Institute for Microbiology, Medical Faculty of Masaryk University and St. Anna Faculty Hospital in Brno

Institute for Microbiology, Medical Faculty of Masaryk University and St. Anna Faculty Hospital in Brno Miroslav Votava, Vladana Woznicová FACTORS OF PATHOGENICITY AND VIRULENCE – I Lecture for 2nd-year students April 6 th , 200 9

MICROBE obligately opportunistically Species: pathogenic pathogenic non-pathogenic Strain: virulent avirulent Individual: sensitive nonspecifically unresponsive or specifically immune Species: susceptible resistant HOST

e.g. Anthrax Vaccine Adsorbed is a sterile product made from filtrates of microaerophilic cultures of an avirulent , nonencapsulated strain of Bacillus anthracis which elaborates the protective antigen during the growth period.

Three elements of pathogenicity and virulence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Transmissibility – I ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Transmissibility – II ,[object Object],[object Object],[object Object],[object Object],[object Object]

Transmissibility – III ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Transmissibility – IV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Invasiveness – entering the host ,[object Object],[object Object],[object Object],[object Object],[object Object]

Adherence factors of bacteria ,[object Object],[object Object],[object Object],[object Object],[object Object]

Adherence factors of other microbes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

http://img.tfd.com http://www.abpi.org.uk

http://human-infections.suite101.com http://www.biotech-weblog.com

Penetration into internal environment – I ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Penetration into internal environment – II ,[object Object],[object Object],[object Object],[object Object],[object Object]

Ability to multiply in vivo ,[object Object],[object Object],[object Object],[object Object]

Ability to spread through the macroorganism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Recommended reading material ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Institute for Microbiology, Medical Faculty of Masaryk University and St. Anna Faculty Hospital in Brno

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Institute for Microbiology, Medical Faculty of Masaryk University and St. Anna Faculty Hospital in Brno