nice slides

1. Microalgal Bioactive metabolites; Their promising role in Cancer
therapy
Dr. Poornachandar. Gugulothu (Assist.Prof.)
Department of Biotechnology (DST-FIST)
Central University of Tamil Nadu
Gmail: poornachandar@cutn.ac.in
Contact Number: 9966943450

2.  Marine algae are among the most promising sources of novel bioactive compounds with interesting
biological effects hence it exhibits many biological activities.
 While huge industrial and therapeutic potential.
Metabolites Activities
Terpenoids, Alkaloids, Polyphenols, Flavonoids
Polyketides, Peptides, Shikimic acid derivatives,
Sugars, steroids, and a large mixture of biogenesis
metabolites
Antitumor, Antidiabetic,
Anticoagulant, Antioxidant, anti-inflammatory,
Anti-microbial, Antiviral, Antimalarial,
Antitubercular, Anti-aging, and Antiprotozoal
Marine algal metabolites, biological activities

3.  Phytochemicals from marine algae, such as peptides, amino acids, lipids, fatty acids, sterols, polysaccharides,
carbohydrates, polyphenols, photosynthetic pigments, vitamins, and minerals.
 Also which can act as potent antioxidants and have beneficial effects as anti-diabetic and chemotherapeutic drugs,
Novel active compounds
Thalassiosira rotula, Skeletonema costatum and
Pseudonitzschia delicatissima. Commercial source, not
from microalgae
Polyunsaturated aldehydes (PUAs Colon adenocarcinoma (Caco-2) Lung
adenocarcinoma (A549) Colon adenocarcinoma
(COLO 205)
Chlorella ellipsoidea Carotenoid extract Colon carcinoma (HCT-116)
Synedra acus Chrysolaminaran (polysaccharide) Colorectal adenocarcinoma (HT-29 and DLD-1)
Dunaliella tertiolecta Violaxanthin (carotenoid already identified in C.
ellipsoidea)
Breast adenocarcinoma (MCF-7)
Cocconeis scutellum Eicosapentaenoic acid (EPA) Breast carcinoma (BT20)
Chaetoseros sp., Cylinrotheca closterium, Odontella
aurita and Phaeodactylum tricornutum
Fucoxanthin (carotenoid) Promyelocytic leukemia (HL-60), Caco-2, colon
adenocarcinoma (HT-29),
Chaetoceros calcitrans EtOH extract AcOEt extract MCF-7 Breast adenocarcinoma (MDA-MB-231)
Amphidinium carterae HL-60 CH3Cl fraction Hexane fraction AcOEt fraction HL60, Skin melanoma (B16F10), A549
Eleven strains of benthic diatoms Ostreopsis ovata
Amphidinium operculatum
MeOH extract HL-60
Navicula incerta Stigmasterol (phytosterol) Liver hepatocellular carcinoma (HepG2)
Phaeodactylum tricornutum Nonyl-8-acetoxy-6-methyloctanoate (NAMO, fatty
alcohol ester) Monogalactosyl glycerols 1
HL-60 Mouse epithelial cell lines (W2, D3)
Skeletonema costatum Skeletonema marinoi Hydrophobic fraction and PUAs Hydrophobic fraction Caco-2 (A2058 not affected) Skin melanoma
(A2058)
Canadian marine microalgal pool Aqueous extract lung carcinoma (H460), prostate carcinoma,
stomach carcinoma (N87), MCF-7, pancreas

4.  Polysaccharides, sulfated polysaccharides, iodine, dieckol,
fucoxanthine, fucoidan, and polyphenols downregulate the
expression of anti-apoptotic protein Bcl-xl, Bcl-2.
 Similarly, they enhance the Bax expression to aid apoptosis.
Fucoidan supports the intrinsic apoptosis via regulating the cytosolic
release of cytochrome C.
 Fucoxanthine and fucoidan induces the expression of caspase 9 and
caspase 3 to induce apoptotic cell death.
 Moreover, fucoidan, fucoxanthine, heterofucans, dieckol, iodine,
and carrageenans induce apoptosis through modulation of caspase 3
activity via death receptor-mediated apoptotic cell death in several
cancer cell lines.
 In addition to this, they also regulate caspase 8 activity inducing
extrinsic apoptosis in different cancer cells
Apoptosis modulation by algal metabolites in cancer prevention

5.  Bioactive compounds are the naturally obtained compounds in small amount mostly derived from plant
resources, algal resource and few from animal resource.
 These are full of nutrition having anti-diabetic, antifungal ,antimicrobial and specifically Anticancerous
property.
 There are hell lot of bio-active compounds discovered till date. They target Apoptosis, Cell cycle, and
pathways of cancer progression like JAK/STAT, mTOR, AKT and ERK, etc. without harming normal adherent
cell there fore, We focus on combined bioactive compounds to target cancer cell with enhanced anti-cancerous
property.
 Algal extracted bioactive compounds capable of exerting biological activities not commonly exhibited by
drugs in the clinic today. In particular, chemotherapeutic regimens containing a compound capable of
selectively targeting cancer cells, such secondary metabolites compound described above, will allow cancers to
be driven into remission and eliminate recurrence.
 These natural product-based formulations as a novel therapeutic strategy to fight human cancers in future.
Conclusion