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CONNECTIVE TISSUE
Connective tissue fibers
1.Collagen fibers
2.Reticular fibers
3.Elastic fibers
2Dr.M.Attia
CONNECTIVE TISSUE
Collagen fibers
Most abundant in the body
Insoluble fibrous protein, forms the major
component of the extracellular matrix.
3Dr.M.Attia
Collagen fibers
CONNECTIVE TISSUE
Colorless in fresh state
Very strong, flexible, inelastic with great
resistance to tension
Affected by weak acids and alkalies.
4Dr.M.Attia
Collagen fibers
LM:
Stains:
H&E: ACIDOPHILIC
Mallory’s trichrome: blue
Van giesson trichrome: green
SHAPE
Long, wavy , unbranched fibers and present in bundles
CONNECTIVE TISSUE
5Dr.M.Attia
CONNECTIVE TISSUE
EM:
Collagen fibers
6Dr.M.Attia
CONNECTIVE TISSUE
Collagen fibers
7Dr.M.Attia
CONNECTIVE TISSUE
Collagen fibers
8Dr.M.Attia
CONNECTIVE TISSUE
Collagen fibers
9Dr.M.Attia
CONNECTIVE TISSUE
Reticular fibers
It is very thin
They are in network like shape around the cells
Recently, it is recognized as aspecial form of collagen fibers
type 3.
10Dr.M.Attia
CONNECTIVE TISSUE
Reticular fibers
11Dr.M.Attia
CONNECTIVE TISSUE
Reticular fibers
Site
Stroma of the organs
Smooth muscles
Endoneurium
12Dr.M.Attia
CONNECTIVE TISSUE
Highly elastic and stretchable in response to tension
Colorless in fresh state
Appear yellow in colour
They are stronge but less than collagen fibers
They are not affected by acids, alkalies, boiling
Destroy by elastase enzyme.
13Dr.M.Attia
CONNECTIVE TISSUE
14Dr.M.Attia
CONNECTIVE TISSUE
Site
 Lung, skin, Urinary bladder
 Wall of the large arteries like Aorta
 Elastic ligaments like : ligamentum flavum,
ligamntum nuchae
15Dr.M.Attia
16Dr.M.Attia

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Connective Tissue Fibers Histology