Rhea Pharmaceutical Sciences is a biopharmaceutical company that has developed a natural supplement called HealthTone for treating viral, bacterial, and fungal infections. HealthTone is derived from essential oils including Gardenia jasminoides, Commiphora myrrha, Boswellia serrate, Foeniculum vulgarae, and Daucus carota. Clinical studies showed that HealthTone has potent antiviral, antibacterial, anti-inflammatory, and antioxidant properties. It was also found to be effective as an adjuvant therapy for COVID-19 patients according to the Armenian Ministry of Health.

2. Rhea Pharmaceutical Sciences biopharmaceutical
company with combined experiences
in natural supplements and chemical molecule design,
synthesis, microbiology and virology research.
Our company’s product portfolio is mainly focused on the
anti-infective market. Our groups research has been
focused on successfully developing different supplements
and molecules for Viral, bacterial and fungal infections.

3. • Throughout years of research, we
have successfully developed an
essential oil compounds which
shows beneficial properties and
efficacy against bacteria and
viruses. In addition, the
compound also shows
immunomodulatory properties
and proven Non-Toxic since it was
derived from all-natural materials.
• The beneficial properties of the
compounds is tested for Human
Use. The result of the studies
regarding the beneficial
properties are summarized in the
table:
Natural Food supplement with Antiviral,
Antibacterial and Immunomodulatory Properties
Summary of beneficial properties for Human Use
Beneficial Properties Test Methodology Results
Antifungal MIC / Inhibition zone Effective
Antibacterial MIC / Inhibition zone Effective
Anti inflammatory In Vitro Surpressing IL-1β,
TNFa, IL6, IL10
Immunomodulator In Vitro Surpressing IL2
Non-specific antiviral In Vitro Activating IFNg
Antitumor In Vivo (Rat Model) Significant (-) in tumor
size
Anticarcinogenic In Vivo (Rat Model) Significant (-) in tumor
size
Antioxidant In Vitro Potent Antioxidant
Introducing HealthTone

4. Immunity
Booster
Antiviral
Antioxidant

5. Gardenia Jasminoides
Commiphora myrrha
Boswellia serrate
Foeniculum vulgarae
Daucus carota
HealthTone consistes :

6. Detailed product description &
usage recommendation
Duration
of Use
General
Information
Usage
Recommendation
Shelf life
& Storage
Conditions
Supplement
Facts
Product
Composition
HealthTone is a Natural food
supplement obtained from extracts
of medicinal plants with a potent
antioxidant property.
General Information
Each ml contains oils from :
- Gardenia jasminoides .......1.8 mg
- Commiphora myrrha........ 1.8 mg
- Boswellia serrata.............. 1.8 mg
- Foeniculum vulgarae........ 1.8 mg
- Daucus carota .................. 1.8 mg
- Olive oil ……………….......up to 1 ml
Product Composition
Repairs and protects cells from oxidative stress and free
radicals.
Supplement Facts
During or after illness, not less than one month.
Duration of Use
1ml twice a day 10-15 minutes
after meals and avoid drinking
liquids for 5 minutes
after administration to support
better absorption of supplement.
Usage Recommendation
18 months. Please use within
one month after first opening.
Shelf Life

7. Registration & recognition by legal bodies
REGISTRATION CERTIFICATE under EURASIA ECONOMIC UNION
Certificate no. : AM.01.48.01.003.E.000024.03.19
Certified as of : March 12th, 2019
Union Members : Armenia, Belarus, Kazakhstan, Kyrgyztan,
Russia
Recognition from Ministry of Health – ARMENIA
Highlighted excerpt from the letter :
“Taking into account the discussion and conclusion of the
meeting conducted by the specialized consultants,
leading scientists, and key opinion leaders from the
Ministry of Health, Health Tone (produced by RHEA
Pharmaceutical) can be considered an adjuvant therapy
for patients infected by SARS-CoV-2 (COVID-19)”.
STATE REGISTRATION CERTIFICATE – INDONESIA
Certificate no. : POM TI204633151
Certified as of : April 2nd, 2020

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RHEA PHARMACEUTICAL, LLC Dear Mrs.
EVGENIA MELKONYAN
Dear Mrs. Melkonyan, I want to share with you
the following information about the
biologically active supplement (HealthTone)
that was designed by Professor Yusef Babikyan
and produced by RHEA Pharmaceutical.
Taking into account the discussion and
conclusion of the meeting conducted by the
specialized consultants, leading scientists, and
key opinion leaders from the Ministry of Health,
HealthTone (produced by RHEA
Pharmaceutical) can be considered an adjuvant
therapy for patients infected by SARS- CoV-2
(COVID- 19).
Respectfully Yours, 23.04.2020
LUSINE KOCHARYAN

9. • Screening of Health Tone for antibacterial activity was done by the disk diffusion method. Results are depicted in the table below :
Bacterial & yeast strains
Health Tone Formulation
10 µl
Tetracycline
30 µg
Fluconazole
40 µg
Staphylococcus aureus ATCC-6538 10.5 ± 1.7 32.1 ± 0.8* ND
Staphylococcus epidermidis ATCC-12228 8.3 ± 0.7 12.3 ± 5.8 ND
Escherichia coli ATCC-8739 7.1 ± 0.05 19.1 ± 1.5* ND
Salmonella entericaserovar Typhimurium ATCC-14028 7.1 ± 0.07 20.5 ± 1.0* ND
Pseudomonas aeruginosa ATCC-9027 12.6 ± 0.4* 8.7 ± 1.5 ND
Micrococcus luteus ATCC-10240 10.3 ± 0.9 28.9 ± 1.0* ND
Candida albicans ATCC-10231 7.1 ± 0.3 ND 27.4 ± 0.9*
Candida albicans NCTC-885-653 7.0 ± 0.03 ND 25.5 ± 1.4*
*) Represent statistical difference (p≤ 0.05) in the size of inhibition zones formed under the paper disc by Health Tone and the control
• Microdilution susceptibility assay was performed for the determination of minimum inhibitory concentration (MIC) and minimum bactericidal
concentration (MBC). Results are depicted in the table below :
Bacterial & yeast strains
Health Tone Formulation
(mg/ml)
Tetracycline
(µg/ml)
Fluconazole
(µg/ml)
Staphylococcus aureus ATCC-6538 2.5 0.006 ND
Staphylococcus epidermidis ATCC-12228 2.5 6.25 ND
Escherichia coli ATCC-8739 2.5 24.8 ND
Salmonella entericaserovar Typhimurium ATCC-14028 2.5 23.5 ND
Pseudomonas aeruginosa ATCC-9027 2.5 13.3 ND
Micrococcus luteus ATCC-10240 2.5 29.4 ND
Candida albicans ATCC-10231 1.25 ND 250
Candida albicans NCTC-885-653 0.625 ND 500
Study of Antibacterial activity against bacteria, yeast strains & pathogenic microorganisms

10. The potent anti-inflammatory activity of Health Tone Oil is expressed by evident surpressing activities of
cytokyne such as IL-1β,TNFa, IL-6, IL-10 in In-Vitro testing. Results are depicted in the charts below :
Study of potent Anti-Inflammatory Activity

11. Dose-dependent alteration of Interferon gamma production in
untreated and E.coli Lipopolysaccharide-treated human
peripheral blood lymphocytes culture
The potent anti-viral activity of Health Tone Oil is
expressed by activation of INFg. Results are
depicted in the charts below :
Study of potent non-specific Anti-Viral Activity

12. Study of Immune Modulating Properties
The potent anti-inflammatory activity of Health Tone Oil is expressed by evident
surpressing activities of cytokyne such as IL-1β, TNFa, IL-6, IL-10 in In-Vitro testing.
Results are depicted in the charts below :

13. Study of potent Anti-Oxidant Activity
We observed that BAV like alfa-tocopherol was able to
promote the scavenging of free radicals, displaying a high
dose–response representing a significant antioxidant activity
0 5 10 15 20 25 30 35 40 45 50
0
10
20
30
40
50
60
70
Concentration (μg/ml)
Inhibition
(%)
alfa-tocopherol
NOF
in vitro antioxidant activity of the NOF was evaluated by DPPH radical scavenging. The oil
interacted with the DPPH by transfer of electron or hydrogen, neutralizing its free radical
character. The oil was able to promote the scavenging of DPPH radical, displaying a high dose–
response (r2 = 0.96), with inhibition varying from 5 to 65 %, at concentrations from 5 to 50 μg/ml.
Compound

14. Study of Immune Modulating Properties :
Modulation of Polymorphonuclear neutrophils respiratory burst & inducing human
Neutrophil phagocytosis
In this study we demonstrated that Health Tone does not affect human PMN spontaneous oxidative burst
but dramatically decreases fMLP- and PMA-induced, oxidative burst of cells (as depicted in the figure &
the table below).
Accordingly, Health Tone could serve as a potential antioxidant capable restoring impaired intracellular
production of ROS in PMN and down-modulation of overwhelming inflammatory response of PMN to
chemotaxis- and phagocytosis-mediated respiratory burst induction.
Human
polymorphonuclear
neutrophils
Spontaneous fMLP PMA E. coli
Whole blood
control
11.2±2.5 57.1±13.9 98±0.8 99.6±0.1
Whole blood +
6*10-3 µg/µl NOF
11.6±3.9 31±9.5• 57.4±2• 56.5±3.2•
Whole blood +
6*10-4 µg/µl NOF
14.5±5.2 37±13.6• 46.6±12.1• 51.7±13.2•
Control NOF 1 NOF 2
0
2
4
6
8
10
%
of
cells
able
to
undergo
phagocytosis
* *

15. Natural essential oils mode of action
Inactivation of infectious bronchitis Virus H120 with Health tone oil
1. Reagent and Material
• HT Oil
• Saline solution 0.85%
• Allantoic fluid of IB H120 Virus
2. Methods
a.Trial will be conducted in 5 group treatments of oil Group
b. Inactivation
• Mix the diluted oil solution using vortex for ± 30 seconds.
• Gently transferred the oil solution to erlenmeyer flask antigen contained.
• Incubate the specimen in a 37°C shaker incubator for 16-18 hours.
c. Inoculation
• Prepare 10 days embryonated eggs for 5 groups of treatment, positive control and negative control group.
• 5 treatment groups : inoculated with 0.2 ml mixture.
• IBV negative control : without inoculation.
• IBV positive control : inoculated with 0.2 ml IBV H120 virus.
• Incubation the eggs for 6 days at 36.5°C incubator with daily observation. Eggs with dead embryos within 24 hours post-inoculation will be
discarded as non-specific.
•At the end of observation all of eggs will be chilled in refrigerator and harvested.

16. Natural essential oils mode of action
INACTIVATION OF INFECTIOUS BRONCHITIS VIRUS H120 WITH HEALTH TONE OIL

17. Clinical study: Health tone solution as a
preventive agent
PURPOSE: The efficacy of Health tone solution as a preventive agent of Covid-19
infection among medical staff.
Main objectives:
• to minimize the Covid-19 infection rate of high risk medical staff in hospitals (using
Health tone solution)
• to evaluate the efficacy of Health tone solution on clinical signs and severity of Covid-
19 infection (using Health tone solution)
COMPARISON:
• percentage of medical staff infected by Covid-19 infection at period before and after
receiving Health tone solution

18. Clinical study: Overview of the study
design and dosage regimen
Organization “Erebuni” medical center , Yerevan Armenia
Total number of participants 240
Selection of departments 7 departments are subject to inclusion:
Covid-19 department
Reception
Intensive therapy
Hemodialysis
Otolaryngology and respiratory diseases
Ophthalmology department
Outpatient department
Duration of research 2 month
Posology and route of administration 1ml twice a day 10-15 minutes after meals and avoid drinking liquids for 5 min after administration.
Output form 30mL amber glass bottle in a carton box, with a screw-on plastic lid and a screw-on glass pipette
included.

19. Key results on product application
Erebuny Hospital data Yerevan ,Armenia (April – June 2020)
Trial on Erebuny Hospital Yerevan, Armenia (April – June 2020)
Department Number of Health Care
Professional (HCP)
Infected HCP before
HealthTone application
Infected HCP after
HealthTone application
Reception 49 3 (6.1%) 1 (2%)
ICU 41 24 (58.5%) 3 (7.3%)
Hemodialysis 24 5 (20%) 1 (2.2%)
ENT 45 2 (4.4%) 1 (2.2%)
GYN / OBS 31 9 (29%) 3 (9.6%)
Policlinic 51 14 (24.4) 3 (9.6%)
Others 13 0 0
Total 240 57 (23.7%) 9 (3.7%)
• The data depicted above was based on the product trial conducted for 1 month starting from late April 2020
to early June 2020.
• Based on the trial, the number infected HCP drop significantly after HealthTone application.
• Findings described above implied HealthTone efficacy in supporting the prevention from COVID-19.

20. Update on cell-based anti-SARS-CoV-2 activity
for Rhea’s essential Oil tested at the University
of Texas Medical Branch (UTMB)
October 24th , 2020

21. Cell-based anti-SARS-CoV-2 activity
Test Result from UTMB issued per 24th October 2020
Experimental Drug Development Centre (EDDC)
and University of Texas Medical Branch (UTMB)
Positive Control
*A549 cells are adenocarcinomic human alveolar basal epithelial cells
Essential Oil in
HealthTone
• The test methodology is comparing
Remdesivir antiviral properties with
Essential Oil Components in Health Tone.
• The left chart indicated Remdesivir which
potently inhibited viral replication in A549
cells infected with SARS-CoV-2.
• The right chart indicated the Essential Oil
component in HealthTone which showing
similar potent properties.

22. Plaque reduction activity of Health Tone Oil in Vero E6 cells
Medium
Health Tone Oil ,
2048 dilution
CC50
(Cytotoxicity)
EC50 SARS-
CoV-2 Plaque
Reduction
Conclusion:
The Health Tone Oil has strong
biological activity.

23. Prediction of Small Molecules Targeting the Severe Acute Respiratory
Syndrome Coronavirus-2 RNA-dependent RNA Polymerase
Nonstructural protein 12/7/8 (nsp12/7/8, RNA-dependent RNA polymerase,
RdRp): Nsp12 is the polymerase which bounds to its essential cofactors, nsp7
and nsp8. It is important in replication and transcription of the viral genome.
The structure of RdRp in complex with RNA and triphosphate form of
Remdesivir (RTP) was downloaded from PDB database with code of 7BV2.Thus
we defined two sites for small molecule docking: the RTP binding site (RTP site),
and the RNA binding site (RNA site) and prepared the target structure. For small
molecules docking, four structures were provided: the complex form of
nsp12/7/8, and the single chain of nsp12, nsp7, and nsp8.
Molecular structure of RdRp.The cartoon with the RTP and RNA binding site is
shown (the top). Remdesivir in the binding cavities is shown in the surface
model with carbon, nitrogen, oxygen, in green, blue, red colors respectively.
Molecular interactions of the Remdesivir and bonds distances with the amino
acid residues at the binding sites are shown (the bottom).

24. Prediction of Small Molecules Targeting the Severe Acute Respiratory
Syndrome Coronavirus-2 RNA-dependent RNA Polymerase
Molecular docking of the 3-
Acetyl-beta-boswellic acid
onto the predicted GTP site
and its molecular interactions
with the RdRp amino acid
residues. Molecular
interactions of the 3-Acetyl-
beta-boswellic acid and bonds
distances with the amino acid
residues at the GTP binding
sites are shown.The 3-Acetyl-
beta-boswellic acid in the stick
model with carbon, nitrogen,
oxygen, in green, blue and red
colors respectively.

25. ligand name Essential oil source docking score (kcal/mol) RF Score Value (pKd) H-bond residues
Remdesivir Synthetic −8.20 7.43 Lys545, Arg553, Asn691,Asp760, Arg836, Asp845, Ser759,Lys500
3-Acetyl-beta-boswellic
acid
Boswellia serrata -9.70 7.90 Asp618,Asn691,Lys545,Asp760,Asp761,Arg553, Arg836, Asp623, Thr687,
Lys551
11-Oxo-beta-boswellic
acid
Boswellia serrata -10.10 7.07 Arg553, Asp760, Lys500, Asp623,Lys545, Thr687, Ser759,Asp761
alfa-pinene Boswellia serrata -6.10 4.44 No H-bonds detected
alfa-thuiene Boswellia serrata -6.20 4.45 No H-bonds detected
furanodiene Commiphora myrrha -8.30 6.68 No H-bonds detected
curzerenone Commiphora myrrha -7.70 6.54 Lys545, Arg836
furanoeudesma-1,3-diene Commiphora myrrha -8.40 6.65 Lys593, Asn691, Ser759
Prediction of HT Small Molecules Targeting the Severe Acute
Respiratory Syndrome Coronavirus-2 RNA-dependent RNA Polymerase

26. Prediction of HT Small Molecules Targeting the Severe Acute
Respiratory Syndrome Coronavirus-2 RNA-dependent RNA Polymerase
ligand name Essential oil source docking score
(kcal/mol)
RF Score Value
(pKd)
H-bond residues
Remdesivir Synthetic −8.20 7.43 Lys545, Arg553, Asn691,Asp760, Arg836, Asp845, Ser759,Lys500
Anethole Foeniculum vulgarae -6.50 4.42 No H-bonds detected
3-hydroxy-p-anisaldehyde Foeniculum vulgarae -9.00 7.19 Lys593, Arg858
Gardenin B Gardenia
Jasminoides
-7.80 5.71 Arg836,Lys545,Asp845, Asn497
Gardoside Gardenia
Jasminoides
-7.80 5.18 Lys545, Arg553, Asn691,Asp623, Arg624, Asp836,
Ser759,Thr687,His439
Geniposide Gardenia
Jasminoides
-7.90 5.34 Lys545, Arg836, Asn691,Asp623, Asp845, Asp760,
Ser759,Thr680,Thr687,Asn497
beta-selinene Daucus carota -7.00 6.32 No H-bonds detected
Bergamotene Daucus carota -7.50 5.85 No H-bonds detected
Apigenin
Daucus carota -9.30 6.40 Asn691,Lys593, Ser759,Asp895,Arg858

27. Docking Properties of the Reference molecules
and Health tone Essential oils compounds at the
ACE2 receptor of SARS-CoV2
Ligand name Ligand source docking score
(kcal/mol)
RF Score Value
(pKd)
H-bond residues*
GR 127935 hydrochloride
hydrate
Synthetic -10.4 7.90 Tyr515, Lys74, Asp350, Tyr385, Lys562, Ser77, Glu375
TNP Synthetic -9.7 7.10 Ser44, Ser47, Asp350, Tyr385, Glu375, Asp382, Gln102, Tyr196, Asp206, Arg393
RS504393 Synthetic -10.6 7.43 Tyr196, Glu208, Lys562, Asn210, Asn394, Glu402, Tyr510, Arg514, Ser511, Asn277, Asn149
3-Acetyl-beta-boswellic acid Boswellia serrata -9.2 7.01 Ser70, Gln102, Asn149, Asp509, Ser511, Arg514, Tyr199, Trp203, Ala348, Asn277, Ser409, Tyr385
11-Oxo-beta-boswellic acid Boswellia serrata -9.2 7.00 Asn277, Asp269, Tyr127, Gln102,Tyr385, Lys187, Tyr202, Tyr199, Trp203, His401, Asn149
alpha-Boswellic acid Boswellia serrata -9.2 7.08 Tyr385, His401, Glu375, Asp382, Asp350, Asn194, Gln98, Ala71, Leu73, Asn277, Asn103
beta-Boswellic acid Boswellia serrata -8.9 6.70 Lys187, Leu116, Gln98, His374, Tyr385
curzerene Commiphora myrrha -5.9 6.40 Arg273, Asp169, Asn149, Ser44, Ser47
furanodiene Commiphora myrrha -6.9 6.03 Asn394
20-Hydroxy
ecdysone
Commiphora myrrha -8.1 7.08 Asp350, Tyr385, Asp382, Ala347, Asn394, Arg514, His401, Arg273, Asn149, Glu398, Tyr199,
Ser511, Asn51, Ser44, Ser47
Alismoxide Commiphora myrrha -6.4 5.71 Tyr385, Asp382, Asp350, Asn394, Arg273, Asn149

28. ligand name Essential oil source docking score (kcal/mol) RF Score Value (pKd) H-bond residues
Costunolide Commiphora myrrha -6.7 5.14 Ser47, Gln102, Ser43, Ser44, Trp69, Arg273
Gardenin B Gardenia Jasminoides -7.3 7.01 Lys562, Glu208,Tyr196, Gln98, Ser511, Glu398, Asn149, Arg273, Arg514,
Glu497, Asp382, Asn103
Shanzhiside Gardenia Jasminoides -7.8 6.58 Tyr196, Glu208, Pro565, Gln102, Lys562, Glu398, Arg514, Ser511, Asn394,
Gln98, Asn210, Arg393, Asp206, Asp382, Ser44
Anisaldehyde Foeniculum vulgarae -6.7 5.21 Asn394, Asp382, Lys562, Tyr196, Gly205, Gln102, Ser511, Trp203, Ser77
Estragole Foeniculum vulgarae -5.6 5.43 Lys562, Ser44
Luteolin Daucus carota -8.3 6.31 Tyr196, Glu208, Asn210, Trp566, Lys562, Asp206, Arg393, Asn394, Arg514,
Glu398, Tyr199, Asp509
Myristicin Daucus carota -5.9 5.07 Lys562, Gln98, Arg393, Asn394
Docking Properties of the Reference molecules
and Health tone Essential oils compounds at the
ACE2 receptor of SARS-CoV2

29. Identification of Potential SARS-CoV-2 Cell Entry Inhibitors in Health
Tone oil by
Structure-Based Virtual Screening Approach
Hotspot 31 and hotspot 353
residues of ACE2 receptor
responsible for recognizing S-
RBD of SARS-CoV-2. GR
hydrochloride hydrate (GRHH)
and 3-acetyl-beta-boswellic acid.
GRHH and 11-oxo-beta-boswellic
acid. GRHH and 20-
hydroxyecdysone. GRHH and
gardenin B. GRHH and
anisaldehyde with. Blue ribbons
corresponds to residues of ACE2
receptor and yellow stick model
represents residues of Ligands.
GRHH ligand shows as green and
others as magenta color.

30. Identification of Potential SARS-CoV-2 Cell Entry Inhibitors in Health Tone oil by
Structure-Based Virtual Screening Approach
Bimodal type of action and “closed two arms
structures” formation by Health Tone oil compounds.
(A) Molecular interactions of 11-Oxo-beta-boswellic
acid with ACE2 receptor hotspot Lys31 and Lys353 and
S-RBD-ACE2 interface. (B) Molecular interactions of
Shanzhiside with ACE2 receptor hotspot Lys31 and
Lys353 and S-RBD-ACE2 interface. (Blue and yellow
ribbons corresponds to Lys353 hotspots and Lys 31
hotspots residues of ACE2 receptor respectively, violet
chains corresponds to S-RBD of Cov2, yellow stick
model represents residues of ligands and GR
hydrochloride hydrate ligand shows as green color.

31. Health tone is Included under BPOM’s list of accompaniment
for clinical trial of herbal products with immune-modulator properties
to help COVID-19 patients
https://www.smartpatients.com/trials/NCT04627519

32. Thank You