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Similar to 34. antiviral agents
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34. antiviral agents
- 2. Antiherpes agents -
Acyclovir, valacyclovir, famciclovir, ganciclovir
idoxuridine, foscarnet
Antiretroviral agents-
a) Nucleoside reverse transcriptase inhibitors
(NRTIs):
Zidovudine, stavudine, lamivudine,
didanosine, zalcitabine, abacavir
- 3. b) Non-nucleoside reverse transcriptase
inhibitors (NNRTIs):
Nevirapine, efavirenz, delavirdine
c) Protease inhibitors:
Ritonavir, indinavir, nelfinavir, saquinavir,
lopinavir
Anti –influenza agents: amantadine
rimantadine
- 4. Selectively taken up by the virus
infected cells
Requires a virus specific enzyme for
conversion to the active metabolite
- 6. Genital herpes simplex infections
Mucocutaneous HSV
Herpetic encephalitis
Herpetic keratitis
Herpes zoster
Chicken pox
- 7. Nausea, vomiting, diarrhoea, headache
Neurotoxicity – tremors, confusion,
disorientation, convulsions
Topical use – irritation, burning & itching