Revolade 12.5mg is mainly indicated for the treatment of patients having lower platelet levels due to chronic immune thrombocytopenia and chronic hepatitis C virus infection @ Apple Pharmaceuticals

1. Revolade 12.5mg tablet | Apple
pharmaceuticals
INDICATION
DOSAGE
MECHANISM
ADME
PRECAUTION
DRUG INTERACTION
STORAGE
MISSED DOSE
SIDE EFFECTS

2.  Revolade 12.5mg is a prescription drug which is used
under the supervision of the doctor.
 Revolade 12.5mg drug may be used as part of a co-
administration therapy. Hence drug may require for
taking it with other medications.
Revolade 12.5mg, Revolade 12.5mg tablet

3. Revolade 12.5mg is mainly indicated for the treatment
of patients having :
 lower platelet levels due to chronic immune
thrombocytopenia
 lower platelet counts due to chronic hepatitis C virus
infection
 Severe aplastic Anemia :
 First line treatment of severe aplastic Anemia
 Treatment of refractory severe aplastic Anemia
INDICATION

4. Chronic Immune Thrombocytopenia
 The recommended dose of Revolade 12.5mg has Initial: 50
mg PO qDay Adjust dose to achieve Control platelet count
(Plt) >50 x 10^9/L to reduces risk of bleeding; not to
exceed 75 mg/day
Chronic Hepatitis C-associated Thrombocytopenia
 The recommended dose of Revolade 12.5mg has Initial: 25
mg PO qDay Dose is Adjust in 25 mg accretion q2weeks
PRN to attain target Plt needed to start/control antiviral
therapy with pegylated interferon and ribavirin; not to
exceed 100 mg/day During antiviral therapy, regulate dose
to stop dose reductions of peginterferon Severe Aplastic
Anemia
DOSAGE

5.  First-line therapy: Concomitant use with standard
immunosuppressive therapy, for patients with serious aplastic
Anemia (SAA) The recommended dose of Revolade: 150 mg PO
qDay for 6 months Do not give more than starting dose; total
duration is 6 months
Refractory SAA
 The drug given for this condition who fail to respond enough to
at least 1 before immunosuppressive therapy The recommended
dose of Revolade 12.5mg: 50 mg PO qDay Adjust dose in 50-mg
accretion q2Weeks PRN to attain target Plt ≥50 x 10^9/L as
required; not exceed 150 mg/day; may take up to 16 weeks for
hematologic response.

6.  Revolade 12.5mg belongs to growth factors which excite
platelet production through the thrombopoietin (TPO)
receptor. Eltrombopag is a thrombopoietin nonpeptide
agonist which have high platelet counts by binding to and
activating the TPO receptor. It stimulates pathways within
the cell to raises the production and development of
marrow progenitor (parent) cells to strengthen platelet
production.
MECHANISM

7. Absorption:
 peak plasma concentration is 2-6 hours
Distribution:
 highly human plasma protein bounding is >99% and in blood
plasma level is 50% to 79%
Metabolism:
 predominantly metabolised through cleavage, oxidation and
conjugation with glucuronic acid.
Elimination:
 Revolade 12.5mg eliminated primarily via feces 59%, along with
31% via renally excreted
 Half-life of Revolade 12.5mg healthy patients is 21-23 hours and
idiopathic thrombocytopenic purpura is 26-35 hours.
ADME

8. PRECAUTION
 The drug causes warning condition call the doctor while
new medication interaction If other blood clot risk factors,
then avoid the drug because it will high level of platelet
counts and blood clots.
 If the patients have cataracts, avoid the drug due to the
drug effects cataracts and make the condition worse.
 Disease progression warning: Avoid using the Revolade
12.5mg while the patients have myelodysplastic syndrome
(MDS), will increases the risk of death.
Revolade 12.5mg, Revolade 12.5mg tablet

9.  Revolade 12.5mg co administration with these drugs ezetimibe,
glyburide, Olmesartan, repaglinide, valsartan, imatinib,
irinotecan, lapatinib, methotrexate, mitoxantrone, Bosentan,
sulfasalazine, and topotecan irinotecan leads increase of side
effects. hence the doctor may reduce your dosage of these
drugs if required.
 Revolade 12.5mg concomitant use with Cholesterol-reducing
drugs like atorvastatin, fluvastatin, rosuvastatin, pravastatin, and
simvastatin, pitavastatin. Have high side effects can contains
muscle pain. The doctor may decrease the dosage of your
cholesterol drugs.
 Revolade 12.5mg combination with Antacids, vitamins, or
supplements which involves Ca, Al, Fe, Se, Zn, or Mg. To stop
interactions, then take Revolade two hours before or four hours
after administrating any of these products.
DRUG INTERACTION

10.  STORAGE
 Store at room temperature 20°C and
25°C.
 Discard the left-out medicine if not used within 30
minutes
 MISSED DOSE
 In case of missed dose, patients must consult with
medical practitioner and follow the instructions given
by them. thereby missed dose should be avoid and
follow the regular dosing schedule.

11.  Lack of appetite
 flu
 diarrhoea
 Urine in dark colour
 Yellowing of your skin
 low red blood cells
 nausea
 fever
 weakness
 pain in head
SIDE EFFECTS

12.  cough
 Abdomen swelling
 Confusion
 Chest pain
 Dyspnea
 Cloudy vision
 Sensitivity to light
 Seeing circles around lights
 Swelling of legs

13.  Phone : 9987711567
 Email : applepharmaceutical@gmail.com
 Email : info@myapplepharma.com
 Website : https://myapplepharma.com/eltrombopag-
12.5mg.php
 https://myapplepharma.com/eltrombopag.p
hp
CONTACT DETAILS