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PREDICTION OF 5-YEAR SURVIVAL OF NON-SMALL CELL LUNG CANCER PATIENTS WITH STAGE III AFTER COMPLETE RESECTIONS Oleg Kshivets, MD, PhD  Department of Surgery, Siauliai Cancer Center, Siauliai, Lithuania 2004 ASCO Annual Meeting, New Orleans, Louisiana, the USA, June 3-8, 2004
Abstract ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Factors: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Main Problem of Analysis of Alive Supersystems (e.g. Lung Cancer Patient Homeostasis):  Phenomenon of «Combinatorial Explosion» ,[object Object],[object Object],[object Object],[object Object]
Basis: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Radical Procedures: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Combined &   E xtensive  R adical  P rocedures with  R esection of  P ericardium,  L eft  A trium,  A orta,  V ena  C ava  S uperior,  V ena  A zygos,  C arina,  Trachea, D iaphragm,  C hest  W all , Ribs, etc…..……………………. 67 Sistematic Mediastinal Lymph Node-N2 Dissection………….. 139
Staging: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Samplings: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adjuvant Therapy after Complete Resections ,[object Object],[object Object]
Survival Rate of Lung Cancer Patients with  Stage III after Complete Resections (n=139): ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Significant  Factors  between Lung Cancer Losses & 5-Year Survivors with Stage III (n=131) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Product-Limit (Kaplan-Maier) Analysis Results in Prediction of Lung Cancer Patients Survival with Stage III after Complete Resections (n=139)  Graph of Survival Times vs. Cum. Proportion Surviving
Cumulative Proportion Lung Cancer Patients Surviving (Kaplan-Meier) (n=139)
Cumulative Proportion Lung Cancer Patients Surviving (Kaplan-Meier)
Results of Multivariate Proportional Hazard Cox Regression Analysis:
Results of Multifactor Analysis in Prediction of Lung Cancer Patients Survival with Stage IIIA & IIIB (n=139)
Results of Discriminant Analysis in Prediction of Lung Cancer Patients Survival with Stage III after Complete Resections (n=131) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Results of Logistic Regression Analysis in Prediction of Lung Cancer Patients Survival with Stage III  after Complete Resections (n=131) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Results of Clustering in Prediction of Lung Cancer Patients  5-Year Survival (n=131)
Results of Clustering in Prediction of Lung Cancer Patients Survival  with Stage III after Complete Resections (n=131) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Results of  Correspondence  Analysis in Prediction of  Lung  Cancer Patients Survival with Stage III (n=131)
Results of Bootstrap Resampling in Prediction of 5-Year Survival of Lung Cancer Patients with Stage III (n=131; subsamplings=935)
Results of Bootstrap Resampling in Prediction of 5-Year Survival of Lung Cancer Patients with Stage III (n=131; subsamplings=935)
Results of  Bootstrap   Simulation  in Prediction of Lung Cancer Patients Survival   with Stage III after Complete Resections (n=131 ; subsamplings=935 )   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Results of Neural Networks Computing in Prediction of Lung Cancer Patients Survival   with Stage III after Complete Resections (n=131)   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Neural Networks in Prediction of Lung Cancer Patients Survival (n=131) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prediction of  Lung  Cancer Patients Survival with Stage III after Complete Resections (n=131) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prediction of  Lung  Cancer Patients Survival with Stage III after Complete Resections (n=131) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lymphocyte  &  Monocyte  Circuit in  Prediction  of Lung Cancer  Patients Survival  with Stage III (n=131)
Ratio of Segmented Neutrophile and Cancer Cell Populations  &  Blood Glucose Level  in  Prediction  of Lung Cancer  Patients Survival with Stage III  (n=131)
Weight  &  Prothrombin Index  in  Prediction  of Lung Cancer  Patients Survival with Stage III  (n=131)
Significant Networks between Clinicopathologic, Biochemic, Hemostasis & Hematologic Data and 5-Year Survival of Lung cancer Patients with Stage III (n=131)
Results of Monte Carlo Simulation in Prediction of Lung Cancer Patients Survival with Stage III (n=131)
SEPATH Networks in Prediction of Lung Cancer Patients Survival with Stage III (n=131)
Holling-Tenner Models of Alive Supersystem “Lung Cancer-Cytotoxic Cell Population ”
Lung Cancer Dynamics
 
Conclusions: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Address: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Kshivets O. Lung Cancer Stage III Surgery

  • 1. PREDICTION OF 5-YEAR SURVIVAL OF NON-SMALL CELL LUNG CANCER PATIENTS WITH STAGE III AFTER COMPLETE RESECTIONS Oleg Kshivets, MD, PhD Department of Surgery, Siauliai Cancer Center, Siauliai, Lithuania 2004 ASCO Annual Meeting, New Orleans, Louisiana, the USA, June 3-8, 2004
  • 2.
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  • 4.
  • 5.
  • 6.
  • 7. Combined & E xtensive R adical P rocedures with R esection of P ericardium, L eft A trium, A orta, V ena C ava S uperior, V ena A zygos, C arina, Trachea, D iaphragm, C hest W all , Ribs, etc…..……………………. 67 Sistematic Mediastinal Lymph Node-N2 Dissection………….. 139
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13. Product-Limit (Kaplan-Maier) Analysis Results in Prediction of Lung Cancer Patients Survival with Stage III after Complete Resections (n=139) Graph of Survival Times vs. Cum. Proportion Surviving
  • 14. Cumulative Proportion Lung Cancer Patients Surviving (Kaplan-Meier) (n=139)
  • 15. Cumulative Proportion Lung Cancer Patients Surviving (Kaplan-Meier)
  • 16. Results of Multivariate Proportional Hazard Cox Regression Analysis:
  • 17. Results of Multifactor Analysis in Prediction of Lung Cancer Patients Survival with Stage IIIA & IIIB (n=139)
  • 18.
  • 19.
  • 20. Results of Clustering in Prediction of Lung Cancer Patients 5-Year Survival (n=131)
  • 21.
  • 22. Results of Correspondence Analysis in Prediction of Lung Cancer Patients Survival with Stage III (n=131)
  • 23. Results of Bootstrap Resampling in Prediction of 5-Year Survival of Lung Cancer Patients with Stage III (n=131; subsamplings=935)
  • 24. Results of Bootstrap Resampling in Prediction of 5-Year Survival of Lung Cancer Patients with Stage III (n=131; subsamplings=935)
  • 25.
  • 26.
  • 27.
  • 28.
  • 29.
  • 30. Lymphocyte & Monocyte Circuit in Prediction of Lung Cancer Patients Survival with Stage III (n=131)
  • 31. Ratio of Segmented Neutrophile and Cancer Cell Populations & Blood Glucose Level in Prediction of Lung Cancer Patients Survival with Stage III (n=131)
  • 32. Weight & Prothrombin Index in Prediction of Lung Cancer Patients Survival with Stage III (n=131)
  • 33. Significant Networks between Clinicopathologic, Biochemic, Hemostasis & Hematologic Data and 5-Year Survival of Lung cancer Patients with Stage III (n=131)
  • 34. Results of Monte Carlo Simulation in Prediction of Lung Cancer Patients Survival with Stage III (n=131)
  • 35. SEPATH Networks in Prediction of Lung Cancer Patients Survival with Stage III (n=131)
  • 36. Holling-Tenner Models of Alive Supersystem “Lung Cancer-Cytotoxic Cell Population ”
  • 38.  
  • 39.
  • 40.