5th Annual DayOne Conference (Nov. 2020)

DayOne
Conference
12. November 2020

© 2020 Basel Area Business & Innovation, all rights reserved.
Join us throughout the day.
Looking forward to hearing your
thoughts + ideas + commentary + takeaways…
#DayOneBasel

Thomas Brenzikofer, Co-Founder DayOne
Manager Networks & Events, Basel Area Business & Innovation

DAY ONE
The Future of Health
19. September 2016
Open Innovation Workshop by the
Precision Medicine Group Basel Area

DayOne is still on the mission to
to shape the future of health

The Future always begins now
That’s why we are DayOne
The first Day of something new

Alain Bindels
Core team
Roche
Andre Moeri
Impact Hub
Basel
Andrea Huber-
Brösamle
ETH Zurich
Andreas Wicki
Kantonsspital
Baselland
Bejal Joshi
T4 Communications
Bhupinder Bhullar
Consultant
Bram Stieltjes
University
Hospital Basel
Christian Bosshard
CSEM
Christian Schneider
University Basel
Douglas Haggstrom
Basel Area Business
& Innovation
Enkelejda Miho
FHNW
Erik Schkommodau
FHNW
Fabian Streiff
Basel Area Business
& Innovation
Frank Kumli
Basel Area Business
& Innovation
Dr. Katrin Crameri
SPHN
Laurenz Baltzer
Karger
Publishing
Melissa Penny
Swiss TPH
Michael Rebhan
Novartis
Nicole Probst-
Hensch
Swiss TPH
Dr. Niko
Beerenwinkel
ETH Zürich,
D-BSSE
Rocco Falchetto
President Swiss
Society for
Porphyria
Peter Groenen
Idorsia
Thomas
Brenzikofer
Basel Area Business
& Innovation
Torsten Schwede
SIB
Viktor Bullain
Global coach
Giancarlo Covino
Helsana

Knowledge partners
In close
collaboration with
Supporting partners
Partners
<
<<<
<<
<<
<
<<<<
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<Hospital Jura
placeholder

1. A community/network
to connect
2. Events to get inspired
3. Catalyst projects to
activate
4. An accelerator program to
grow
5. A hub for life sciences and
innovation to establish
your presence in Europe
6. Workspaces to
collaborate

DayOne is the
Healthcare Innovation
initiative managed by
Basel Area Business &
Innovation
With a special support by by the
canton of Basel-Stadt

Bright Idea 1:
How to build a health data ecosystem
Nishant Sinha, Deloitte Consulting

Bright Idea 2:
Value based healthcare
– or per aspera ad astra:
Carolina Aguilar, INVALUE/Dot2Dot

Bright Idea 3:
Validation center
- fast track for digital health:
Jens Eckstein, Univ. Hospital Basel

Bright Idea 4:
Personalized nutrition
and health extension:
James Bauly, DSM

30 Projects Champions
Are ready for the Open
Innovation Session

Welcome the patient champions
of the DayOne Health Hack

The DayOne
Health Hack
A true ecosystem
effort
Reinventing Healthcare,
co-creating a new
breed of solutions
starting with people
who are patients

DayOne Health Hack Consortium and Partners
© 2020 Basel Area Business & Innovation, all rights reserved.

12 patient
Interviews
Steven Bourke,
Eupati
4 key-areas
- Awareness and literacy
- Data interoperability
- Sharing with patient community
- Measuring causal factors
2 half days workshop with 10
patients, 35 experts, 12 partners, 8
moderators, 13 sessions
Provided by Experientia
13 Miro Boards
164 how-might-
we-cards
98 idea cards
curated 14 patient challenges,
by Health Hacking Lab – 15 great projects

Giovanni Nisato, Innovation Horizons
Steven Bourke, EUPATI
Abhi Verma, Health Hacking Lab

Ecosystem Stakeholder Award
Project “Self Radar”: Andrew Bryant
Consortium Partner:
Giancarlo Covino, Helsana
Daniel Leutenegger, Takeda
Muriel Bekto, Microsoft,
Oliver Shergold, Novartis

Health Hacker Award
Project “Project Health Companion”: Arben Nuhija
Consortium Partner:
Michele Visciola, Experientia

Patient Champion Award
Project “Hawkings Mate”: Petronela Sandulache
Consortium Partner:
Stefanie Derzsi, Roche

15 Great Projects
Check them out: https://2020.healthhack.solutions/
WhachaCallit Med* DataMosaic
Hawking's Mate* <So Hum> every breath you take!
shock-absorber-connect MyJOURNEY platform
Health Companion* My Health Data Core*
digiCoach Odyssey
HealthCareSolutionsRedefined DocRefConsulter
KlarMD* Self-Radar*
Katarina for patients
*part of the Open Innovation Session

DayOne Health Hack
Reinventing Healthcare, co-
creating a new breed of
solutions -- starting with
people who are patients

Manuel Kammermann, Arcondis
Main Sponsor

09:45 4 bright ideas
1) How to build a health data ecosystem
2) Value based healthcare – or per aspera ad astra
3) Validation center: fast track for digital health
4) Personalized nutrition and health extension
James Bauly, DSM
10:30 Executive talk
Thomas Szucs
Professor University of Basel
President of the Board Helsana
Agenda

Bright Idea 1
How to build a health data ecosystem

DayOne
Health Data
Scenario Project
2020

Wisdom of the Crowd
50+ experts
3 Sessions, 18+ hours of workshop
pulling together knowledge and insights
co-creating tangible outcome:
10 Scenarios

© Scenario Management International AG 55
Map of the Future
55
6
1
10
5
9
4 8
3
7
2
Traditional system –
moderate growth
BigTechs drive traditional
(monopolistic) system forward
MedTech as trusted
health partner
Competition drives
cooperation
Free market
meets regulation
Low tech –
high health literacy
Power to the patients
Global health
authority
Resurgence of
nationalism
Capital and
incumbents drive
tech focused
innovation
creating a vendor
market
Democratization of
Tech and Data access
drive innovation
creating prosumer
market
Consumer behavior
drives innovation
creating a Buyer
Market
Government drives
innovation (if at all)
creating a flat
Market
One-world-framework
for holistic growth

© Scenario Management International AG 56
Map of the Future
Health data
56
6
1
10
5
9
4 8
3
7
2
Ow
VC
Tr
Mn
Inf
Std
Citizen
Ownership
of data
Open
infrastructure
High trust
in data
Strong
monetization
of data
Broad data
value chain
High
standardization
of data
Ow
VC
Tr
Mn
Inf
Std
Ow
VC
Tr
Mn
Inf
Std
Ow
VC
Tr
Mn
Inf
Std
Ow
VC
Tr
Mn
Inf
Std
Ow
VC
Tr
Mn
Inf
Std
Ow
VC
Tr
Mn
Inf
Std
Ow
VC
Tr
Mn
Inf
Std
Ow
VC
Tr
Mn
Inf
Std

Data Ecosystem of Future
Nishant Sinha
12 Nov 2020

Copyright © 2020 Deloitte Development LLC. All rights reserved. 2
Convergence Between Life Science, Healthcare And Technology, Leading To Innovative
Digital Health Solutions
Healthcare
(Providers and
Registries)
Technology
Vendors (AI,
automation,
Apps..)
Life Science
& MedTech
companies
Convergence
Focus on Patients
• Market shifts in healthcare i.e.
from treatment to
prevention or personalized
care, are significant and affect
all players
• Industry borders will blur
as digital technology will
disrupt, while bringing value to
patients’ lives
• Partnerships and data
exchange emerge to achieve
better patient outcome,
opening opportunities for
Analytics
• Increasing realization about
data ownership and sharing
• Healthcare cost pressure and uncertain
health economy drives interest in
financial sustainability
• Adapting to changing consumer needs,
demands and expectations (I.e. Apps.,
home-test kits)
• Using new care delivery models to improve
access to and affordability of
healthcare
• Market complexity increase by new
partnerships, new disrupting players
• How to scale innovative analytics and
AI technologies into healthcare, while
staying legally compliant
• Legacy ways of working and lack of
standards hinder the exchange of patient
and outcomes data
Convergence Challenges
The Future of Health is now…

The Future of Health
Power new ways to
complete enabling tasks
and address jobs-to-be-
done in the future
Radically interoperable data
and open, secure platforms
Primarily aimed to sustain
wellbeing, providing care only
in the rare instances when
wellbeing fails

Patient Expectations And Increasing Choices To Fulfil The Aspired Level Of Service Will
Further Accelerates Disruption
Present
In traditional models of change tech leads charge,
followed by business models, and then regulation
14 years 21 years
Paceofinnovation
Perception is linear…
Reality is
exponential…
7 years
TECHNOLOGICAL DEVELOPMENT
Moore’s law: the power of chips,
bandwidth and computers doubles
approximately every 18 months
Trendsunderlying
exponentialgrowth
Additive manufacturing (e.g., 3D printing)
Artificial intelligence (e.g. ML, NLP)
Biomedical engineering (e.g. stem cells)
Connectivity (e.g., 5G, IoT)
MOBILE PHONES:
The number of mobile phones
worldwide doubled in the last
48 months
DNA SEQUENCING:
From $1 billion and 13 years to
<$100 and <1 hour
DATA STORAGE:
From $569 per GB to
<$0.01
THE HUMAN FACTOR
Technology development feeds and
enables various trends in society:
Well-being
Decentralization
DIY
Social connection
In health care, regulatory
bodies (e.g., FDA) are
working to keep up with the
pace of change spearheaded
by innovative entrants
Understood… Directional… Unknown
Quantum computing (e.g., supersonic drug design)
Data liquidity (e.g., cloud, blockchain)
Extended reality (e.g. AR, VR, spatial computing)
Nanotechnology (e.g., smart fabrics)
Robotics (e.g., robotic surgery)
WhatWeWANTversusWhatWe
HAVEversusWhatWeThinkWeWill
GET

Data Ecosystem of Today Data Ecosystem of Future
There Are 6 Key Areas Where Data Ecosystems Will Evolve
Evolving Data Ecosystems
• Data Owner
• Terms and Condition
• Organization Efficiency
• Unidirectional Data Flow
• Data Traceability Limited
• Limited Access to Data Through
Standard Protocols
• Data Custodian
• Usage Transparency
• Patient / User Experience
• Fully Open Platform
• Security of Data
• Ease of Access / Share
WE KNOW WHAT IS BEST FOR YOU WE DO WHAT IS BEST FOR YOU

Key Questions to Answer For Organizations
1 Where is the data?
2 Can I and should I use it?
3 Can I share it?
4 Who owns the data?
5 Responsibilities during a
breach?
Chat bots
Health records
Cloud based applications
Mobile devices
Mobile Network
Medical Devices
Eating habits
Social Media
Health
Management
Communities

“The best way to predict the future is to create it.”

Bright Idea 2
Value based healthcare – or per aspera ad astra

1
© INVALUE; All Rights Reserved
PER ASPERA
AD ASTRA
PER ASPERA, AD ASTRA
CAROLINA AGUILAR
CO-FOUNDER DOT2DOT & INVALUE
Outcomes Driven Ecosystems

IN THIS 30% YOU DIE
WHERE WOULD YOU GO IF YOU HAD A HEALTH PROBLEM??
SOURCE: https://www.bhi.nsw.gov.au/BHI_reports/mortality/Mortality-following-hospitalisation

3
SOURCE: EIT Health VBHC Implementation Guide 2020
WHERE WOULD YOU GO IF YOU HAD A HEALTH PROBLEM??

VALUE CARE IMPLEMENTATION SEEMS HARD…..

6
VALUE CARE IMPLEMENTATION IT IS ACTUALLY HARD….
VARIATIONS IN
CLINICAL PRACTICE
COMPLEX CARE PATHWAYS
DATA FRAGMENTATION
TRANSACTION-BASED
INCENTIVES

1. Not everybody is ready for VBHC
2. This is more like a crossing of the chasm journey
3. It’s an ecosystem, not a single man journey
1. Economics need to work for the ecosystem. Short-term versus long term balance is key!
2. We can not be sure incentives are rightly placed on the system. Changes will be needed, Building TRUST is key!
3. The ability to understand and model risk is a must!
HOWEVER UNDERSTANDING THE HURDLES, WE CAN OVER COME THEM
RELATIONSHIP-DRIVEN
ECONOMICALLY-DRIVEN
1. Fragmented Healthcare Systems
2. Appropriate data-gathering, analytical, and operational capabilities are required.
3. Significant payer and provider infrastructure is necessary to monitor real life outcomes-based
agreement.
STRUCTURAL & OPERATIONALLY-DRIVEN

9
WHEN FOCUSING ON THE EARLY ADOPTERS, WONDERS HAPPEN!
RELATIONSHIP BOOSTERS
THINK WHERE TO BUILD YOUR VBHC ECOSYSTEM
SOURCE: The Economist, Intelligent Unit 2017

1
0
THE EARLY ADOPTERS ARE READY FOR TRANSPARENCY!! …WHICH
BRINGS THE RIGHT INCENTIVES
SOURCE: EIT Health Implementation Book 2020
RELATIONSHIP BOOSTERS

11
IDENTIFY CHALLENGES
IN DISEASE JOURNEY
1
IDENTIFY THE OUTCOMES
THAT MATTERS TO YOUR
PATIENT POPULATION
2
REDEFINE THE DISEASE JOURNEY
TO INCREASE OUTCOMES &
DECREASE COST
3
MAP & ENGAGE THE DISEASE
ECOSYSTEM
4
DEMONSTRATE THE VALUE FOR
THE HEALTHCARE SYSTEM5
BENCHMARK & EXPAND6
© INVALUE; All Rights Reserved
DIGITAL STRATEGY
STRUCTURAL & OPERATIONAL BOOSTERS
PUT THE RIGHT PROCESS WITH THE RIGHT STAKEHOLDERS

12
STRUCTURAL & OPERATIONAL BOOSTERS
PUT THE RIGHT PROCESS WITH THE RIGHT STAKEHOLDERS
1
2
Presentation Title (Edit on Slide Master) | June 1, 2015 |
Confidential, for Internal Use Only
THE DIABETER MODEL – WINNER OF EUROPEAN VBHC AWARD 2018
SOURCE: EIT Health Implementation Book 2020

13
TIGHT THE RIGHT FINANCIAL PLAN TO THE MODEL
SUSTAINAIBLE ECONOMIC PARTNERSHIPS

Bright Idea 3
Validation center: fast track for digital health

DayOne Conference – Shaping the future of health
Jens Eckstein, Basel
Clinical Validation Center:
Fast track for digital health

• Ground truth of algorithms from “healthy individuals”
• Lack of understanding for the needs of patients, HCPs, Hospitals
• Standards often perceived as “obstacles” rather than quality
• Different Business Model (Data driven vs. fee for service)
Why is the transfer of commercial mobile
sensor technology to healthcare difficult?

Basler Band
Projekt
Heart rate
Rhythm
HRV
Respiration rate
Activity
Saturation
Body core temperature
Blood pressure
Mobile Monitoring

Projekt
… for outpatients – will come 2021

Future Friday @ USB
• Open to all employees and external partners
• Low threshold to enter
• Tailored support for six months
• Competitive setting
• Fast track to clinical use

Clinical validation center for applied e-health
• Uncomplicated testing and consulting
• Iterative agile development
• Highest health care standards
• Access to patients
(if needed and approved by ethics committee)

Why?
• It’s fun
• Leverage the potential around us
• Get & keep innovative people on board
• Optimize our care for our patients
• Early access to cutting edge innovation
• Return on invest
• Proud employees and happy patients

Summary
• Integration of new technologies into health care
require adaptation to the specific environment
• It’s always about team-work
• Be prepared to fail
• Retry if you do so ;-)
• Keep the owners of the ideas in the drivers seat

The people who make it happen 
Dept. D&ICT: M.Strasser
CMIO Team: B.Hölz, J.Timiliotis, B.Blümke, P.Serfözö, A.Winterhald
er,
N.Brasier, F.DeIeso, M.Mutke, M.D‘Souza, U.Schmitt, E.Seger,...
Board & employees of Unispital Basel, external partners
and....our patients

Join us tomorrow live at noon
for the Future Friday @ USB:
www.unispital-basel.ch/futurefrida
y
Kontakt: jens.eckstein@usb.ch

Bright Idea 4
Personalized nutrition and health extension
James Bauly, DSM

Personalization is everywhere…
2Page

Personalized Nutrition is an opportunity to improve health and wellness
3Page

Personalized nutrition product solutions range from cohort-based to
fully individualized
MASS CUSTOMIZED n=“a few”
eg Personal Pill Packs
FULLY INDIVIUALIZED n=1
eg Panaceutic Food Pouches
eg Granules in stick packs
TARGETED COHORTS n=many
eg Eye Health formula
(standard supplement)
4Page

Personalized Immunity Concept
AVA
Receive insights on your
nutritional gaps
Quickly see which lifestyle factors are
influencing overall immunity
Receive personalized product information
addressing your specific needs
End users can track key elements contributing to healthy immunity and can select relevant micronutrient options

6
Key partnerships in Elite Sports

7
Personalized Nutrition improvements in blood biomarkers of
several vitamins and omegas in elite footballers
Results of participants, who were taking the supplement regularly (N=17 of 30 participants)
Continuous improvement over all three tests.
Median is within the optimum area.
Endurance| Cognitive Function| Mood
Continuous improvement over all three tests. Median is
within the optimum range after three tests.
Anti-Inflammatory| Sports Performance| Reduction of Muscle Injury

8
Users reported improvements in key performance drivers
STRESS
Sleep quality
Stress resistance
Scale: 1 = very bad ßà 5 = very good
PHYSIQUE & HEALTH
Scale: 1 = no problems ßà 5 = many problems
Infections
Heart beats
RECOVERY
Fatigue
Mood swings
Scale: 1 = never ßà 5 = always
Tracked through self assessment

DSM Nutritional Products
Health & Nutrition Campus
Kaiseraugst

Executive talk
Thomas Szucs
Professor University of Basel
President of the Board Helsana

Networking Break
1) Topic Areas
2) Random

Where is Thomas?
Find him in a session to win one of 5 goodie bags
• Chocolate box
• Set of notebooks for your ideas
• Pens to fill them up with
• Startup Guide of Switzerland
1:1 Networking Sessions
3 minute each
All art credits for Where's Waldo/ Where's Wally go to the creators of the character Martin Handford,
Dreamworks Animation Television and Peacock and owners of the trademark

Session Two
How to make it
happen

11:30 Entrepreneurs Talk
Alexandra Greenhill, Founder Careteam Technologies (Canada)
Siva Ramamoorthy, serial entrepreneur and investor (India)
Followed by a panel with Doug Häggstrom, DayOne Acceleration
12:15 How to create a digital health venture - the DayOne approach
Doug Häggström and Roberto Roberto Iannone, Zoundream
Followed by welcome Special Guest and Introduction to the afternoon
Agenda

Alexandra Greenhill, Founder Careteam Technologies

Your next step in digital health™
What it takes to bring a digital
health venture to success
Dr. Alexandra T. Greenhill
CEO and Chief Medical Ofﬁcer
Careteam Technologies

www.getcareteam.com
The digital transformation of healthcare
Digitise what exists:
EMRs, apps
The future is now:
Virtual first care
Add new:
Telehealth, FHIR
Phase I Phase IIIPhase II
2010s1990s -2000s NOW

www.getcareteam.com
CARE in the
COMMUNITY
SOCIAL
SUPPORT
PRIMARY
CARE
OTHER
PROVIDERS
SPECIALTY
CARE
HOSPITALS
REHAB and
FACILITIES
HOME
CARE
INSURANCE
PHARMA
Patient and family ASSOCIATIONS

www.getcareteam.com
Diagram of a cancer patient journey. Source: DeepDive Oncology 2017.

www.getcareteam.com
FAMILY PATIENT
CLINICIANS PAYMENT
RULES

www.getcareteam.com
George Berger
patient
Marie Berger
wife
Lisa Berger
daughter
Primary
care
Specialty
care
Insurance
Home
careAssocia
tions
Pharma
DevicesApps
Other
services

www.getcareteam.com
Address the
whole person
Focus on prevention
and planning
LIFE
Referral
Discharge Notification
Referral/
Consult
Referral/
Consult
Referral/
Consult
HEALTH

www.getcareteam.com
A virtual care coordination and collaboration platform
Decision-makersHealth teams
Healthcare-grade privacy,
security, medico-legal
Sharing enabled with
Privacy-by-Patient™
Integrations with
health and life tech
CLINICAL WORKFLOW
Patients Families
PATIENT WORKFLOW

www.getcareteam.com
www.physicianinnovator.com

www.getcareteam.com
Contact
Alexandra T. Greenhill M.D.
CEO | Chief Medical Ofﬁcer
agreenhill@getcareteam.com
www.getcareteam.com
Your next step in digital health™

Doug Häggstrom, DayOne Acceleration

How to create a digital health venture - the DayOne
approach
Doug Häggström, DayOne, and Roberto Roberto
Iannone, Zoundream

Aurelie Moser, Introduction to the Venture Journey

and be back at 13.30
for the Open Innovation session!

Wrap up
Take home
messages
DayOne Conference
12. November 2020

Fabian Streiff, Head of DayOne,
Basel Area Business & Innovation

Shaping the future of health together
© 2019 Basel Area, Switzerland, all rights reserved.
Visit the site- just relaunched for you!
 www.dayone.swiss
Expert Event: Public Health
 Save the date 08.12.20
Apply for the Accelerator
 @ dayone.swiss/accelerator
Sign up
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Continue the conversation
 LinkedIn @baselarea-business-innovation
 Twitter @baselarea #dayonebasel

Thank you
Follow us at
www.dayone.swiss
DayOne is the Healthcare Innovation initiative managed by
Basel Area Business & Innovation

5th Annual DayOne Conference (Nov. 2020)

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