrelation function (VACF) coupling with Fourier transformation, converting the MD results into the power spectra. This evaluation provided the positions and patterns of calculated spectra in very good agreements with available IR and Raman data, which can confirm the appropriation of the selected theoretical level in the simulation protocol to acquire the properties of these hydrated anions. Keywords: Molecular Dynamics, Sulfoxy anion, Velocity autocorrelation function, Vibration spectra Speaker 12
  24. 24. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page24 ABSTRACTS OF POSTER PRESENTATION (CONTENT UNEDITED)
  25. 25. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page25 Index Abstracts of Posters Section Author Title Designation Inorganic Chemistry Fadhil Lafta Faraj, Hapipah Mohd Ali, Hamid Khaledi and Noraini Ahmad A meso-substituted β- dialdiminate-bis(phenolate) ligand in Mn III , Co III , Co II ,, Ni II and Cu II complexes INORG 1 Nurul Azimah Ikmal Hisham, Hamid Khaledi, and Hapipah Mohd Ali Di- and trinuclear metal complexes derived from pyrazolylindolenine INORG 2 Ainnul Hamidah Syahadah Azizan, Nurfarhanim Abu Bakar, Teh Kai Ni, Gwaram Nura Suleiman, Hapipah Mohd Ali and Hamid Khaledi Reduction of carbon-carbon double bonds of Chalcone using phenylsulfonyl hydrazide INORG 3 Mok Piew Heng, Kong Wai Tan, Seik Weng Ng, Yoke Kqueen Cheah, Sabrina Sukardi Synthesis and characterization of nickel (II) complex bearing a Schiff base with a testosterone moiety and its biological properties INORG 4 Farhatun Najat Maluin, Sharifah Mohamad, Ninie S. A. Manan Ionic Liquid as the morphology template for polyaniline/ nano-hematite composite INORG 5 Subathra Sinniah, Sharifah Mohamad, Ninie S.A. Manan Synthesis and Characterization of Fe3O4 Nanoparticles Coated with β- CD-IL INORG 6 Norbani Abdullah and Noha Said A. Bedowr Single-molecule magnet and magnetic coordination polymers with mesogenic properties INORG 7 Abeer Abduljaleel Ibrahim, Hapipah Mohd Ali, Hamid Khaledi Spectroscopic and X-ray crystallographic studies on Pd +2 and Pt +2 complexes of flexidentate Schiff base ligand derived from indole-7- thiosemicarbazone and their anticancer activity INORG 8 Shin Thung Chew, Kong Mun Lo and Kong Wai Tan Synthesis, Structural Characterization And Biological Properties Of Copper Complexes With Ligands Containing Phosphonium Substituents INORG 9 Sze Koon Lee, Kong Wai Tan, Hoi Ling Seng Zinc (II) Complex Bearing A Cationic Schiff Base With A Bromomethyl Group: INORG 10
  26. 26. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page26 Synthesis, Spectroscopic Characterizations And Biological Study On E.Coli Topoisomerase I Activity Hana Bashir Shawish, Mohd Jamil Maah Synthesis and Characterization of Nickel complexes - New Insights into the Structure and Bonding of Thiourea Diamine Derivatives INORG11 Ishak, D. H. A., Ooi, K. K., Ang, K. P., Akim, A. M., Cheah, Y. K., Nordin, N., Halim, S. N. A., Seng, H. L. & Tiekink, E. R. T.1 A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway INORG12 Kit May Chow and Kong Mun Lo Organometallic Chemistry INORG13 Pannee Leeladee, Guy N. L. Jameson, Maxime Siegler and David Goldberg A High-Valent Iron Imido Corrolazine: Generation and Evidence of NR Group Transfer INORG14 Richard C.S. Wong and Mei Lee Ooi Isolation And Characterisation Of Novel Organometallic Derivatives Of Multidentate Phosphine Bis[(o- methylthio)phenyl]phenylpho sphine and Tris[(o- methylthio)phenyl]phosphine INORG15 Wang Chunyan and Suresh Valiyaveettil Study of cytotoxic effects of green synthesized silver nanoparticles with different capping agents on tumor cells INORG16 Aina Mardia Akhmad Aznan, A. P. Safwan, Zanariah Abdullah, Trupta Kaulgud, Hadi D. Arman, Matthew Mahindaratne, Laurie E. McNeil, and Edward R. T. Tiekink Supramolecular metathesis: cation exchange in salts derived from the sulfa-drug, sulfathiazole INORG17
  27. 27. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page27 Section Author Title Designation Organic / Natural products Nur Atiqah Mohd Nasuha and Yeun-Mun Choo Dyes From Natural Resources ORG 1 Katrina Mohamad Khidzir, Sit Foon Cheng and Cheng Hock Chuah Volatile Components of Fresh Jasminum sambac Buds and the Potential Antioxidant Activities of its Methanolic Extract ORG 2 Chun Hui Ang, Sit Foon Cheng, Chavasiri Warinthorn and Cheng Hock Chuah Antioxidant Potential of Tannin-rich n-Butanol Extract from Elaeis guineensis Leaf ORG 3 Wei Seng Ng, Sit Foon Cheng, Choy Sin Lee and Cheng Hock Chuah Synthesis of Palm Oil-Based Polyester Polyols ORG 4 Wai-Ming Kok, Sit-Foon Cheng and Cheng-Hock Chuah Long Chain Saturated Structured Lipids via Enzymatic Interesterification using Lipase Rhizomucor miehei (Lipozyme RM IM) ORG 5 Lim Jun Lee, Gan Chew Yan, Low Yun Yee, Lim Siew Huah and Kam Toh Seok Alkaloid from Alstonia rostrata ORG 6 Rojrit Rojanathanes, Kobkun Saepang, Supakit Seawpakorn, Patchanita Thamyongkit, and Wittawat Keawsongsang Pyridine-Based Molecular Pincer for Transition Metal Complexation ORG 7 Shah Bakhtiar Nasir and Noorsaadah Abd Rahman Aza Diels-Alder Rection of Cyclic Imine with Danishefsky’s Diene ORG 8 Chun Keng Thy, Chin Fei Chee and Noorsaadah Abd Rahman Total Synthesis of (±)- Cyclollicinone ORG 9 Jia Ti Tee, Chin Fei Chee and Noorsaadah Abd Rahman Total synthesis of (+)- Morusalbanol A and (+)- Sorocein B ORG 10 Nurul Izzatil Aisya Asri, Issha Nadirah Ismail, Hairul Anuar Tajuddin, and Zanariah Abdullah Preparation and Fluorescence Behaviour Of Coumarin Terminated Monolayer On Silver Particle ORG11 Mohd Helmi Hussaini Dullah, Zanariah Abdullah, Hairul Anuar Tajuddin Synthesis and Fluorescence Characterization Of Azo- Coumarin And Azo-Naphthol ORG12 Issha Nadirah Ismail, Nurul Izzatil Aisya Asri, Hairul Anuar Tajuddin, and Zanariah Abdullah. Alkyl Disulfide as an Alternative Absorbate for Monolayer Formation on Silver Particles ORG13
  28. 28. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page28 Section Author Title Designation Physical / Polymer / Composites / Material chemistry Nirosa Raman, Kavirajaa Pandian Sambasevam and Phang Sook Wai Comparison studies of polyaniline nanocomposite with & without TiO2 for hydrazine detection PHY 1 Misni Misran, Teo Yin Yin, Woo Juin Onn, Vicit Rizal Eh Suk, and Yew Han Choi Fatty acid nanoparticle for topical and oral delivery applications PHY 2 T. H. Ali, R. S. D. Hussen and T. Heidelberg Y-shaped Carbohydrate Surfactants by ‘Click Chemistry’ for Oil-in-Water Emulsions PHY 3 Nurshafiza Shahabudin, Rosiyah Yahya and Seng Neon Gan Preparation of microcapsules containing alkyd resin as core PHY 4 M.S. Nusari and A. Mainal Adsorption of Methylene blue onto Chitosan-Based Activated Carbon: Isotherm and Kinetic Studies PHY 5 Vannajan Sanghiran Lee, Vertika Gautam, Wei Lim Chong, Sharifuddin M. Zain, Noorsaadah Abd. Rahman Hot-Spot Motif Characterization of Interface between a Designed Ankyrin- Repeat Protein and Its Target Kinase PHY 6 Pedram Azari, Haris Akram, Gan Seng Neon, Rosiyah Yahya, Wong Chiow San, Belinda-Pingguan Murphy An in vitro biological evaluation of electrospun poly(3-hydroxybutyrate) and bovine hydroxyapatite composite scaffold for bone tissue engineering PHY 7 Pameswari Subramani,Yeong Siang Chiam, Seng Neon Gan, Sook Wai Phang Synthesis, Characterization And Application Of Polyaniline (PAni) Optical Sensor For pH Detection PHY 8 Zahrabatoul Mosapour Kotena, Reza Behjatmanesh–Ardakani, Rauzah Hashim Hydrogen bonds formation in α/β-D-mannose and n-octyl- α/β-D-mannopyranoside using AIM and NBO analyses PHY 9 Abbas Abdulameer Salman and Thorsten Heidelberg Bio-Functionalization of Inorganic Nanoparticles PHY 10 Vannajan Sanghiran Lee, Kanchanok Kodchakorn, Jitrayut Jitonnom, Piyarat Nimmanpipug, Prachya Kongtawelert, Bhusana Premanode, Wei Lim Chong, Sharifuddin M. Zain, Noorsaadah Abd. Rahman Exploration on the Role of Metal Cofactors and Water on the Catalytic Mechanism of Creatininase-Creatinine in Aqueous Solution from Molecular Dynamics Simulation/Quantum Study PHY11 Shabnam Bakhshaei, Sharifah Mohamad, Sharifuddin Md Zain Synthesis and characterization of of new sol–gel titanium(IV) butoxide– cyanopropyltriethoxysilane in cooperated with imidazolium- based ionic liquids PHY12 Naimah Haron, Nor Asrina Sairi, Mohamed Kheireddine Aroua, Yatimah Alias Effect of Water Concentration on the Structural and Diffusion Properties of PHY13
  29. 29. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page29 Guanidinium Trifluoromethanesulfonate Ionic Liquid− Mixture Nor Asrina Sairi, Mohd Azlan Kassim, Rozita Yusoff, Mohamed Kheireddine Taieb Aroua CO2 Capture in Ionic Liquid: A review on mixed solvent systems PHY14 Zati Ismah Ishak, Nor Asrina Sairi, Yatimah Alias, Mohamed Kheireddine Taieb Aroua Transesterification reaction: Facile reaction by ionic liquids as catalyst – A review PHY15 Wan Melissa Diyana Wan Normazlan, Vijaya Ranganathan, Usman Ali Rana, Nor Asrina Sairi, Yatimah Alias and Douglas MacFarlane The Role of Hydrogen Bonding by New Protic Ionic Liquids in Driving Phase Separation or Phase Miscibility in UCST Ternary Mixtures. PHY16 Prompong Pienpinijtham, Xiao Xia Han, Sanong Ekgasit, and Yukihiro Ozaki A Fabrication of Surface- Enhanced Raman Scattering (SERS) Substrate Using an Ionic Surfactant-Mediated Langmuir-Blodgett Method PHY17 Supamas Kanjanakunthon, Nipaka Sukpirom and Puttaruksa Varanusupakul Electrospun Titanium Dioxide Fibers as Stationary Phase in Thin Layer Chromatography PHY18 Anucha Koedtruad, Koichiro Mitsuke and Soamwadee Chaianansutcharit Effects of Sintering Temperature on Conductivity and Oxygen Permeation of La0.3Sr0.7Co0.9Fe0.1O3 Perovskite PHY19 Norazlinaliza Salim, Rauzah Hashim and Noraini Ahmad Formation of Branched-Chain Glycolipids Nano-Emulsions for Topical Drug Delivery Systems PHY20 Faheem Ahmed Qaid, Abdul Hamid bin Yahaya and Rosiyah binti Yahya Kinetic and isotherm adsorption of phenol from wastewater using activated carbons prepared from jatropha seed husks by KOH activation PHY21 Yee Ting Chong, Norazilawati Muhamad Sarih, Sie Tiong Ha, Rezaul Karim Sheikh Synthesis and Mesomorphic Properties of Schiff’s Base Ester with Terminal Methoxy Substituent PHY22 Olla .H.Sharhan, Abdul Hamid Yahaya and Mohamed Mahmoud Nasef Preparation and characterization of poly (3- hydroxybutyric acid)/poly(vinyl acetate) thin films PHY23 Sung-Jin Park, Nam-Young Kang, Anandhkumar Raju, Xiao Wei Emmiline Ang, Animesh Samanta, Seong- Wook Yun and Young-Tae Chang Development of in vivo Inflammation Imaging Probes PHY24 Nam-Young Kang, Sung-Chan Lee, Sung-Jin Park, Seong- Development of in vivo imaging probes for PHY25
  30. 30. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page30 Wook Yun, and Young-Tae Chang pancreatic islets by Diversity Oriented Fluorescence Library Approach (DOFLA) Young-Tae Chang and Seong- Wook Yun Fluorescent chemical imaging probes for live stem cells PHY26 Animesh Samanta,Kaustabh Kumar Maiti, U. S. Dinish and Young-Tae Chang Near-Infrared Raman Reporters for SERS-based in vivo Cancer detection PHY27 Wan Hamdah Wan Ahmad Effect Of Pure Cationic Micelle ([Ctabr]T On The Rate Of Alkaline Hydrolysis Of N- (2-Aminophenyl)Phthalimide PHY28 Norazizah A. Razak, Nor Saadah M. Yusof and M. Niyaz Khan Quantitative Correlation Between Counterion (X) Affinity to Cationic Micelles and X-Induced Micellar Growth for X = 2,6- Dichlorobenzoate Ions PHY29 Ashok Keerthi, Yeru Liu, Qing Wang, Suresh Valiyaveettil Multidonor Substituted Perylene Dyes through Unusual Bromination of Perylene Monoimide PHY30 Perakassh veloo, Yen Nee Koh, Sook Wai Phang Morphology Studies of Doped Polyaniline Nanocomposites Containing TiO2 Nanoparticles and Graphene Nanoplatelets PHY31 Muhammad Adil Mansoor, Muhammad Mazhar and Zainudin Artfin. Development of Photosensitive Ceramic Thin Films for Photovoltaic Applications PHY32
  31. 31. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page31 Section Author Title Designation Analytical / Environmental Adam Henry Sivapatham, Nadiya Taha Darwish, Mai Mai Khoo and Sook Mei Khor Development of a Reusable Biosensor for Small Molecules AN-EV 1 Mehwish Jamil Noor, Muhammad Aqeel Ashraf, Mushtaq Ahmad,Amber latif, Sonia Fatima Identification and Evaluation of Air Pollution Tolerance Index of Plant Species under the Impacts of Marble Industry Pollutants of AN-EV 2 Rizwana Naureen, Imran Hashmi, Mohd, Jamil Maah, Ismail Yusoff, Muhammad Aqeel Ashraf Biodegradation Studies of Dichlorvos under Different Sets of Conditions AN-EV 3 Shiau Yi Tan and Kah Hin Low Prediction of cetirizine hydrochloride content in medication tablet using ATR- FTIR and PLS AN-EV 4 Mehrnaz Ashrafi, Sharifah Mohamad, Ismail Yusoff, Fauziah Shahul Hamid Remediation of Heavy Metal Contaminated Soil Using Banana Stem as the Organic Fixing Additive AN-EV 5 Fathiah Zubaidi, Guan Huat Tan, Choo Yeun Mun Development and Validation of Liquid Chromatography Tandem Mass Spectrometer (LCMSMS) for the Simultaneous Determination of Common Drugs of Abuse in Forensic Cases in Malaysia: Application to Dried Blood Stain (DBS) AN-EV 6 Ummi Noor Salhah Masseren, Tay K.S, Abas M.R.B Preliminary Result On Screening Of Pharmaceuticals In Hospital Sungai Buloh Wastewater Treatment Plant AN-EV 7 Jarinya Sittiwong, Fuangfa Unob Detection of creatinine in urine samples by gold nanoparticles AN-EV 8 Kanet Wongravee, Tewalak Parnklang, Yukihiro Ozaki, Chuchaat Thammacharoen, Sanong Ekgasit Chemometric Analysis of Spectroscopic Data on Shape Evolution of Silver Nanoparticles Induced by Hydrogen Peroxide AN-EV 9 H.H. Mohammad, Khalisanni Khalid, Kheng Soo Tay, Sharifuddin Md. Zain, Rashid Atta Khan The Influence of Triton-X on the Evaporation Rate of Methanol- An analysis using Reversed-Flow Gas Chromatography (RF-GC) Methodologies AN-EV 10 Ramakrishna Mallampati, Ong Pin Jin, Suresh Valiyaveettil Efficient removal of engineered nanoparticles from water using renewable resources AN-EV11
  32. 32. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page32 Section Author Title Designation UM Undergraduate poster Final Year Project and Internship Mak Oi Wei, Maheswari D/O Paliyanny Multi-residue Analysis of β- Agonists in Tissues by LC- MS/MS UP 1 Ong Pei Pei and Dr. Ng Mei Han Extraction Of Phytonutrients From Crude Palm Oil And Red Palm Oil Using Ionic Liquid UP 2 Su-Han Ng and Toh-Seok Kam Alkaloids from Alstonia sp. UP 3 Sim-Yee Cha, Bonnie Yen- Ping Tay, and Pei-Meng Woi Analysis of Compound P, A By-Product of Palm-Based Ester Using HPLC-MWD UP 4
  33. 33. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page33 A meso-substituted β-dialdiminate-bis(phenolate) ligand in Mn III , Co III , Co II , Ni II and Cu II complexes Fadhil Lafta Faraj*, Hapipah Mohd Ali, Hamid Khaledi and Noraini Ahmad Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia E-mail: fadhil_960@yahoo.com Abstract Copper, nickel, manganese and cobalt complexes have been synthesized from a new ligand derived from condensation reaction of 2-aminophenol and 2-(3,3-dimethylindolin-2-ylidene) malonaldehyde. The structures of ligand and complexes were characterized by FT-IR, UV– Vis, TGA, 1 H and 13 C-NMR spectroscopy and magnetic susceptibility measurements, elemental analysis and X-ray crystallographic analysis. Keywords: 2-(3,3-dimethylindolin-2-ylidene) malonaldehyde, 2-aminophenol, complexes INORG 1
  34. 34. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page34 Di- and trinuclear metal complexes derived from pyrazolylindolenine Nurul Azimah Ikmal Hisham*, Hamid Khaledi, and Hapipah Mohd Ali. 1 Department of Chemistry University of Malaya, 50603 Kuala Lumpur,Malaysia *Email: nurulaziemahikmal@gmail.com Abstract Reactions of the 2,3,3-trimethylindolenine with Vilsmeier reagent (DMF/POCl3) produced aminomethylene-malonaldehyde which reacted with hydrazine to obtain the corresponding pyrazolylindolenine. The heterocycle was used in the synthesis of a series of di- and trinuclear metal complexes. The structures were characterized by single crystal X-ray diffraction and magnetic susceptibility. Keywords: Dinuclear, Trinuclear, Metal complexes, Pyrazolylindolenine Suggested Reading : 1. R. M. Aghdam, M. M. Baradarani & A. Afghan, Curr. Chem. Lett. 2 (2013) 13. 2. J.E. Cosgriff, G.B. Deacon, Angew. Chem., Int. Ed. 37 (1998) 286. 3. O. Kahn, Molecular Magnetism, Wiley-VCH, Weinheim, 1993. INORG 2
  35. 35. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page35 Reduction of carbon-carbon double bonds of Chalcone using phenylsulfonyl hydrazide Ainnul Hamidah Syahadah Azizan*, Nurfarhanim Abu Bakar, Teh Kai Ni, Gwaram Nura Suleiman, Hapipah Mohd Ali and Hamid Khaledi Department of chemistry, Faculty of Science, University of Malaya. *Email: nura_suleiman@yahoo.com Abstract The reactions of substituted chalcones with phenylsulfonyl hydrazide in ethanol resulted in the reduction of the carbon-carbon double bond of the chalcones. While in the presence of sodium acetate, the reactions gave the corresponding ketones as the sole product, in acidic conditions, along with the ketones, sulfones were generated. The reactions were also carried out in solvent-free conditions were the ketones were obtained as the sole-products. The products were all characterized by IR and NMR spectroscopy and also X-ray crystallographic analysis. Keywords: Chalcones, Phenylsulfonyl hydrazide, carbon-carbon reduction Suggested Reading: 1. Smit C., Fraaije M.W. and Minnaard A. J. (2008). Reduction of Carbon−Carbon Double Bonds Using Organocatalytically Generated Diimide, J. Org. Chem., 73, 9482–9485 2. Li, J.P.; Zhang, Y.X.; Ji, Y. (2008). Selective 1,4-reduction of chalcones with Zn/NH4Cl/C2H5OH/ H2O. J. Chin. Chem. Soc., 55, 390–393. INORG 3
  36. 36. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page36 Synthesis and characterization of nickel (II) complex bearing a Schiff base with a testosterone moiety and its biological properties Mok Piew Heng1,2 , Kong Wai Tan2 , Seik Weng Ng2 , Yoke Kqueen Cheah1 , Sabrina Sukardi1 1 Department of Biomedical Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia 2 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. Email: mokpiew@gmail.com Abstract A Schiff base ligand L was prepared by refluxing equimolar amount of testosterone and thiosemicarbazide in boiling ethanol with continuous stirring for 6 hours. Crystal of L was obtained from slow evaporation ethanol at room temperature. Its nickel (II) complex 1 were synthesized and precipitated upon addition of nickel acetate into ethanolic solution of L. Complex 1 was recrystallized from mixture of DMF:methanol (3:8). These compounds sythesized were characterized by using FTIR, CHN, 1 H-NMR, and X-ray crystallography. These spectroscopic methods confirmed the formation of L from condensation of testosterone and thiosemicarbazide. Besides, X-ray study also proved that complex 1 is in a slightly distorted square planar environment. L acts as a bidentate OS-donor ligand, whereby a mononuclear complex 1 is coordinated to 2 L via 2 imine nitrogens and 2 tautomeric thiol sulfurs. The inhibitory effects of L and 1 on E. coli topoisomerase I were evaluated by agarose gel electrophoresis. However, both compounds failed to inhibit topoisomerase I even at high compound concentration (500 µM). The DNA binding ability of these compounds were determined by UV-vis spectroscopy and the intrinsic binding constants (Kb) for the interaction of the compounds with calf thymus DNA were determined by employing Wolfe-Shimmer equation. Complexation with nickel dramatically increased the binding ability. Keywords: Testosterone, Thiosemicarbazide, Nickel, Schiff base, DNA binding INORG 4
  37. 37. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page37 Ionic Liquid as the morphology template for polyaniline/ nano-hematite composite Farhatun Najat Maluin*, Sharifah Mohamad, Ninie S. A. Manan Department of Chemistry, University Malaya, 50603 Kuala Lumpur. *Email: farha.naj@siswa.um.edu.my Abstract The synthesis and morphology of polyaniline/hematite(α-Fe2O3) was explored using an imidazolidium base ionic liquids (ILs). A series of ILs with different length of alkyl chain with several types of anions (Cl, BF4, PF6 and NTf2) have been tested. A direct chemical synthesis of polyaniline-ferric oxide was prepared via interface polymerization. This polymerization occurs between the layer of ionic liquid and immiscible solvent. The reactions were simple and fast as the green thin layer of polyaniline in the interface can be observed immediately. The composite were subjected to the structural characterization by Infrared spectroscopy (FT-IR), X-ray Diffraction (XRD) and UV spectroscopy. The FT-IR result confirmed the formation of polyaniline in the composite while the XRD result confirmed the presence of hematite in the composite. The morphology of the nanocomposites was confirmed with Field Emission Scanning Microscopy (FESEM) and Transmission Electron Microscopy (TEM). The size, shape and distribution of nanoparticle of hematite loading in nanocomposite of polyaniline-ferric oxide were determined. In addition, the magnetic susceptibility of polyaniline/nano-hematite composite has been investigated by using Guoy balance magnetometer. Keywords: Ionic Liquid, Polyaniline, nano-hematite INORG 5
  38. 38. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page38 Synthesis and Characterization of Fe3O4 Nanoparticles Coated with β-CD-IL Subathra Sinniah*, Sharifah Mohamad, Ninie S.A. Manan Department of Chemistry, Faculty of Sciences, University Malaya, 50603 Kuala Lumpur, Malaysia *Email: suba_28@yahoo.com Abstract Beta Cyclodextrin-Ionic liquid (β-CD-IL) coated with iron oxide nanoparticles (FeNPs) were synthesized by chemical co-precipitation method. The structure and morphology of prepared complex was characterized using X Ray Diffaction (XRD), Tramission Electron Microscope (TEM), Fourier Transform Infrared Spectroscopy (FT-IR), Thermal Gravimetric Analysis (TGA) and Field Emission Scanning Electron Microscopy (FESEM). The results of analysis confirmed the proposed complex as the product. The FESEM showed β-CD-IL-FeNPs have mean diameter (between 10 to 30nm). Keywords: Beta Cyclodextrin, Ionic liquid, Fe3O4 Nanoparticles INORG 6
  39. 39. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page39 Single-molecule magnet and magnetic coordination polymers with mesogenic properties Norbani Abdullah and Noha Said A. Bedowr* Chemistry Department, University of Malaya, 50603 Kuala Lumpur, Malaysia *Email: e.m.t.p1432@gmail.com Abstract Single molecule magnets and magnetic coordination polymers are examples of advanced low- dimensional materials, especially for spintronic applications. They may be constructed from copper(II) ion and ditopic ligands, such as 2,2’-bipyridine and 4,4’-bipyridine. This paper reports the synthesis and characterization of a single molecule magnet, [Cu2(ɳ2 -(OOCR)2(ɳ1 -(OOCR)2(2,2'-bpy)].H2O (1), and a coordination polymer, {[Cu2(ɳ2 -(OOCR)2(ɳ1 -(OOCR)2(2,2'-bpy)(4,4'-bpy)].H2O}n (2), where R = CH3(CH2)14. These complexes were characterized by elemental analyses, FTIR and UV-vis spectroscopies, magnetic susceptibility, differential scanning calorimetry (DSC) and optical polarized microscopy (OPM). Both complexes showed weak antiferromagnetic interactions between the square pyramidal Cu(II) centres, and exhibit mesomorphisms. Keywords: Cu(II), Single molecule magnet, Coordination polymer, Magnetic, Mesomorphism INORG 7
  40. 40. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page40 Spectroscopic and X-ray crystallographic studies on Pd+2 and Pt+2 complexes of flexidentate Schiff base ligand derived from indole-7- thiosemicarbazone and their anticancer activity Abeer Abduljaleel Ibrahim* , Hapipah Mohd Ali, Hamid Khaledi Chemistry Department, Faculty of science, University of Malaya, 50603 Kuala Lumpur, Malaysia *Email : marwa2002@siswa.um.edu.my Abstract A new indolyl-imine ligand was synthesized by the condensation reaction of indole-7- carbaldehyde with thiosemicabazide . This ligand was reacted with Pd+2 and Pt+2 . The chemical structures and purities of the complexes were evaluated by 1 HNMR and X-ray crystalloghraphy. In the palladium complex, the Schiff base molecule acts as a tridantate- N,N,S ligand to chelate the metal center via its indole and azomethine nitrogens and thiolate sulfur atoms to afford a complex of the type 2:1 (ligand/metal ratio) in square planner coordination geometry. Also,the Schiff base coordinates Pt+2 ion as a tridentate ligand via N,N,S atoms to form a complex of the type 1:1(ligand/metal) in square planner geometry. Anticancer activity of the ligand and its complexes are investigated in vitro assay. Suggested Pathway: Keywords: Thiosemicarbazone, Platinum complex, Palladium complex, Crystal structure, Anticancer assay INORG 8
  41. 41. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page41 Synthesis, Structural Characterization And Biological Properties Of Copper Complexes With Ligands Containing Phosphonium Substituents Shin Thung Chew*, Kong Mun Lo and Kong Wai Tan Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia * E-mail: shinthung@live.com.my Abstract The interaction between anticancer drugs and nucleic acids has attracted much attention in molecular pharmacology, pharmaceutical chemistry and biological chemistry. It is commonly believed that DNA is one of the main target of many antitumor agents. In this connection, a series of copper complexes containing phosphonium substituted hydrazones was synthesized and further reacted with diamine ligands. All the compounds were characterized by elemental analysis and spectroscopic methods (FT-IR, NMR and UV-Vis) and in the case of crystalline products by X-ray crystallography. In addition, the DNA binding and nucleolytic properties of these Schiff base complexes were evaluated by using spectroscopic methods and gel electrophoresis. The topoisomerase I inhibition was also carried out in an attempt to investigate the ability of complexes to inhibit the topoisomerase I enzyme. Keywords: Hydrazones, DNA binding, topoisomerase I inhibitor, copper complexes INORG 9
  42. 42. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page42 Zinc (II) Complex Bearing A Cationic Schiff Base With A Bromomethyl Group: Synthesis, Spectroscopic Characterizations And Biological Study On E.Coli Topoisomerase I Activity Sze Koon Lee, Kong Wai Tan, Hoi Ling Seng Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia. Email: Louiskoon@gmail.com Abstract A new cationic schiff base (STB) was synthesized by refluxing (3-Formyl-4-hydroxybenzyl) triphenylphosphonium chloride with 2-bromoethylamine.HBr. The ligand treated with zinc acetate salts in 1:1 molar ratios afforded the new metal complex, ZnSTB. Schiff base and its zinc complex formation have been confirmed by using IR, NMR, CHN and x-ray diffraction analysis. STB can be dissolved in most of the polar solvent, whereas ZnSTB only dissolve in DMF and DMSO. X-ray diffraction study shows that ZnSTB is four coordinated and the coordination geometry around zinc (II) is tetrahedral. Two bromine atoms are attached to the central zinc in cis-position and the singly deprotonated STB acts as an ON-donor ligand. The inhibition effect of STB and ZnSTB on E.coli topoisomerase I have been evaluated by gel electrophoresis. Results show that the inhibitory effect of STB is further enhanced upon complexation with zinc. Figure 1: Structure of STB INORG 10
  43. 43. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page43 Figure 2: Structure of ZnSTB Figure 3: Effect of various concentrations of STB on the inhibition of E.coli topoisomerase I activity Figure 4: Effect of various concentrations of ZnSTB on the inhibition of E.coli topoisomerase I activity Keywords: Zinc, cationic, schiff base, triphenylphosphine, topoisomerase
  44. 44. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page44 Synthesis and Characterization of Nickel complexes - New Insights into the Structure and Bonding of Thiourea Diamine Derivatives Hana Bashir Shawish*, Mohd Jamil Maah Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia * Email: shawishhana@yahoo.com Abstract Three series of nickel(II) complexes with thiourea ligands have been synthesized. Complexes of the formula [Ni(RNHCSNHRR̀ )2] and [Ni2(RNHCSNHRR̀ )2(NN)2]X where R= phenyl, R̀ = o-phenylamine, p-phenylamine and o-aminopyridine, NN= N,N bidentate ligand, X= NO3 - ; Cl- , have been characterized by elemental analysis, UV-Vis, IR, NMR spectroscopic studies as well as single crystal X-ray diffraction. Thiourea diamine ligands have been coordinated to nickel(II) and the differing binding modes of the ligands in the absence and presence of co- ligands have been investigated. The crystal structures of the complexes show that the reaction of thiourea ligands with nickel(II) salts yields mononuclear diamagnetic complexes with thiourea ligand coordinates as bidentate NS donors, while the reaction of nickel salts with the thiourea ligands in the presence of 1,10-phenanthroline or 2,2-bipyridine affords binuclear paramagnetic complexes with the thiourea ligands coordinate as tridentate NNS donors. The ligands and their nickel complexes were subjected to test their DNA topoisomerase I inhibition efficiency. Keywords: Nickel(II) complexes, Thiourea, Diamine Derivatives, Binuclear complexes, DNA Topoisomerase I INORG 11
  45. 45. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page45 A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway Ishak, D. H. A.1 , Ooi, K. K.2 , Ang, K. P.2 , Akim, A. M.2* , Cheah, Y. K.2 , Nordin, N.3 , Halim, S. N. A.1 , Seng, H. L.1 & Tiekink, E. R. T.1** 1 Department of Chemistry, University of Malaya, 50603, Kuala Lumpur, Malaysia. 2 Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia. 3 Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia. *Email: abdah@upm.edu.my **Email: Edward.Tiekink@um.edu.my Abstract The compound with R = CH2CH3 in Bi(S2CNR2)3 (1) is highly cytotoxic against a range of human carcinoma, whereas that with R = CH2CH2OH (2) is considerably less so. Both 1 and 2 induce apoptosis in HepG2 cells with some evidence for necrosis induced by 2. Based on DNA fragmentation, caspase activities and human apoptosis PCR-array analysis, both the extrinsic and intrinsic pathways of apoptosis have been shown to occur. While both compounds activate mitochondrial and FAS apoptotic pathways, compound 1 was also found to induce another death receptor-dependent pathway by induction of CD40, CD40L and TNF- R1 (p55). Further, 1 highly expressed DAPK1, a tumour suppressor, with concomitant down- regulation of XIAP and NF-κB. Cell cycle arrest at the S and G2/M phases correlates with the inhibition of the growth of HepG2 cells. The cell invasion rate of 2 is 10-fold higher than that of 1, a finding correlated with the down-regulation of survivin and XIAP expression by 1. Compounds 1 and 2 interact with DNA through different binding motifs with 1 interacting with AT- or TA-specific sites followed by inhibition of restriction enzyme digestion; 2 did not interfere with any of the studied restriction enzymes. Keywords: Bismuth, Apoptosis, Metallopharmaceuticals, Cell cycle, NF-κB INORG 12
  46. 46. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page46 Organometallic Chemistry Kit May Chow* and Kong Mun Lo University Malaya, Faculty of Science, Department of Chemistry, Kuala Lumpur, 50603, Malaysia. *Email: kitmaychow@siswa.um.edu.my Abstract Organotin(IV) complexes have received considerable attention because of their biological properties, particularly antitumor, antibacterial and antifungal activity. An important class of organotin(IV) complexes with potential biological activities are those derived from ligands containing nitrogen and oxygen donor atoms. The easily accessibility and structural features made them the target of numerous biological and catalytic studies. New diorganotin(IV) and monoorganotin(IV) complexes have been synthesized from the reaction of the corresponding diorganotin(IV) dichloride or diorganotin(IV) dibromide with tridentate ligands such as (E)- 4-chloro-N’-(2-hydroxy-4-methoxybenzylidene)benzohydrazide and (E)-4-chloro-N’-(3,5- dichloro-2-hydroxybenzylidene)benzohydrazide in methanol. All the complexes were characterized by elemental analysis, IR and NMR (1 H and 13 C) spectroscopic studies, and their molecular structures have been confirmed by single crystal X-ray diffraction analysis. Keywords: Organotin Compounds (OTCs), Mononuclear organotin(IV) complexes, Crystal structure INORG 13
  47. 47. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page47 A High-Valent Iron Imido Corrolazine: Generation and Evidence of NR Group Transfer Pannee Leeladee1,3 , Guy N. L. Jameson2 , Maxime Siegler1 and David Goldberg1, * 1 Department of Chemistry, The Johns Hopkins University, Baltimore, 21218, USA 2 Department of Chemistry and MacDiarmid Institute for Advanced Materials and Nanotechnology, University of Otago, Dunedin 9054, New Zealand Present Address: 3 Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand *Email: pannee.l@chula.ac.th Abstract Iron-nitrogen multiply bonded compounds have been postulated as key intermediates in biological transformation (e.g. dinitrogen reduction in nitrogenase) and industrial processes (e.g. Haber-Bosch process). However, synthesis and characterization of such species remains challenging. Herein, generation of a new high-valent Fe-imido corrolazine complex is reported. Reaction of FeIII (TBP8Cz) (TBP8Cz = octakis(4-tert-butylphenyl)corrolazinato) and commercially available chloramine-T afforded a new species assigned as [FeIV (TBP8Cz+• )(NTs)] (Ts = 4-toluenesulfonyl) at room temperature. This new compound was characterized by UV-vis, EPR (X-band (15 K), g = 2.10, 2.00) and Mössbauer ( = -0.05 mm s-1 , EQ = -2.95 mm s-1 ) spectroscopies. [FeIV (TBP8Cz+• )(NTs)] was shown to perform stoichiometric and catalytic NTs transfer to triphenylphosphine (PPh3) giving the phospharane product, Ph3P=NTs, monitored by 31 P-NMR. Kinetic data were also consistent with the proposed NTs transfer mechanism. The reaction mixture of FeIII (TBP8Cz) + chloramine-T + PPh3 gave two new Fe corrolazine compounds i.e. [FeIV (TBP8Cz)(NPPh3)] and [FeIII (TBP8Cz)(OPPh3)], which were determined by X-ray crystallography. Full characterization of the [FeIII (TBP8Cz)(OPPh3)] structure was obtained by independently preparing the compound from FeIII (TBP8Cz) and OPPh3. This pure [FeIII (TBP8Cz)(OPPh3)] offers a benchmark for spectroscopic study on FeIII corrolazine in a structurally defined compound. INORG 14
  48. 48. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page48 Isolation And Characterisation Of Novel Organometallic Derivatives Of Multidentate Phosphine Bis[(o-methylthio)phenyl]phenylphosphine and Tris[(o-methylthio)phenyl]phosphine Richard C.S. Wong* and Mei Lee Ooi Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia *E-mail: richard@um.edu.my Abstract Multidentate phosphine ligands containing thiolaryl groups have been in the limelight in recent years because of its lability towards soft metal complexes via its σ-donor and π- acceptor properties. Phosphine complexes are common in a variety of catalytic reactions, and the ability to control cis/trans isomerism via attractive interactions opens up possibilities for controlling the mechanisms of homogeneous catalytic reactions. In this work, we report the reactivity of bis(o-methylthiophenyl)phenylphosphine and tris(o- methylthiophenyl)phenylphosphine, acting as bidentate, tridentate and tetradentate ligands, respectively. Herein, we reported the syntheses and isolation of 8 novel complexes which were fully characterized by 1 H, 13 C and 31 P NMR, I.R. spectroscopy and single crystal X-ray crystallography. Keywords: multidentate, thioaryl, lability, synthesis, isolation. INORG 15
  49. 49. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page49 Study of cytotoxic effects of green synthesized silver nanoparticles with different capping agents on tumor cells Wang Chunyan and Suresh Valiyaveettil* Department of Chemistry, Faculty of Science, 3 Science Drive 3, National University of Singapore, Singapore 117543 Abstract Metal nanoparticles (NPs) have been found in a wide range of commercially available consumer products ranging from cosmetics to household detergents. This is especially true for silver (Ag) NPs, which showed antimicrobial effects. Recently, various green approaches have been used for preparing Ag NPs, as they may reduce or eliminate the toxic effects towards the environment and ultimately to human being. In our study, we explore preparation of Ag NPs using ginger, coffee and mint extracts at room temperature. The as-synthesized nanostructures were characterized using transmission electron microscopy and UV spectroscopy. The toxicity of Ag NPs with respective capping agents was studied using human cervical cancer cells (HeLa) and hepatocellular carcinoma cells (HepG2). Furthermore, the level of toxicity was evaluated using changes in cell morphology, cell viability and oxidative stress. Toxicity of Ag NPs is dependent on both concentration and chemical nature of capping agents. Ag-mint NPs induced significant toxicity as competed to the other three NPs, with a viability of only 30% at a concentration of 25 µg/ml. The poster will discuss the synthesis, characterization and toxicity studies of AgNPs in detail. Acknowledgement: The authors acknowledge the support from Department of Chemistry, National University of Singapore for funding and technical support. WC thanks the National University for a graduate scholarship. INORG 16
  50. 50. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page50 Supramolecular metathesis: cation exchange in salts derived from the sulfa- drug, sulfathiazole Aina Mardia Akhmad Aznan,a A. P. Safwan,a Zanariah Abdullah,a Trupta Kaulgud,b Hadi D. Arman,b Matthew Mahindaratne,b Laurie E. McNeil,c and Edward R. T. Tiekink*a a Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. b Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249-0698, USA c Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3255, USA *E-mail: Edward.Tiekink@gmail.com; Fax: +60 3 79674204; Tel: +60 3 7967 6775 Abstract Co-crystallisation of equimolar quantities of sulfathiazole (STL) with each of 1,4- diazabicyclo[2.2.2]octane (DABCO) and piperazine (PIP) lead to the facile formation of salts [DABCOH][STL_H] (1) and [PIPH][STL_H] (2), respectively. Crystallography shows the formation of aniline-N–H...O(sulfonyl) hydrogen bonds between anions to form undulating and zig-zag layers, respectively, with the cations being connected to these by charge-assisted N–H...N(thioazole) interactions. The salts were also investigated by 1 H NMR, IR and Raman spectroscopies as well as by DSC. Solid-state grinding competition experiments were monitored by PXRD. When 2 was ground with an equimolar amount of DABCO, substitution of the PIPH+ cation by DABCOH+ was proven, i.e. supramolecular metathesis had occurred, an observation correlated with the more efficient crystal packing observed in 1 cf. 2. INORG 17
  51. 51. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page51 Dyes From Natural Resources Nur Atiqah Mohd Nasuha* and Yeun-Mun Choo Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia *Email: atiqah_nasuha@siswa.um.edu.my Abstract Roots of Morinda citrifolia (Mengkudu, Engkudu, or Noni) have been used traditionally by Iban community from Sarawak, Malaysia as a natural dye to produce yellow-orange shades. M. citrifolia is known to have a broad range of therapeutic effects due to its antioxidant activities. These include antiviral, antibacterial, anticancer activities as well as analgesics effects. In the present study, the chemical components were separated using various chromatographic methods. The structures were established by spectroscopic methods, particularly 2D NMR and MS. Keywords: Morinda citrifolia; Anthraquinones; Antioxidants ORG 1
  52. 52. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page52 Volatile Components of Fresh Jasminum sambac Buds and the Potential Antioxidant Activities of its Methanolic Extract Katrina Mohamad Khidzir, *Sit Foon Cheng and Cheng Hock Chuah. Unit of Research on Lipids, Department of Chemistry, Faculty of Science, University of Malaya,50603, Kuala Lumpur, Malaysia. * E-mail: sfcheng@um.edu.my Abstract We report on the volatile components of the methanolic extract from the fresh buds of Jasminum sambac which is categorized under the olive family, Oleaceae. A headspace solid - phase micro extraction (HS-SPME) method was utilized for profiling the volatile compounds released from fresh buds of Jasminum sambac. A 100 µm polydimethylsiloxane fibre was used to absorb and desorb the volatile compounds from the equilibrium headspace generated by the fresh buds. A gas chromatography-mass spectrometry coupled with the HS-SPME was employed for the confirmation of identity and quantification of volatiles extracted. Volatile components found include farnesene, linalool, cadiene and muurolene. The antioxidant properties of the methanolic extract at different concentrations (50, 100, 250, 500 and 1000 ppm) were then examined by estimating the capability to scavenge DPPH free radicals. It was interestingly found that the methanolic extract has an IC50 value of 208.33 µg/mL compared to Butylated hydroxytoluene (BHT) which is 13.67 µg/mL. Keywords: Jasminum sambac, buds, solid phase micro extraction, antioxidant ORG 2
  53. 53. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page53 Antioxidant Potential of Tannin-rich n-Butanol Extract from Elaeis guineensis Leaf Chun Hui Ang1 , *Sit Foon Cheng1 , Chavasiri Warinthorn2 and Cheng Hock Chuah1 1 Unit of Research on Lipids, Department of Chemistry, Faculty of Science, University of Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia 2 Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand *Email: sfcheng@um.edu.my Abstract Aqueous fraction partitioned from methanolic extract of fresh Elaeis guineensis leaf was found to exhibit antioxidant activity in various in-vitro bioactivity evaluation assays including DPPH radical-scavenging activity assay, lipid peroxidation (LPO) inhibition assay and beta-carotene bleaching assay, as compared to butylated hydroxytoluene (BHT) as standard. This active aqueous fraction was subjected to further fractionation to gain n-butanol tannin-rich sticky solid, then purified chromatographically by Sephadex LH-20 and RP C-18 silica gel columns. Phytochemical screening on these purified fractions suggested that Elaeis guineensis leaf has great potential to be used as natural antioxidant and worthy of further investigations. Keywords: Elaeis guineensis, antioxidant, tannins, n-butanol ORG 3
  54. 54. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page54 Synthesis of Palm Oil-Based Polyester Polyols Wei Seng Ng1 , * Sit Foon Cheng1 , Choy Sin Lee2 and Cheng Hock Chuah1 1 Unit of Research on Lipids (URL), Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. 2 Department of Pharmaceutical Chemistry, School of Pharmacy and Health Sciences, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia. *Email: sfcheng@um.edu.my Abstract Palm oil-based polyester polyols were prepared from palm oil-based glycerol monostearate (GMS) and glutaric acid in a solvent free and non-catalyzed condition. The effect of temperature and effect of ratio of functionality (OH:COOH) were studied. This reaction involved esterification reaction with evolving water. Deacidification of GMS was carried out before proceeding to synthesis of polyester polyol. The acid value and hydroxyl value of polyester polyol were measured according to AOCS Official Method Te 2a-64 and AOCS Official Method Cd 13-60 (1993) respectively. From the study of the effect of temperature, the acid value decreased from 163.67 to 28.38 mg NaOH/g sample at the temperature of 190℃. Further decrement of acid value to 24.19 mg NaOH/g sample was recorded at the temperature of 200℃. Hydroxyl values of polyester polyols were measured in the range of 82 to 225 mg KOH/g sample. The polyester polyol were also characterized with 1 H & 13 C NMR, FTIR, GPC, LCMS and HPLC. Polyester polyol exhibited the characteristic peaks at about 3550 and 1732 cm-1 which attributed to -OH & - C=O stretching of ester group, respectively, confirming the formation of polyester polyols. The molecular weights of polyester polyols were recorded in the range of 560 to 34039 Dalton. Keywords: dicarboxylic acid; palm oil-based monoglyceride; polyester polyol Suggested Reading: 1. Lee, C. S., Lee, S. C. (2011). Preparation of polyester polyol from epoxidized palm olein. Chinese Journal of Chemistry, 29(4), 840-846. 2. Abdel Hakim, A. A., Mosa Nassar, Aisha Emam, Maha Sultan. (2011). Preparation and characterization of rigid polyurethane foam prepared from sugar-cane bagasse polyol. Materials Chemistry and Physics, 129, 301-307. 3. Lin, S., Zhou, J.,Chen, J. (2009). Microwave synthesis of polyester polyol used for polyurethane soles. Faming Zhuanli Shenqing, CN 101538358 A 20090923. ORG 4
  55. 55. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page55 Long Chain Saturated Structured Lipids via Enzymatic Interesterification using Lipase Rhizomucor miehei (Lipozyme RM IM) Wai-Ming Kok, *Sit-Foon Cheng. and Cheng-Hock Chuah. Unit of Research on Lipids (URL), Department of Chemistry, Faculty of Science, University of Malaya. *Email: sfcheng@um.edu.my Abstract There were several reports relating positional fatty acid distributions and fatty acids composition of triacyglycerols with obesity. Unsaturated fatty acid at sn-2 position is absorbed through intestinal mucosa in the form of monoacyglycerol, while the free saturated fatty acids from sn-1 and sn-3 positions are hardly absorbed and easily excreted. That is especially evidenced for long and saturated fatty acids. In the present study, structured lipids of long and saturated fatty acids were synthesized. High oleic sunflower oil (HOS) and behenic acid ethyl ester were interesterified using sn-1,3-specific lipase (10 m/m% of total substrates), Rhizomucor miehei (Lipozyme RM IM), at 65°C for 2 hours. The synthesized structured lipids were characterized and quantified using 13 C NMR as containing 65.1 mol% of SFA, 28.7 mol% of MUFA, 6.2 mol% of PUFA at sn-1,3 positions and 81.8% of MUFA, 18.2% of PUFA at sn-2 position. Overall, there were 42.9 mol% of SFA, 46.8 mol% of MUFA and 10.2 mol% of PUFA at sn-1,2,3 positions. Keywords: Enzymatic interseterification, lipase, triacyglycerols, qCNMR. ORG 5
  56. 56. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page56 Alkaloid from Alstonia rostrata Lim Jun Lee1, *, Gan Chew Yan2 , Low Yun Yee1 , Lim Siew Huah1 and Kam Toh Seok1 1 Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia. 2 University Malaysia of Computer Science & Engineering, Ground Floor, Menara Z10, No.2, Jalan Alamanda 2, Presint 1, 62000 Putrajaya, Wilayah Persekutuan, Malaysia. *Email: junlee1988@um.edu.my Abstract A total of 20 alkaloids were isolated and characterized from the bark extract of Malayan Alstonia Rostrata (Apocynaceae), including six leuconolam-rhazinilam alkaloids, four strychnan alkaloids, two vallesiachotaman alkaloids, a corynanthean alkaloid, an asipidospermatan alkaloid, an uleine alkaloid, a vallesamine alkaloid, an akuammiline alkaloid, two skythantine alkaloids and a 2,7-napthiridine alkaloid. The structures were determined using NMR and MS analysis. Keywords: Alstonia Rostrata; Apocynaceae; Alkaloids ORG 6
  57. 57. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page57 Pyridine-Based Molecular Pincer for Transition Metal Complexation Rojrit Rojanathanes*1 , Kobkun Saepang2 , Supakit Seawpakorn2 , Patchanita Thamyongkit1 , and Wittawat Keawsongsang1 1 Department of Chemistry, Faculty of Science, Chulalongkorn University 2 Program in Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn University *Email: rojrit@hotmail.com Abstract Two novel molecular pincers was successfully synthesized from chelidamic acid. Both molecular pincers contains 5 nitrogen atoms forming two different pocket sizes. The nitrogen-rich cavities are designed for complexation with some transition metal ions. Carboxylic group was introduced onto the 4- position of the central pyridine core as a linker for further application in solar cell technology. The carboxylic group was successfully fabricated by two different methods, chromate oxidation and copper-free Sonogashira coupling. Keywords: pincer, chelidamic, picolinic, complexation ORG 7
  58. 58. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page58 Aza Diels-Alder Rection of Cyclic Imine with Danishefsky’s Diene Shah Bakhtiar Nasir and Noorsaadah Abd Rahman Department of Chemistry, Faculty of Science, University of Malaya *Email: shah_bakhtiar85@yahoo.com, noorsaadah@um.edu.my Abstract Danishefsky’s diene is a diene with a formal name trans-1-methoxy-3-trimethylsilyloxy-1,3- butadiene. It has been known for its efficiency in Diels-Alder reactions. Calculation of the energy for the reaction between cyclic imine derivatives and Danishefsky’s Diene were carried out to determine the energy level and the selectivity for the Aza Diels-Alder reaction. The calculation used density functional theory (DFT) basis set to discern the selectivity and the transition state of the reactions. This information then will further use for the total synthesis of Mitraphylline. Keywords: Aza Diels-Alder, Danishefsky’s Diene, Density Functional Theory (DFT) ORG 8
  59. 59. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page59 Total Synthesis of (±)-Cyclollicinone Chun Keng Thy, Chin Fei Chee and Noorsaadah Abd Rahman Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia E-mail: ckthy1984@yahoo.com Abstract Cycloillicinone and illicarborene A were isolated from the Illicium anisatum1 and Illicium arborescens2. This compound belongs to the class of phytoquinoids which are known for their antitumor and cytotoxic activities. In this presentation, the total synthesis of a racemic cycloillicinone is described. The key step is Diels-Alder cycloaddition reaction between a β- trans-ocimene and a racemic illicinone A. A chiral Corey-Bakshi-Shibata (CBS) oxazaborolidine was used as catalyst in the reaction. The β-trans-ocimene is commercially available and the racemic illicinone A was prepared in 4 steps from commercially available sesamol via alkylation, Claisen rearrangement, prenylation and finally prenyl migration3. In summary, the (±)-cyclollicinone was prepared in 5 steps with a total yield of 19.0% ORG 9
  60. 60. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page60 Keywords: cycloillicinone; illicarborene A; Diels-Alder cycloaddition reaction References 1. Kubo, M., Shima, N., Harada, K., Hioki, H., & Fukuyama, Y. (2011). New prenylated C6-C3 compounds from the twigs of Illicium anisatum. Chemical and Pharmaceutical Bulletin, 59, 898-901. 2. Liaw, C. C., Chen, Y. C., Fazary, A. E., Hsieh, J. L., Chen, S. Y., & Chien, C. T. (2013). A novel prenylated C6-C3 compound with estrogen-like activity from the fruits of Illicium arborescens. Phytochemistry letters, 6, 397-402. 3. Lei, X., Dai, M., Hua, Z., & Danishefsky, S. J. (2008). Biomimetic total synthesis of tricycloillicinone and mechanistic studies toward the rearrangement of prenyl phenyl ethers. Tetrahedron Letters, 49, 6383-6385.
  61. 61. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page61 Total synthesis of (+)-Morusalbanol A and (+)-Sorocein B Jia Ti Tee, Chin Fei Chee and Noorsaadah Abd Rahman Chemistry Department, Faculty of Science, University of Malaya, 68100, Kuala Lumpur, MALAYSIA. *Email: jennytee12302um.edu.my Abstract Morusalbanol A and sorocein B are biologically active oxabicyclic compounds which appear to originate from an intramolecular cyclisation /ketalisation of a cis-trans mulberry Diels-Alder adduct (i.e. 1 & 2). Due to its sparse distribution of its natural plant source, there has been no report on the synthesis of these compounds since its first isolation in 1991. Our work involved the synthesis of Morulsalbanol A (1) and Sorocein (2). In this presentation, we describe the synthesis of the key intermediates (3) and (4) leading to Morulsalbanol A (1) and Sorocein (2), respectively through the Diels-Alder reaction (DA) (Scheme 1). To investigate the effect of different substituents on the DA reaction, model studies have been carried out using various chalcones containing hydroxy (OH), methoxy (OMe) and ethoxymethoxy (EOM) groups. The presence of hydroxyl group at C2’ position was found to be essential for the intermolecular cycloaddition reaction. However, the low yield of product was obtained when the hydroxyl group at C2’ position was replaced with a methoxy group and no product observed for the one without hydroxyl group at C2’ position. Further efforts toward the total synthesis of morusalbanol A and Sorecein B are underway. Keywords: Diels-Alder reaction, Morusalbanol A, Sorocein B ORG 10
  62. 62. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page62 Preparation and Fluorescence Behaviour Of Coumarin Terminated Monolayer On Silver Particle Nurul Izzatil Aisya Asri*, Issha Nadirah Ismail, Hairul Anuar Tajuddin, and Zanariah Abdullah Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. * Corresponding author: izzatilaisya@siswa.um.edu.my Abstract Coumarin and their derivatives are known fluorescent compounds potentially used for chemical sensors and biosensors. In this work, self-assembled monolayer with coumarin terminated was successfully prepared from chemisorptions of (1) onto silver particles. The method was applied according to Brust et.al with minor modification. The adsorbate structure (1) was purified and confirmed under 1 H NMR, 13 C NMR, FTIR and LCMS. The formation of the monolayer was investigated using FTIR, UV-visible and Fluorescence Spectrometers. The size of the particle suspension was determined at around 141.7 nm. The fluorescence of the monolayer was similar to with the emission of adsorbate in Ethanol indicates that monolayer of coumarin successfully formed on the silver surface. O OO S O OO S (1) Keywords: coumarin, self-assembled monolayer, fluorescence. ORG 11
  63. 63. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page63 Synthesis and Fluorescence Characterization Of Azo-Coumarin And Azo-Naphthol Mohd Helmi Hussaini Dullah, Zanariah Abdullah, Hairul Anuar Tajuddin Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur Email: helmihussaini@ymail.com Abstract Azo compounds are widely used as dyes and colorants. They are also used as laser dyes, optical brighteners and fluorescent. In this work, azo-coumarin and azo-naphthol have been synthesized by coupling of 7-hydroxycoumarin and 2-naphthol with diazonium salts intermediate. The products were purified and confirmed by 1 H NMR, 13 C NMR, FTIR, UV- visible absorption and elemental analysis. The presence of IR transmission at 1470-1508 cm-1 indicates the formation of -N=N- in both products. Their absorption and fluorescence behavior were also characterized. Absorption occurred between 320-350 nm either in ethanol or chloroform suggesting that the products are chromophores. Azo linkages was found as reliable way to modify both naphthol and coumarin including their fluorescence character. Keywords: azo-coumarin, azo-naphthol, diazotization, fluorescence ORG 12
  64. 64. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page64 Alkyl Disulfide as an Alternative Absorbate for Monolayer Formation on Silver Particles Issha Nadirah Ismail, Nurul Izzatil Aisya Asri, Hairul Anuar Tajuddin, and Zanariah Abdullah. Chemistry Department , Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. Email: issha89@siswa.edu.my Abstract Two types of self-assembled monolayers on silver particles have been derived from alkyl disulfides with methyl and hydroxyl terminals. Both alkyl disulfides were synthetically prepared and purified before further analyzed using spectroscopic methods. Silver particles were then prepared from reduction of silver nitrate using phase transfer method in the presence of the alkyl disulfides. The products were purified either by solvent extraction or filtration with copious amount of solvents. Alkyl disulfide with hydroxyl terminal produced highly hydrophilic monolayer protected silver particles and the other absorbate with methyl terminal produced highly hydrophobic monolayer. The similar method was repeated with common alkyl thiols for background experiment. All samples were analyzed from FTIR and UV-visible absorption. The presence of strong -CH2- band indicated the formation of organic monolayers. Broad signal for alkyl disulfide with hydroxyl terminal was observed at around 3100 cm-1 , evident of hydroxyl terminated monolayer that consistent with our prediction and the background experiment. The formation of silver particles was indicated from absorption band above 400 nm. The results suggesting that disulfide group is also practical for anchoring group for the formation of self-assembled monolayer on silver particles. ORG 13
  65. 65. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page65 Comparison studies of polyaniline nanocomposite with & without TiO2 for hydrazine detection Nirosa Raman*, Kavirajaa Pandian Sambasevam and Phang Sook Wai Department of Chemistry, Faculty of Science, University of Malaya *Email: pinkyphang@gmail.com Abstract This work presents the comparison of PANI and PANI/TiO2 nanocomposite chemical sensors for hydrazine detection. The PANI and PANI/TiO2 films were prepared by chemical oxidative polymerization of aniline by ammonium persulfate in the presence of dioctyl sulfosuccinate sodium salt (AOT) as a dopant. The polymers were characterized by UV-Vis, FT-IR, FESEM and conductivity study. Besides, the response of the chemical sensors in terms of conductivity was measured at room temperature by using four point probe method. PANI and PANI/TiO2 sensor response for hydrazine detection was evaluated based on the wavelength shift of conducting and non-conducting states of PANI upon exposure to hydrazine at different concentrations. PANI/TiO2 exhibited better performance compared to PANI due to the complementary behaviour of TiO2 nanoparticles. As conclusion, PANI/TiO2 nanocomposite can be potentially applied for hydrazine detection. Keywords: Polyaniline, TiO2, Hydrazine, Nanocomposite Suggested Reading: 1. Yuzhen Li et. al., Applied Surface Science 273 (2013) 135-143. 2. E. Subramanian et. al., Indian Journal of Engineering & Material Sciences 19 (2012) 237-244. 3. M. Nagaraja et. al., Synthetic Metals 159 (2009) 718-722. PHY 1
  66. 66. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page66 Fatty Acid Nanoparticle For Topical and Oral Delivery Applications Misni Misran*, Teo Yin Yin, Woo Juin Onn, Vicit Rizal Eh Suk, Yew Han Choi Colloid and Surface Laboratory, Department of Chemistry, University of Malaya, 50603 Kuala Lumpur Contact: +603-79676776/4079 Abstract Fatty acid nanoparticle is nano-sized colloidal system that has extensively been investigated for controlled drug delivery, cosmetic and pharmaceutical application. Fatty acid nanoparticles are prepared using fatty acids which possesses negligible toxicity, biocompatible and avoids the use of organic solvents in the preparation makes them as promising delivery system. In this work, a cost effective fatty acid nanoparticles with a wide range of particle size (from 50 nm to 500 nm) were developed for topical and oral applications. Figure 1: TEM micrograph (left) and confocal laser scanning micrograph (right) of fatty acid nanoparticles The TEM micrograph of fatty acid nanoparticles showed that they were spherical shape and laser confocal laser scanning micrograph revealed that lipophilic dye was successfully incorporated into the solid matrix of nanoparticles. Fatty acid nanoparticles with high encapsulation efficiency had successfully been developed by modified its composition with liquid fatty acid. High actives loaded fatty acid nanoparticles was then incorporated into base cream to evaluate its in vitro release using Franz Diffusion Cell. Fatty acid nanoparticles enriched cream demonstrated a controlled release for the period of 24 hours. Our finding PHY 2
  67. 67. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page67 suggests that the fatty acid nanoparticles prepared could be a promising delivery system for the enhancement of the therapeutic efficacy in the topical and oral application. Figure 2: Fatty acid nanoparticles prepared with different mean particle size Keywords: Fatty acid, Nanoparticle, Topical delivery, Oral delivery Patent Filled No.: PI2013002585
  68. 68. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page68 Y-shaped Carbohydrate Surfactants by ‘Click Chemistry’ for Oil-in-Water Emulsions T. H. Ali, R. S. D. Hussen* and T. Heidelberg Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur *Email: r_syahila@um.edu.my Abstract A series of Y-shaped, sugar-based surfactants varying in the linkage between two hydrophilic glucose units and a hydrophobic hydrocarbon chain were prepared by copper(I) assisted azide-alkyne cycloaddition (CuAAC). The compounds were obtained in moderate overall yields of 23-39% based on 6-7-step processes involving a chromatographic purification. The chemical structures were confirmed by proton nuclear magnetic resonance spectroscopy, and the physical-chemical properties, i.e. self-assembly, Kraftt and cloud temperatures, air-water interface behaviour as well as oil-in-water emulsions, were studied. While one compound displayed a cubic phase, all others exclusively formed micellar solutions. All Krafft temperatures were below 10 °C and no clouding was observed up to 80 °C. The air-water interface investigations revealed an influence of the linkage on the critical micelle concentration (CMC). Besides, the linkage also affected the emulsion behaviour. Keywords: Non-ionic surfactants, Carbohydrate surfactants, Y-shaped surfactants, Wedges shaped surfactants, Click chemistry synthesis PHY 3
  69. 69. Abstract -Poster 5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR Page69 Preparation of microcapsules containing alkyd resin as core Nurshafiza Shahabudin, Rosiyah Yahya and Seng Neon Gan Chemistry Department, Science Faculty, University of Malaya, 50603 Kuala Lumpur, Malaysia *Email: shafizashah@siswa.um.edu.my Abstract This work reports the preparation of poly(urea-melamine-formaldehyde) (PUMF) microcapsules with a core of palm oil-based alkyd resin and the PUMF as the shell. Poly(vinyl alcohol) (PVA) and ethylene maleic anhydride (EMA) were used as a viscosity modifier. The effect of various parameters on the microencapsulation of the PUMF-alkyd microcapsules was studied, these include dispersed phase to continuous phase ratio, agitation rate and surfactants concentration. The microcapsules obtained were inspected using digital microscopy, optical microscopy (OM) and also scanning electron microscopy (SEM). The alkyd core content and the PUMF shell materials was verified using Fourier transform infrared (FTIR) and differential scanning calorimetry (DSC). Thermal analysis by TGA has shown that the core and shell materials have different thermal stabilities. The resultant microcapsules appear white-yellowish and free-flowing, and have a rough, porous shell which was formed by PUMF nanoparticles. Their diameters range from 500 to 150 microns. The size of the microcapsules is controllable by the agitation rate and the ratio of the dispersed phase to continuous phase. Keywords: poly(urea-melamine-formaldehyde), alkyd, microcapsule, polymerization, surfactant Suggested Reading: 1. BROWN, E. N., KESSLER, M. R., SOTTOS, N. R. & WHITE, S. R. 2003. In situ poly(urea-formaldehyde) microencapsulation of dicyclopentadiene. Journal of Microencapsulation, 20, 719-730. 2. SURYANARAYANA, C., RAOB, K. C. & KUMARA, D. 2008. Preparation and characterization of microcapsules containing linseed oil and its use in self-healing coatings. Progress in Organic Coatings, 63, 72-78. 3. THEN, S., GAN S. N. & KASIM, N. H. A. 2011. Performance of Melamine Modified Urea–Formaldehyde Microcapsules in a Dental Host Material. Journal of Applied Polymer Science, 122, 2557-2562. PHY 4

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