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Lecture 1 Supplementary slides.pptx
- 1. In the rest of this lecture, you will see many metabolic pathways with a lot of chemical structure You don't need to memorize all of them, but you need to be able to pull the information out when needed I use them as examples to show what kind of chemical transformations cells usually do, and which chemicals are abundant in cells. This information is critical when we want to produce a new product via metabolic engineering.
- 2. Glc G6p Gap R5p Pyr AcCoA amino acids Oaa αkg Glu NH4 + Basic metabolic pathways Amino acid synthesis E. coli's as example
- 3. Basic metabolic pathways Glutamate family of AAs Glc G6p Gap Pyr AcCoA Oaa αkg
- 4. Basic metabolic pathways Glutamate family of AAs Glc G6p Gap Pyr AcCoA Oaa αkg Glu NH4 + Pro Gln Arg Asp Ornithine
- 5. Basic metabolic pathways Aspartate family of AAs Glc G6p Gap Pyr AcCoA Oaa αkg
- 6. Basic metabolic pathways Aspartate family of AAs Glc G6p Gap Pyr AcCoA Oaa αkg Asp Asn Lys Ile Thr Met homoserine
- 7. Basic metabolic pathways Aspartate family of AAs – Ile Glc G6p Gap R5p Pyr AcCoA Oaa αkg Asp Thr CO2 Pyr Ile homoserine
- 8. Basic metabolic pathways Aspartate family of AAs – Met Glc G6p Gap R5p Pyr AcCoA Oaa αkg Asp homoserine SucCoA Suc Cys Met
- 9. Basic metabolic pathways Aspartate family of AAs – Lys Glc G6p Gap R5p Pyr AcCoA Oaa αkg Asp Pyr SucCoA Suc CO2 Lys
- 10. Basic metabolic pathways Pyruvate family of AAs Glc G6p Gap Pyr AcCoA Oaa αkg Ala Val AcCoA CO2 Leu CO2
- 11. Basic metabolic pathways Serine family of AAs Glc G6p Gap Pyr AcCoA Oaa αkg 3pg Ser Gly AcCoA Cys
- 12. Basic metabolic pathways Aromatic family of AAs Glc G6p Gap Pyr AcCoA Oaa αkg Pep Pep Trp Tyr Phe E4P See supplementary slides for the complete pathway
- 13. Basic metabolic pathways Aromatic family of AAs - Tyr & Phe Tyr Phe CO2 CO2
- 14. Basic metabolic pathways Aromatic family of AAs - Trp Gap Ser Trp
- 15. Basic metabolic pathways Amino acid - Histidine & PPP Glc G6p Gap Pyr His E4p F6p Gap S7p R5p X5p CO2
- 16. Glc G6p Gap R5p nucleotides Pyr AcCoA Oaa αkg deoxy nucleotides Basic metabolic pathways Nucleotide biosynthesis E. coli's as example
- 17. Basic metabolic pathways Purine nucleotide synthesis Glc G6p Gap R5p Gly Cho-Thf Thf CO2 Cho-Thf Thf IMP
- 18. Basic metabolic pathways Purine nucleotide synthesis IMP AMP GMP ADP ATP dADP dATP GDP GTP dGDP dGTP
- 19. Basic metabolic pathways Pyrimidine nucleotide synthesis Glc G6p Gap R5p CO2 UMP CTP UTP UDP dUDP dUMP dTMP dTTP CDP dCDP dCTP orotate See supplementary slides for the complete pathway
- 20. Basic metabolic pathways Pyrimidine nucleotide synthesis - orotate
- 21. http://chemistry.umeche.maine.edu/CHY251/dlwrong.html Chiral molecules D: dexter (on the right) L: laevus (on the left) R: rectus (right-handed) S: sinister (left-handed) D-glyceraldehyde L-glyceraldehyde Gold standard D-cysteine D-erythrose L-threose Take home message: the DL system is ambiguous and not scalable