Presentation given during Cost AMiCI meeting in Tallinn Nov 2017 by Tanel Tenson Professor in the technology of antimicrobial compounds University of Tartu Estonia

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Tanel Tenson
University of Tartu
Institute of Technology
Emergence and spread of antibiotic resistance
Tanel Tenson
Professor in the technology of antimicrobial compounds
University of Tartu
Estonia
Background: Biology (microbiology, biochemistry, molecular biology)
Research interests:
Mechanisms of antibiotic action
Emergence and spread of antibiotic resistance

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WHERE DOES
THE RESISTANCE EMERGE?
DOG CHILD

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1. ANTIBIOTIC RESISTANCE
NETWORK
MECHANISMS OF RESISTANCE

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HORIZONTAL GENE TRANSFER
1. TRANSDUCTION
2. TRASFORMATION
DNA
DNA
DNA
HORIZONTAL GENE TRANSFER
3. CONJUGATION

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MOBILE GENETIC ELEMENTS
plasmids
transposons
2. MULTIRESISTANCE

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MULTIRESISTANCE – NOT ONLY ANTIBIOTICS
NOT ONLY ANTIBIOTICS
Acinetobacter baumannii strain AYE exhibits
an 86-kb genomic region termed a resistance
in which 45 resistance genes are clustered.
At the homologous location, the SDF strain exhibits a
20 kb-genomic island flanked by transposases
but devoid of resistance markers.
Such a switching genomic structure might
be a hotspot that could explain the rapid acquisition
of resistance markers under antimicrobial pressure.
Sequence similarity and phylogenetic analyses confirm
that most of the resistance genes found
in the A. baumannii strain AYE have been recently acquired from
bacteria of the genera Pseudomonas, Salmonella, or Escherichia.

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Figure 2. Layout of the Complete AbaR1 Inserted into the AYE Strain ATPase‐Encoding Gene
Fournier P-E, Vallenet D, Barbe V, Audic S, et al. (2006) Comparative Genomics of Multidrug Resistance in Acinetobacter baumannii. PLoS
Genet 2(1): e7. doi:10.1371/journal.pgen.0020007
http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020007
HOW SAFE IS SOAP?

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Blair and Piddock, 2009
EFFLUX PUMPS
Herbert P. Schweizer 2002, Genetics and Molecular Research

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3. ANTIBIOTIC RESISTANCE CAN BE CO‐SELECTED
WITH RESISTANCE TO HEAVY METALS
AND DESINFECTANTS