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ARTFICIAL INTELLIGENCE, SYSTEM ANALYSIS AND SIMULATION MODELING IN PREDICTION OF  5-YEAR SURVIVAL OF CARDIOESOPHAGEAL CANCER  PATIENTS AFTER COMPLETE LEFT THORACOABDOMINAL ESOPHAGOGASTRECTOMIES   Oleg Kshivets, MD, PhD   Department of Surgery, Siauliai Public Hospital & Cancer Center, Lithuania The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Abstract ,[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Data ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Radical Procedures ,[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Schemas of Procedures The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Procedures
One-Stage  Esophagogastroplasty or Esophagoenteroplasty
Schemas of Combined Procedures The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Schemas of D3 Lymphadenectomy The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Staging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Survival Rate ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
General Cardioesophageal Cancer Patients Survival  after Complete Left Thoracoabdominal Esophagogastrectomies (Kaplan-Meier) ( n=150 ) The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Univariate Analysis in Prediction of Cardioesophageal Cancer Patients Survival  ( n=150 )
Results of Univariate Analysis in Prediction of Cardioesophageal Cancer Patients Survival  ( n=150 )
Results of Univariate Analysis in Prediction of Cardioesophageal Cancer Patients Survival  ( n=150 ) The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Cox Regression Modeling in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 )   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Cox Regression Modeling in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 )   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Discriminant Analysis   in  Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Logistic Regression Analysis   in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chi2=105.11; df=15;  P=0.0000 ; Odds ratio=86.70 The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Correspondence Analysis in Prediction of Cardioesophageal Cancer Patients Survival (n=150)   The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Multi-Factor Clustering of Clinicopathological Data in Prediction of Cardioesophageal Cancer Patients Survival (n=150) The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Neural Networks  in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of  Kohonen Self-Organizing  Neural Networks Computing  in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150)   The 60th Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Neural Networks Computing   in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 )   Error=0.0011; Area under ROC Curve=1.00; Correct Classification Rate=100% ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Bootstrap Simulation  in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 )   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Bootstrap Simulation  in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 )   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Results of Bootstrap Simulation  in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 )   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Ratio of Lymphocytes to Cancer Cells & Glucose Level  in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 )   The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Prognostic SEPATH-Model of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies, n=150   The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Holling-Tenner Models of Cardioesophageal  Cancer Cell Population and  Cytotoxic Cell Population Dynamics
Cardioesophageal Cancer Dynamics
Conclusions: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Conclusions: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA
Address: Oleg Kshivets  M.D., Ph.D., Consultant Thoracic, Abdominal, General Surgeon & Surgical Oncologist  ,[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th  Annual Meeting of Society of Surgical Oncology  March 15-18, 2007, Washington , DC, the USA

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Kshivets O. Cardioesophageal Cancer Surgery

  • 1. ARTFICIAL INTELLIGENCE, SYSTEM ANALYSIS AND SIMULATION MODELING IN PREDICTION OF 5-YEAR SURVIVAL OF CARDIOESOPHAGEAL CANCER PATIENTS AFTER COMPLETE LEFT THORACOABDOMINAL ESOPHAGOGASTRECTOMIES Oleg Kshivets, MD, PhD Department of Surgery, Siauliai Public Hospital & Cancer Center, Lithuania The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 2.
  • 3.
  • 4.
  • 5. Schemas of Procedures The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 7. One-Stage Esophagogastroplasty or Esophagoenteroplasty
  • 8. Schemas of Combined Procedures The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 9. Schemas of D3 Lymphadenectomy The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 10.
  • 11.
  • 12. General Cardioesophageal Cancer Patients Survival after Complete Left Thoracoabdominal Esophagogastrectomies (Kaplan-Meier) ( n=150 ) The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 13. Results of Univariate Analysis in Prediction of Cardioesophageal Cancer Patients Survival ( n=150 )
  • 14. Results of Univariate Analysis in Prediction of Cardioesophageal Cancer Patients Survival ( n=150 )
  • 15. Results of Univariate Analysis in Prediction of Cardioesophageal Cancer Patients Survival ( n=150 ) The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 16.
  • 17.
  • 18.
  • 19.
  • 20. Results of Correspondence Analysis in Prediction of Cardioesophageal Cancer Patients Survival (n=150) The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 21. Results of Multi-Factor Clustering of Clinicopathological Data in Prediction of Cardioesophageal Cancer Patients Survival (n=150) The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 22.
  • 23. Results of Kohonen Self-Organizing Neural Networks Computing in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150) The 60th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.
  • 29. Ratio of Lymphocytes to Cancer Cells & Glucose Level in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 30. Prognostic SEPATH-Model of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies, n=150 The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA
  • 31. Holling-Tenner Models of Cardioesophageal Cancer Cell Population and Cytotoxic Cell Population Dynamics
  • 33.
  • 34.
  • 35.