W2O Group's president and author of Storytizing, Bob Pearson spoke at the US Chamber of Commerce's #healthforward event. He shared key insights on innovations in healthcare.

1. Innovations in Healthcare
Key Drivers of Change
October 18, 2016
US Chamber of Commerce
Washington, DC
1 Contents are proprietary and confidential.

2. Three Major Drivers of Innovation
SCIENCEBIG DATA AI, MACHINE LEARNING &
NEURAL NETWORKS
2 Contents are proprietary and confidential.
The Information Genome
Everything we do, inside
or out, can be monitored
Our bodies and all we do
are the next frontier for
search
Patterns = Products Personalization becomes
mainstream
Our intellectual capital is
magnified when we
enable software to learn
on its own
Pattern-based learning
will lead to more
personalized solutions
The combination of
science and technology
opens up new thinking for
treatment, services and
solutions

3. And often require previously unrelated areas to merge
Innovation eras take time to develop
3
The Web
First plan for WWW in 1989
The genome meets its match
with AI
Precision of knowledge powers
rare disease innovation
Health data attracts
technology entrepreneurs
Time
Artificial Intelligence
1952-56 timeframe
Human Genome Project
Launched 1990
Completed 2003

4. A look at our future is forming……
4 Contents are proprietary and confidential.

5. What if we combine high volume semiconductor
and pharmaceutical technology?
5 Contents are proprietary and confidential.

6. An ingestible sensor the size of a grain of sand, a
patch, an app and a provider portal are combined
We can track patients thousands of miles away,
see if they took the medicine, what their
pharmacokinetics are and where it was made
This is Proteus Digital Health
6 Contents are proprietary and confidential.

7. What if we could figure out how to edit disease?
7 Contents are proprietary and confidential.

8. The CRISPR–Cas9 system
Treat and edit disease
Target and study particular DNA sequences
Send proteins to precise DNA targets to turn genes
on or off
Bayer & CRISPR Therapeutics form JV
8 Contents are proprietary and confidential.

9. What new medical disciplines will form as a
result of technology and healthcare
converging?
9 Contents are proprietary and confidential.

10. Bioelectronics medicine
A new discipline combining molecular medicine, neurophysiology, biomedical
engineering, deciphering and manipulating the electrical signal produced by the
nervous system to communicate information
Neural bypass technology allowed a paralyzed person, for the first time, to regain
movement through the use of a brain implant. Therapies can be developed that
work by recording, stimulating, and blocking neural signaling
Chad Bouton and The Feinstein Institute for Medical Research
10 Contents are proprietary and confidential.

11. What is the promise of virtual reality in health?
11 Contents are proprietary and confidential.

12. Train physicians anywhere in the world
Distract burn victims via VR and decrease their
pain
Help veterans learn to deal with PTSD
It is a matter of our applied imagination
12 Contents are proprietary and confidential.

13. What if we can unlock the power of our immune
system to fight disease and replace more toxic
therapies?
13 Contents are proprietary and confidential.

14. The power of Immunotherapy
Anti PD-1 immunotherapy blocks the pathway so
our immune system can do its job
14 Contents are proprietary and confidential.

15. How can technology and machines improve
what humans do?
15 Contents are proprietary and confidential.

16. Robotic-assisted minimally invasive surgery
guided by MDs
Intuitive Surgical
16 Contents are proprietary and confidential.

17. What new minds are tackling health issues?
17 Contents are proprietary and confidential.

18. Jeff Huber (Google) joins newly formed Grail, a
joint venture of Illumina, Jeff Bezos, Bill Gates
& Google Ventures
Goal: develop a proactive cancer-detecting blood
test to identify the tiny bits of cancer DNA that
are hanging out in our blood but are currently
undetectable.
18 Contents are proprietary and confidential.

19. What if all or most of our health data could be
integrated?
19 Contents are proprietary and confidential.

20. The equivalent of our data immune system
Will we unlock its power?
20 Contents are proprietary and confidential.

21. Personalization is being redefined
Your body is an untapped data source
Data, AI and robotics are drivers of innovation
Any disease or disorder is fair game today
21 Contents are proprietary and confidential.

22. The United States of America has an
unprecedented opportunity to drive a new era of
innovation
Technology and Healthcare partnerships will
lead to exponential advance for the next few
decades
22 Contents are proprietary and confidential.

23. Innovation will accelerate at a greater pace
in the years ahead
23 Contents are proprietary and confidential.

24. Organizations will struggle to keep up…..
Martec’s Law
24 Contents are proprietary and confidential.

25. Political and business interests must align
around improving the health of all people
25 Contents are proprietary and confidential.

26. Our role in supporting innovators
Will we create an environment that can accelerate innovation, transform health outcomes and drive our
economy?
Clarity of Rules
How we regulate
Ambiguity stifles
investment
Clarity of Payment
Return on investment
If payment is unclear,
entrepreneurs find other
things to innovate
Ability to Learn
Together
The Role of FDA
FDA and innovators should
commit to learn together,
stay on top of what’s next
and evolve thinking at the
same pace
Ability to Evolve
Together
New regulations
If we evolve together, we
save years, even decades
of misaligned regulatory
standards and innovative
advances

27. Everyone is counting on us to succeed!
The journey continues….
27 Contents are proprietary and confidential.